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16,300 grants matching “fatty liver disease”
Inflammation, HDL and class B Scavenger Rectors
$296,804Deneys Rem Van Der Westhuyzen · University Of Kentucky · P01 · FY2011 · HL
Hepatic Lipid Mobilization by Nuclear Hormone Receptors
$296,757Yoon-Kwang Lee · Northeast Ohio Medical University · R01 · FY2013 · DK
Hepatic Lipid Mobilization by Nuclear Hormone Receptors
$296,757Yoon-Kwang Lee · Northeast Ohio Medical University · R01 · FY2015 · DK
Hepatic Lipid Mobilization by Nuclear Hormone Receptors
$296,757Yoon-Kwang Lee · Northeast Ohio Medical University · R01 · FY2014 · DK
Hepatic Lipid Mobilization by Nuclear Hormone Receptors
$296,757Yoon-Kwang Lee · Northeast Ohio Medical University · R01 · FY2016 · DK
Hepatic Lipid Mobilization by Nuclear Hormone Receptors
$296,757Yoon-Kwang Lee · Northeast Ohio Medical University · R01 · FY2017 · DK
Role of FXR in Renal Disease of Metabolic Syndrome and Aging
$296,743Moshe Levi · University Of Colorado Denver · R01 · FY2010 · AG
Structure and Function of Serum Amyloid A in Health and Disease
$296,685Olga Gursky · Boston University Medical Campus · R01 · FY2024 · GM
Toward Repurposing a Commonly-Used Medication for the Treatment of Pediatric Severe Obesity
$296,647Claudia K Fox · University Of Minnesota · R01 · FY2024 · DK
Targeting galectin-3 to intervene COVID-19
$296,637Hafiz Ahmed · Glycomantra, Inc. · R43 · FY2023 · AI
MOLECULAR Genetic Mouse CORE
$296,594Richard A Flavell · Yale University · P30 · FY2014 · DK
MOLECULAR Genetic Mouse CORE
$296,594Richard A Flavell · Yale University · P30 · FY2016 · DK
MOLECULAR Genetic Mouse CORE
$296,594Richard A Flavell · Yale University · P30 · FY2015 · DK
MOLECULAR Genetic Mouse CORE
$296,593Richard A Flavell · Yale University · P30 · FY2017 · DK
Gene Delivery and Addiction
$296,506Brandon Harvey · National Institute On Drug Abuse · ZIA · FY2017 · DA
Analysis of new compounds to treat familial hypercholesterolemia
$296,495Stephen A Duncan · Gruthan Bioscience Llc · R41 · FY2020 · HL
Oxidized Linoleic Acid, Aldosterone, and Obesity
$296,493Theodore L Goodfriend · University Of Wisconsin-Madison · R01 · FY2007 · HL
Regulation and function of the circadian factor Period2
$296,450Seung-Hee Yoo · University Of Texas Hlth Sci Ctr Houston · R01 · FY2015 · GM
OBESITY IS A STATE OF METABOLIC DYSFUNCTIONS AND CHRONIC LOW-GRADE INFLAMMATION, WHICH ARE CAUSALLY LINKED TO OBESITY CO-MORBIDITIES, SUCH AS NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND TYPE 2 DIABETES. WE HAVE SOUGHT THE IDENTIFICATION OF NEW AGRICULTURAL CROPS THAT MAY BE CONSUMED TO COMBAT OBESITY AND ITS ASSOCIATED DISEASES. EDIBLE BROWN SEAWEEDS EXERT ANTI-OBESITY, ANTI-HYPERLIPIDEMIC, AND ANTI-DIABETIC ACTIVITIES. THEREFORE, THERE HAS BEEN A GROWING INTEREST IN THE HEALTH BENEFITS OF SEAWEED PRODUCTS IN THE U.S., CONSEQUENTLY EXPANDING SEAWEED FARMING IN THE EASTERN COASTAL STATES. HOWEVER, STUDIES ON THE HEALTH BENEFITS OF U.S.-GROWN SEAWEED ARE VERY LIMITED. OUR RECENT STUDY PROVIDES EVIDENCE THAT CONSUMPTION OF SUGAR KELP (SACCHARINA LATISSIMA), A MAJOR EDIBLE BROWN ALGA GROWN IN THE U.S., PREVENTS THE DEVELOPMENT OF OBESITY AND ITS ASSOCIATED METABOLIC DISTURBANCES, INFLAMMATION, AND FIBROSIS IN THE LIVER AND WHITE ADIPOSE TISSUE OF DIET-INDUCED OBESITYMICE. INTERESTINGLY, MICE FED SUGAR KELP EXHIBITED DRASTIC ALTERATIONS IN THE GUT MICROBIOME, WHICH HAS AN ENORMOUS IMPACT ON THE HOST'S ENERGY METABOLISM. ALSO, POLYSACCHARIDES IN BROWN SEAWEEDS ACT AS PREBIOTICS. THEREFORE, OUR PRELIMINARY FINDINGS INDICATE A POTENTIAL CONTRIBUTION OF THE GUT MICROBIOTA TO THE HEALTH BENEFITS OF SUGAR KELP. WE WILL STUDY IN THE PROJECT WHETHER SUGAR KELP CONSUMPTION PREVENTS OBESITY AND ITS ASSOCIATED ABNORMALITIES BY ALTERING THE GUT MICROBIOTA WHOSE METABOLITES ENHANCE ENERGY EXPENDITURE BY FACILITATING BROWNING OF WHITE ADIPOSE TISSUE AND INCREASINGFECAL ENERGY EXCRETION DUE TO ITS HIGH FIBER CONTENT. ALSO, AS CONCERNS ON POTENTIAL ADVERSE EFFECTS OF IODINE AND HEAVY METALS EXIST WITH SUGAR KELP CONSUMPTION, WE WILL EVALUATE THEIR TOXICITY IN VIVO.
$296,436University Of Connecticut · · FY2022 · National Institute of Food and Agriculture
Sources, Transport, Exposure and Effects of PFASs (STEEP)
$296,431Angela L Slitt · University Of Rhode Island · P42 · FY2021 · ES
Mechanisms of PDGF-C induced Hepatocellular Carcinogenesis
$296,400Jean S Campbell · University Of Washington · R01 · FY2007 · CA
Mechanisms of PDGF-C Induced Hepatocellular Carcinogenesis
$296,400Jean S Campbell · University Of Washington · R01 · FY2009 · CA
Mechanisms of PDGF-C Induced Hepatocellular Carcinogenesis
$296,400Jean S Campbell · University Of Washington · R01 · FY2010 · CA
Mechanisms of PDGF-C Induced Hepatocellular Carcinogenesis
$296,400Jean S Campbell · University Of Washington · R01 · FY2008 · CA
Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
$296,241Shannon Marie Bailey · University Of Alabama At Birmingham · R01 · FY2011 · AA