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141,003 grants matching “cytokine”
Antecedents of Suicidal Behavior Related Neurobiology
$2,508,684Joseph J Mann · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · P50 · FY2022 · MH
Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response
$2,508,454Jamey P Weichert · University Of Wisconsin-Madison · P01 · FY2021 · CA
Pharmaco Response Signatures and Disease Mechanism
$2,507,018Peter Karl Sorger · Harvard Medical School · U54 · FY2012 · HG
Pharmaco Response Signatures and Disease Mechanism
$2,507,018Peter Karl Sorger · Harvard Medical School · U54 · FY2013 · HG
Anti-NMDA Receptor Antibodies in Adult Brain Dysfunction: Lessons from Lupus
$2,506,124Betty Diamond · Feinstein Institute For Medical Research · P01 · FY2025 · AI
Genetic Approaches To Understanding Organ Development and Function
$2,503,076Lothar Hennighausen · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2018 · DK
Investigating Transcriptional Responses to the Environment
$2,502,667Karen L Adelman · National Institute Of Environmental Health Sciences · ZIA · FY2014 · ES
Lymphoma Specialized Program of Research Excellence (SPORE) in Human Cancer
$2,500,000George J Weiner · University Of Iowa · P50 · FY2018 · CA
A Multi-Center Group to Study Acute Liver Failure
$2,500,000William M Lee · Ut Southwestern Medical Center · U01 · FY2014 · DK
A Multi-Center Group to Study Acute Liver Failure
$2,500,000William M Lee · Ut Southwestern Medical Center · U01 · FY2012 · DK
A Multi-Center Group to Study Acute Liver Failure
$2,500,000William M Lee · Ut Southwestern Medical Center · U01 · FY2013 · DK
A Multi-'omic Analysis of the Vaginal Microbiome during Pregnancy
$2,500,000Gregory A Buck · Virginia Commonwealth University · U54 · FY2014 · HD
Open-label extension of a 3-month blinded clinical trial of PTI-125
$2,499,896Lindsay H Burns · Cassava Sciences, Inc · R44 · FY2020 · AG
Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders
$2,499,658Joan L Luby · Washington University · R01 · FY2024 · MH
Expression, Structure/function, Regulation, and Roles of PDE3 Isoforms
$2,499,647Vincent Manganiello · National Heart, Lung, And Blood Institute · ZIA · FY2012 · HL
INFECTION AND DISEASE ADVERSELY IMPACT PERFORMANCE, GROWTH, MORBIDITY AND MORTALITY IN PRODUCTION ANIMALS AND HAS MAJOR ECONOMIC IMPACTS ON COMMERCIAL POULTRY PRODUCTION. THIS IS EXACERBATED BY CONSUMER WORRIES ABOUT ANTIBIOTIC USE, WHICH PRESSURES PRODUCERS TO USE ALTERNATIVE STRATEGIES TO PREVENT INFECTION. AN ILLUSTRATING EXAMPLE IS THE AVIAN INFLUENZA OUTBREAK OF 2015, WHICH HAS BEEN DESCRIBED AS THE WORST IN US HISTORY WITH THE LOSS OF OVER 48 MILLION BIRDS (CHICKEN AND TURKEY). THIS EVENT UNDERSCORES THE NEED TO FUNCTIONALLY ANNOTATING THE CHICKEN GENOME TO UNDERSTAND COMPLEX GENETIC TRAITS SUCH AS DISEASE RESISTANCE, WHICH IN TURN COULD SERVE AS A POWERFUL TOOL TO ENSURE SUSTAINABLE AGRICULTURAL SYSTEMS. FURTHERMORE, IN POULTRY PRODUCTION, ADDITIONAL FACTORS AFFECTING COMMERCIAL AND ECONOMIC PERFORMANCE NEED TO BE CONSIDERED IN BREEDING. FACTORS INCLUDING INTESTINAL HEALTH, EGG LAYING PERFORMANCE OR GROWTH EFFICIENCY IN BROILERS CERTAINLY ARE OF PARTICULAR ECONOMIC SIGNIFICANCE.TO IMPROVE OUR UNDERSTANDING OF THE UNDERLYING MECHANISMS CONTROLLING THESE AND OTHER TRAITS, IDENTIFICATION OF CIS-REGULATORY ELEMENTS ON THE GENOME IS WARRANTED. THESE REGULATORY ELEMENTS CONTROL THE EXPRESSION OF GENES AND CONSEQUENTLY PHENOTYPE; HOWEVER, THE TARGETED TISSUES AND CELLS FOR ANALYSIS NEED TO BE DETERMINED FOR EACH TRAIT OF INTEREST, AS THESE REGULATORY ELEMENTS ARE TISSUE SPECIFIC, AND EVEN DIFFER FROM CELL TO CELL WITHIN A GIVEN TISSUE. ADDITIONALLY, ENVIRONMENTAL FACTORS SUCH AS NUTRITION INTERACT WITH EPIGENETIC MODIFIERS WORKING AT THESE REGULATORY ELEMENTS, THUS MAKING IT POSSIBLE TO PROMOTE THE EXPRESSION OF DESIRABLE PRODUCTIVE TRAITS BY MANAGEMENT.IN THE PAST, SELECTIVE BREEDING OF POULTRY HAS RESULTED IN IMPROVED FEED CONVERSION RATIOS IN BROILERS, ALBEIT AT THE COST OF DECREASED IMMUNE COMPETENCE AND GREATER SUSCEPTIBILITY TO DISEASE. IN CONTRAST, SOME LINES OF BIRDS ARE KNOWN TO BE MORE RESISTANT TO A VARIETY OF PATHOGENS.THE EMERGENCE OF ANTIMICROBIAL RESISTANCE SUGGESTS THAT GENETIC RESISTANCE TO DISEASE WOULD PROVIDE AN ADVANTAGE OVER THE USE OF ANTIMICROBIALS. WHILE PARAMETERS OF IMMUNE COMPETENCE, SUCH AS ANTIBODY PRODUCTION, PHAGOCYTIC ACTIVITY AND CYTOKINE PRODUCTION OF THE HOST ARE KNOWN, THE GENETIC AND MOLECULAR BASIS FOR DISEASE RESISTANCE IS STILL NOT WELL UNDERSTOOD. IT HAS BECOME APPARENT THAT PATHOGENS INTERACT WITH EPIGENETIC REGULATORS OF THE HOST, AIDING IMMUNE EVASION AND REPLICATION OF THE PATHOGEN.IDENTIFICATION OF REGULATORY ELEMENTS AND THEIR INFLUENCE ON TARGET GENES DIRECTLY RESPONSIBLE FOR ENHANCED IMMUNITY IN POULTRY IS CRUCIAL IN ORDER TO SELECT FOR TRAITS THAT IMPROVE DISEASE RESISTANCE FOR BREEDING PURPOSES AND FLOCK HEALTH.
$2,499,551Western University Of Health Sciences · · FY2018 · National Institute of Food and Agriculture
Interrogating the molecular underpinnings of metastatic colonization
$2,498,874Jonathan Hernandez · Division Of Basic Sciences - Nci · ZIA · FY2022 · CA
Systemic Autoimmunity
$2,497,545Mariana Kaplan · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2021 · AR
Environmental/genetic Risk Factors and Pathogenesis of Autoimmune Disease
$2,497,417Frederick Miller · National Institute Of Environmental Health Sciences · ZIA · FY2020 · ES
Role of microbiome in cancer and inflammation
$2,496,470Giorgio Trinchieri · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
T Cell Costimulatory Pathways: Functions and Interactions
$2,495,776Arlene H Sharpe · Harvard Medical School · P01 · FY2020 · AI
T Cell Costimulatory Pathways: Functions and Interactions
$2,495,776Arlene H Sharpe · Harvard Medical School · P01 · FY2022 · AI
T Cell Costimulatory Pathways: Functions and Interactions
$2,495,776Arlene H Sharpe · Harvard Medical School · P01 · FY2023 · AI
T Cell Costimulatory Pathways: Functions and Interactions
$2,495,776Arlene H Sharpe · Harvard Medical School · P01 · FY2021 · AI
Neuroinflammatory mechanisms of aging-related vascular cognitive impairment (VCI)
$2,495,260Nabil J. Alkayed · Oregon Health & Science University · RF1 · FY2017 · AG