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17,054 grants matching “genome editing”
Myoediting of Duchenne Muscular Dystrophy
$1,605,786Eric N Olson · Ut Southwestern Medical Center · P50 · FY2022 · HD
Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular Interactions
$1,603,401Sally Temple · Regenerative Research Foundation · U01 · FY2023 · AG
Molecular Genetics Of Heritable Human Disorders
$1,602,501Janice Chou · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2022 · HD
CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects
$1,602,269Aaron M Zorn · Cincinnati Childrens Hosp Med Ctr · P01 · FY2023 · HD
Engineering programmable enzymes for proteome editing
$1,602,000Xin Zhou · Dana-Farber Cancer Inst · DP2 · FY2023 · GM
NEI Genetic Engineering Core
$1,601,981Lijin Dong · National Eye Institute · ZIC · FY2020 · EY
Differentiation of human induced pluripotent stem cells as a tool to study the effects of type 2 diabetes loci.
$1,601,188Leslie J Baier · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2021 · DK
Myoediting of Duchenne Muscular Dystrophy
$1,600,891Eric N Olson · Ut Southwestern Medical Center · P50 · FY2020 · HD
Modeling Huntingtons disease in iPSC-derived astrocytes
$1,600,421Carlos Tristan · National Center For Advancing Translational Sciences · ZIA · FY2025 · TR
SMCHD1 and hypothalamic neurogenesis
$1,600,421Carlos Tristan · National Center For Advancing Translational Sciences · ZIA · FY2025 · TR
Functional consequences of putative analgesic receptor activation in human DRG neuronal cultures from healthy donors
$1,600,421Carlos Tristan · National Center For Advancing Translational Sciences · ZIA · FY2025 · TR
FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement
$1,600,000Peng Jin · Emory University · P50 · FY2020 · HD
FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement
$1,600,000Peng Jin · Emory University · P50 · FY2023 · HD
FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement
$1,600,000Peng Jin · Emory University · P50 · FY2021 · HD
FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement
$1,600,000Peng Jin · Emory University · P50 · FY2022 · HD
INFLUENZA OR FLU IS ONE OF TOP 3 ECONOMIC DISEASES AFFECTING THE PORK INDUSTRY. IN HUMANS, IT CAUSES UP TO 41,000 HUMAN FATALITIES IN UNITED STATES AND UPWARDS OF 500,000 CASUALTIES WORLDWIDE. PIGS SERVE AS RESERVOIRS FOR SWINE, AVIAN, AND HUMAN VIRUSES AND PRODUCE NOVEL HIGH POTENCY STRAINS, SIMILAR TO THE "SWINE FLU" PANDEMIC H1N1 STRAIN. OUR HYPOTHESIS IS THAT ELIMINATING RECEPTORS FOR VIRAL ENTRY AND INTERFERING WITH VIRAL REPLICATION WILL SERVES AS A DUAL MECHANISM FOR PROTECTING THE PIGS FROM VIRAL INFECTION, AND TRANSMISSION OF FLU TO HUMAN AND PIG HOSTS. THERE ARE THREE OBJECTIVES IN THE PROPOSAL: 1) ASSEMBLE AND VALIDATE GENOME EDITING TOOLS TO DELETE THE RECEPTOR FOR FLU VIRUS ENTRY, AND PREVENT VIRAL PROPAGATION; 2) GENERATE RECOMBINANT PIGS; AND 3) TEST THE RECOMBINANT PIGS FOR SUSCEPTIBILITY TO INFECTION BY SWINE AND HUMAN TYPE ADAPTED VIRUSES TO INFECTION AND DISSEMINATION. WE EXPECT TO DEVELOP A PIG MODEL OF INFLUENZA RESEARCH AND IDENTIFY DRUGGABLE TARGETS. FROM AGRICULTURAL STAND POINT, WE ANTICIPATE ELIMINATION OF FLU FROM COMMERCIAL SWINE HERDS.
$1,600,000University Of Maryland, College Park · · FY2015 · National Institute of Food and Agriculture
FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement
$1,600,000Peng Jin · Emory University · P50 · FY2024 · HD
EDGE: Developing techniques for linking genotype to phenotype in amphibians
$1,599,999Lauren A O'Connell · Stanford University · · FY2018 · BIO
Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia
$1,599,191Gregory E Crawford · Duke University · R01 · FY2025 · MH
Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia
$1,599,191Gregory E Crawford · Duke University · R01 · FY2022 · MH
Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia
$1,599,191Gregory E Crawford · Duke University · R01 · FY2023 · MH
Beyond GWAS: High Throughput Functional Genomics & Epigenome Editing to Elucidate the Effects of Genetic Associations for Schizophrenia
$1,599,191Gregory E Crawford · Duke University · R01 · FY2024 · MH
Task Order 02 Award - "Chronic Disease Validation & Analyses in the Sister Study"
$1,599,101Dale Sandler · Social And Scientific Systems, Inc. · N01 · FY2018 · ES
CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects
$1,598,939Aaron M Zorn · Cincinnati Childrens Hosp Med Ctr · P01 · FY2025 · HD
Behavioral Genomics of Alcohol Neuroadaptation
$1,597,360Tamara J. Phillips · Oregon Health & Science University · P60 · FY2022 · AA