Sort
15,273 grants matching “antimicrobial resistance”
Targeting DHFR to Design Antimicrobial Agents
$263,991Amy C. Anderson · University Of Connecticut Storrs · R01 · FY2010 · GM
Antimicrobial Resistance and Therapeutic Discovery Training Program
$263,961William Maurice Shafer · Emory University · T32 · FY2022 · AI
Th17 Cytokines and Lung Immunity
$263,948Jay K Kolls · University Of Pittsburgh At Pittsburgh · R37 · FY2017 · HL
Microscopy-Based Antimicrobial Susceptibility Testing (MAST)
$263,805James E Kirby · Beth Israel Deaconess Medical Center · R21 · FY2018 · AI
MRI: Acquisition of a Rheometer for Interdisciplinary Material Science Research and Training of Undergraduate Researchers
$263,763Ryan McGorty · University Of San Diego · · FY2019 · ENG
Initiation and Regulation of Immune Protease Pathways
$263,713Haobo Jiang · Oklahoma State University Stillwater · R01 · FY2009 · GM
M. genitalium Susceptibility and Treatment
$263,654Lisa E Manhart · University Of Washington · U19 · FY2006 · AI
Engineered bacteriophage as a platform to deliver nucleic acid based therapeutics to bacteria to disperse biofilms in implant-associated infections such as prosthetic joint infections
$263,500Jeffrey Alan Radding · Enbiotix, Inc. · R43 · FY2016 · AI
STRUCTURE/FUNCTION RELATIONSHIPS OF HPPK
$263,468Michigan State University · R01 · FY2000 · GM
Proteoglycans in Microbial Pathogenesis and Host Defense
$263,375Baylor College Of Medicine · R01 · FY2005 · HL
Proteoglycans in Microbial Pathogenesis and Host Defense
$263,375Baylor College Of Medicine · R01 · FY2003 · HL
Proteoglycans in Microbial Pathogenesis and Host Defense
$263,375Baylor College Of Medicine · R01 · FY2002 · HL
Proteoglycans in Microbial Pathogenesis and Host Defense
$263,375Baylor College Of Medicine · R01 · FY2004 · HL
Molecular mechanisms of immunosuppression induced by superanfigens
$263,373Keun Seok Seo · Mississippi State University · P20 · FY2017 · GM
Mechanisms of Antibiotic Efflux in Campylobacter
$263,372Qijing Zhang · Iowa State University · R01 · FY2008 · DK
Mechanisms of Antibiotic Efflux in Campylobacter
$263,287Qijing Zhang · Iowa State University · R01 · FY2009 · DK
Animal Model Core
$263,156Gerard J Nau · Miriam Hospital · P20 · FY2019 · GM
Novel adjunctive therapy for drug resistant Gram-negative pathogens
$263,098Robert Ernest William Hancock · University Of British Columbia · R33 · FY2015 · AI
Laboratory Studies of Abnormal Host Defense and Immunoregulatory Diseases
$263,008Kol Zarember · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
An essential transcription regulator in Pseudomonas aeruginosa
$263,000Simon L Dove · Boston Children'S Hospital · R21 · FY2014 · AI
PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) CAUSES THE MOST COSTLY DISEASE TO SWINE PRODUCTION IN THE UNITED STATES. DISEASE CAUSED BY THIS VIRUS OFTEN INVOLVES SECONDARY BACTERIAL PATHOGENS, WHICH EXACERBATES RESPIRATORY DISEASE AND INCREASES ANTIMICROBIAL ADMINISTRATION IN YOUNG GROWING PIGS. ALTHOUGH COMMERCIAL VACCINES ARE USED TO REDUCE THE EFFECTS OF PRRSV ON SWINE HEALTH, THE CURRENTLY AVAILABLE VACCINES ARE CONSIDERED INADEQUATE FOR DISEASE CONTROL. ALTERNATIVE STRATEGIES FOR CONTROL OF PRRSV IS NEEDED TO MAINTAIN SWINE HEALTH AND WELFARE WHILE LESSENING THE ECONOMIC EFFECTS OF THIS DISEASE ON PORK PRODUCERS. THE GOAL OF THIS WORK IS TO INVESTIGATE THE GUT MICROBIOME AS AN ALTERNATIVE TOOL FOR PRRSV CONTROL DUE TO ITS IMPACT ON THE IMMUNE SYSTEM AND OUTCOME AFTER INFECTION. OBJECTIVES OF THE WORK INCLUDE INVESTIGATING THE EFFECTS OF MICROBIOME MODULATION ON OUTCOME OF SWINE WITH RESPIRATORY DISEASE AND IDENTIFYING WHAT BENEFICIAL MICROBES ARE ASSOCIATED WITH IMPROVED HEALTH. WE ANTICIPATE THE DATA GENERATED IN THIS PROJECT WILL ALLOW US TO CHARACTERIZE AND DETERMINE THE GUT MICROBES WHICH IMPROVE PIG HEALTH IN THE PRESENCE OF PRRSV. OUR GOAL IS TO DETERMINE HOW BENEFICIAL GUT MICROBES MAY BE USED AS A PREVENTATIVE MEDICINE TOOL TO REDUCE THE EFFECTS OF RESPIRATORY DISEASE AND DECREASE THE NEED FOR ANTIMICROBIALS IN SWINE. THE IMPACTS OF THIS WORK WILL IMPROVE ANIMAL WELFARE AND ANIMAL HEALTH, LESSEN THE ECONOMIC LOSSES TO PRODUCERS ASSOCIATED WITH PRRSV, AND REDUCE THE RISK OF ANTIMICROBIAL RESISTANCE IN SWINE.
$262,796Kansas State University · · FY2020 · National Institute of Food and Agriculture
NMR STUDIES OF BACTERIAL SIGNAL TRANSDUCTION
$262,711Brandeis University · R01 · FY2000 · GM
University of Pittsburgh Training Program in Antimicrobial Resistance
$262,633Lee H. Harrison · University Of Pittsburgh At Pittsburgh · T32 · FY2022 · AI
Disposable Microfluidic Devices for Point of Care Diagnostics
$262,625Catherine M. Klapperich · Boston University (Charles River Campus) · R21 · FY2009 · AI
Antimicrobial Lipids within the Oral Cavity
$262,500Philip Wesley Wertz · University Of Iowa · R01 · FY2008 · DE