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91,797 grants matching “obesity”
Epidemiology of Venous Thrombosis and Pulmonary Embolism
$776,400Aaron R Folsom · University Of Minnesota · R01 · FY2017 · HL
Neighborhoods and Cardiovascular Risk and Resilience in Rural Communities
$776,364Mahasin S Mujahid · University Of California Berkeley · R01 · FY2024 · HL
National Gnotobiotic Resource Center
$776,328Ryan Balfour Sartor · Univ Of North Carolina Chapel Hill · P40 · FY2024 · OD
National Gnotobiotic Resource Center
$776,328Ryan Balfour Sartor · Univ Of North Carolina Chapel Hill · P40 · FY2025 · OD
Primary Care Obesity Prevention: One or Multiple Targets
$776,323Nicolas Stettler · Children'S Hosp Of Philadelphia · R01 · FY2007 · HL
Physical Activitiy and Obesity Program
$776,304Joe Kyle · South Carolina Department Of Public Health · U58 · FY2012 · DP
Component A: A multi-level study of community context and type 2 diabetes and coronary heart disease using electronic health record and new primary data across nested geographies in Pennsylvania
$776,257Annemarie Gregory Hirsch · Geisinger Clinic · U01 · FY2019 · DP
Glycemic Profile of Pregnancy Consortium Biostatistics Research Center
$776,254Denise M Scholtens · Northwestern University At Chicago · U01 · FY2025 · DK
Virtual Housecalls: Redesigning Pediatric Primary Care Adolescent Obesity Treatment
$776,248Melanie K Bean · Virginia Commonwealth University · R01 · FY2025 · DK
Development of a Bariatric Mannequin System to Enable Realistic Examination Simulations of Obese Patients
$776,242John Paul Condon · Innovative Design Labs, Inc. · R44 · FY2022 · DK
Developmental Funds
$776,186Robert L Ferris · University Of Pittsburgh At Pittsburgh · P30 · FY2022 · CA
Developmental Funds
$776,186Robert L Ferris · University Of Pittsburgh At Pittsburgh · P30 · FY2023 · CA
Developmental Funds
$776,186Robert L Ferris · University Of Pittsburgh At Pittsburgh · P30 · FY2024 · CA
Sleep and Obesity in Toddlers from Mexican American Families
$776,150Darcy Ann Thompson · University Of Colorado Denver · R01 · FY2022 · HL
Nutritional and Biochemical/Genetic Markers of Cancer
$776,107Brigham And Women'S Hospital · R01 · FY2004 · CA
Changes in Bone Quality, Sarcopenia and Fat Distribution in HIV/HCV Patients after HCV Therapy
$776,106Vincent Lo Re · University Of Pennsylvania · R01 · FY2022 · AI
Alcohol Metabolism, Functional Consequences and Apoptosis Signaling Mechanism
$776,088Byoung-Joon Song · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2011 · AA
Cardiovascular Health and Needs Assessment in Washington D.C.
$776,076Tiffany Powell-Wiley · National Heart, Lung, And Blood Institute · ZIA · FY2018 · HL
Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults
$775,988John F Alcorn · University Of Pittsburgh At Pittsburgh · R01 · FY2023 · AI
Testing the Efficacy of a Technology-Assisted Weight Management Intervention within Patient-Centered Medical Homes: The GEM (Goals for Eating and Moving) Study
$775,976Melanie Jay · New York University School Of Medicine · R01 · FY2016 · DK
OBESITY AFFECTS A SIGNIFICANT PROPORTION OF THE U.S. POPULATION AND IS CHARACTERIZED BY ALTERED GUT MICROBIOMES, IMPAIRED CARDIO- AND IMMUNOPROTECTIVE HDL FUNCTIONS, AND PRO-INFLAMMATORY IMMUNE PROFILES, THEREBY INCREASING CHRONIC DISEASE RISK WHILE IMPAIRING IMMUNE DEFENSES. THE GUT MICROBIOME AND ASSOCIATED METABOLOME REGULATE HDL AND IMMUNE PATHWAYS THAT DIFFER BY SEX, AND REPRESENT PROMISING TARGETS TO MITIGATE OBESITY-ASSOCIATED DISEASE. OUR PREVIOUS WORK DEMONSTRATES THAT, COMPARED TO EGG WHITES, WHOLE EGGS IMPROVE HDL, INFLAMMATORY, AND IMMUNE PROFILES TO VARYING DEGREES IN HEALTHY AND METABOLIC SYNDROME POPULATIONS; HOWEVER, IT IS UNKNOWN WHETHER GUT MICROBIOME CHANGES ARE MEDIATING THESE EFFECTS, OR WHETHER THESE EFFECTS ARE SEX-SPECIFIC. THEREFORE, THE LONG-TERM GOAL OF THIS PROJECT IS TO EVALUATE THE GUT MICROBIOME ROLE IN MEDIATING WHOLE EGG EFFECTS ON HDL AND IMMUNE PROFILES BY SEX AND METABOLIC PHENOTYPE. WE WILL CONDUCT A RANDOMIZED CROSSOVER INTERVENTION TRIAL WITH HEALTHY WEIGHT AND OBESITY GROUPS TO TEST OUR HYPOTHESIS THAT, COMPARED TO EGG WHITE INTAKE, WHOLE EGGS WILL PROVIDE GREATER GUT HEALTH-PROMOTING COMPONENTS TO IMPROVE GUT MICROBIOTA COMPOSITION, FECAL AND SERUM METABOLOMES, AND MEASURES OF GUT INFLAMMATION AND INTEGRITY (OBJECTIVE 1); HDL COMPOSITION, EFFLUX AND ANTIOXIDANT CAPACITY, AND IMMUNOMODULATORY FUNCTIONS (OBJECTIVE 2); AND CLINICAL, FUNCTIONAL, AND OMICS-BASED IMMUNE PROFILES (OBJECTIVE 3); AND THAT SEX, METABOLIC PHENOTYPE, AND GUT MICROBIOME PROFILES WILL DICTATE HDL AND IMMUNE RESPONSES TO EGG INTAKE. THIS STUDY DIRECTLY ADDRESSES USDA NIFA FOOD AND HUMAN HEALTH PRIORITIES BY INVESTIGATING THE INTERRELATIONSHIP OF EGGS (AND IMPORTANT U.S. AGRICULTURAL PRODUCT), THE GUT MICROBIOME, AND CHRONIC DISEASE PATHWAYS TO INFORM PERSONALIZED NUTRITION RECOMMENDATIONS THAT SUPPORT HUMAN HEALTH.
$775,934University Of Connecticut · · FY2025 · National Institute of Food and Agriculture
Targeting Endothelial Epsins to Ameliorate Myocardial Ischemia
$775,931Hong Chen · Boston Children'S Hospital · R01 · FY2025 · HL
Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults
$775,914John F Alcorn · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · AI
Glucagon-mediated glycemic effect in humans with and without rerouted gut after bariatric surgery
$775,865Marzieh Salehi · University Of Texas Hlth Science Center · R01 · FY2025 · DK
Treating Sleep Apnea in Type 2 Diabetes Mellitus: A Randomized Clinical Trial
$775,833Naresh Punjabi · Johns Hopkins University · R01 · FY2016 · HL