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15,273 grants matching “antimicrobial resistance”
Development of Antimicrobial Peptides to Target Gram-negative Pathogens
$299,971Robert S Hodges · Aurora Oncology, Inc. · R43 · FY2017 · AI
Inhalable Gallium Nitrate Anti-Infective Powder for CF
$299,960Vu L. Truong · Aridis Pharmaceuticals, Llc · R43 · FY2009 · AI
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FOODBORNE ILLNESS IMPACTS NEARLY 50 MILLION PEOPLE IN THE UNITED STATES PER YEAR, CAUSING SEVERE ECONOMIC DAMAGES AND HEALTHCARE BURDENS. THERE IS AN URGENT NEED FOR MORE EFFECTIVE STRATEGIES TO MANAGE PATHOGEN TRANSMISSION ACROSS FOOD AND AGRICULTURAL SYSTEMS. THIS PROPOSAL AIMS TO DEFINETHE SPATIAL AND TEMPORAL DISTRIBUTIONS OF EXPANSIVE GENOMIC DIVERSITY OF FOODBORNE PATHOGENS BY INTEGRATING OPEN-SOURCE MOLECULAR DATA WITH ARTIFICIAL INTELLIGENCE (AI) AND MACHINE LEARNING (ML) TECHNOLOGIES, IN ORDER TO INFORM PRACTICAL APPLICATIONS THAT WILL PROMOTE FOOD SAFETY. FOCUSING ON A VARIETY OF PATHOGENS THAT PRESENT UNIQUE RISKS (I.E.,CAMPYLOBACTER JEJUNI,CRONOBACTER SAKAZAKII, ANDLISTERIA MONOCYTOGENES), WE WILL BUILD AND VALIDATE A COMPUTATIONAL WORKFLOW TO UNDERSTAND HOW SELECTIVE PRESSURES ACROSS FOOD CHAINS DRIVE BACTERIAL ENVIRONMENTALTROPISMS (E.G., GENES UNDERLYING PERSISTENCE, ANTIMICROBIAL RESISTANCE, OR VIRULENCE LINKED TO SPECIFICSOURCE TYPES). LEVERAGING PUBLICLY AVAILABLE GENOMIC AND PHENOTYPIC DATA WILL ENABLE HIGH-THROUGHPUT IDENTIFICATION OF NEW MOLECULAR MARKERS ASSOCIATED WITH FOODBORNE PATHOGEN TRANSMISSION AND EVOLUTION. THESE DATA WILL FURTHER SERVE AS KEY REFERENCE MATERIAL TO IMPROVE STRATEGIES FOR PATHOGEN MOLECULAR SURVEILLANCE WITH METAGENOMICS. OVERALL, THE ANALYTICAL FRAMEWORK THAT WEDEVELOP AND PROMOTE FOR USE BY THE FOOD SAFETY RESEARCH COMMUNITY WILL HAVE APPLICATIONS THAT EXTEND TO BROADER FOODBORNE PATHOGEN GROUPS AND EMERGING FOOD SAFETY CONCERNS.
$299,958University Of Maryland, College Park · · FY2023 · National Institute of Food and Agriculture
Self Assembling High Affinity Peptides for Point of Care Drug-Device Combinations
$299,957Shrikumar Ambujakshan Nair · Affinergy ,Inc · R43 · FY2008 · AI
FOOD-BORNE ZOONOTIC TRANSMISSION OF PATHOGENS EXPRESSING CARBAPENEMASE-MEDIATED ANTIMICROBIAL RESISTANCE AS AN EMERGING FOOD SAFETY ISSUE
$299,955Ohio State University, The · · FY2014 · National Institute of Food and Agriculture
Smart Bioreactor for Large-scale High Titer Phage Prep
$299,946Tanu Singhal · Cfd Research Corporation · N43 · FY2021 · AI
Research Initiation Award: Antagonistic Bacteriophage and Metal Combination Treatment to Combat the Spread of Antimicrobial Resistance
$299,942Rasheena Edmondson · Bennett College · · FY2019 · EDU
Novel Biosensor for Detecting Antibiotic Resistance
$299,922Nomadics, Inc. · R43 · FY2001 · AI
Novel Biosensor for Detecting Antibiotic Resistance
$299,922Nomadics, Inc. · R43 · FY2002 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BIOFILMS CONTAINING PATHOGENIC BACTERIA CAN PERSIST ON FOOD CONTACT SURFACES (FCS) FOR YEARS CAUSING REPEATED CONTAMINATION OF FOOD PRODUCTS. THIS IS A MAJOR CHALLENGE FOR FOOD SAFETY IMPACTING NOT ONLY THE FOOD PROCESSING SECTOR BUT ALSO PUBLIC HEALTH THE ECONOMY AND THE ENVIRONMENT. WHILE ROUTINE CLEANING CAN HELP MITIGATE THIS ISSUE ITS EFFICACY DECLINES ON SURFACES WITH NOOKS AND CRANNIES CONVEYOR BELTS AND RUBBER GASKETS WHERE BIOFILMS MAY FIND SHELTER. AS A RESULT HARMFUL BACTERIA SUCH AS LISTERIA MONOCYTOGENES AND SALMONELLA ENTERICA CAN EVADE CLEANING PROCESSES AND LEAD TO FOODBORNE ILLNESS OUTBREAKS PLACING SIGNIFICANT BURDENS ON BOTH HEALTHCARE SYSTEMS AND THE FOOD INDUSTRY. THE LONG-TERM GOAL OF THIS PROJECT IS TO ENHANCE FOOD SAFETY BY APPLYING MECHANO-BACTERICIDAL (MB) NANOPATTERNS FOUND IN NATURE (E.G. CICADA WINGS) TO FCS THROUGH PRACTICAL NANOFABRICATION METHODS. UNLIKE TRADITIONAL CHEMICAL APPROACHES THESE MB NANOPATTERNS INACTIVATE BACTERIA BY PHYSICALLY RUPTURING THEIR CELLS WITHOUT RELEASING BIOCIDES INTO THE SURROUNDING FOOD. THIS OFFERS A SAFER AND MORE SUSTAINABLE APPROACH TO CONTROLLING BACTERIAL CONTAMINATION ON FCS. INITIALLY IN THIS SEED PROJECT WE AIM TO DEVELOP NANOFABRICATION METHODOLOGIES TO CREATE MB NANOPATTERNS ON FLAT STAINLESS STEEL (SS) AND GASKET POLYMER (GP) SURFACES. THESE NANOPATTERNED SURFACES WILL THEN BE EVALUATED FOR THEIR ANTIMICROBIAL EFFICACY AGAINST KEY FOODBORNE PATHOGENS INCLUDING LISTERIA AND SALMONELLA IN MODEL SYSTEMS AS WELL AS REAL FOOD MATRICES.THE PROJECT HAS THREE MAIN GOALS: (1) DEVELOP PRACTICAL METHODS TO CREATE BACTERIA-KILLING SURFACE COATINGS USING STAINLESS STEEL AND GASKET POLYMERS; (2) TEST HOW WELL THESE SURFACES CAN KILL HARMFUL BACTERIA LIKE LISTERIA AND SALMONELLA; AND (3) EVALUATE HOW DURABLE THESE SURFACES ARE INCLUDING THEIR CHEMICAL RESISTANCE MECHANICAL STRENGTH AND HOW EASY THEY ARE TO CLEAN. IF SUCCESSFUL THIS PROJECT COULD PROVIDE A FOUNDATION FOR APPLYING THESE PHYSICS-BASED BACTERIA-KILLING SURFACES TO MORE COMPLEX EQUIPMENT USED IN FOOD PROCESSING SUCH AS CONVEYOR BELTS AND RUBBER GASKETS.
$299,917Virginia Polytechnic Institute & State University · · FY2025 · National Institute of Food and Agriculture
Applying Association Mining and Group Based Trajectory Analyses to Characterize Spatial Temporal Trends of Community-Onset Antibiotic Resistant Staphylococcus aureus Infections in Children
$299,914Lilly Hsi-Chih Immergluck · Morehouse School Of Medicine · U54 · FY2025 · MD
Inhalable Gallium Nitrate Anti-Infective Powder for CF
$299,869Vu L. Truong · Aridis Pharmaceuticals, Llc · R43 · FY2010 · AI
High throughput antibiotic discovery from the uncultivated microbial majority.
$299,867Amy Lynn Spoering · Novobiotic Pharmaceuticals, Llc · R43 · FY2011 · AI
A Novel Therapeutic Peptide to Treat P. aeruginosa Infection in Cystic Fibrosis Patients
$299,836Neil A Fanger · Virtici, Llc · R43 · FY2019 · AI
Induction and Modulation of Host Responses by UPEC
$299,811Anthony J Schaeffer · Northwestern University At Chicago · R01 · FY2013 · DK
SQ109 for treatment of MDR-TB
$299,797Leo Einck · Sequella, Inc. · R43 · FY2011 · AI
Midwest Virtual Laboratory of Pathogen Transmission in Healthcare Settings (MVL-PATHS)
$299,761Majid Bani Yaghoub · University Of Missouri Kansas City · U01 · FY2022 · CK
Phospholipid antimetabolite lipid ether amines for topical treatment of chronic wounds and associated biofilms.
$299,749Artem S Svetlov · Integumed, Llc · R41 · FY2021 · DK
Rapid and broad pathogen profiling system for infection in newborn
$299,734Mridu Sinha · Meliolabs Inc. · R43 · FY2019 · AI
A Novel Combination Therapy to Treat Biofilm-based Pneumonia Infections
$299,733Elke Lipka · Tsrl, Inc. · R41 · FY2019 · AI
Rapid and Simple Paper Strip Test for the Multiplexed Detection of Gastrointestinal Pathogens at the Point-of-Need
$299,726Chang Hee Kim · Godx, Inc. · R43 · FY2017 · TR
Stable cationic bacteriochlorins for antimicrobial photodynamic therapy
$299,692Jonathan Sidney Lindsey · Nirvana Pharmaceuticals, Inc. · R41 · FY2008 · AI
Selective agents against C. difficile infection
$299,684Dallas Hughes · Novobiotic Pharmaceuticals, Llc · R43 · FY2014 · AI
Development of A Narrow Spectrum Anti-Tubercular Agent
$299,661Karen G. Anthony · L2 Diagnostics, Llc · R43 · FY2019 · AI
EF-Tu binding Tetrazoles targeting MDR Neisseria gonorrhoeae
$299,659Zachary David Aron · Microbiotix, Inc · R43 · FY2019 · AI