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17,828 grants matching “crispr”
Characterization of TMEM251 that causes a new type of severe lysosome storage disease
$424,308Ming Li · University Of Michigan At Ann Arbor · R01 · FY2025 · HD
Functional dissection of clonal hematopoiesis
$424,288Leonard I Zon · Massachusetts General Hospital · P01 · FY2019 · HL
Functional dissection of clonal hematopoiesis
$424,288Leonard I Zon · Massachusetts General Hospital · P01 · FY2021 · HL
Functional dissection of clonal hematopoiesis
$424,288Leonard I Zon · Massachusetts General Hospital · P01 · FY2020 · HL
Network-based prediction and validation of causal schizophrenia genes and variants
$424,175Manolis Kellis · Broad Institute, Inc. · R01 · FY2016 · MH
Genomic Instability as A Driver of Stem Cell Exhaustion
$424,139Thomas A Rando · University Of California Los Angeles · R01 · FY2025 · AG
Functional Genomics and Genetics Shared Resource
$424,119Alea Mills · Cold Spring Harbor Laboratory · P30 · FY2018 · CA
Epigenetic Therapy to Treat Radiation-induced Xerostomia
$424,102Isabelle M.a. Lombaert · University Of Michigan At Ann Arbor · R01 · FY2023 · DE
CRISPR gene therapies targeting tau in Alzheimer's disease and tauopathies
$424,095Todd Jonathan Cohen · Univ Of North Carolina Chapel Hill · R21 · FY2023 · AG
Functional Genomics and Genetics Shared Resource
$424,090Alea Mills · Cold Spring Harbor Laboratory · P30 · FY2017 · CA
Functional Genomics and Genetics Shared Resource
$424,079Christopher Vakoc · Cold Spring Harbor Laboratory · P30 · FY2020 · CA
Functional Genomics and Genetics Shared Resource
$424,079Alea Mills · Cold Spring Harbor Laboratory · P30 · FY2019 · CA
Aging and organismal proteostasis-Project 4 RM
$424,061Richard I. Morimoto · Northwestern University · P01 · FY2021 · AG
Tubulin microtentacles in detached mammary epithelial cells
$424,018Stuart S Martin · University Of Maryland Baltimore · R01 · FY2023 · CA
Tubulin microtentacles in detached mammary epithelial cells
$424,018Stuart S Martin · University Of Maryland Baltimore · R01 · FY2025 · CA
Folic Acid Supplementation and Colitis-associated Colon Carcinogenesis
$423,946Margie L. Clapper · Research Inst Of Fox Chase Can Ctr · R01 · FY2022 · CA
Modeling and druggable-genome screening of glioblastoma invasion using regional biopsy-guided biomaterials systems
$423,892Manish Aghi · University Of California, San Francisco · R01 · FY2020 · CA
Regulation of adipose lipid metabolism by new lipid droplet protein
$423,886Hei Sook Sul · University Of California Berkeley · R01 · FY2019 · DK
Regulation of adipose lipid metabolism by new lipid droplet protein
$423,886Hei Sook Sul · University Of California Berkeley · R01 · FY2018 · DK
Regulation of adipose lipid metabolism by new lipid droplet protein
$423,886Hei Sook Sul · University Of California Berkeley · R01 · FY2017 · DK
Regulation of adipose lipid metabolism by new lipid droplet protein
$423,886Hei Sook Sul · University Of California Berkeley · R01 · FY2021 · DK
Regulation of adipose lipid metabolism by new lipid droplet protein
$423,886Hei Sook Sul · University Of California Berkeley · R01 · FY2020 · DK
> 550 MILLION POUNDS OF INSECTICIDES ARE USED ANNUALLY IN THE US, BUT OUR UNDERSTANDING OF THE POISONING PROCESSES IN INSECTS IS FAR FROM COMPLETE.OUR OVERALL GOAL IS TO CHARACTERIZE THE GENETIC VARIATION THAT CONTROLS THE VARIATION IN SENSITIVITY OF A NAÏVE (I.E. SUSCEPTIBLE) POPULATION TO INSECTICIDES AND IDENTIFY THE GENES INVOLVED IN THE POISONING PROCESS. WE WILL COMPLETE THREE OBJECTIVES:1- USING GENOME-WIDE ASSOCIATION STUDIES OF THE DROSOPHILA GENETIC REFERENCE PANEL (DGRP), WE WILL IDENTIFY ALLELES AND GENES RESPONSIBLE FOR VARIATION IN RESPONSE TO INSECTICIDE POISONING USING TWO INSECTICIDES TO WHICH THE SPECIES IS NAÏVE: CHLORANTRANILIPROLE AND BROFLANILIDE.2- USING TRANSCRIPTOMICS, WE WILL CHARACTERIZE THE GENE REGULATORY NETWORKS THAT CONTROL INDUCIBLE RESPONSES FOLLOWING EXPOSURE TO CHLORANTRANILIPROLE AND BROFLANILIDE. WE WILL EXAMINE THE TIME COURSE OF TRANSCRIPTIONAL RESPONSE TO EXPOSURE WITH THESE INSECTICIDES. WE WILL THEN EXPAND TO CHARACTERIZE DIFFERENCES BETWEEN LINES FROM THE DGRP PANEL WITH DIFFERENT SURVIVAL PHENOTYPE TO THE INSECTICIDES. THIS WILL IDENTIFY THE VARIANTS WITH ALTERED EXPRESSION AND GENES/GENE NETWORKS THAT CONTROL INSECTICIDE SENSITIVITY.3- WE WILL VALIDATE FUNCTIONALLY THE ROLE OF THE CANDIDATE GENES BY RNAI, NULL LINES AND/OR OVEREXPRESSION LINES, AND THE ROLE OF SELECT SNPS (FROM OBJECTIVES 1 AND 2) USING CRISPR ALLELE REPLACEMENT.OF NOTE, OBJECTIVE 1 AND 2 ARE COMPLEMENTARY AS THEY WILL GIVE US 2 UNBIASED APPROACHES TO IDENTIFY BOTH GENES THAT FUNCTIONALLY UNDERLIE SUSCEPTIBILITY TO INSECTICIDES AND GENES ASSOCIATED WITH THE RESPONSE TO INSECTICIDES.
$423,812Cornell University · · FY2020 · National Institute of Food and Agriculture
Specification of Treg cells: FOXP3 functional facets
$423,750Christophe O Benoist · Harvard Medical School · R01 · FY2015 · AI
Specification of Treg cells: FOXP3 functional facets
$423,750Christophe O Benoist · Harvard Medical School · R01 · FY2016 · AI