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21,281 grants matching “influenza”
US-China Collab: Comparative evolution and ecology of swine influenza viruses in China and the United States
$2,499,991Xiu-Feng H Wan · University Of Missouri-Columbia · · FY2021 · BIO
US-Israel Collab: Pathogens and disease transmission in migratory birds along the Palearctic-African flyway
$2,499,966Wayne M Getz · University Of California-Berkeley · · FY2016 · BIO
PATHOGENS RANGING FROM INFLUENZA VIRUS TO BACTERIA IN HOSPITALS PERIODICALLY UNDERGO MAJOR EVOLUTIONARY JUMPS IN THEIR PHENOTYPES, ENABLING THEM TO EVADE HOST IMMUNE RESPONSES AND INTERVENTIONS. WE CONTEND THAT WHILE UNDERSTANDING THE GENETICS OF THESE EVENTS IS IMPORTANT FOR MITIGATING ASSOCIATED ADVERSE HEALTH OUTCOMES, SO TOO IS UNDERSTANDING THE ECOLOGICAL CONTEXT IN WHICH THESE EVENTS OCCUR. SEGMENTED VIRUSES TRANSMITTED BY MIDGES IN DIVERSE RUMINANT COMMUNITIES OFFER THE POSSIBILITY OF UNDERSTANDING HOW MULTIPLE INTERACTING MECHANISMS FACILITATE, OR LIMIT, OPPORTUNITIES FOR GENETIC EXCHANGE TO OCCUR BETWEEN DISTINCT VIRUS STRAINS THROUGH THE PROCESS OF REASSORTMENT. OUR STUDY FOCUSES ON BLUETONGUE VIRUS (BTV) AND EPIZOOTIC HEMORRHAGIC DISEASE VIRUS (EHDV), WHICH UNDERGO REASSORTMENT REGULARLY IN TRANSMISSION SYSTEMS WORLDWIDE AND IN OUR STUDY SYSTEM IN RANGELAND IN THE ROCKY MOUNTAINS. THE ECOLOGICAL CONTEXT FOR THE EMERGENCE OF REASSORTANT VIRAL STRAINS EMPHASIZES THE ECOLOGY OF THE CULICOIDES MIDGES THAT VECTOR THESE VIRUSES. LIFE TRAITS OF BOTH THE VIRUSES AND VECTORS ARE LIKELY TO BE HIGHLY TEMPERATURE SENSITIVE, WHICH WE HYPOTHESIZE AFFECTS THE RATE AT WHICH REASSORTMENT OCCURS AND WHERE REASSORTANTS ARE LIKELY TO BE TRANSMITTED BY VECTORS. THIS PROCESS FURTHERMORE TAKES PLACE IN THE CONTEXT OF DIVERSE RUMINANT COMMUNITIES AT THE DOMESTICATED ANIMAL - WILDLIFE INTERFACE, WITH INTERACTIONS AMONG THOSE ANIMALS LIKELY PLAYING A ROLE FOR DIVERSE STRAINS TO MEET AND FOR REASSORTANTS TO SPREAD. OUR PROPOSED STUDY SYSTEM IN NORTH AMERICA IS UNIQUELY VALUABLE FOR INVESTIGATING THIS DYNAMIC IN THAT IT OFFERS A PLATFORM TO INTENSIVELY STUDY ONE KEY MIDGE VECTOR SPECIES (C. SONORENSIS) BUT MULTIPLE WILD AND DOMESTIC RUMINANT HOST SPECIES ACROSS REGIONS WITH WIDE ECOLOGICAL GRADIENTS. THROUGHOUT, WE INTEGRATE LABORATORY, FIELD, AND MODELING APPROACHES TO ADDRESS THESE QUESTIONS.
$2,499,926Colorado State University · · FY2019 · National Institute of Food and Agriculture
INFECTION AND DISEASE ADVERSELY IMPACT PERFORMANCE, GROWTH, MORBIDITY AND MORTALITY IN PRODUCTION ANIMALS AND HAS MAJOR ECONOMIC IMPACTS ON COMMERCIAL POULTRY PRODUCTION. THIS IS EXACERBATED BY CONSUMER WORRIES ABOUT ANTIBIOTIC USE, WHICH PRESSURES PRODUCERS TO USE ALTERNATIVE STRATEGIES TO PREVENT INFECTION. AN ILLUSTRATING EXAMPLE IS THE AVIAN INFLUENZA OUTBREAK OF 2015, WHICH HAS BEEN DESCRIBED AS THE WORST IN US HISTORY WITH THE LOSS OF OVER 48 MILLION BIRDS (CHICKEN AND TURKEY). THIS EVENT UNDERSCORES THE NEED TO FUNCTIONALLY ANNOTATING THE CHICKEN GENOME TO UNDERSTAND COMPLEX GENETIC TRAITS SUCH AS DISEASE RESISTANCE, WHICH IN TURN COULD SERVE AS A POWERFUL TOOL TO ENSURE SUSTAINABLE AGRICULTURAL SYSTEMS. FURTHERMORE, IN POULTRY PRODUCTION, ADDITIONAL FACTORS AFFECTING COMMERCIAL AND ECONOMIC PERFORMANCE NEED TO BE CONSIDERED IN BREEDING. FACTORS INCLUDING INTESTINAL HEALTH, EGG LAYING PERFORMANCE OR GROWTH EFFICIENCY IN BROILERS CERTAINLY ARE OF PARTICULAR ECONOMIC SIGNIFICANCE.TO IMPROVE OUR UNDERSTANDING OF THE UNDERLYING MECHANISMS CONTROLLING THESE AND OTHER TRAITS, IDENTIFICATION OF CIS-REGULATORY ELEMENTS ON THE GENOME IS WARRANTED. THESE REGULATORY ELEMENTS CONTROL THE EXPRESSION OF GENES AND CONSEQUENTLY PHENOTYPE; HOWEVER, THE TARGETED TISSUES AND CELLS FOR ANALYSIS NEED TO BE DETERMINED FOR EACH TRAIT OF INTEREST, AS THESE REGULATORY ELEMENTS ARE TISSUE SPECIFIC, AND EVEN DIFFER FROM CELL TO CELL WITHIN A GIVEN TISSUE. ADDITIONALLY, ENVIRONMENTAL FACTORS SUCH AS NUTRITION INTERACT WITH EPIGENETIC MODIFIERS WORKING AT THESE REGULATORY ELEMENTS, THUS MAKING IT POSSIBLE TO PROMOTE THE EXPRESSION OF DESIRABLE PRODUCTIVE TRAITS BY MANAGEMENT.IN THE PAST, SELECTIVE BREEDING OF POULTRY HAS RESULTED IN IMPROVED FEED CONVERSION RATIOS IN BROILERS, ALBEIT AT THE COST OF DECREASED IMMUNE COMPETENCE AND GREATER SUSCEPTIBILITY TO DISEASE. IN CONTRAST, SOME LINES OF BIRDS ARE KNOWN TO BE MORE RESISTANT TO A VARIETY OF PATHOGENS.THE EMERGENCE OF ANTIMICROBIAL RESISTANCE SUGGESTS THAT GENETIC RESISTANCE TO DISEASE WOULD PROVIDE AN ADVANTAGE OVER THE USE OF ANTIMICROBIALS. WHILE PARAMETERS OF IMMUNE COMPETENCE, SUCH AS ANTIBODY PRODUCTION, PHAGOCYTIC ACTIVITY AND CYTOKINE PRODUCTION OF THE HOST ARE KNOWN, THE GENETIC AND MOLECULAR BASIS FOR DISEASE RESISTANCE IS STILL NOT WELL UNDERSTOOD. IT HAS BECOME APPARENT THAT PATHOGENS INTERACT WITH EPIGENETIC REGULATORS OF THE HOST, AIDING IMMUNE EVASION AND REPLICATION OF THE PATHOGEN.IDENTIFICATION OF REGULATORY ELEMENTS AND THEIR INFLUENCE ON TARGET GENES DIRECTLY RESPONSIBLE FOR ENHANCED IMMUNITY IN POULTRY IS CRUCIAL IN ORDER TO SELECT FOR TRAITS THAT IMPROVE DISEASE RESISTANCE FOR BREEDING PURPOSES AND FLOCK HEALTH.
$2,499,551Western University Of Health Sciences · · FY2018 · National Institute of Food and Agriculture
RFA-IP-22-004, Evaluating respiratory virus vaccine effectiveness in a large, diverse healthcare system
$2,495,017Richard K Zimmerman · University Of Pittsburgh At Pittsburgh · U01 · FY2022 · IP
Programming Long-lasting Immunity to Coronaviruses (PLUTO)
$2,494,973Viviana A Simon · Icahn School Of Medicine At Mount Sinai · P01 · FY2025 · AI
Programming Long-lasting Immunity to Coronaviruses (PLUTO)
$2,494,973Viviana A Simon · Icahn School Of Medicine At Mount Sinai · P01 · FY2024 · AI
Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG)
$2,492,267David S Stephens · Emory University · UM1 · FY2020 · AI
HPMI: Host Pathogen Mapping Initiative
$2,489,172Nevan J Krogan · University Of California, San Francisco · U19 · FY2023 · AI
Viral Respiratory Pathogens Research Unit
$2,484,680Robert B Couch · Baylor College Of Medicine · N01 · FY2011 · AI
RFA-IP-22-004, CORVETS - Cleveland Ohio Respiratory Viruses Vaccines Effectiveness across Traditional Risk Factors and Social Determinants of Health
$2,484,354Elie Saade · University Hospitals Of Cleveland · U01 · FY2022 · IP
RFA-IP-22-004, Multidisciplinary Approach to Understanding Vaccine Efficacy and Transmission of Viral Respiratory Tract Infections in the Real World
$2,483,947Stacey House · Washington University · U01 · FY2022 · IP
Pre-clinical Vaccine Development for Respiratory Viruses
$2,480,852Richard A Koup · National Institute Of Allergy And Infectious Diseases · ZIC · FY2022 · AI
Pre-clinical Vaccine Development for Respiratory Viruses
$2,480,852Wing Pui Kong · National Institute Of Allergy And Infectious Diseases · ZIC · FY2023 · AI
Oklahoma Center for Respiratory and Infectious Diseases
$2,476,566Lin Liu · Oklahoma State University Stillwater · P20 · FY2013 · GM
HPMI: Host Pathogen Mapping Initiative
$2,475,950Nevan J Krogan · University Of California, San Francisco · U19 · FY2024 · AI
MICROBIOLOGY AND INFECTIOUS DISEASES BIOLOGICAL RESOURCE REPOSITORY (MID-BRR)
$2,475,142Timothy T Stedman · American Type Culture Collection · N01 · FY2015 · AI
Discovery of adjuvants via novel modulation of innate immune pathways for vaccines against influenza
$2,474,188Aaron Esser-Kahn · University Of Chicago · N01 · FY2019 · AI
DEVELOPMENT OF SMALL-MOLECULE DUAL ADJUVANT SYSTEM FOR INFLUENZA VIRUS VACCINE
$2,471,790Jennifer Lapek · Scripps Institution Of Oceanography · N01 · FY2023 · AI
Structural and mechanistic studies of herpesvirus entry into host cells
$2,471,000Ekaterina Heldwein · Tufts University Boston · DP2 · FY2007 · OD
BSL3 management and practice of infectious disease research at HTRL
$2,469,118Dominique M Missiakas · University Of Chicago · UC7 · FY2023 · AI
Services for the Preclinical Development of Therapeutic Agents
$2,468,707Jon Carl Mirsalis · Sri International · N01 · FY2011 · AI
Virus-induced Cell Fate Decisions in Anti-Viral Immunity
$2,465,241Troy D Randall · University Of Alabama At Birmingham · U19 · FY2015 · AI
A deep longitudinal analysis of next generation influenza vaccines in older adults
$2,465,186Duygu Ucar · Jackson Laboratory · U01 · FY2024 · AI
BSL3 management and practice of infectious disease research at HTRL
$2,464,978Dominique M Missiakas · University Of Chicago · UC7 · FY2024 · AI