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17,054 grants matching “genome editing”
Dissecting and Targeting RB1-Mutant Osteosarcoma
$404,705Dung-Fang Lee · University Of Texas Hlth Sci Ctr Houston · R01 · FY2025 · CA
Dynamics of Clathrin Coat Formation in Cells
$404,657Tomas Kirchhausen · Boston Children'S Hospital · R01 · FY2017 · GM
Dynamics of Clathrin Coat Formation in Cells
$404,657Tomas Kirchhausen · Boston Children'S Hospital · R01 · FY2016 · GM
Dynamics of Clathrin Coat Formation in Cells
$404,657Tomas Kirchhausen · Boston Children'S Hospital · R01 · FY2018 · GM
Gene Editing Core
$404,630David R Liu · Jackson Laboratory · U19 · FY2024 · NS
Point-of-care optical spectroscopy platform and novel ratio-metric algorithms for rapid and systematic functional characterization of biological models in vivo
$404,576Caigang Zhu · University Of Kentucky · R01 · FY2024 · DE
Genetic and Epigenetic Determinants of Centromere Identity
$404,375Barbara Mellone · University Of Connecticut Storrs · R35 · FY2025 · GM
CAREER: Understanding the Interdependence of the Microenvironment and Nuclear Organization in Stem Cell Aging
$404,355Carlos A Aguilar · Regents Of The University Of Michigan - Ann Arbor · · FY2021 · ENG
Mechanisms of developmental buffering
$404,350James Tucker Nichols · University Of Colorado Denver · R01 · FY2025 · DE
Mechanisms of resistance to ALK inhibitors in ALK-rearranged lymphoma
$404,316Roberto Chiarle · Boston Children'S Hospital · R01 · FY2015 · CA
Bioinformatics Strategies for Genome Wide Association Studies
$404,309Jason H. Moore · University Of Pennsylvania · R01 · FY2019 · LM
Engineering HIV-specific T cells that have improved function and persistence
$404,263E. John Wherry · University Of Pennsylvania · U19 · FY2021 · AI
PNA Nanoparticles for Gene Editing In Vivo
$404,237Peter M Glazer · Yale University · U01 · FY2020 · AI
PNA Nanoparticles for Gene Editing In Vivo
$404,237Peter M Glazer · Yale University · U01 · FY2021 · AI
PNA Nanoparticles for Gene Editing In Vivo
$404,236Peter M Glazer · Yale University · U01 · FY2022 · AI
THIS PROJECT SUPPORTS THE MISSION OF THE AGRICULTURAL EXPERIMENT STATION BY ADDRESSING THE HATCH ACT AREA(S) OF: PLANT AND ANIMAL PRODUCTION, PROTECTION, AND HEALTH; MOLECULAR BIOLOGY; BIOTECHNOLOGYSTRIPE RUST IS A DEVASTATING FUNGAL DISEASE THAT THREATENS GLOBAL WHEAT PRODUCTION, WITH ESTIMATED GLOBAL LOSSES OF AROUND 1 BILLION DOLLARS PER YEAR. RECENTLY, THE WTK1 GENE WAS IDENTIFIED FROM A WILD WHEAT RELATIVE THAT PROVIDES BROAD-SPECTRUM RESISTANCE AGAINST THE FUNGAL PATHOGEN CAUSING STRIPE RUST. DESPITE THE IMPORTANCE OF THIS DISEASE, HOW WTK1 CONFERS DISEASE RESISTANCE REMAINS UNKNOWN. THIS GRANT WILL FOCUS ON IDENTIFYING HOW WTK1 PERCEIVES THE FUNGAL PATHOGEN CAUSING STRIPE RUST AND SIGNALS INSIDE WHEAT CELLS TO CONFER DISEASE RESISTANCE USING CUTTING-EDGE PROTEIN-PROTEIN AND GENOME EDITING TECHNOLOGIES. A GREATER UNDERSTANDING OF WTK1-MEDIATED DISEASE RESISTANCE WILL PROVIDE IMPORTANT MECHANISTIC INSIGHT INTO SIGNALING NETWORKS IN PLANT DISEASE RESISTANCE. A KEY GOAL OF THIS PROJECT IS TO INTEGRATE RESEARCH WITH THE TEACHING AND TRAINING OF A DIVERSE STUDENT BODY. THE PI WILL COLLABORATE WITH A LOCAL MIDDLE SCHOOL TO DEVELOP HANDS-ON PLANT LABORATORY MODULES THAT WILL UTILIZE WHEAT GENETICS TO ILLUSTRATE THE CONNECTION BETWEEN GENOTYPE AND PHENOTYPE. THESE LABORATORY MODULES WILL BE IMPLEMENTED IN THE 7TH GRADE SCIENCE CURRICULUM, WILL BE INEXPENSIVE, SUSTAINABLE, AND REACH >1,000 STUDENTS DURING THE COURSE OF THE PROJECT.
$404,192University Of California, Davis · · FY2020 · National Institute of Food and Agriculture
Mapping endogenous protein dynamics in living cells
$404,184Bo Huang · University Of California, San Francisco · R01 · FY2019 · GM
Molecular and cellular mechanisms underlying the nerve dependence of regeneration
$404,158Maria Antonietta Tosches · Columbia Univ New York Morningside · R35 · FY2022 · GM
Hematology Training Program
$404,067Margaret Goodell · Baylor College Of Medicine · T32 · FY2021 · DK
Molecular tools for targeting RNA
$404,040Patrick Hsu · Salk Institute For Biological Studies · R01 · FY2019 · GM
Predicting and controlling polygenic health traits using probabilistic models and evolution-inspired gene editing
$403,825Moises Exposito-Alonso · Carnegie Institution Of Washington, D.C. · DP5 · FY2023 · OD
How cells monitor the integrity of their translation apparatus
$403,825Kamena Kostova · Carnegie Institution Of Washington, D.C. · DP5 · FY2020 · OD
Predicting and controlling polygenic health traits using probabilistic models and evolution-inspired gene editing
$403,825Moises Exposito-Alonso · Carnegie Institution Of Washington, D.C. · DP5 · FY2020 · OD
Predicting and controlling polygenic health traits using probabilistic models and evolution-inspired gene editing
$403,825Moises Exposito-Alonso · Carnegie Institution Of Washington, D.C. · DP5 · FY2021 · OD
How cells monitor the integrity of their translation apparatus
$403,825Kamena Kostova · Carnegie Institution Of Washington, D.C. · DP5 · FY2021 · OD