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38,696 grants matching “als”
LIM-HD/bHLH Combinatorial Code in Motoneurons
$512,048Soo-Kyung Lee · Oregon Health & Science University · R01 · FY2011 · NS
RNA-based regulation of TDP-43 nuclear export in ALS/FTD
$511,899Lindsey Renae Hayes · Johns Hopkins University · R01 · FY2022 · NS
Dynamics of Kinesins, Dyneins, and Myosins
$511,856Paul R Selvin · University Of Illinois At Urbana-Champaign · R01 · FY2007 · AR
RNA Recombination in Coronaviruses
$511,834Andrew Laurence Routh · Scripps Research Institute, The · R01 · FY2024 · AI
NIA Confocal Imaging Facility
$511,703Fred Indig · National Institute On Aging · ZIC · FY2017 · AG
Characterization and Treatment of the Scarred Vocal Fold
$511,570Diane M Bless · University Of Wisconsin-Madison · R01 · FY2009 · DC
Mechanisms of BDNF and Glucocorticoid Action
$511,507Moses Victor Chao · New York University School Of Medicine · R01 · FY2012 · MH
Using mitochondrial Ca2+ uptake as a therapeutic target for ALS
$511,505Lan Wei-Lapierre · University Of Florida · R56 · FY2021 · NS
Core B
$511,433Bjorn E Oskarsson · Mayo Clinic Jacksonville · P01 · FY2024 · NS
Promoting Behavioral Change for Oral Health in American Indian Mothers and Childr
$511,383Terrence S. Batliner · University Of Colorado Denver · U54 · FY2013 · DE
Use of Mouse Models of Human Rhabdomyosarcoma to Study Progression to Metastasis
$511,345Glenn T. Merlino · Division Of Basic Sciences - Nci · Z01 · FY2008 · CA
Determining How Defective Nucleo-Cytoplasmic Trafficking Leads To Neurodegeneration In C9orf72-Related ALS And FTD
$511,285Evangelos Kiskinis · Northwestern University At Chicago · R01 · FY2020 · NS
IN SPITE OF RECENT PROGRESS IN DIAGNOSING WAVES IN MARS ATMOSPHERE THERE ARE MANY UNRESOLVED QUESTIONS REGARDING THE VARIABILITY OF THESE GLOBAL-SCALE WAVES AND TIDES THE SECONDARY WAVES GENERATED BY THEIR INTERACTIONS AND THE IMPACTS OF THE ENTIRE SPECTRUM OF THESE WAVES ON MARS' UPPER ATMOSPHERE IN RELATION TO IN-SITU SOLAR FORCING. IT IS OBVIOUS THAT THE CONFLUENCE OF THE RELATIVELY RECENT OBSERVING CAPABILITIES GIVEN BY THE MRO AND MAVEN MISSIONS HOLDS THE PROMISE TO SIGNIFICANTLY ADVANCE OUR UNDERSTANDING AND QUANTIFICATION OF THE VERTICAL COUPLING OF WAVES IN MARS UPPER ATMOSPHERE. THE OVERALL OBJECTIVE OF THE PROPOSED RESEARCH IS TO QUANTIFY THE SPATIAL AND TEMPORAL VARIABILITY OF NEUTRAL DENSITIES IN MARS THERMOSPHERE (150-200 KM) AND TO BETTER UNDERSTAND THE ORIGINS OF THIS VARIABILITY IN TERMS OF WAVES ORIGINATING IN LOWER ATMOSPHERE REGIONS AND IN-SITU SOLAR FORCING. IT IS USEFUL TO TRANSLATE THIS OBJECTIVE INTO THREE BASIC QUESTIONS THAT WE SEEK TO ANSWER AS A RESULT OF THIS PROPOSED RESEARCH. Q1: TO WHAT DEGREE IS SOLAR IRRADIANCE RESPONSIBLE FOR SHORT-TERM (<30-SOL) NEUTRAL DENSITY VARIABILITY IN MARS THERMOSPHERE (C.A. 150-200 KM) DURING SOLAR QUIET TO MEDIUM CONDITIONS? Q2: HOW PREVALENT ARE PW-TIDE AND UFKW-TIDE INTERACTIONS IN MARS THERMOSPHERE AND WHAT ADDED LATITUDE LONGITUDE AND TEMPORAL VARIABILITY DO THEY IMPOSE? Q3: IS THERE EVIDENCE TO SHOW THAT THE ABOVE PW-TIDE AND UFKW-TIDE INTERACTIONS ORIGINATE IN MARS MIDDLE ATMOSPHERE? THREE MAJOR ADVANCES PROVIDE SOME CONFIDENCE THAT ANSWERS TO THE ABOVE QUESTIONS CAN BE ACHIEVED. FIRST CONCURRENT SOLAR IRRADIANCE AND COMPOSITION (CO2 AR N2 CO) MEASUREMENTS FROM MAVEN S EXTREME ULTRA-VIOLET MONITOR (EUVM) AND NEUTRAL GAS AND ION MASS SPECTROMETER (NGIMS) OFFER THE UNPRECEDENTED OPPORTUNITY TO STUDY SOLAR FORCING EFFECTS ON MARS THERMOSPHERE DENSITIES FROM THE SAME OBSERVATIONAL PLATFORM. SECOND THE PROPOSED PSEUDOLONGITUDE SPECTRAL ANALYSIS METHOD (SEE SECTION 4) WAS DEMONSTRATED TO BE SUCCESSFUL AT IDENTIFYING NONLINEAR WAVE-WAVE INTERACTIONS IN MAVEN S OBSERVATIONS [GASPERINI ET AL. 2018]. THIRD AS NOTED IN SECTION 1 OBSERVATIONS AND MODELS HAVE REACHED A LEVEL OF SOPHISTICATION AND AGREEMENT THAT WE HAVE SOME REASONABLE IDEA ABOUT THE GLOBAL-SCALE WAVES AND TIDAL COMPONENTS THAT ARE RESPONSIBLE FOR DYNAMICALLY COUPLING THE 60-80 KM REGION TO THE 150-200 KM REGION. THE MRO AND MAVEN DATA TO BE UTILIZED ARE BRIEFLY DESCRIBED IN THE NEXT SECTION. IN SECTION 4 THE METHODOLOGIES AND TASKS THROUGH WHICH WE PLAN TO USE THESE DATA TO ANSWER Q1-Q3 ARE DESCRIBED INCLUDING THE EXPECTED TIMELINE. THE ANTICIPATED OUTCOMES SCIENTIFIC IMPORTANCE AND RELEVANCE TO NASA AND MDAP STRATEGIC OBJECTIVES OF THE PROPOSED RESEARCH ARE DESCRIBED IN SECTION 5. ROLES QUALIFICATIONS AND RESPONSIBILITIES ARE DISCUSSED IN SECTION 6.
$511,264Atmospheric & Space Technology Research Associates Llc · · FY2021 · National Aeronautics and Space Administration
Establishing Strategies to Ameliorate Amyloid Pathology in Light Chain Amyloidosis
$511,005Rockland L Wiseman · Scripps Research Institute, The · R01 · FY2022 · DK
Establishing Strategies to Ameliorate Amyloid Pathology in Light Chain Amyloidosis
$511,005Rockland L Wiseman · Scripps Research Institute, The · R01 · FY2021 · DK
Renal Macrophage Biology
$510,944Xuebin Qin · Tulane University Of Louisiana · R01 · FY2023 · DK
Preclinical models, biomarkers, and therapy for myotonic dystrophy type 1
$510,858Maurice S Swanson · University Of Rochester · P50 · FY2020 · NS
Biochemical and molecular heterogeneity of human TDP-43 proteinopathies in age-related dementias
$510,842Silvia Porta Antolinez · University Of Pennsylvania · R01 · FY2025 · AG
SCIENCE GOALS AND OBJECTIVES IN A RECENT WORK THE PROPOSERS HAVE IDENTIFIED A SUBSET OF SOLAR WIND AND OF INTERPLANETARY CORONAL MASS EJECTIONS (ICMES) OBSERVED BY ACE/SWICS WHOSE ANOMALOUS CHARGE STATE COMPOSITION SHOWS A LACK OF FULLY STRIPPED IONS (SUCH AS C6+ N7+ AND O8+ ZHAO ET AL. 2016) WHILE PRESERVING A NORMAL COMPOSITION FOR ALL OTHER SPECIES. THIS COMMON ANOMALY INDICATES THAT BOTH THESE SOLAR WIND AND ICME ANOMALOUS PLASMA PARCELS MAY HAVE SAME FUNDAMENTAL ACCELERATION PROCESS IN THE SOLAR CORONA WHICH MUST BE DIFFERENT FROM THE REGULAR SOLAR WIND AND DISCRIMINATES AGAINST FULLY STRIPPED IONS. THIS PECULIAR SIGNATURE CAN BE USED TO DIRECTLY INVESTIGATE THE PLASMA ACCELERATION PROCESS THAT HAS GENERATE IT. WE PROPOSE A THREE-YEAR RESEARCH PROGRAM TO STUDY THOSE ANOMALOUS SOLAR WIND AND ICMES WITH THE FOLLOWING SCIENCE GOALS: 1) TO THOROUGHLY CHARACTERIZE THE IN-SITU PROPERTIES OF THESE ANOMALOUS SOLAR WIND AND ICMES AND TO INVESTIGATE THEIR VARIATION ALONG THE SOLAR CYCLE; 2) TO IDENTIFY THEIR SOURCE REGIONS IN THE SOLAR ATMOSPHERE AND TO DETERMINE THEIR PROPERTIES; 3) TO IDENTIFY AND UNDERSTAND THE ACCELERATION PROCESS THAT PROPELS THESE PLASMA PARCELS INTO THE INTERPLANETARY SPACE. MISSION DATA WE WILL ACCOMPLISH THESE GOALS BY USING OBSERVATIONS FROM SPACE INSTRUMENTS ACROSS THE HELIOPHYSICS SYSTEM OBSERVATORY (HSO): ACE WIND STEREO SDO SOHO HINODE AND IRIS AND THE OBSERVATION OF THE JOINT ESA-NASA MISSION ULYSSES. METHODOLOGY THIS INVESTIGATION WILL BE CARRIED OUT IN THREE STEPS: 1) WE WILL ANALYZE THE COMPLETE DATASET OF THE SOLAR WIND INSITU MEASUREMENTS OBTAINED BY ACE ULYSSES AND WIND TO IDENTIFY ALL PLASMA PARCELS HAVING ANOMALOUS COMPOSITION AND DETERMINE THEIR IN-SITU PROPERTIES BOTH IN THE SOLAR WIND AND IN ICMES. 2) WE WILL MAP THE IN-SITU SOLAR WIND OBSERVATIONS BACK TO THE SURFACE OF THE SUN AND STUDY THE PROPERTIES OF THE SOURCE REGIONS. THE BACK-MAPPING WILL BE CARRIED OUT BY COMBINING THE POTENTIAL FIELD SOURCE SURFACE (PFSS) AND THE CURRENT SHEET SOURCE SURFACE (CSSS) MODELS WITH THE SOHO/MDI SDO/HMI AND HINODE/SOT DATA. THE PHYSICAL PROPERTIES OF THE SOURCE REGIONS WILL BE MEASURED USING STANDARD PLASMA DIAGNOSTICS TECHNIQUES UTILIZING THE EUV AND XRAY OBSERVATIONS FROM THE IMAGING AND SPECTROSCOPIC INSTRUMENTS ON BOARD SOHO STEREO HINODE AIA AND IRIS. THE MAGNETIC PROPERTIES OF THE WIND CORONAL SOURCE REGION WILL ALSO BE EVALUATED BY THE SEPARATRIX-WEB (S-WEB) STRUCTURE CALCULATED FROM PFSS MODEL. 3) THE ANOMALOUS WINDS IN-SITU CHARACTERISTICS AND THE PROPERTIES IN THEIR CORONAL SOURCE REGIONS WILL BE ANALYZED IN LIGHT OF LEADING MAGNETIC ACCELERATION PROCESSES TO DETERMINE THE RELATIONSHIP TO THE MAGNETIC RECONNECTION THAT ACCELERATES THESE WINDS AND TO EXAMINE IF THERE ARE DISTINCT FEATURES IN THE RECONNECTION PROCESS THAT ARE RESPONSIBLE FOR THE WINDS ANOMALOUS PROPERTIES. RELEVANCE TO MISSION AND DECADAL SURVEY GOALS THE PROPOSED INVESTIGATION IS AIMED AT DETERMINING THE FUNDAMENTAL ACCELERATION PROCESSES GENERATING THE SOLAR WIND AND ICMES. UNDERSTANDING OF THESE ANOMALOUS SOLAR WIND AND ICME EVENTS WILL PROVIDE INSIGHTS INTO HOW ICME AND SOLAR WIND PLASMAS ARE ACCELERATED AND HOW THEIR PROPERTIES ARE AFFECTED BY CORONAL CONDITIONS AND MAGNETIC CONNECTION IN SOLAR WIND SOURCE REGIONS: SUCH GOALS ARE RELEVANT TO ALL THE HSO MISSIONS WE WILL UTILIZE. THE PROPOSED INVESTIGATION IS ALSO RELEVANT TO TWO OF THE GOALS OF THE HELIOPHYSICS DECADAL SURVEY: 1) DETERMINE THE ORIGINS OF THE SUN S ACTIVITY AND PREDICT THE VARIATIONS IN THE SPACE ENVIRONMENT; 4) DISCOVER AND CHARACTERIZE THE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE. THE PROPOSED INVESTIGATION IS ALSO CENTRAL TO NASA S STRATEGIC GOAL 1.4 UNDERSTAND THE SUN AND ITS INTERACTIONS WITH EARTH AND THE SOLAR SYSTEM INCLUDING SPACE WEATHER .
$510,821Regents Of The University Of Michigan · · FY2020 · National Aeronautics and Space Administration
CAREER: Navigating Thermodynamic Landscapes for Phase Equilibria Predictions using Molecular Modeling and Machine Learning
$510,796Yamil J Colon · University Of Notre Dame · · FY2022 · ENG
Renal Macrophage Biology
$510,738Xuebin Qin · Tulane University Of Louisiana · R01 · FY2022 · DK
Cognitive Processing and Sentence Comprehension in SLI
$510,705James W Montgomery · Ohio University Athens · R01 · FY2010 · DC
Infant Brain and Behavioral Signatures of Later Emerging Risk for Psychopathology
$510,702Jed Thomas Elison · University Of Minnesota · R01 · FY2015 · MH
Elucidating the molecular signaling of Cadmium Carcinogenesis
$510,684Chendil Damodaran · Texas A&M University Health Science Ctr · R01 · FY2022 · ES
Interplay Between SERPINB1 and TLR2/TLR4 in Beta Cell Regeneration
$510,649Ling Qi · University Of Michigan At Ann Arbor · R01 · FY2020 · DK