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38,696 grants matching “als”
Development of Single Molecule Chromatin Interaction Assays (smChIA) in Single Nuclei
$570,526Chia-Lin Wei · Jackson Laboratory · R01 · FY2022 · GM
Intervention for Teens with ADHD and Substance Use
$570,518William E Pelham · Florida International University · R01 · FY2015 · DA
Studies of Histone Functions in Chromatin; H2AX and DNA DSBs
$570,504William Bonner · Division Of Basic Sciences - Nci · ZIA · FY2015 · CA
ASSESSMENT CORE
$570,489Ami Klin · Yale University · P50 · FY2010 · MH
Lineage reprogramming for hearing loss: development of drug screening and gene therapy approaches
$570,385Neil Segil · University Of Southern California · R01 · FY2016 · DC
Pharmacoepidemiology and Pharmacogenetics of a Statin AE
$570,316Bruce M Psaty · University Of Washington · R01 · FY2006 · HL
A Reinforcement Intervention for Increasing HIV Testing Among At-Risk Women
$570,241Kristyn Zajac · University Of Connecticut Sch Of Med/Dnt · R01 · FY2019 · MD
Orthography and phonology in word learning as a predictor of dyslexia in children with language impairment
$570,211Tiffany P Hogan · Mgh Institute Of Health Professions · R01 · FY2022 · DC
MULTI-CENTER TRIAL OF LIMITING PGY2&3 RESIDENT WORK HOURS ON PATIENT SAFETY-DCC
$570,062Katie L Stone · California Pacific Med Ctr Res Institute · U01 · FY2012 · HL
Caregiving, Attachment, and Regulation of Emotion (CARE)
$570,028Susan S Woodhouse · Lehigh University · R01 · FY2014 · HD
Genetic and Pharmacogenetic Modifiers of Cancer Risk and Intervention Outcomes
$570,013Mark H Greene · Division Of Cancer Epidemiology And Genetics · ZIA · FY2010 · CA
HIGH RESOLUTION AL-MG CHRONOLOGY OF CHONDRULES AND IMPLICATION TO THE EVOLUTION OF PROTOPLANETARY DISK CHONDRULES IN PRIMITIVE METEORITES ARE CONSIDERED TO RECORD CHEMICAL PROPERTIES AND ISOTOPE RESERVOIRS OF DUST PARTICLES EXISTED IN THE PROTO-PLANETARY DISK. BY USING THE SHORT-LIVED NUCLIDE CHRONOMETER 26AL-26MG (HALF LIFE: 0.7 MILLION YEARS MA) FORMATION TIME OF MOST CHONDRULE ARE ESTIMATED AT 2-3 MA AFTER THE FORMATION OF REFRACTORY INCLUSIONS. HOWEVER DETAILED SYSTEMATICS AMONG AL-MG AGES CHONDRULES IN COMPARISON TO THEIR CHEMICAL AND ISOTOPE PROPERTIES ARE NOT WELL-RESOLVED MAINLY DUE TO THE LIMITATION OF ANALYTICAL UNCERTAINTIES IN INFERRED AGES (TYPICALLY 0.2-0.5 MA). THE GOAL OF THE STUDY IS TO OBTAIN 0.1 MA PRECISIONS AND ACCURACY FOR INFERRED AL-MG AGES IN ORDER TO ADDRESS SEVERAL QUESTIONS THAT WOULD HELP US TO CONSTRAIN DISK EVOLUTION AND CHONDRULE FORMATION MODELS (1) TOTAL RANGE OF CHONDRULE FORMATION AGES IN A SINGLE CHONDRITE GROUP (2) TIME DIFFERENCE BETWEEN FEO-RICH AND FEO-POOR CHONDRULES IN A SINGLE CHONDRITE GROUP (3) TEST PARTIAL MELTING OF PORPHYRITIC CHONDRULES FROM MAGNESIUM ISOTOPE RATIOS OF OLIVINE AND PYROXENE. CHONDRULES ARE SELECTED FROM MULTIPLE PRIMITIVE CHONDRITES THAT WE HAVE ALREADY STUDIED IN THE PAST AND ARE KNOWN TO HAVE MINIMAL EFFECTS OF SECONDARY PROCESSES IN THE PARENT BODIES. SELECTED CHONDRULES WERE EXAMINED BY USING ELECTRON MICROSCOPIES (SCANNING ELECTRON MICROSCOPE ELECTRON MICROPROBE ANALYZER) AND LASER RAMAN SPECTROMETRY AND ANALYZED FOR AL-MG CHRONOLOGY BY USING IMS 1280 AT WISCSIMS. ADDITIONAL OXYGEN ISOTOPE ANALYSES WOULD BE ALSO PERFORMED FOR THOSE THAT WERE NOT ANALYZED PREVIOUSLY. WE WILL DEVELOP METHOD OF HIGH TIME RESOLUTION AL-MG CHRONOLOGY WITH UPGRADED HIGH BRIGHTNESS PRIMARY OXYGEN ION SOURCE. WE WILL ALSO STUDY O-ISOTOPE RATIOS OF CRYSTALLINE SILICATE IN GIANT CLUSTER IDP WHICH ARE CONSIDERED TO BE COMETARY ORIGIN. THE RESULTS FROM IDPS WILL BE COMPARED TO THOSE OF WILD 2 PARTICLES. THE PROPOSED RESEARCH IS TO STUDY CHEMICAL AND ISOTOPIC PROPERTIES OF EARLY SOLAR SYSTEM MATERIALS AND WOULD ENHANCE OUR UNDERSTANDING OF PROTOPLANETARY DISK EVOLUTION. THEREFORE IT IS RELEVANT TO THE SCOPE OF THE EMERGING WORLDS PROGRAM.
$570,000University Of Wisconsin System · · FY2017 · National Aeronautics and Space Administration
DEVELOPMENTAL PATHWAYS OF CHILD CONDUCT PROBLEMS
$569,961University Of Pittsburgh At Pittsburgh · R01 · FY2002 · MH
Hematopathology Diagnosis
$569,946Elaine Jaffe · Division Of Basic Sciences - Nci · ZIA · FY2012 · CA
Targeting FTO to treat acute myeloid leukemia
$569,941Jianjun Chen · Beckman Research Institute/City Of Hope · R01 · FY2021 · CA
THE FORMER PRESENCE OF 60FE IN THE SOLAR SYSTEM HAS BEEN DETECTED IN METEORITES. HOWEVER IN ORDER TO USE THE 60FE-60NI SYSTEM TO ADDRESS FUNDAMENTAL QUESTIONS ABOUT THE ASTROPHYSICAL CONDITIONS AND CHRONOLOGY OF THE SOLAR SYSTEM S FORMATION THE INITIAL 60FE /56FE RATIO OF THE SOLAR SYSTEM MUST BE CONSTRAINED. PROGRESS TOWARD CONSTRAINING THE INITIAL ABUNDANCE OF 60FE IN THE SOLAR SYSTEM HAS BEEN HINDERED BY DISCREPANCIES BETWEEN IN SITU AND BULK ANALYSES AND LIKELY STEM FROM LATE-STAGE OPEN-SYSTEM FE-NI MOBILIZATION. THE (60FE/56FE)SS RATIOS INFERRED FROM BULK CHONDRULE ANALYSES ARE ALL CONSISTENT WITH<3 10-8. AN INITIAL RATIO AT THIS LEVEL IS MORE CONSISTENT WITH 60FE BEING INHERITED FROM THE GALACTIC BACKGROUND DURING THE SUN S FORMATION. IN SITU ANALYSES OF CHONDRULES OFTEN INFER INITIAL SOLAR SYSTEM RATIOS THAT ARE AN ORDER OF MAGNITUDE HIGHER THAN ESTIMATES BASED ON BULK DATA. TELUS ET AL. (2017) INFER AN (60FE/56FE)SS BETWEEN 5 10-8 AND 3 10-7 BASED ON 60NI EXCESSES OF 20 TO 70 IN CHONDRULES FROM UNEQUILIBRATED ORDINARY CHONDRITES. HOWEVER ISOCHRONS FOR CHONDRULES THAT HAVE RESOLVED EXCESSES IN 60NI ARE OFTEN SIGNIFICANTLY DISTURBED BASED ON THE POOR CORRELATION BETWEEN EXCESS 60NI AND THE FE/NI RATIOS. SYNCHROTRON X-RAY FLUORESCENCE MAPPING OF UNEQUILIBRATED ORDINARY CHONDRITES CHONDRULES SHOWS EVIDENCE FOR EXTENSIVE OPEN-SYSTEM FE-NI REDISTRIBUTION BETWEEN CHONDRULES AND THE SURROUNDING MATRIX MATERIAL (TELUS ET AL. 2016) PROVIDING AN EXPLANATION FOR THE POORLY CORRELATED INTERNAL ISOCHRONS AND THE DISCREPANCIES BETWEEN IN SITU AND BULK FE-NI DATA. TO BETTER UNDERSTAND THE 60FE-60NI SYSTEMATICS IN CHONDRULES AND TO CONSTRAIN THE INITIAL ABUNDANCE OF 60FE IN THE SOLAR SYSTEM WE WILL CARRY OUT COORDINATED IN SITU AND BULK FE-NI ANALYSES IN CHONDRULES FROM VARIOUS CHONDRITES. THIS STUDY IS DIVIDED INTO 5 PARTS: 1.) WE WILL FIRST THOROUGHLY CHARACTERIZE CHONDRULES FROM VARIOUS CHONDRITES USING SYNCHROTRON X-RAY FLUORESCENCE PRIOR TO ISOTOPE ANALYSES. 2.) WE WILL SYNTHESIZE MATRIX-MATCHED STANDARDS. 3.) WE WILL CARRY OUT IN SITU FE-NI SECONDARY ION MASS SPECTROMETRY USING THE NEW HYPERION DUOPLASMATRON SOURCE ON A LARGE GEOMETRY SIMS WHICH MAKES IT POSSIBLE TO MEASURE NI ISOTOPES IN SITU TO HIGHER PRECISION AND SPATIAL SCALES THAN BEFORE ALLOWING US TO TARGET AREAS IN BETWEEN FE-NI ALTERATION VEINS. 4.) A SUBSET OF SAMPLES WILL BE ANALYZED FOR IN SITU FE-NI ISOTOPES USING RESONANCE IONIZATION MASS SPECTROMETRY. THIS TECHNIQUE PROVIDES HIGHER NI YIELDS AND LITTLE TO NO INTERFERENCES. 5.) A SUBSET OF SAMPLES WILL BE ANALYZED FOR HIGH PRECISION BULK FE-NI ANALYSES USING ICPMS. COMBINING DETAILED 3-DIMENSIONAL SYNCHROTRON X-RAY MAPPING OF THE FE-NI DISTRIBUTION IN CHONDRULES WITH COORDINATED IN SITU AND BULK ISOTOPE ANALYSES IS THE MOST EFFECTIVE WAY TO FINALLY CONSTRAIN THE INITIAL 60FE/56FE RATIO OF THE SOLAR SYSTEM. THIS STUDY HAS BROAD IMPLICATIONS FOR THE STELLAR SOURCE OF SHORT-LIVED RADIONUCLIDES THE CONDITIONS OF THE SOLAR SYSTEM S FORMATION AND THE CHRONOLOGY OF EARLY SOLAR SYSTEM PROCESSES. IT IS RELEVANT TOWARDS NASA EMERGING WORLDS GOAL TO ADDRESS FUNDAMENTAL QUESTIONS ABOUT HOW THE SOLAR SYSTEM FORMED AND EVOLVED. REFERENCES: TELUS M. HUSS G. R. OGLIORE R. C. NAGASHIMA K. HOWARD D. L. NEWVILLE M. G. AND TOMKINS A. G. (2016) MOBILITY OF IRON AND NICKEL AT LOW TEMPERATURES AND IMPLICATIONS FOR 60FE-60NI SYSTEMATICS OF CHONDRULES FROM UNEQUILIBRATED ORDINARY CHONDRITES. GEOCHIM. COSMOCHIM. ACTA 178 87-105. TELUS M. HUSS G. R. NAGASHIMA K. OGLIORE R. C. AND TACHIBANA S. (2017 IN REVIEW) IN SITU 60FE-60NI SYSTEMATICS OF CHONDRULES FROM UNEQUILIBRATED ORDINARY CHONDRITES
$569,782University Of California Santa Cruz · · FY2020 · National Aeronautics and Space Administration
Targeting FTO to treat acute myeloid leukemia
$569,670Jianjun Chen · Beckman Research Institute/City Of Hope · R01 · FY2020 · CA
Cannabinoid Receptors and Associated Proteins-Renewal
$569,659Allyn C Howlett · Wake Forest University Health Sciences · R01 · FY2025 · DA
Clinical Research in ALS & Related Disorders for Therapeutic Development (CReATe) - Project Core #1
$569,575Michael Benatar · University Of Miami School Of Medicine · U54 · FY2021 · NS
Automating Behavioral Coding via Text-Mining and Speech Signal Processing
$569,562David Charles Atkins · University Of Washington · R01 · FY2012 · AA
Genetic dissection of auditory circuit assembly
$569,543Lisa V Goodrich · Harvard Medical School · R01 · FY2024 · DC
Genetic dissection of auditory circuit assembly
$569,543Lisa V Goodrich · Harvard Medical School · R01 · FY2023 · DC
Genetic dissection of auditory circuit assembly
$569,543Lisa V Goodrich · Harvard Medical School · R01 · FY2022 · DC
Family-Based Treatment for Parental Substance Abuse and Child Maltreatment
$569,481Cynthia Cupit Swenson · Medical University Of South Carolina · R01 · FY2013 · DA
Molecular Targeted Photoimmunotherapy for Bladder Cancer
$569,459Piyush Agarwal · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA