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15,273 grants matching “antimicrobial resistance”
Salmonella Antimicrobial Peptide Resistance
$278,119John S Gunn · Ohio State University · R01 · FY2008 · AI
Designed Host Defense Pepties for the Topical Treatment of Diabetic Foot Ulcers
$278,046Louis Edward Clemens · Riptide Bioscience, Inc. · R43 · FY2018 · DK
Project 3: Immunoassays for Human and Environmental Monitoring
$278,035Bruce D Hammock · University Of California At Davis · P42 · FY2012 · ES
Role of clonal expansion in HIV-1 persistence
$277,997Ya-Chi Ho · Yale University · R01 · FY2024 · AI
Lasso Peptide Discovery
$277,962Aaron James Link · Princeton University · R01 · FY2016 · GM
Mechanism of Enzymes Mediating Resistance in Pseudomonas
$277,826Marcelo Carlos Sousa · University Of Colorado · R01 · FY2007 · AI
Prevention of Cerebrospinal Fluid (CSF) Shunt Infections
$277,783Tamara Danielle Simon · Children'S Hospital Of Los Angeles · R01 · FY2022 · NS
Proteomic analysis of api2-MALT1 positive gastric MALT lymphoma
$277,682Kojo Seys Elenitoba-Johnson · University Of Michigan At Ann Arbor · R01 · FY2012 · CA
Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants
$277,658James Carter Rice · Scripps Research Institute, The · R21 · FY2009 · DK
Biology of the Apicomplexan Plastid
$277,627Boris Striepen · University Of Georgia · R01 · FY2010 · AI
MS diagnostic bacterial identification library
$277,419David Robinson Goodlett · University Of Maryland Baltimore · R01 · FY2014 · GM
A PRIMARY SOURCE OF CONTAMINATION IN DAIRY PRODUCTS IS THE FORMATION OF BIOFILMS ON THE SURFACES OF MILK MANUFACTURE EQUIPMENT, POSING RISKS TO PUBLIC HEALTH AND ECONOMIC STABILITY. WHILE CHEMICAL DISINFECTANTS ARE WIDELY USED TO TREAT BIOFILMS, THEIR USE CAN LEAD TO SIGNIFICANT ISSUES, INCLUDING THE DEVELOPMENT OF ANTIMICROBIAL-RESISTANT BACTERIA. AN ALTERNATIVE APPROACH INVOLVES USING NATURAL CATIONIC ANTIMICROBIALS, WHICH ARE HIGHLY EFFECTIVE AGAINST BIOFILMS. HOWEVER, THEIR APPLICATION IN DAIRY MANUFACTURING IS CHALLENGED BY THEIR TENDENCY TO INTERACT WITH NEGATIVELY CHARGED RESIDUAL MILK PROTEINS, SIGNIFICANTLY DIMINISHING THEIR ANTIMICROBIAL ACTIVITY. THE OVERALL GOAL OF THIS STUDY IS TO ENABLE THE EFFECTIVE USE OF NATURAL CATIONIC ANTIMICROBIALS FOR STERILIZING DAIRY PROCESSING EQUIPMENT. WE PROPOSE TO DEVELOP A SMART CHARGE-REVERSAL POLYMER (PLYS-DA) THAT CARRIES A NEGATIVE CHARGE UNDER NEUTRAL CONDITIONS TO PREVENT INTERACTION WITH MILK PROTEINS BUT REGAINS A POSITIVE CHARGE IN THE ACIDIC MICROENVIRONMENT OF A BIOFILM. THIS CHARGE- REVERSAL PROPERTY ALLOWS PLYS-DA TO ACT AS AN EFFECTIVE ANTIMICROBIAL AGENT UNDER SUCH CONDITIONS. TO FURTHER ENHANCE ANTIMICROBIAL EFFICACY, PH-SENSITIVE ANTIBIOFILM POLYELECTROLYTE NANOPARTICLES WILL BE FABRICATED THROUGH THE ELECTROSTATIC COMPLEXATION OF PLYS-DA WITH VARIOUS CATIONIC ANTIMICROBIAL POLYPEPTIDES, AIMING TO ACHIEVE A BROADER SPECTRUM OF ANTIMICROBIAL EFFECTS. THE ANTIBIOFILM EFFICACY OF OUR DEVELOPED CHARGE-REVERSAL POLYMER AND PH-SENSITIVE NANOPARTICLES WILL BE THOROUGHLY EVALUATED AND VALIDATED.
$277,407University Of Missouri System · · FY2025 · National Institute of Food and Agriculture
Cytoskeletal Keratins in Epithelial Immunity to Bacterial Keratitis
$277,375K. P. Connie Tam · Cleveland Clinic Lerner Com-Cwru · R01 · FY2017 · EY
Burkholderia pseudomallei antimicrobial resistance mechanisms
$277,259Herbert P. Schweizer · Colorado State University · U54 · FY2010 · AI
Effect of Bacteria and Mechanical Loading on Degradation of the Composite-Tooth I
$277,105Jack L. Ferracane · Oregon Health & Science University · R01 · FY2012 · DE
Project-003
$277,100Cynthia Nau Cornelissen · Georgia State University · U19 · FY2021 · AI
Training in Interdisciplinary Research to Prevent Infections (TIRI)
$276,927Elaine Lucille Larson · Columbia University Health Sciences · T32 · FY2014 · NR
Task A02: Murine models of Ascending UTI Infection caused by Drug-Resistant Bacteria
$276,917David Beasley · University Of Texas Med Br Galveston · N01 · FY2020 · AI
Collaborative Research: Host-environment-pathogen interactions in a model coral disease system
$276,909Greta Aeby · University Of Hawaii · · FY2010 · GEO
Complement mediated lysis resistance genes of Leishmania
$276,869Jeffrey K Beetham · Iowa State University · R01 · FY2007 · AI
Control of placental infection by decidual NK cell secreted granulysin
$276,750Jack L Strominger · Harvard University · R21 · FY2016 · HD
Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
$276,650Marjorie H Barnes · Microbiotix, Inc · R43 · FY2009 · AI
Lasso Peptide Discovery
$276,607Aaron James Link · Princeton University · R01 · FY2017 · GM
HTS assay development for bacterial transcription factors
$276,585Joseph Thomas Wade · Wadsworth Center · R01 · FY2015 · GM
Molecular Basis of Multidrug Binding and Transport by the MATE Transporters
$276,184Min Lu · Rosalind Franklin Univ Of Medicine & Sci · R01 · FY2010 · GM