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38,696 grants matching “als”
Characterization of Dentate Mossy Cell-restricted Genetic Manipulation Mice
$542,296Kazutoshi Nakazawa · National Institute Of Mental Health · Z01 · FY2007 · MH
Pretreatment Change in Drinking: Relationship to Treatment Outcome
$542,290Paul R Stasiewicz · State University Of New York At Buffalo · R01 · FY2014 · AA
State medical marijuana laws and MTF teen marijuana use and attitudes since 1991
$542,242Deborah S. Hasin · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · R01 · FY2012 · DA
THE CURIOSITY ROVER HAS DETECTED BACKGROUND ATMOSPHERIC CH4 LEVELS OF 0.7 PPBV WITH SPIKES TO 7 PPBV [WEBSTER ET AL. 2015]. OF THE MANY MECHANISMS TO INJECT CH4 INTO THE MARTIAN ATMOSPHERE (E.G. SERPENTINIZATION UV DESTRUCTION OF ACCRETED ORGANICS ETC.) METHANOGENESIS IS THE ONLY BIOLOGICAL PROCESS PROPOSED [REID ET AL. 2006] THAT MIGHT BE ACTIVE IN THE SHALLOW SUBSURFACE ON MARS. ALSO LIQUID BRINES COMPOSED OF MG-PERCHLORATE MG-CHLORATE AND NA-PERCHLORATE HAVE BEEN DETECTED IN ACTIVE RECURRING SLOPE LINEAE (RSL) ON STEEP CRATER WALLS ON MARS [OJHA ET AL. 2015]. THE EXPERIMENTS OUTLINED HEREIN WILL ESTABLISH THE LOW-PRESSURE LOW-TEMPERATURE LOW-OXYGEN (PO2) AND HIGH PERCHLORATE AND CHLORATE SALT LIMITS FOR METABOLISM GROWTH AND CH4 PRODUCTION OF PSYCHROPHILIC METHANOGENS UNDER SIMULATED MARTIAN CONDITIONS. FURTHERMORE THE EXPERIMENTS WILL CHARACTERIZE THE TRANSCRIPTOMIC AND PROTEOMIC ALTERATIONS IN METHANOGENS WHEN GROWN UNDER CONDITIONS THAT MAY PERSIST IN SHALLOW SUBSURFACE RSL BRINES.THE RESEARCH WILL BE DIVIDED INTO TWO SECTIONS IN WHICH THE SCHUERGER LAB WILL FOCUS ON CHARACTERIZING THE LOW-PRESSURE LOWTEMPERATURE LOW-PO2 AND HIGH-SALT LIMITS OF GROWTH FOR PSYCHROPHILIC OR PSYCHROTOLERANT METHANOGENS FOR WHICH COMPLETE GENOMES EXIST (E.G. METHANOGENIUM FRIGIDIUM DSM 16458 METHANOCOCCOIDES BURTONII DSM 6242). THE ONSTOTT LAB WILL FOCUS ON CHARACTERIZING THE VARIABILITY OF THE TRANSCRIPTOMES AND PROTEOMES OF THE METHANOGENS AS FUNCTIONS OF EXPOSURE TO INCREASINGLY MARS-LIKE CONDITIONS TESTING THE LOW-PRESSURE LOW-TEMPERATURE LOW-PO2 AND HIGH PERCHLORATE/CHLORATE SALT LIMITS FOR METABOLISM AND GROWTH.A MARS SIMULATION CHAMBER (SCHUERGER LAB) WILL BE CONFIGURED WITH TWO INDEPENDENT MICROBIAL ASSAY CHAMBERS (MAC; UNITS ONHAND) IN WHICH THE BULK ATMOSPHERE OF EACH MAC UNIT CAN BE INDIVIDUALLY SAMPLED WITH A QUADRUPOLE MASS-SPEC RESIDUAL GAS ANALYZER (RGA; OPERATIONAL; MINIMUM DETECTION OF CH4 IS 0.5 PPM AT 0.7 KPA (7 MBAR)) OR GAS CHROMATOGRAPH (GC; MINIMUM DETECTION OF CH4 IS 3 PPM A 0.7 KPA). EXPERIMENTS WILL FOCUS ON THE METABOLIC RESPONSES OF THE METHANOGENS BETWEEN 5.0 KPA (THE CURRENT LOW PRESSURE GROWTH LIMIT FOR METHANOGENS [KRAL ET AL. 2011]) AND 0.7 KPA (MARTIAN SURFACE PRESSURE).WE WILL EXAMINE THE TEMPORAL EXPRESSION OF GENES USING RNA-SEQ AND PROTEOME ANALYSES USING LC-MS/MS AS THE METHANOGENS ARE SUBJECTED TO VARYING PRESSURE TEMPERATURE PO2 AND PERCHLORATE/CHLORATE SALT CONDITIONS. THE ASSEMBLED MRNA CONTIGS AND PROTEIN PEPTIDES WILL BE MAPPED TO THE HOST GENOMES AND THEIR COVERAGE AND ABUNDANCE MEASURED RESPECTIVELY. WE WILL USE A FLUORESCENT MOLECULAR BEACON TARGETING THE MCRA MRNA TO DETERMINE WHAT PROPORTION OF CELLS ARE ACTIVELY PRODUCING CH4 THEREBY PROVIDING A SPECIFIC CELLULAR CH4 PRODUCTION RATE UNDER THE DIVERSE CONDITIONS LISTED ABOVE. THE COMBINATION OF THESE TWO TOOLS WILL PROVIDE A COMPLETE PICTURE OF THE RESPONSE OF THE DIFFERENT METHANOGEN STRAINS TO DECREASING PRESSURE AND TEMPERATURE THE PRESENCE OF LOW PO2 AND TO ELEVATED PERCHLORATE/CHLORATE SALT LEVELS WHEN COMPARED TO CONTROL INCUBATIONS AT 0 DEGREE C AND 101.3 KPA IN STANDARD LIQUID MEDIA.THE PROPOSAL IS RELEVANT TO THE C.5 EXOBIOLOGY PROGRAM BASED ON: (1) THE RESEARCH WILL "..SEEK TO DETERMINE THE BIOLOGICAL AND ENVIRONMENTAL FACTORS LEADING TO-THE POTENTIAL DISTRIBUTION OF COMPLEX LIFE IN THE UNIVERSE " AND (2) THE RESEARCH WILL STUDY THE "ESTABLISHMENT OF LIFE UNDER CONDITIONS PREVAILING ON OTHER PLANETARY BODIES..;" NAMELY THE GROWTH OF A PLAUSIBLE METHANOGENIC MICROBIAL COMMUNITY IN ACTIVE RSL FEATURES ON MARS.
$542,194University Of Florida · · FY2017 · National Aeronautics and Space Administration
Drinking Contexts and DWI: Implications for Prevention
$542,132Westat, Inc. · R01 · FY2004 · AA
Development and conduct of allogeneic stem cell transplant and autologous stem cell gene therapy for inherited immune deficiencies
$542,130Elizabeth Kang · National Institute Of Allergy And Infectious Diseases · ZIA · FY2025 · AI
Intervention to Reduce Depression Among Elder Abuse Victims: Type 1 Hybrid Trial of Tele-PROTECT
$542,081Jo Anne Sirey · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · MH
Study the role(s) of p53 in embryonic stem cells
$542,071Jing Huang · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA
Targeting FTO to treat acute myeloid leukemia
$542,055Jianjun Chen · Beckman Research Institute/City Of Hope · R01 · FY2024 · CA
Lay Coach-led Early Palliative Care for Underserved Advanced Cancer Caregivers
$541,965James N. Odom · University Of Alabama At Birmingham · R37 · FY2023 · CA
OBJECTIVES: THE PRIMARY GOAL OF THIS STUDY IS TO CREATE A DATA ASSIMILATION FRAMEWORK USING INTERFEROMETRIC SYNTHETIC-APERTURE RADAR (INSAR) AND GPS DATA FOR SEVERAL ALEUTIAN VOLCANIC SYSTEMS (E.G. ATKA SEGUAM MAKUSHIN OKMOK WESTDAHL AND AKUTAN) TO DETECT PRECURSORS AND MAKE PROGRESS TOWARDS THE EVENTUAL GOAL OF PROVIDING ERUPTION FORECASTS IN COORDINATION WITH THE ALASKA VOLCANO OBSERVATORY (AVO). SATELLITE INSAR OBSERVATIONS DETECT VOLCANO DEFORMATION AND PROVIDE EARLY WARNING OF VOLCANIC UNREST PROVIDING CRITICAL INSIGHT INTO THE EVOLUTION OF THE UNDERLYING MAGMA SYSTEM (E.G. BIGGS ET AL. 2014). HOWEVER A QUANTITATIVE MODEL-DATA FUSION FRAMEWORK IS NECESSARY TO EFFICIENTLY UTILIZE INSAR DATA AND PROVIDE UPDATES OF VOLCANIC SYSTEMS IN NEAR-REAL TIME. THE ENSEMBLE KALMAN FILTER (ENKF) HAS PROVEN EFFECTIVE FOR COMBINING GEODETIC DATA WITH VOLCANO MODELS TO FORECAST THE EVOLUTION OF MAGMA SYSTEM STABILITY THROUGH TIME (GREGG AND PETTIJOHN 2016; ZHAN AND GREGG 2017; ZHAN ET AL. 2017). THE VOLCANO ENKF APPROACH HAS SUBSEQUENTLY BEEN ADAPTED FOR HIGH-PERFORMANCE COMPUTING (HPC) APPLICATIONS ALLOWING FOR THE INCORPORATION OF MORE SOPHISTICATED 3D MAGMA RESERVOIR MODELS. THESE RECENT ADVANCEMENTS HAVE CREATED AN EXCITING OPPORTUNITY TO DEVELOP VOLCANO-SPECIFIC MODELS TO TRACK FUTURE UNREST AND ERUPTION POTENTIAL. WE PROPOSE TO USE THE VOLCANO ENKF HPC APPROACH TO BUILD A DATA ASSIMILATION-MONITORING FRAMEWORK FOR HIGH-RISK VOLCANO SYSTEMS IN REMOTE AREAS OF THE ALEUTIAN ARC. WE WILL FOCUS OUR INVESTIGATION ON SIX VOLCANOES IN THE ALEUTIANS CLASSIFIED AS HIGH PRIORITY BY AVO: ATKA SEGUAM MAKUSHIN OKMOK WESTDAHL AND AKUTAN. GIVEN THE CHALLENGE OF COLLECTING GROUND-BASED MEASUREMENTS AT THESE SYSTEMS WE WILL FOCUS OUR EFFORTS ON OPTIMIZING THE USE OF SATELLITE INSAR DATA AND USE GPS DATA WHERE AVAILABLE. IN PARTICULAR WE PROPOSE TO ANALYZE GEODETIC OBSERVATIONS TO PRODUCE TIME SERIES SURFACE DEFORMATION DATA THAT WILL BE COMBINED WITH THERMOMECHANICAL FINITE ELEMENT MODELS FOR EACH VOLCANO TARGET. ANALYSIS OF HISTORICAL ERUPTIONS AT EACH SYSTEM WILL BE USED TO OPTIMIZE THE APPROACH AND PROVIDE HINDCASTS FOR INVESTIGATING ERUPTION PRECURSORS AND HISTORICAL STRESS THRESHOLDS. EACH MODEL WILL BE RUN FORWARD IN TIME TO PROVIDE A CURRENT SYSTEM STATUS ANALYSIS. WORKING IN COORDINATION WITH COLLEAGUES AT THE ALASKA VOLCANO OBSERVATORY THESE PRESENT-DAY OPTIMIZED MODELS WILL PROVIDE A BASIS FOR FUTURE NEAR REAL-TIME FORECASTING EFFORTS. METHODS: (1) WE WILL DEVELOP A NEW OPTIMIZED INSAR TIME SERIES WORKFLOW. HISTORICAL DATA WILL BE ANALYZED TO PROVIDE A FRAMEWORK FOR SWIFT PROCESSING OF NEW INSAR DATA. (2) WE WILL USE THE VOLCANO ENKF HPC TECHNIQUE TO ASSIMILATE UPDATED GEODETIC TIME SERIES DATA AND PROVIDE HINDCASTS . (3) WE WILL ANALYZE 3D THERMOMECHANICAL FINITE ELEMENT MODELS (GREGG ET AL. 2012 2013 2015) TO EVALUATE THE STRESS EVOLUTION OF THE SYSTEM AND INVESTIGATE ERUPTION PRECURSORS AND TRIGGERING MECHANISMS FOR HISTORICAL ERUPTIONS. (4) THE OPTIMIZED MODELS WILL ESTABLISH A PRESENT DAY BASELINE AND PROVIDE ANALYSIS OF CURRENT ACTIVITY FORECASTS AND SYSTEM STABILITY. SIGNIFICANCE TO NASA S MISSION: (1) NATURAL HAZARDS: A PRIMARY GOAL OF NASA S EARTH SCIENCE RESEARCH PROGRAM IS TO CHARACTERIZE THE DYNAMICS OF EARTH S SURFACE AND INTERIOR IMPROVING THE CAPABILITY TO ASSESS AND RESPOND TO NATURAL HAZARDS AND EXTREME EVENTS. THE PROPOSED STUDY AIMS TO ESTABLISH A MODEL-DATA FUSION TECHNIQUE TO COMBINE VOLCANO GEODYNAMIC MODELS WITH SATELLITE INSAR DATA TO INVESTIGATE ERUPTION PRECURSORS. (2) NASA EARTH OBSERVING SYSTEM DATA AND INFORMATION SYSTEM (EOSDIS): THE VOLCANOES INVESTIGATED IN THIS PROJECT WILL ADVANCE EOSDIS WHICH IN A FEW YEARS WILL PROVIDE SUB-DAILY SAR ACQUISITIONS FOR ALL MAJOR VOLCANIC CRISES. (3) NASA-ISRO: OUR PROPOSED MODEL-DATA FUSION FRAMEWORK FOR ERUPTION FORECASTING WILL PROVIDE CRITICAL TESTS BEFORE THE PROPOSED NASA-ISRO SAR MISSION GOES ONLINE.
$541,921University Of Illinois · · FY2020 · National Aeronautics and Space Administration
Imaging Cortical Dopamine Transmission in Alcohol Dependence
$541,876Rajesh Narendran · University Of Pittsburgh At Pittsburgh · R01 · FY2012 · AA
Entry and replication of positive-sense, RNA viruses
$541,801Joseph Marcotrigiano · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
Discrimination of nonself by innate immune receptors
$541,801Joseph Marcotrigiano · National Institute Of Allergy And Infectious Diseases · ZIA · FY2017 · AI
C2 domain therapeutics for muscular dystrophy
$541,661Robert J Bloch · University Of Maryland Baltimore · R01 · FY2024 · AR
ASSESSMENT CORE
$541,624Ami Klin · Yale University · P50 · FY2011 · MH
Metastasis of PTEN Mutant Prostate Cancer
$541,620Lloyd C Trotman · Cold Spring Harbor Laboratory · R01 · FY2023 · CA
The roles of p53 in embryonic stem cells
$541,591Jing Huang · Division Of Basic Sciences - Nci · ZIA · FY2015 · CA
Laboratory Resource
$541,529Neal L Benowitz · University Of California, San Francisco · P30 · FY2012 · DA
Autoimmunity, calorie restriction, and core body temperature
$541,500Roberto G Baccala · San Diego Biomedical Research Institute · R21 · FY2025 · AI
Integrated Genomic Discovery and Functional Validation of Colorectal Cancer Loci
$541,494Calvin J Kuo · Stanford University · U01 · FY2012 · CA
3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease
$541,461Kathryn R Nightingale · Duke University · R01 · FY2023 · EB
COMMUNITY VIOLENCE & YOUTH: AFFECT, BEHAVIOR, ACADEMICS
$541,461Michele R Cooley · Johns Hopkins University · R01 · FY2006 · DA
Clinical and Administrative
$541,414Bruce L Miller · University Of California, San Francisco · P01 · FY2015 · AG
CAREER: Enabling clean energy: assessing criticality of byproduct metals
$541,083Gabrielle Gaustad · Rochester Institute Of Tech · · FY2015 · ENG