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38,696 grants matching “als”
Immunoregulation in AIDS
$530,398Norman L Letvin · Beth Israel Deaconess Medical Center · R01 · FY2006 · AI
Biomechanical characterization of vocal fold tissues
$530,238Roger W Chan · Ut Southwestern Medical Center · R01 · FY2009 · DC
Project 3: Identifying transcriptional driver genes and targeting transcription in TSC
$530,163David J. Kwiatkowski · Brigham And Women'S Hospital · P01 · FY2018 · CA
Overview: Multisystemic Approach to Early Math Development and Math Learning Disability
$530,145David C Geary · University Of Missouri-Columbia · P20 · FY2022 · HD
The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma
$530,098Olivier Elemento · Weill Medical Coll Of Cornell Univ · R01 · FY2015 · CA
The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma
$530,098Olivier Elemento · Weill Medical Coll Of Cornell Univ · R01 · FY2016 · CA
The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma
$530,098Olivier Elemento · Weill Medical Coll Of Cornell Univ · R01 · FY2017 · CA
The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma
$530,098Olivier Elemento · Weill Medical Coll Of Cornell Univ · R01 · FY2018 · CA
Metabolomic Signatures Linking ALS to Persistent Organic Pollutant Exposures
$530,000Eva L Feldman · University Of Michigan At Ann Arbor · R01 · FY2020 · TS
ALZHEIMERS RESEARCH PROJECT: Alzheimer's disease drug development
$529,901Nigel H. Greig · National Institute On Aging · ZIA · FY2025 · AG
Understanding the Multiple-levels of Influence on Access to Care for Latino Youth
$529,872Alexander N Ortega · Drexel University · R01 · FY2021 · MD
A novel embryonic transcriptional cascade required for adult social and repetitive behavior
$529,731Anthony J Wynshaw-Boris · Case Western Reserve University · R01 · FY2019 · MH
High-Throughput Genomic Approaches to Identify ALS Genes
$529,594Massachusetts General Hospital · R01 · FY2005 · NS
Laboratory Resource
$529,468Neal L Benowitz · University Of California, San Francisco · P30 · FY2014 · DA
Evaluation and Treatment of Obsessive Compulsive and Related Disorders
$529,453Susan Swedo · National Institute Of Mental Health · ZIA · FY2011 · MH
Metastasis of PTEN Mutant Prostate Cancer
$529,446Lloyd C Trotman · Cold Spring Harbor Laboratory · R01 · FY2022 · CA
Genomic Screen To Identify Alzheimers Disease Genes
$529,367Duke University · R01 · FY2005 · NS
Pharmacology & ImmunoPathology (PIP) Core
$529,260Veronique Dartois · Weill Medical Coll Of Cornell Univ · U19 · FY2023 · AI
MiR-218 regulatory networks in adult mice and its relationship to ALS
$529,100Samuel L. Pfaff · Salk Institute For Biological Studies · R21 · FY2021 · NS
TDP43 IN CIRCULATING NEURON DERIVED EXTRACELLULAR VESICLES AS PROGNOSTIC AND DIAGNOSTIC ALS BIOMARKER
$529,028Neurodex Inc · · FY2025 · Defense Health Agency
IGF::OT::IGF RD CORONERY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) UMN FI
$528,955Pamela Shreiner · University Of Minnesota · N01 · FY2017 · HL
Prevention of Suicidality in College Students: A Common Core Process Approach
$528,830Steven C Hayes · University Of Nevada Reno · R01 · FY2011 · MH
SATELLITE ALTIMETRY IS THE ONLY PRACTICAL TECHNIQUE FOR MAPPING INTERNAL TIDES ON A GLOBAL SCALE. HOWEVER THE TRADITIONAL POINT-WISE HARMONIC ANALYSIS HAS ITS INHERENT LIMITATIONS IN EXTRACTING INTERNAL TIDES FROM SATELLITE ALTIMETER DATA BECAUSE OF THE COMPLEX NATURE OF THE GLOBAL INTERNAL TIDE FIELD AND MESOSCALE CONTAMINATION. WE HAVE DEVELOPED A PLANE WAVE FIT METHOD TO ADDRESS THIS CHALLENGE. IN THIS METHOD INTERNAL TIDES ARE EXTRACTED USING DATA IN A FITTING WINDOW (ABOUT ONE WAVELENGTH) RATHER THAN AT ONE SINGLE SITE. THIS MAPPING TECHNIQUE IS SUPERIOR TO POINT-WISE HARMONIC ANALYSIS FOR THE FOLLOWING REASONS: FIRST IT SEPARATELY RESOLVES INTERNAL TIDAL WAVES WITH DIFFERENT PROPAGATION DIRECTIONS; SECOND IT SUPPRESSES MESOSCALE CONTAMINATION BY EXTRACTING INTERNAL TIDES WITH BOTH SPATIAL AND TEMPORAL COHERENCE. TAKING ADVANTAGE OF 20 YEARS OF MULTISATELLITE SSH MEASUREMENTS WE HAVE CONSTRUCTED GLOBAL MAPS OF M2 S2 O1 AND K1 INTERNAL TIDES. RECENTLY WE HAVE MADE SIGNIFICANT PROGRESS IN EXAMINING THE TEMPORAL VARIABILITY OF THE INTERNAL TIDE FIELD. WE DIVIDE THE MULTIYEAR ALTIMETER DATA INTO SMALL TIME WINDOWS. THIS ENABLES US TO CONSTRUCT YEARLY INTERNAL TIDE FIELDS FROM 1995 ONWARD. THIS ANALYSIS WILL LEADS TO THE NEXT-GENERATION INTERNAL TIDE MODEL IN WHICH THE AMPLITUDE AND PHASE ARE TIME VARIABLES. THE TRAVEL TIME CHANGES OF INTERNAL TIDES ARE AFFECTED BY THE UPPER OCEAN WARMING. THUS WE BRING UP A NEW CONCEPT OF INTERNAL TIDE OCEANIC TOMOGRAPHY (ITOT) TO MONITOR OCEAN WARMING ON A GLOBAL SCALE. ITOT IS MUCH LIKE ACOUSTIC TOMOGRAPHY (MUNK ET AL. 1995) BUT THAT THE WORK WAVE IS INTERNAL TIDES. ITOT MEASURES OCEAN TEMPERATURE CHANGES BY PRECISELY MEASURING TRAVEL TIME CHANGES OF LONG-RANGE INTERNAL TIDES. ITOT OFFERS A LONG-TERM LOW-COST ENVIRONMENTALLY-FRIENDLY TECHNIQUE FOR MONITORING GLOBAL OCEAN WARMING. MORE RECENTLY WE HAVE EVALUATED THE PERFORMANCE OF OUR INTERNAL TIDE MODEL IN THE CENTRAL NORTH PACIFIC USING 4 YEARS OF CRYOSAT-2 DATA. WE FOUND SIGNIFICANT VARIANCE REDUCTION BEFORE AND AFTER THE M2 INTERNAL TIDE CORRECTION. THE RESULT SUGGESTS THAT OUR INTERNAL TIDE MODEL IS A RELIABLE AND EFFICIENT MODEL. WE PROPOSE TO CONDUCT SUCH KIND OF EXAMINATION ON THE GLOBAL SCALE AND USING DATA FROM OTHER SATELLITES. IN ADDITION IT IS ALSO BENEFICIAL TO INTER-COMPARE INTERNAL TIDE MODELS CONSTRUCTED USING DIFFERENT MAPPING TECHNIQUES. OUR PROPOSED WORK WILL FOCUS ON THE FOLLOWING THREE TOPICS: (1) CONSTRUCTION OF THE NEXT-GENERATION MODEL WITH TIME-VARIABLE AMPLITUDE AND PHASE: (A) CONSTRUCT 20 YEARLY INTERNAL TIDE FIELDS FROM 1995 2014; (B) CONSTRUCT 12 MONTHLY INTERNAL TIDE FIELDS; (C) QUANTIFY THE TEMPORAL VARIATIONS OF AMPLITUDE AND PHASE. (2) DEVELOPMENT OF THE ITOT TECHNIQUE FOR MONITORING GLOBAL OCEAN WARMING: (A) EXAMINE ALONG-BEAM PHASE CHANGES; (B) BUILD TRANSFER FUNCTION FROM SPEED CHANGE RATE TO OCEAN TEMPERATURE CHANGE; (C) CALIBRATE WITH FIELD MEASUREMENTS (E.G. ARGO XBT AND MOORINGS). (3) EVALUATION AND IMPROVEMENT OF OUR INTERNAL TIDE MODEL: (A) REFINE PARAMETERS IN PLANE WAVE FITTING REGION BY REGION; (B) COMPARE WITH OTHER ALTIMETER-BASED INTERNAL TIDE MODELS; (C) EVALUATE OUR MODEL USING ALTIMETER DATA FROM OTHER SATELLITES. THIS PROPOSAL ECHOES THE OSTST SOLICITATION OF NASA AS FOLLOWS. (1) THIS PROPOSAL UTILIZES OVER 20 YEARS OF MULTISATELLITE ALTIMETER DATA (T/P JASON-1/2 ERS-1/2 ENVISAT AND GFO) TO CONSTRUCT THE NEXT-GENERATION INTERNAL TIDE MODEL. MEANWHILE ALTIMETER DATA FROM OTHER SATELLITES (CRYOSAT-2 ALTIKA AND SENTINEL-3) WILL BE USED TO EVALUATE OUR INTERNAL TIDE MODEL. (2) OUR INTERNAL TIDE MODEL MAY BE USED TO CORRECT INTERNAL TIDE SIGNALS IN SWOT AS WELL AS PREVIOUS NADIR-LOOKING ALTIMETER MISSIONS. (3) THE PROPOSED ITOT TECHNIQUE CAN INFER THE SEA LEVEL RISE CAUSED BY HYDROSTATIC THERMAL EXPANSION SEPARATED FROM CONTRIBUTION OF MELTING ICE. ITOT SUPPORTS NASA'S OPERATION AND APPLICATION OF ALTIMETER SATELLITES.
$528,736University Of Washington · · FY2017 · National Aeronautics and Space Administration
Muscarinic acetylcholine receptor subtypes: physiological roles
$528,731Jurgen Wess · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2015 · DK
Dysregulation of Cav1.2 by beta amyloid peptide
$528,700Johannes W Hell · University Of California At Davis · R01 · FY2025 · AG