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34,240 grants matching “atherosclerosis”
Hepatocyte Abca1, cholesterol trafficking, and lipid mobilization
$500,496John S Parks · Wake Forest University Health Sciences · R01 · FY2019 · HL
Depression and CHD--Cellular Molecular Mechanisms
$500,392Duke University · R01 · FY2005 · HL
Caspase-1 Activation by the Inflammasomes
$500,359Emad S. Alnemri · Thomas Jefferson University · R01 · FY2014 · AR
Post-lysosomal cholesterol trafficking networks
$500,340Daniel S Ory · Washington University · R01 · FY2018 · HL
Family Study of Carotid Atherosclerosis and Stroke Risk
$500,264Ralph Lewis Sacco · University Of Miami School Of Medicine · R01 · FY2016 · NS
Cell Cycle Control of Restenosis by apoE
$500,244Richard Assoian · University Of Pennsylvania · P01 · FY2009 · HL
Systemic Endothelial Consequences of Periodontal Disease
$500,220Salomon Amar · Boston University Medical Campus · R01 · FY2007 · DE
Chicago Healthy Aging Low Risk MRI Angiography (CHARISMA) Study
$500,181Donald M Lloyd-Jones · Northwestern University At Chicago · R01 · FY2010 · HL
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin
$500,019Gregory Burke · Wake Forest University Health Sciences · N01 · FY2021 · HL
Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
$500,000Alexandra Rose Lucas · University Of Florida · RC1 · FY2010 · HL
Novel Technologies to Identify Preclinical Coronary Disease in High Risk Families
$500,000Lewis C Becker · Johns Hopkins University · RC1 · FY2010 · HL
A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
$500,000Anita P Courcoulas · University Of Pittsburgh At Pittsburgh · RC1 · FY2010 · DK
Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
$500,000Jane E Freedman · Univ Of Massachusetts Med Sch Worcester · UH2 · FY2013 · TR
A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
$500,000Anita P Courcoulas · University Of Pittsburgh At Pittsburgh · RC1 · FY2009 · DK
Copy Number Variants (CNVs) and Subclinical Atherosclerosis in MESA
$500,000Stephen S. Rich · University Of Virginia · RC1 · FY2010 · HL
Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
$500,000Alexandra Rose Lucas · University Of Florida · RC1 · FY2009 · HL
HIGH FIELD MR SCANNER FOR IN VIVO ANIMAL STUDIES
$500,000University Of Texas Hlth Sci Ctr Houston · S10 · FY2000 · RR
AN IVEM FOR HIGH RESOLUTION ELECTRONS CRYO-MICROSCOPY
$500,000Boston University Medical Campus · S10 · FY2000 · RR
A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
$500,000Guillermo A Ameer · Northwestern University At Chicago · RC1 · FY2009 · HL
Multiphoton Confocal Microscopy for Biomedical Research
$500,000Madesh Muniswamy · Temple Univ Of The Commonwealth · S10 · FY2010 · RR
Novel Technologies to Identify Preclinical Coronary Disease in High Risk Families
$500,000Lewis C Becker · Johns Hopkins University · RC1 · FY2009 · HL
THE LONG-TERM GOAL OF THIS STUDY IS TO IDENTIFY WHETHER DIETARY SUPPLEMENTATION OF STRAWBERRIES PREVENTS THE DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN METABOLIC SYNDROME (METS). CARDIOVASCULAR DISEASE SUCH AS ATHEROSCLEROSIS IS THE LEADING CAUSE OF DEATH IN THE UNITED STATES. METS IS ANIMPORTANT RISK FACTOR FOR CARDIOVASCULAR MORTALITY, AND VASCULAR INFLAMMATION PLAYS A MAJOR ROLE IN THE DEVELOPMENT OF VASCULARDISEASE IN METS. ATHEROSCLEROSIS IS A CONDITION IN WHICH PLAQUE BUILDS UP INSIDE THE BLOOD VESSEL, LEADING TO HARDENING ANDNARROWING OF BLOOD VESSELS. CHOLESTEROL, FATTY SUBSTANCES, AND CELLULAR WASTE PRODUCTS FORM THE HARD PLAQUE INSIDE THE BLOODVESSEL. AS ATHEROSCLEROSIS PROGRESSES, THE PLAQUE SIZE CAN INCREASE AND BLOCK THE BLOOD FLOW THROUGH BLOOD VESSELS IN THE HEART,BRAIN, LEGS, ARMS OR KIDNEYS. AS A RESULT, THE RISK FOR HEART ATTACK, STROKE, AND OTHER KINDS OF HEALTH PROBLEMS INCREASES.METABOLIC SYNDROME CAUSES THE DEVELOPMENT AND PROGRESSION OF ATHEROSCLEROSIS. DUETO THE CURRENT EPIDEMIC OF METABOLICSYNDROME, THERE IS AN URGENT NEED TO DEVELOP NEW STRATEGIES TO REDUCE HEART DISEASE IN METABOLIC SYNDROME. OUR RESEARCH ISAIMED TO IDENTIFY NEW AND COST EFFECTIVE STRATEGIES, SUCH AS DIETARY RECOMMENDATIONS THAT CAN REDUCE VESSEL COMPLICATIONS AND PROMOTE OVERALL HEART AND BLOOD VESSEL HEALTH.ANTHOCYANINS ARE ONE OF THE MOST ABUNDANT PLANT COMPOUNDS AND ARE WIDELY AVAILABLE IN BLUEBERRIES, STRAWBERRIES, AND RASPBERRIES. STUDIES SUPPORT THE IMPORTANCE OF BERRIES IN THE REGULAR DIET. EVIDENCE SHOWS THAT EATING 2-3 SERVINGS OFSTRAWBERRIES PER WEEK LOWERS THE RISK OF TYPE 2 DIABETES AND REDUCES THE RISK OF HEART ATTACKS. THE GOOD BACTERIA IN THE GUT HELPS TO METABOLIZE THE BERRY ANTHOCYANINS INDICATING IT MAY PLAY A CRUCIAL ROLE IN MEDIATINGTHE VASCULAR BENEFICIAL EFFECTS OF BERRY FRUITS. OUR PRELIMINARY DATA SHOW THATEATING STRAWBERRIES REDUCES BLOOD PRESSURE AND HELPS VESSELS REMAIN HEALTHY IN MICE THAT HAVE DIABETES. IN ADDITION, DIETARY STRAWBERRIESINCREASED THE GOODGUT BACTERIA IN DIABETIC MICE. HOWEVER, STUDIES ARE LACKING THAT INVESTIGATE (I) THE MOLECULAR MECHANISMS THAT ARE INVOLVED IN THE BENEFICIAL VASCULAR EFFECTS OF STRAWBERRIES, (II) THE ROLE OF GUT BACTERIA IN MEDIATING THESE BENEFICIAL EFFECTS, AND (III)ACTIVE COMPONENTS INVOLVED.THE PROPOSED STUDY WILL IDENTIFY THE ROLE OF GUT BACTERIA IN MEDIATING THE VASCULAR BENEFICIAL EFFECTS OF STRAWBERRIES AND THE ACTIVE COMPONENTS INVOLVED IN THE BENEFICIAL EFFECTS OF STRAWBERRY. THE PROJECT IS EXPECTED TO HAVE SIGNIFICANT EFFECT ON HUMAN HEALTH BECAUSE THE RESULTS FROM THIS STUDY COULD POTENTIALLY LEAD TO LOWER-COST, YET EFFECTIVE STRATEGIES TO REDUCE DEATH AND ILLNESS DUE TO HEART AND VESSEL COMPLICATIONS IN PEOPLE WITH METABOLIC SYNDROME.
$500,000University Of Utah · · FY2019 · National Institute of Food and Agriculture
Multiphoton upgrade of confocal microscope for live organ and tissue imaging
$500,000Madesh Muniswamy · University Of Pennsylvania · S10 · FY2007 · RR
Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
$500,000Jane E Freedman · Univ Of Massachusetts Med Sch Worcester · UH2 · FY2014 · TR
CAREER: Elucidation of the Physical Principles the Govern Endothelial Structure and Function
$500,000Robert Steward · The University Of Central Florida Board Of Trustees · · FY2021 · ENG