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38,696 grants matching “als”
Mechanistic studies and therapeutics for ALS-FTD linked to UBQLN2 mutations
$504,381Mervyn J Monteiro · University Of Maryland Baltimore · R01 · FY2019 · NS
Mechanistic studies and therapeutics for ALS-FTD linked to UBQLN2 mutations
$504,381Mervyn J Monteiro · University Of Maryland Baltimore · R01 · FY2020 · NS
A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
$504,213Arvin Dar · Sloan-Kettering Inst Can Research · R01 · FY2023 · CA
Morphology and Chemsitry of Lateral Composition Modulations
$504,204Joanna Millunchick · Regents Of The University Of Michigan - Ann Arbor · · FY2003 · MPS
CHABMAP (Cyanobacterial Harmful Algal Bloom Mapping and Analyses Platform) technology automates the quantification of toxic CyanoHABs exposure epochs for any waterbody.
$504,200Nathan Torbick · Applied Geosolutions, Llc · R44 · FY2020 · ES
HCC-Small: RSVP IconCHAT - A Brain Computer Interface for Icon-based Communication
$504,098Deniz Erdogmus · Northeastern University · · FY2009 · CSE
Allergic Condition Susceptibility Polymorphisms and Glioma Risk
$504,006Judith Schwartzbaum · Ohio State University · R01 · FY2011 · CA
Longitudinal Imaging of Patients at Clinical Risk for Psychosis.
$503,974Scott A Small · Columbia University Health Sciences · R01 · FY2013 · MH
Dysregulation of p97/VCP disease mutants in IBM and FTLD-U
$503,946Tsui-Fen Chou · California Institute Of Technology · R01 · FY2022 · NS
Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLD
$503,933Madesh Muniswamy · University Of Texas Hlth Science Center · R01 · FY2024 · DK
Regulatory immune cells in immune suppression: The role of tBregs
$503,916Arya Biragyn · National Institute On Aging · ZIA · FY2018 · AG
Antimalarial Pharmacology in HIV Coinfected Children and Pregnant Women in Uganda
$503,880Francesca T. Aweeka · University Of California, San Francisco · R01 · FY2015 · HD
OBJECTIVES: THE PATTERNS OF MODERATELY VOLATILE ELEMENT (MVE) DEPLETION IN THE SILICATE PORTIONS OF PLANETARY BODIES ARISE FROM TWO MAIN PROCESSES: VOLATILE LOSS (OR INCOMPLETE CONDENSATION) AND CORE FORMATION. THE OBJECTIVE OF THIS PROPOSAL IS TO COMBINE MODELS OF PLANET GROWTH AND VOLATILE LOSS WITH ELEMENT PARTITIONING EXPERIMENTS AND CALCULATIONS TO EXPLORE THE ORIGIN OF THE MVE PATTERNS IN EARTH MARS VESTA AND THE ANGRITE PARENT BODY (APB). IN PARTICULAR WE WILL INVESTIGATE WHETHER VOLATILE LOSS FROM PARTIALLY MOLTEN PLANETESIMALS CAN EXPLAIN THE OBSERVATIONS AND WHETHER CONVENTIONAL OR GRAND TACK -STYLE ACCRETION MODELS WORK BETTER. METHODS: WE WILL BEGIN WITH OUR EXISTING CORE FORMATION MODEL COUPLED TO DYNAMICAL ACCRETION SIMULATIONS. SUCCESSFUL SIMULATIONS ARE REQUIRED TO MATCH THE NON-VOLATILE ELEMENT CONCENTRATIONS (V CR CO MO) AND TIMINGS FROM THE HF-W SYSTEM FOR EARTH MARS AND VESTA. FOR EARTH NUCLEOSYNTHETIC MO ISOTOPE MEASUREMENTS (INDICATING CONTRIBUTIONS FROM BOTH RESERVOIRS) MUST ALSO BE MATCHED. WE WILL ALSO CARRY OUT HIGH-PRESSURE EXPERIMENTS TO DETERMINE THE PARTITIONING OF PB AND AG. SUCCESSFUL CORE FORMATION MODELS WILL THEN BE USED WITH EXISTING AND OUR NEW PARTITIONING DATA TO PREDICT THE EXPECTED MVE CONCENTRATIONS (E.G. PB AG ZN RB GE K CU NA MN LI CO NI). DISCREPANCIES BETWEEN THE MEASURED AND PREDICTED CONCENTRATIONS WILL INDICATE VOLATILE LOSS OR INCOMPLETE CONDENSATION. HERE WE WILL FOCUS ON THE FORMER AS AN END-MEMBER BASED ON ISOTOPIC EVIDENCE OF LOSS OF SI AND MG. TO MODEL VOLATILE LOSS WE WILL BEGIN WITH THE PARAMETERIZATION OF SOSSI ET AL. (2019). THIS SHOWS THAT VOLATILE LOSS DEPENDS PRIMARILY ON THE MELT TEMPERATURE AND THE OXYGEN FUGACITY. THE OXYGEN FUGACITY AND GROWTH HISTORIES OF PLANETESIMALS ARE SET BY THE CORE FORMATION AND ACCRETION MODELS THE REMAINING VARIABLE IS THE TEMPERATURE DISTRIBUTION. INITIALLY WE WILL TREAT THIS AS A FREE PARAMETER AND USE MONTE CARLO SIMULATIONS TO DETERMINE WHAT KINDS OF DISTRIBUTIONS ARE ACCEPTABLE. PRELIMINARY TESTS SUGGEST A BIMODAL TEMPERATURE DISTRIBUTION WORKS WELL. WE WILL THEN PROCEED TO INVESTIGATE THE PHYSICS OF MELT PRODUCTION AND VOLATILE LOSS. WE WILL TRACK PLANETESIMAL GROWTH AND MELTING FROM IMPACTS TO DETERMINE WHEN AND FOR HOW LONG MAGMA IS EXPOSED AT THE SURFACE. WE WILL TRACK THE EVOLUTION OF ELEMENTAL AND ISOTOPIC CONCENTRATIONS USING THE APPROACH OF YOUNG ET AL. (2019). THE EVOLVING SIZE OF THE PLANETESIMAL IS IMPORTANT TO INCLUDE AS VOLATILE LOSS SHUTS DOWN FOR ROUGHLY MOON-MASS OBJECTS AND SO TOO IS THE MIXING OF PLANETESIMALS HAVING EXPERIENCED DIFFERENT HISTORIES. THE MODEL TIMING OF VOLATILE LOSS IS PARTICULARLY IMPORTANT FOR THE PD-AG AND U-PB SYSTEMS WHICH ARE CHRONOMETERS SIMILAR TO HF-W BUT SENSITIVE TO VOLATILE LOSS AS WELL AS CORE FORMATION. WE WILL TRACK THE EVOLUTION OF THESE ISOTOPIC SYSTEMS FOR COMPARISON WITH AVAILABLE MEASUREMENTS. SIGNIFICANCE: THIS PROPOSAL WILL EXAMINE THREE BIG QUESTIONS: WHETHER VOLATILE LOSS DURING PLANETESIMAL GROWTH IS RESPONSIBLE FOR THE ELEMENTAL DEPLETION PATTERNS WHAT STYLE OF PLANETARY ACCRETION (E.G. GRAND TACK VS. CONVENTIONAL) IS MOST CONSISTENT WITH THE OBSERVATIONS AND WHEN VOLATILE LOSS HAPPENED DURING THE ACCRETION PROCESS. EVEN PARTIAL ANSWERS TO THESE QUESTIONS WILL SHARPEN OUR PICTURE OF HOW ACCRETION PROCEEDED IN THIS SOLAR SYSTEM AND WILL MAKE PREDICTIONS (E.G. AG ISOTOPIC SIGNATURES FOR MARS) WHICH ARE TESTABLE. RELEVANCE: THIS PROJECT EXAMINES PROCESSES OPERATING DURING THE ACCRETION OF PLANETESIMAL- AND EMBRYO-SIZE OBJECTS. IT IS THEREFORE RELEVANT TO THE EW OBJECTIVES AND SPECIFICALLY FITS WITHIN "STUDIES RELATED TO THE ACCRETION OF SOLAR SYSTEM BODIES AFTER DISSIPATION OF THE PROTOPLANETARY DISK".
$503,870University Of California Santa Cruz · · FY2021 · National Aeronautics and Space Administration
Vulnerability to Prenatal Glucocorticoids Programs Infant Development
$503,834Elysia Poggi Davis · University Of California-Irvine · R01 · FY2010 · HD
Function and Pathogenic Mechanism of LRRK2 in Parkinson's Disease
$503,811Huaibin Cai · National Institute On Aging · ZIA · FY2014 · AG
LEPTIN-- SIGNALING, TARGETS AND RESISTANCE
$503,810Beth Israel Deaconess Medical Center · R37 · FY2004 · DK
Computational Tools For Bioinformatics And Genome Analysis
$503,805Calvin A Johnson · Center For Information Technology · ZIH · FY2017 · CT
Group Antenatal Care to Promote a Healthy Pregnancy and Optimize Maternal and Newborn Outcomes: A Cluster Randomized Controlled Trial
$503,784Jody Rae Lori · University Of Michigan At Ann Arbor · R01 · FY2021 · HD
Simultaneous dose and dose rate optimization for clinical FLASH proton radiotherapy
$503,780Hao Gao · University Of Kansas Medical Center · R01 · FY2022 · CA
Neuroimaging of Dedifferentiation and Memory Across the Lifespan
$503,751Denise Cortis Park · University Of Texas Dallas · R37 · FY2008 · AG
Immune activating syncytiotrophoblast microvesicles and danger associated molecular patterns in preeclampsia risk
$503,730Surendra Sharma · University Of Texas Med Br Galveston · R01 · FY2023 · AI
Modification Of The Antigenicity & Virulence Of Rotaviruses By Reverse Genetics
$503,645John Patton · National Institute Of Allergy And Infectious Diseases · ZIA · FY2010 · AI
Finding Genes for Human Prostate Cancer
$503,597Elaine Ostrander · National Human Genome Research Institute · ZIA · FY2019 · HG
Volunteer Telephone Continuing Care for Adolescents with AOD Use Disorders
$503,577Mark D Godley · Chestnut Health Systems, Inc. · R01 · FY2014 · AA
Mechanistic studies and therapeutics for ALS-FTD linked to UBQLN2 mutations
$503,564Mervyn J Monteiro · University Of Maryland Baltimore · R01 · FY2017 · NS