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24,576 grants matching “microbiome”
Autoimmunity risk alleles compromising B cell anergy
$457,386John C. Cambier · University Of Colorado Denver · R01 · FY2018 · AI
Autoimmunity risk alleles compromising B cell anergy
$457,386John C. Cambier · University Of Colorado Denver · R01 · FY2020 · AI
Genetic and Molecular Basis of Longevity
$457,333Gary B. Ruvkun · Massachusetts General Hospital · R01 · FY2018 · AG
Genetic and Molecular Basis of Longevity
$457,333Gary B. Ruvkun · Massachusetts General Hospital · R01 · FY2020 · AG
Genetic and Molecular Basis of Longevity
$457,333Gary B. Ruvkun · Massachusetts General Hospital · R01 · FY2019 · AG
Genetic and Molecular Basis of Longevity
$457,333Gary B. Ruvkun · Massachusetts General Hospital · R01 · FY2016 · AG
Genetic and Molecular Basis of Longevity
$457,333Gary B. Ruvkun · Massachusetts General Hospital · R01 · FY2017 · AG
Redox Regulation of Gingival Inflammation
$457,260Juhi Bagaitkar · Research Inst Nationwide Children'S Hosp · R01 · FY2023 · DE
Linking diet, gut microbiota and autoimmune disease: Bacteria induced phytoestrogen metabolites impact immune function in Experimental Autoimmune Encephalitis
$457,072Ashutosh Kumar Mangalam · University Of Iowa · R01 · FY2020 · AI
The role of the microbiome in HPV-associated cervical cancer in women with HIV
$456,989Anne-Catrin Uhlemann · Columbia University Health Sciences · R01 · FY2022 · CA
THE OVERALL OBJECTIVE OF THIS INTEGRATED RESEARCH PROPOSAL IS TO IDENTIFY GENOMIC MARKERS ASSOCIATED WITH EFFICIENT PLANT DECONSTRUCTION BY RUMEN MICROBIOME TO IMPROVE SELECTION FOR MILK PRODUCTION EFFICIENCY AND IMPROVE CURRENT PRACTICES ON THE GENETIC SELECTION OF DAIRY CATTLE. THE PROPOSED STUDIES WILL ADVANCE THE FIELD OF NUTRIENT UTILIZATION AND EFFICIENCY ADDRESSING THE IMPACT OF GASTROINTESTINAL MICROBIOME AND HOST GENETICS INFLUENCE ON MILK PRODUCTION EFFICIENCY. A DEEPER UNDERSTANDING OF THE GENETIC STRUCTURE ASSOCIATED WITH THE RUMEN MICROBIOME AND ITS MODULATION OF MILK PRODUCTION EFFICIENCY WILL BE IDENTIFIED CONTRIBUTING TO THE NEXT GENERATION OF GENOMIC MARKERS TO ADVANCE MILK PRODUCTION EFFICIENCY.
$456,946University Of California, Davis · · FY2020 · National Institute of Food and Agriculture
The Genomics and Antagonism of Pathobiont Colonization
$456,871Anthony W Maresso · Baylor College Of Medicine · U19 · FY2020 · AI
ROS responses during Vibrio cholerae infection
$456,861Jun Zhu · University Of Pennsylvania · R01 · FY2020 · AI
Role of Intestinal Barrier Integrity in Modulating the Host Glycome During COVID-19
$456,773Mohamed Abdel Mohsen · Wistar Institute · R01 · FY2020 · DK
Nutritional immunity during Salmonella infection
$456,731Manuela Raffatellu · University Of California, San Diego · R37 · FY2025 · AI
Characterization of the role of neuropeptide VIP-mediated fucosylation in alcohol associated liver disease
$456,719Zhong-Bin Deng · University Of Louisville · R01 · FY2024 · AA
Pr 4: Immune Responses to Fungi Associated with Crohn's Disease.
$456,606David M. Underhill · Cedars-Sinai Medical Center · P01 · FY2018 · DK
Bacterial Interference to Prevent Staphylococcus aureus Infection
$456,602Paul J Planet · Children'S Hosp Of Philadelphia · R01 · FY2018 · AI
POLLINATORS PROVIDE BILLIONS OF DOLLARS IN CROP POLLINATION ANNUALLY, AND PATHOGENS HAVE BEEN IMPLICATED IN BEE DECLINES. NUTRITION AND DIET ARE IMPORTANT FACTORS IN BEE HEALTH AND PATHOGEN RESISTANCE. WE DISCOVERED THAT SUNFLOWER POLLEN DRAMATICALLY REDUCED CRITHIDIA INFECTION IN BUMBLE BEES AND NOSEMA INFECTION IN HONEY BEES, PROVIDING INNOVATIVE OPTIONS FOR IMPROVING BEE HEALTH VIA POLLEN SUPPLEMENTS AND PLANTINGS. HOWEVER, WE DO NOT KNOW HOW SUNFLOWER POLLEN REDUCES BEE PATHOGENS. HERE, WE FOCUS ON CRITHIDIA INFECTION IN BUMBLE BEES AS A MODEL SYSTEM TO UNDERSTAND MECHANISMS UNDERLYING EFFECTS OF SUNFLOWER POLLEN, USING LABORATORY EXPERIMENTS TO EVALUATE MULTIPLE, NON-MUTUALLY EXCLUSIVE MECHANISMS. IN OBJECTIVE 1, WE WILL ASSESS HOW SUNFLOWER POLLEN TRAITS DRIVE EFFECTS, INCLUDING POLLEN CHEMISTRY, NUTRITION, AND MORPHOLOGY. IN OBJECTIVE 2, WE WILL INVESTIGATE MECHANISMS ASSOCIATED WITH HOW BEES RESPOND TO SUNFLOWER POLLEN, INCLUDING CHANGES IN GUT TRANSIT TIME, GENE EXPRESSION, IMMUNE FUNCTION, AND THE GUT MICROBIOME. OUR PROPOSAL ADDRESSES THE MAIN PROGRAM PRIORITY TO "SUPPORT BASIC AND APPLIED RESEARCH TO PROMOTE HEALTHY POPULATIONS OF ANIMAL POLLINATORS" AS WELL AS THE PRIORITY TO "DEVELOP AND EVALUATE INNOVATIVE TOOLS, STRATEGIES OR TECHNOLOGIES TO FACILITATE EFFORTS TO INCREASE POLLINATOR HEALTH." DISCOVERING THE MECHANISM BY WHICH A SIMPLE CHANGE IN DIET CAN SO EFFECTIVELY REDUCE DISEASE WILL ACCELERATE TRANSLATION OF OUR DISCOVERY INTO APPLICATIONS MEDIATING BEE HEALTH AND BREEDING PROGRAMS FOR UNDERLYING FLORAL TRAITS. GIVEN THE AGRICULTURAL VALUE OF POLLINATORS, UNDERSTANDING THE MECHANISMS DRIVING THE EFFECTS OF DIET QUALITY ON BEE HEALTH IS A KEY COMPONENT OF EFFECTIVE MANAGEMENT STRATEGIES.
$456,503North Carolina State University · · FY2019 · National Institute of Food and Agriculture
MiR-204 regulates type 1 IP3R/Ca2+ axis to control vascular smooth muscle cell contractility and blood pressure: Potential role of the gut microbiome
$456,447Modar O. Kassan · University Of Tennessee Health Sci Ctr · R01 · FY2020 · HL
Baby Observational and Nutritional Study of Cystic Fibrosis
$456,406Bonnie W Ramsey · Seattle Children'S Hospital · R01 · FY2014 · DK
MUCH OF THE UNITED STATES AGRICULTURAL SYSTEM RELIES ON BREEDING DESIRABLE TRAITS THAT INCLUDE HIGH YIELD, DISEASE SUPPRESSION, AND DROUGHT TOLERANCE, AMONG OTHERS. ONE OF THE CONSTRAINTS OF RELYING ON BREEDING TECHNIQUES TO IMPROVE CROP TRAITS IS THE ISSUE OF TIME. FOR MOST BREEDING PROGRAMS, ONE SELECTION CYCLE OCCURS ANNUALLY, WHICH MEANS THAT WE HAVE ONLY 35 BREEDING CYCLES UNTIL 2050--A CRITICAL GLOBAL TIME POINT THAT CENTERS ON THE QUESTION OF HOW TO FEED OVER 9 BILLION PEOPLE. IT IS UNLIKELY THAT BREEDING ALONE WILL PROVIDE THE SOLUTIONS TO INCREASE YIELDS FOR SUSTAINING HUMAN POPULATION GROWTH, WHILE ALSO RESPONDING TO CHANGES IN CLIMATE. OUR RESEARCH PROJECT ADDRESSES THIS CONCERN BY INITIATING RESEARCH THAT FOCUSES ON ASSEMBLING COLLECTIONS OF SOIL MICROBIOTA--BACTERIA, FUNGI, AND VIRUSES--THAT ALTOGETHER, REINFORCE DESIRABLE CROP TRAITS. IN ESSENCE, WE ARE "BREEDING" GROUPS OF PLANT-ASSOCIATED MICROBIOTA THAT ARE ABLE TO ENHANCE PLANT YIELD BY ENRICHING PLANT ROOT ZONES WITH BENEFICIAL MICROORGANISMS. AT PRESENT, MANY TOP AGRIBUSINESS COMPANIES, INCLUDING MONSANTO, SYNGENTA, DUPONT, AND BASF, ARE INVESTING IN MICROBIAL-BASED METHODS THAT INFLUENCE CROP TRAITS. INDUSTRY IS RELYING PRIMARILY ON A SINGLE SPECIES OR STRAIN OF MICROORGANISM AS AN INOCULANT IN PLANT SEEDS OR DIRECTLY INTO SOILS. OUR APPROACH DIFFERS IN THAT IT INCLUDES COMPLEX COMMUNITIES OF MICROORGANISMS THAT ARE ASSEMBLED THROUGH REPEATED SELECTIONS ON THE PLANT HOST TRAIT, SUCH AS BIOMASS OR SEED YIELD. THE SHORT LIFECYCLE OF BACTERIA AND THEIR ABILITY TO SHIFT POPULATION STRUCTURE RAPIDLY, IN RESPONSE TO SELECTION, FACILITATES THE BREEDING OF SOIL MICROBIOTA FOR PLANT PRODUCTION SYSTEMS.BY 2050, THE HUMAN POPULATION IS EXPECTED TO REACH OVER 9 BILLION PEOPLE, WITH THE MAJORITY CONCENTRATED IN AFRICA, SOUTHERN ASIA, AND EASTERN ASIA. FOR PARTS OF THESE SECTIONS OF THE WORLD, IT IS CHALLENGING TO DEVELOP INTENSIVE AGRICULTURAL SYSTEMS ROUTINELY USING INDUSTRIAL AMMONIA FERTILIZERS TO SUSTAIN HIGH YIELDS. SYNTHETIC FERTILIZERS (BASED ON THE HABER-BOSCH PROCESS) CONSUME HIGH AMOUNTS OF FOSSIL FUEL ENERGY IN THEIR MANUFACTURE AND CONTRIBUTE TO CHRONIC NONPOINT SOURCE POLLUTION IN HOTSPOTS OF AGRICULTURAL PRODUCTION, SUCH AS FOUND IN THE SALINAS VALLEY AREA OF CALIFORNIA. DEVELOPING A PLANT MICROBIOME FOCUS TO INTERNATIONAL CROP PRODUCTION WILL HELP PROMOTE SUSTAINED YIELDS IN MAJOR PARTS OF THE WORLD LACKING THE CAPACITY FOR INDUSTRIAL-BASED AGRICULTURE, IN ADDITION TO MAINTAINING CROP PRODUCTIVITY IN THE U.S. MANY CROPPING SYSTEMS ALREADY INCLUDE A FOCUS ON THE MICROBIOME FOR IMPROVED NUTRIENT MANAGEMENT; THESE INCLUDE RHIZOBIA FOR LEGUMES AND SEVERAL ARBUSCULAR MYCORRHIZAL FUNGI (AMF) FOR CEREAL CROPS. HOWEVER, PLANTS THAT DO NOT FORM ASSOCIATIONS WITH SYMBIONTS RELY HEAVILY ON FERTILIZER ADDITIONS. BRASSICA CROP PRODUCTION (MANY CULTIVARS OF WHICH SERVE AS THE GREEN VEGETABLE STAPLE OF MANY POPULATIONS IN DEVELOPING COUNTRIES) WOULD BENEFIT HEAVILY FROM GREATER NITROGENMANAGEMENT VIA SOIL BIOTIC MANIPULATIONS, AND SERVE AS A MODEL FOR ADDITIONAL CROPS THAT DO NOT FORM SYMBIOTIC RELATIONSHIPS.THE PROPOSED RESEARCH WILL INCLUDE SEQUENCING OF THE MICROBIOMES IN AN EFFORT TO IDENTIFY WHO COMPRISES THE MICROBIOMES THAT ARE ASSOCIATED WITH AN ENHANCED SEED YIELD PHENOTYPE AND CORRESPONDING HIGH NITROGEN CAPTURE TRAITS. WE WILL BE USING 16S AND 18S BAR-CODED PAIRED-END READS FOR CHARACTERIZATION OF THE SOIL MICROBIOME USING THE ILLUMINA HISEQ PLATFORM. THE SEQUENCING METHODS WILL ALLOW US TO ASSESS HOW THE MICROBIOMES CHANGE IN COMMUNITY COMPOSITION OVER GENERATIONS OF SELECTION, IN RELATION TO THE DEVELOPMENT OF HIGHER SEED YIELD IN THE HOST PLANTS. FUNCTIONAL ANALYSIS USING PLANT RNA-SEQ, SOIL EXTRACELLULAR ENZYME ACTIVITY, PLANT TISSUE 15N ENRICHMENT, AND NITROGEN MINERALIZATION WILL HELP EXPLAIN HOW THE MICROBIOMES ARE MODIFYING PLANT PHENOTYPES VIA PLANT GENE EXPRESSION AND COORDINATED RESOURCE GAIN. THESE FUNDAMENTAL INVESTIGATIONS INTO THE INTERACTIONS OF PLANTS AND THEIR ASSOCIATED MICROBIOTA WILL HELP PAVE THE WAY FOR MICROBIOME-ENHANCEMENT OF AGRICULTURAL PRODUCTION SYSTEMS.
$456,318Cornell University · · FY2016 · National Institute of Food and Agriculture
(PQ10) Enhancing responses to immune checkpoint blockade in melanoma via modulation of the microbiome
$456,293Jennifer A. Wargo · University Of Tx Md Anderson Can Ctr · R01 · FY2020 · CA
Tregs, Gut Microbiome and Immune Responses in HIV-Exposed and Unexposed Infants
$456,248Adriana Weinberg · University Of Colorado Denver · U01 · FY2020 · AI
Research Center in Environmental Health - Administrative Core
$456,220Helmut Zarbl · Rbhs-School Of Public Health · P30 · FY2017 · ES