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1,049,261 grants matching “t cell”
Carbon Monoxide: Novel Opportunities for Therapy
$2,850,109Augustine M Choi · Brigham And Women'S Hospital · P01 · FY2012 · HL
Epigenetic regulation through the formation and resolution of R loops
$2,850,000Kavitha Sarma · Wistar Institute · DP2 · FY2017 · NS
The Alliance NCTN Biorepository and Biospecimen Resource
$2,849,375Mark A Watson · Washington University · U24 · FY2025 · CA
San Diego Center for Systems Biology: From Maps to Models
$2,849,208Jeff M Hasty · University Of California, San Diego · P50 · FY2015 · GM
Defining signatures for immune responsiveness by functional systems immunology
$2,849,006David A. Hafler · Yale University · U19 · FY2011 · AI
A Severe Hemophilia A Intergenerational Cohort Research Program for the Study of Factor VIII Immunogenicity
$2,849,004Jill Marie Johnsen · University Of Washington · UH3 · FY2025 · HL
Bioengineered Antibodies in Cancer Imaging and Therapy
$2,849,003City Of Hope/Beckman Research Institute · P01 · FY2004 · CA
Mechanisms of Recovery from Viral Pneumonia
$2,848,690Karen M Ridge · Northwestern University At Chicago · P01 · FY2021 · HL
Integrating innate and adaptive pathways in vaccine responses
$2,848,678Jeffrey Victor Ravetch · Rockefeller University · U19 · FY2018 · AI
PDT Optimization and Mechanisms
$2,848,446Sandra O Gollnick · Roswell Park Cancer Institute Corp · P01 · FY2019 · CA
Adaptive Optics Retinal Imaging
$2,848,312Johnny Tam · National Eye Institute · ZIA · FY2021 · EY
Molecular Epidemiology Studies of Occupational and Environmental Exposures
$2,848,233Nathaniel Rothman · Division Of Cancer Epidemiology And Genetics · Z01 · FY2008 · CA
(Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
$2,848,211Scott G Kitchen · University Of California Los Angeles · U19 · FY2024 · AI
Women's Interagency HIV Study (WIHS) III
$2,848,192Howard Minkoff · Suny Downstate Medical Center · U01 · FY2006 · AI
The NBC2: Growing a Regional and National Bioeconomy, One Locale at a Time
$2,848,146Margaret Bryans · Montgomery County Community College · · FY2012 · EDU
(Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
$2,848,126Scott G Kitchen · University Of California Los Angeles · U19 · FY2023 · AI
Spinal Circuits for the Control of Dextrous Movement
$2,848,115Martyn D Goulding · Salk Institute For Biological Studies · U19 · FY2021 · NS
Molecular profiling and immunomodulatory interventions
$2,848,007Abraham Na Shaked · University Of Pennsylvania · U01 · FY2006 · AI
FPDS BASE DESCRIPTION MULTIPLE YEAR AWARD AND INCREMENTAL FUNDING FOR YEARS ONE TO FIVE. THIS PROPOSAL IS ENTITLED "RELIVING THE PAST: EXPERIMENTAL EVOLUTION OF MAJOR TRANSITIONS IN THE HISTORY OF LIFE." THIS IS AWARDED IN RESPONSE TO COOPERATIVE AGREEMENT NOTICE (CAN) NO. NNH13ZDA017C NASA ASTROBIOLOGY INSTITUTE CYCLE SEVEN (7). THE PRINCIPAL INVESTIGATOR IS DR. RAPHAEL F. ROSENZWEIG WITH UNIVERSITY OF MONTANA (UMT). PROJECT SUMMARY: TO ILLUMINATE THE LAWS THAT PRODUCE DARWIN'S "TANGLED BANK" REMAINS ONE OF BIOLOGY'S GRAND CHALLENGES ONE THAT REQUIRES UNDERSTANDING HOW DIFFERENCES AMOUNT FORMS ARE SELECTED FOR AND HOW INTERDEPENDENCE AMOUNT FORMS IS ENFORCED. IN NATURAL ENVIRONMENTS MEETING THIS CHALLENGE IS COMPLICATED BY THE FACT THAT SELECTION PRESSURES OFTEN VARY WIDELY OVER SPACE AND THROUGH TIME. LABORATORY EVOLUTION EXPERIMENTS WITH MICROBIAL POPULATION OFFER AN ATTRACTIVE ALTERNATIVE BY WHICH TO STUDY UNDER CONTROLLED CONDITIONS BOTH THE DYNAMIC INTERPLAY BETWEEN GENOTYPE AND PHENOTYPE AND THE INTERACTIONS AMONG PHENOTYPES IN SIMPLE COMMUNITIES. INDEED BECAUSE THE PRINCIPAL ACTORS IN THE FIRST 2.5 BILLION YEARS OF LIFE S DRAMA WERE EXCLUSIVELY MICROBES WE ARE OBLIGATED TO USE THESE FORMS TO UNLOCK THE SECRETS OF LIFE'S TRANSITIONS FROM SIMPLE AUTOCATALYTIC UNITS TO SELF-ORGANIZING SELF-REPLICATING ENERGY TRANSDUCTION SYSTEMS THAT RANGE IN COMPLEXITY FROM SINGLE CELLS TO ECOSYSTEMS. OUR TEAM IS RESPONDING TO NAI CAN 7 WITH A MULTIDISCIPLINARY PROPOSAL TO ADDRESS: WHAT FORCES BRING ABOUT MAJOR TRANSITIONS IN THE EVOLUTION OF BIO-COMPLEXITY? OUR PROGRAM AIMS TO MEET THE GRANT CHALLENGE OF ILLUMINATING AND INTERPRETING THE LAWS THAT PRODUCE THE "TANGLED BANK" SO THAT WE MAY BETTER UNDERSTAND AND APPRECIATE THE GRANDEUR IN THE VIEW OF LIFE....THAT WHILST THIS PLANET HAS GONE CYCLING ON ACCORDING TO THE FIXED LAW OF GRAVITY FROM SO SIMPLE A BEGINNING ENDLESS FORMS MOST BEAUTIFUL AND MOST WONDERFUL HAVE BEEN AND ARE BEING EVOLVED. THE LAWS ORIGINAL INFERRED BY DARWIN WERE THOSE THAT GIVE RISE TO NATURAL SELECTION WHICH IS A CONSEQUENCE OF NATURAL VARIATION INHERITANCE OF VARIATION AND THE DIFFERENTIAL REPRODUCTION AND SURVIVORSHIP OF VARIANTS ACCORDING TO THEIR FITNESS. 150 YEAR LATER WE NOW RECOGNIZE THE IMPORTANCE OF OTHER FACTORS IN PARTICULAR CHANGE WHETHER IN THE FORM OF GENETIC DRIFT OR HISTORICAL CONTINGENCY. OUR KNOWLEDGE OF THE MECHANISM OF INHERITANCE CONTINUES TO BE REFINED BY NEW INSIGHTS INTO WHAT CONSTITUTES A GENE HOW GENES INTERACT AND HOW MUTATION RATE ITSELF IS SUBJECT TO NATURAL SELECTION. OUR ASTROBIOLOGY PROJECT IS ORGANIZED AROUND A SET OF QUESTIONS RELATED TO MAJOR TRANSITIONS IN THE HISTORY OF LIFE WHEN INDEPENDENTLY REPLICATING ENTITIES COMBINE IN TO LARGER MORE COMPLEX WHOLES: (I) HOW DO ENZYMES AND METABOLIC NETWORKS EVOLVE? (II) HOW DID THE EUKARYOTIC CELL SPECIFICALLY THE CELL THAT CONTAINED A MITOCHONDRION COME TO BE? (III) HOW DO SYMBIOSES ARISE? (IV) HOW DOES MULTICELLULARITY EVOLVE? AND (V) HOW DO PLEIOTROPY EPISTASIS AND MUTATION RATE CONSTRAIN THE EVOLUTION OF NOVEL TRAITS? A UNIFYING THEM UNDERLYING THESE QUESTIONS IS: HOW DO COOPERATIVE VS. COMPETITIVE INTERACTIONS PLAY OUT IN DRIVING MAJOR TRANSITIONS? SEEKING THE ANSWERS TO THESE QUESTIONS FALLS SQUARELY WITHIN ASTROBIOLOGY WHICH IS THE STUDY OF THE ORIGINS EVOLUTION DISTRIBUTION AND FUTURE OF LIFE IN THE UNIVERSE AND HELPS TO ADDRESS THE FIRST OF OUR DISCIPLINE S THREE PRINCIPAL QUESTIONS: HOW DOES LIFE BEGIN AND EVOLVE?
$2,847,985University Of Montana · · FY2015 · National Aeronautics and Space Administration
(Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
$2,847,927Scott G Kitchen · University Of California Los Angeles · U19 · FY2021 · AI
(Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
$2,847,671Scott G Kitchen · University Of California Los Angeles · U19 · FY2022 · AI
Synaptic integration and intrinsic firing properties of basal ganglia neurons
$2,846,848Zayd M Khaliq · National Institute Of Neurological Disorders And Stroke · ZIA · FY2025 · NS
LRP4 deficiency in Alzheimer's disease development
$2,846,666Wen-Cheng Xiong · Case Western Reserve University · RF1 · FY2020 · AG
Targeting Cellular Senescence to Extend Healthspan
$2,846,464Sundeep Khosla · Mayo Clinic Rochester · P01 · FY2020 · AG
Nanotherapy for Vulnerable Plaque
$2,846,417Jeffrey W Smith · Sanford Burnham Prebys Medical Discovery Institute · U01 · FY2008 · HL