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34,240 grants matching “atherosclerosis”
Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
$500,000Jane E Freedman · Univ Of Massachusetts Med Sch Worcester · UH2 · FY2013 · TR
THE LONG-TERM GOAL OF THIS STUDY IS TO IDENTIFY WHETHER DIETARY SUPPLEMENTATION OF STRAWBERRIES PREVENTS THE DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN METABOLIC SYNDROME (METS). CARDIOVASCULAR DISEASE SUCH AS ATHEROSCLEROSIS IS THE LEADING CAUSE OF DEATH IN THE UNITED STATES. METS IS ANIMPORTANT RISK FACTOR FOR CARDIOVASCULAR MORTALITY, AND VASCULAR INFLAMMATION PLAYS A MAJOR ROLE IN THE DEVELOPMENT OF VASCULARDISEASE IN METS. ATHEROSCLEROSIS IS A CONDITION IN WHICH PLAQUE BUILDS UP INSIDE THE BLOOD VESSEL, LEADING TO HARDENING ANDNARROWING OF BLOOD VESSELS. CHOLESTEROL, FATTY SUBSTANCES, AND CELLULAR WASTE PRODUCTS FORM THE HARD PLAQUE INSIDE THE BLOODVESSEL. AS ATHEROSCLEROSIS PROGRESSES, THE PLAQUE SIZE CAN INCREASE AND BLOCK THE BLOOD FLOW THROUGH BLOOD VESSELS IN THE HEART,BRAIN, LEGS, ARMS OR KIDNEYS. AS A RESULT, THE RISK FOR HEART ATTACK, STROKE, AND OTHER KINDS OF HEALTH PROBLEMS INCREASES.METABOLIC SYNDROME CAUSES THE DEVELOPMENT AND PROGRESSION OF ATHEROSCLEROSIS. DUETO THE CURRENT EPIDEMIC OF METABOLICSYNDROME, THERE IS AN URGENT NEED TO DEVELOP NEW STRATEGIES TO REDUCE HEART DISEASE IN METABOLIC SYNDROME. OUR RESEARCH ISAIMED TO IDENTIFY NEW AND COST EFFECTIVE STRATEGIES, SUCH AS DIETARY RECOMMENDATIONS THAT CAN REDUCE VESSEL COMPLICATIONS AND PROMOTE OVERALL HEART AND BLOOD VESSEL HEALTH.ANTHOCYANINS ARE ONE OF THE MOST ABUNDANT PLANT COMPOUNDS AND ARE WIDELY AVAILABLE IN BLUEBERRIES, STRAWBERRIES, AND RASPBERRIES. STUDIES SUPPORT THE IMPORTANCE OF BERRIES IN THE REGULAR DIET. EVIDENCE SHOWS THAT EATING 2-3 SERVINGS OFSTRAWBERRIES PER WEEK LOWERS THE RISK OF TYPE 2 DIABETES AND REDUCES THE RISK OF HEART ATTACKS. THE GOOD BACTERIA IN THE GUT HELPS TO METABOLIZE THE BERRY ANTHOCYANINS INDICATING IT MAY PLAY A CRUCIAL ROLE IN MEDIATINGTHE VASCULAR BENEFICIAL EFFECTS OF BERRY FRUITS. OUR PRELIMINARY DATA SHOW THATEATING STRAWBERRIES REDUCES BLOOD PRESSURE AND HELPS VESSELS REMAIN HEALTHY IN MICE THAT HAVE DIABETES. IN ADDITION, DIETARY STRAWBERRIESINCREASED THE GOODGUT BACTERIA IN DIABETIC MICE. HOWEVER, STUDIES ARE LACKING THAT INVESTIGATE (I) THE MOLECULAR MECHANISMS THAT ARE INVOLVED IN THE BENEFICIAL VASCULAR EFFECTS OF STRAWBERRIES, (II) THE ROLE OF GUT BACTERIA IN MEDIATING THESE BENEFICIAL EFFECTS, AND (III)ACTIVE COMPONENTS INVOLVED.THE PROPOSED STUDY WILL IDENTIFY THE ROLE OF GUT BACTERIA IN MEDIATING THE VASCULAR BENEFICIAL EFFECTS OF STRAWBERRIES AND THE ACTIVE COMPONENTS INVOLVED IN THE BENEFICIAL EFFECTS OF STRAWBERRY. THE PROJECT IS EXPECTED TO HAVE SIGNIFICANT EFFECT ON HUMAN HEALTH BECAUSE THE RESULTS FROM THIS STUDY COULD POTENTIALLY LEAD TO LOWER-COST, YET EFFECTIVE STRATEGIES TO REDUCE DEATH AND ILLNESS DUE TO HEART AND VESSEL COMPLICATIONS IN PEOPLE WITH METABOLIC SYNDROME.
$500,000University Of Utah · · FY2019 · National Institute of Food and Agriculture
CAREER: Elucidation of the Physical Principles the Govern Endothelial Structure and Function
$500,000Robert Steward · The University Of Central Florida Board Of Trustees · · FY2021 · ENG
CAREER: Force-activated Protein Dynamics in Mechanobiology
$500,000Brenton D Hoffman · Duke University · · FY2015 · ENG
Murine Cardiovascular MRI
$500,000University Of Iowa · S10 · FY2003 · RR
Targeting the relief of chronic pain with orally active peroxynitrite decompositi
$499,999William Neumann · Southern Illinois Univ At Edwardsville · RC1 · FY2009 · AR
Epidemiologic Study of Risk Factors and Biomarkers of Atrial Fibrillation
$499,997Alvaro Alonso · University Of Minnesota · RC1 · FY2009 · HL
Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
$499,996Naomi K Fukagawa · University Of Vermont & St Agric College · RC1 · FY2009 · ES
Genetics and Personalized Medicine: From Population Studies to Clinical Therapy
$499,975Christie M Ballantyne · Baylor College Of Medicine · P30 · FY2010 · HL
Reasons for Racial Disparities in Venous Thromboembolism
$499,963Neil Adrian Zakai · University Of Vermont & St Agric College · RC1 · FY2009 · HL
Building Interdisciplinary Careers/Women's Health/UC Davis
$499,957Claire Pomeroy · University Of California At Davis · K12 · FY2008 · HD
Building Interdisciplinary Careers/Women's Health/UC Davis
$499,957Claire Pomeroy · University Of California At Davis · K12 · FY2009 · HD
Building Interdisciplinary Careers/Women's Health/UC Davis
$499,957Claire Pomeroy · University Of California At Davis · K12 · FY2007 · HD
Genetics of Atherosclerosis in a Murine Model
$499,947Jonathan D Smith · Cleveland Clinic Lerner Com-Cwru · P50 · FY2008 · HL
Neuroprotective Engineering Based on Innate Responses to Stroke
$499,922Shu Q Liu · Northwestern University · · FY2014 · ENG
Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes
$499,863R Graham Barr · Columbia University Health Sciences · RC1 · FY2009 · HL
Genetic Risk Stratification to Identify Individuals for Early Statin Therapy
$499,855Marc S Sabatine · Brigham And Women'S Hospital · RC1 · FY2009 · HL
RAGE, DIAPH1 and IRF7 and Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Disease
$499,778Ann Marie Schmidt · New York University School Of Medicine · P01 · FY2024 · HL
Role of MMPs in arterial calcification
$499,703Raul J Guzman · Beth Israel Deaconess Medical Center · R56 · FY2017 · HL
Elucidating the Dissolution Mechanisms of Mineral Scale by Molecular Modifiers
$499,680Jacinta Conrad · University Of Houston · · FY2024 · ENG
BMAL1/ARNTL plays a critical, non-circadian role in secondary tissue damage after contusive SCI
$499,606Michal Hetman · University Of Louisville · R01 · FY2024 · NS
RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
$499,588Robert Schneider · Institute For Prevention Research · RC1 · FY2010 · HL
Molecular Mechanisms in Abdominal Aortic Aneuysm
$499,585Bo Liu · University Of Wisconsin-Madison · R01 · FY2017 · HL
Long non-coding RNA-mediated chromatin remodeling in angiogenesis
$499,426Zhen Bouman Chen · Beckman Research Institute/City Of Hope · R01 · FY2022 · HL
Long non-coding RNA-mediated chromatin remodeling in angiogenesis
$499,426Zhen Bouman Chen · Beckman Research Institute/City Of Hope · R01 · FY2021 · HL