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1,049,261 grants matching “t cell”
GENOMIC AND IMMUNOMIC MECHANISMS OF RESISTANCE DURING DARATUMUMAB POST STEM CELL TRANSPLANTATION IN PATIENTS WITH POOR-RISK T CELL LYMPHOBLASTIC LYMPHOMA LEUKEMIA
$2,660,756New York Medical College · · FY2025 · Defense Health Agency
Personalized small molecule therapy for severe asthma and cystic fibrosis.
$2,660,551Benjamin M Gaston · Case Western Reserve University · P01 · FY2016 · HL
Anatomical characterization of neuronal cell types of the mouse brain
$2,660,531Hong-Wei Dong · University Of California Los Angeles · U01 · FY2020 · MH
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
$2,660,334Stephen C Harrison · Boston Children'S Hospital · P01 · FY2020 · AI
IGF::OT::IGF Pathology Peer Review and Pathology Support for the DNTP and DIR at NIEHS Integrated Logistics Systems (ILS); Contract: ; FY15 funding to fund the base contract award; CAN 8010787
$2,660,326Jr, Edward Adams · Integrated Laboratory Systems, Llc · N01 · FY2015 · ES
Stem Cell Transplantation: Basic/Clinical Research
$2,660,181Rainer F. Storb · Fred Hutchinson Cancer Research Center · P01 · FY2008 · HL
Role of Viral Reservoirs in the Pathogenesis of HIV Disease
$2,660,139Tae-Wook Chun · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
High Resolution Analysis of Env-directed B Cells to Accelerate Vaccine Design
$2,659,788Richard Thomas Wyatt · Scripps Research Institute, The · P01 · FY2014 · AI
Perivascular Adipose Tissue (PVAT) as a Central Integrator of Vascular Health
$2,659,602Stephanie W Watts · Michigan State University · P01 · FY2025 · HL
Nuclear Architecture and Disease
$2,659,572Thomas A Misteli · Division Of Basic Sciences - Nci · ZIA · FY2020 · CA
High Resolution Analysis of Env-directed B Cells to Accelerate Vaccine Design
$2,659,329Richard Thomas Wyatt · Scripps Research Institute, The · P01 · FY2017 · AI
Brain-wide screen for a neural pacemaker of aging
$2,659,103Karl Alexander Deisseroth · Stanford University · R01 · FY2021 · AG
Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT )
$2,658,963Michael L. Terrin · University Of Maryland Baltimore · R01 · FY2012 · AG
RECENT THEORETICAL WORK SUGGESTS THAT AN EARLY STEP IN THE ORIGIN OF LIFE WAS THE EMERGENCE OF ENSEMBLES OF CHEMICALS THAT INTERACTED WITH ONE ANOTHER TO COLLECTIVELY PROPAGATE: IN THE PRESENCE OF REPLENISHING INPUTS OF CHEMICAL PRECURSORS (FOOD) AND ENERGY ALL CHEMICALS IN THE ENSEMBLE ARE PRODUCED BY THE ACTIONS OF OTHER CHEMICALS IN THE ENSEMBLE. FURTHERMORE ADVANCES IN EVOLUTIONARY THEORY SUGGEST THAT IF THESE INTERACTING MOLECULAR ENSEMBLES WERE SPATIALLY STRUCTURED FOR EXAMPLE BY BEING ADSORBED ONTO THE SURFACES OF SUBMERGED MINERALS THEY WOULD BE LIKELY TO EVOLVE ADAPTIVELY. SPECIFICALLY A PROCESS CALLED NEIGHBORHOOD SELECTION WOULD TEND TO ENRICH FOR ENSEMBLES WITH PROGRESSIVELY IMPROVED ABILITIES TO COLONIZE NEW MINERAL GRAINS. SINCE THE ABILITY TO PROPAGATE (GROW) AND EVOLVE ADAPTIVELY ARE TWO KEY FEATURES OF LIFE ANY ENSEMBLE HAVING THESE PROPERTIES WOULD BE LIFE-LIKE EVEN IF IT WERE NOT ORGANIZED INTO CELL-LIKE COMPARTMENTS AND LACKED ANY DIGITAL GENETIC ENCODING. THE PROPOSED RESEARCH WILL USE THEORY AND LABORATORY EXPERIMENT TO BETTER UNDERSTAND THE ORIGIN AND EVOLUTION OF SURFACE-ASSOCIATED LIFE-LIKE INTERACTING MOLECULAR ENSEMBLES (SLIMES). GUIDED BY ARTIFICIAL ECOSYSTEM SELECTION A METHOD USED IN MICROBIAL ECOLOGY WE WILL EXPLORE THE BEHAVIOR OF SETS OF CHEMICALS ASSOCIATED WITH MINERAL GRAINS TO SEE IF THEY ARE CAPABLE OF RESPONDING TO AN ARTIFICIAL SELECTION PRESSURE.
$2,658,933University Of Wisconsin System · · FY2020 · National Aeronautics and Space Administration
Infrastructure for Translational Neuroscience Center
$2,658,771Avindra Nath · National Institute Of Neurological Disorders And Stroke · ZIA · FY2014 · NS
Neuropathogenesis of Retroviral Infections
$2,658,771Avindra Nath · National Institute Of Neurological Disorders And Stroke · ZIA · FY2014 · NS
Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
$2,658,770Augustine M Choi · Weill Medical Coll Of Cornell Univ · P01 · FY2021 · HL
Evolutionary dynamics of melanoma metastasis
$2,658,675Richard Mark White · Sloan-Kettering Inst Can Research · DP2 · FY2013 · CA
INBRE: KUMC: ADMINISTRATIVE CORE
$2,658,581Joan Sherar Hunt · University Of Kansas Medical Center · P20 · FY2010 · RR
Bacterial and Host Heterogeneity in TB latency, persistence and progression
$2,658,286David Alland · Rutgers Biomedical And Health Sciences · U19 · FY2023 · AI
Bacterial and Host Heterogeneity in TB latency, persistence and progression
$2,658,286David Alland · Rbhs-New Jersey Medical School · U19 · FY2022 · AI
Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses
$2,658,245Shane P Crotty · La Jolla Institute For Immunology · U19 · FY2021 · AI
Novel hematopoietic stem cell engineering and transplantation approaches for HIV cure
$2,658,178Paula M Cannon · University Of Southern California · U19 · FY2021 · HL
Clarifying the Optimal Application of SLT Therapy (COAST) Trial
$2,657,465Stephen R Wisniewski · University Of Pittsburgh At Pittsburgh · UG1 · FY2021 · EY
Moffitt Cancer Center Support Grant
$2,657,144William S. Dalton · H. Lee Moffitt Cancer Ctr & Res Inst · P30 · FY2011 · CA