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51,593 grants matching “hepatitis”
Adenosine receptors and metacolic homeostasis
$617,514Thurl E. Harris · University Of Virginia · R01 · FY2025 · DK
Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic Steatosis
$617,477Phyllis C Tien · Northern California Institute/Res/Edu · R01 · FY2012 · AI
Small Molecule Inhibitors Targeting Adenovirus
$617,449Charles E McKenna · University Of Southern California · R01 · FY2021 · AI
A new hepatocyte-specific ligand for gene delivery
$617,364So C Wong · Mirus Bio Corporation · R44 · FY2008 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOME FOODS, SUCH AS CEREALS, NUTS, FRUITS, AND COFFEE BEANS, ARE SUSCEPTIBLE TO CERTAIN MOLDS OR FUNGI THAT PRODUCE TOXINS KNOWN AS MYCOTOXINS. CONSUMPTION OF MYCOTOXINS-CONTAMINATED FOOD CAN RESULT IN VARIOUS TOXICOLOGICAL EFFECTS SUCH AS TOXIC HEPATITIS, EDEMA, HEMORRHAGE, AND KIDNEY FAILURE. THE US FOOD AND DRUG ADMINISTRATION AND WORLD HEALTH ORGANIZATION HAVE RELEASED STRICT REGULATORY GUIDELINES FOR THE MAJOR MYCOTOXIN CLASSES IN FOOD PRODUCTS. EFFECTIVE ANALYTICAL TECHNIQUES FOR DETECTING MYCOTOXINS ARE CRITICALLY IMPORTANT TO MONITOR AND PREVENT CONTAMINATED FOODS. NEVERTHELESS, MOST CURRENT ANALYTICAL TECHNIQUES FOR MYCOTOXIN DETECTION REQUIRE SOPHISTICATED AND EXPENSIVE EQUIPMENT, COMPLICATE DETECTION PROCEDURES, AND HIGH COST, WHICH IMPOSE GRAND CHALLENGES FOR EXTENSIVE IMPLEMENTATION OF MYCOTOXIN DETECTION IN FOOD INDUSTRY. THIS PROJECT IS COMMITTED TO DEVELOPING A SIMPLE, SENSITIVE, AND LOW-COST TECHNIQUE FOR DETECTION OF MYCOTOXINS IN FOODS. THE TECHNIQUE RELIES ON UNIQUE METALLIC NANOSCALE PARTICLES (NANOPARTICLES) THAT POSSESS ENZYME-LIKE ACTIVITIES. THE METALLIC NANOPARTICLES ACTING AS ENZYME MIMICS CAN GENERATE INTENSE COLOR SIGNAL THROUGH CATALYSIS. THE COLOR SIGNAL CAN BE CONVENIENTLY DETECTED AND QUANTIFIED BY AN INEXPENSIVE SPECTROPHOTOMETER. AFTER CONJUGATION WITH BIOMOLECULES, THE METALLIC NANOPARTICLES CAN BE USED AS COLORIMETRIC LABELS FOR SENSITIVE DETECTION OF MYCOTOXINS. THE SUCCESS OF THIS PROJECT WILL BE OF GREAT BENEFIT TO FOOD AND AGRICULTURE SYSTEMS BY OFFERING A SIMPLE, SENSITIVE, AND AFFORDABLE TECHNIQUE FOR MYCOTOXIN DETECTION.
$617,327The University Of Central Florida Board Of Trustees · · FY2024 · National Institute of Food and Agriculture
The Transitional Liver Clinic (TLC): Reducing Liver Disease Readmission
$617,284Eric Orman · Indiana University Indianapolis · R01 · FY2024 · DK
Career Development and Outreach in Musculoskeletal, Autoimmune and Skin Disease
$617,275Mario Cerritelli · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIJ · FY2009 · AR
Native Transformations Opiate Project
$617,235Stacy M. Rasmus · Northwest Indian College · S06 · FY2020 · GM
In Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted Therapy
$617,228Craig Lewis Duvall · Vanderbilt University · R01 · FY2021 · CA
GB Virus type C Natural History, Epidemiology, HIV Interaction
$617,141Jack T Stapleton · University Of Iowa · R01 · FY2008 · AI
Neural Bases of Cephalic Phase Endocrine Responses
$617,105Alan C Spector · Florida State University · R01 · FY2020 · DK
Bio-digital Rapid Alert to Identify Neuromorbidity
$616,964Robert S. Clark · University Of Pittsburgh At Pittsburgh · R01 · FY2023 · NS
A Human-Centered Pharmacogenomic Screen of Metformin Action
$616,879Jose Carlos Florez · Massachusetts General Hospital · R01 · FY2014 · DK
Heat shock protein 90 in alcoholic liver disease: targeting macrophage Function
$616,844Pranoti Mandrekar · Univ Of Massachusetts Med Sch Worcester · R01 · FY2024 · AA
Lipogenesis, lipoprotein flux & CVD risk: role of meal composition & frequency
$616,825Jean-Marc Schwarz · Touro University Of California · R01 · FY2017 · HL
Role of the GI lymphatic system in hormonal signaling and nutrient metabolism
$616,764Patrick Powing Tso · University Of Cincinnati · R01 · FY2018 · DK
Designing T-cell Based HIV Vaccines using Peptide-MHC Surface Morphology
$616,751Ha Youn Lee · University Of Southern California · R01 · FY2017 · AI
Drug tourism to Mexico: Impact of Mexicos new drug law on HIV-HCV-TB in US IDUs
$616,726Richard S Garfein · University Of California, San Diego · R01 · FY2013 · DA
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
$616,693Robert A Schnoll · University Of Pennsylvania · R01 · FY2022 · CA
Targeting Oncogenic PKA signaling mechanisms
$616,676John D Gordan · University Of California, San Francisco · R01 · FY2024 · CA
The Epitranscriptome as a Novel Mechanism of Arsenic-Induced Diabetes.
$616,651Ana Navas-Acien · Columbia University Health Sciences · R01 · FY2024 · ES
Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection
$616,561Stacy Michelle Horner · Duke University · R01 · FY2022 · AI
Identification and Regulation of RNA Modification by HIV infection and Methamphetamine
$616,551Tariq M Rana · University Of California, San Diego · R01 · FY2019 · DA
Etiology of Persistent Microalbuminuria in Nigeria
$616,525William Wester · Vanderbilt University Medical Center · R01 · FY2021 · DK
The UCLA Center in Early Detection of Liver Cancer
$616,494Xianghong Jasmine Zhou · University Of California Los Angeles · U01 · FY2022 · CA