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38,696 grants matching “als”
Complex Neurodegenerative Disorders Clinic
$597,608Mary Kay Floeter · National Institute Of Neurological Disorders And Stroke · ZID · FY2019 · NS
Designing a Plan of Action for Better Access and Quality of Surgery for African-Americans with Gastrointestinal Cancers in the Deep South
$597,411Maria Pisu · University Of Alabama At Birmingham · R01 · FY2023 · MD
Neighborhood, social connectedness, and allostatic load in US Chinese immigrants
$597,379Carolyn Y Fang · Research Inst Of Fox Chase Can Ctr · R01 · FY2023 · MD
Oligodendroglial Dysfunction in C9orf72 ALS and FTD
$597,360Jeffrey D Rothstein · Johns Hopkins University · R01 · FY2018 · NS
Oligodendroglial Dysfunction in C9orf72 ALS and FTD
$597,360Jeffrey D Rothstein · Johns Hopkins University · R01 · FY2020 · NS
Oligodendroglial Dysfunction in C9orf72 ALS and FTD
$597,360Jeffrey D Rothstein · Johns Hopkins University · R01 · FY2019 · NS
Oligodendroglial Dysfunction in C9orf72 ALS and FTD
$597,360Jeffrey D Rothstein · Johns Hopkins University · R01 · FY2021 · NS
Pharmacology & ImmunoPathology (PIP) Core
$597,325Veronique Dartois · Weill Medical Coll Of Cornell Univ · U19 · FY2025 · AI
TMEM106B in neurodegenerative disease
$597,250Alice S Chen-Plotkin · University Of Pennsylvania · R01 · FY2021 · NS
ANALYZING GENESIS SOLAR WIND SAMPLES BY ION MICROPROBE. THE GENESIS MISSION WAS CARRIED OUT TO RETURN A SAMPLE OF THE SOLAR WIND TO EARTH IN ORDER TO OBTAIN PRECISE ISOTOPIC COMPOSITIONS AND ABUNDANCES OF THE ELEMENTS IN THE SOLAR WIND. OUR LABORATORY HAS BEEN ANALYZING GENESIS SAMPLES FOR SEVERAL YEARS AND WE HAVE DEVELOPED STATE-OF-THE-ART TECHNIQUES TO OBTAIN HIGH-PRECISION ISOTOPIC AND ELEMENTAL COMPOSITIONS. WE COLLECT BACK-SIDE DEPTH PROFILES IN IMAGE MODE USING RASTER ION IMAGING TO COLLECTED IMAGE STACKS THAT WE CAN THEN PROCESS. EACH PIXEL IN THE IMAGE IS A DEPTH PROFILE. WE ALIGN THE STACK IN X AND Y TO ACCOUNT FOR BEAM DRIFT. THEN WE ALIGN THE PIXELS IN THE IMAGE SO THAT THE PEAK OF THE SOLAR WIND AND THE BREAKTHROUGH AT THE SURFACE ARE AT THE SAME DEPTH IN ALL PIXELS. WE THEN COMBINE THE PIXELS TO PRODUCE THE FINAL DEPTH PROFILE FOR THAT MEASUREMENT. WE HAVE ALSO LEARNED HOW TO RELIABLY STANDARDIZE THE MEASUREMENTS. WE PROPOSE TO LEVERAGE WHAT WE HAVE LEARNED TO MAKE MEASUREMENTS OF THE FLUENCES AND ISOTOPIC COMPOSITIONS OF A VARIETY OF ELEMENTS IN THE GENESIS COLLECTORS. USING A CS PRIMARY BEAM WE WILL MEASURE C O AND S IN SI COLLECTORS AND SI IN SAPPHIRE COLLECTORS. USING AN O PRIMARY ION BEAM WE WILL MEASURE AL CA CR AND FE IN SI COLLECTORS AND NA IN EITHER DOS OR SAPPHIRE COLLECTORS. TECHNIQUES WILL HAVE TO BE DEVELOPED TO WORK THE THE SAPPHIRE COLLECTORS BUT OUR PRELIMINARY WORK SHOWS HOW THIS CAN BE DONE. SAMPLE PREPARATION WILL BE DONE AT BERKELEY STANDARDIZATION WILL BE DONE COLLABORATIVELY BETWEEN BERKELEY UH FSU ASU AND CALTECH THE MEASUREMENTS WILL BE DONE AT UH PIT DEPTHS WILL BE MEASURED AT ASU AND THE DATA REDUCTION WILL BE DONE AT UH WITH INPUT FROM BERKELEY AND WASH. U. PAPERS REPORTING THE DATA WILL BE WRITTEN AT UH ALTHOUGH THE ENTIRE TEAM WILL HAVE INPUT INTO THE FINAL DOCUMENT. THIS WORK WILL HELP MAXIMIZE THE SCIENTIFIC RETURN OF THE GENESIS MISSION THOUGH DIRECT ANALYSIS OF SAMPLES THAT GENESIS RETURNED TO EARTH. THE GENESIS MISSION IS EXPLICITLY CALLED OUT IN THE REQUEST FOR PROPOSALS AS ONE OF THE TARGETS FOR THE LARS PROGRAM (C.18 2.1.1). ACCOMPANYING THIS PROPOSAL IS A PLANETARY MAJOR EQUIPMENT REQUEST TO OBTAIN A NEW RF PLASMA OXYGEN ION SOURCE FOR THE CAMECA IMS 1280 ION MICROPROBE. THIS SOURCE WOULD GREATLY FACILITATE THE WORK ON ELEMENTS THAT MAKE POSITIVE IONS (NA AL CA CR TI FE MN NI ETC) BY PROVIDING MUCH GREATER LONG TERM STABILITY (CLEANING UP OUR DEPTH PROFILES) AND A MUCH SMALLER SPOT SIZE (DE-SMEARING OUR DEPTH PROFILES). IF WE DO NOT GET THE SOURCE THE WORK CAN AND WILL STILL BE DONE BUT THE UNCERTAINTIES WILL BE LARGER
$597,000University Of Hawaii · · FY2017 · National Aeronautics and Space Administration
Sex-dependent shifts in behavioral profiles and cortical signaling following adolescent binge drinking
$597,000Nicole Ashley Crowley · Pennsylvania State University, The · R01 · FY2025 · AA
Candidate Gene Analysis of Persistent AD/HD
$596,945Allison E Ashley-Koch · Duke University · R01 · FY2006 · NS
Actin Filament Network Remodeling, Disassembly and Turnover
$596,923Bruce L Goode · Brandeis University · R01 · FY2013 · GM
The role of N6-methyladenosine RNA modification in programmed and aberrant DNA mutagenesis in B cells
$596,917Uttiya Basu · Columbia University Health Sciences · R01 · FY2025 · AI
Health Effects Of Exposures In Agriculture
$596,847Dale P Sandler · National Institute Of Environmental Health Sciences · ZIA · FY2016 · ES
WE PROPOSE AN INVESTIGATION OF MOMENTUM PROCESSES IN SOLAR ERUPTIONS BY COMBINING MULTI-INSTRUMENT OBSERVATIONS AND STATE-OFTHE- ART NUMERICAL MODELING. THE CORONAL LORENTZ FORCE CAN BE ESTIMATED USING HIGH-CADENCE PHOTOSPHERIC VECTOR MAGNETOGRAMS AND EXHIBITS A RAPID AND PERMANENT CHANGE DURING MAJOR ERUPTIONS. PRELIMINARY INVESTIGATIONS (SUN ET AL. 2015 2016) SUGGEST AN EXCESS OF THE LORENTZ FORCE IMPULSE COMPARED TO CME MOMENTUM (THE EXCESS PROBLEM ) AND THIS IMPULSE IS APPARENTLY SIGNIFICANTLY GREATER FOR ERUPTIVE FLARES (WITH CMES) COMPARED TO NON-ERUPTIVE FLARES (WITHOUT CMES). WE WILL ADDRESS THE FOLLOWING QUESTIONS: (1) HOW DOES PHOTOSPHERIC MAGNETIC FIELD EVOLVE DURING SOLAR ERUPTIONS? HOW IS IT RELATED TO THE EVOLUTION OF THE LORENTZ FORCE? (2) HOW DOES THE OBSERVED LORENTZ FORCE IMPULSE (AND ITS TEMPORAL AND SPATIAL DISTRIBUTION) RELATE TO THE CME MOMENTUM? ARE THERE SYSTEMATIC DIFFERENCES BETWEEN ERUPTIVE AND NON-ERUPTIVE FLARES? (3) WHAT CAN WE LEARN FROM MHD MODELS ABOUT THE SPATIAL AND TEMPORAL DISTRIBUTION OF VARIOUS MOMENTUM PROCESSES? CAN WE USE DATA-DRIVEN NUMERICAL MODELING TO EXPLAIN THE OBSERVATIONAL RESULTS? METHODOLOGY: OUR PROPOSED INVESTIGATION WILL ANALYZE NEW 135S VECTOR MAGNETOGRAMS FROM SDO/HMI CORONAL EUV AND CORONAGRAPH IMAGES FROM SDO STEREO AND SOHO IN CONJUNCTION WITH RUNNING MHD SIMULATIONS OF CME INITIATION USING THE CGEM/RADMHD CODE. WE PROPOSE THE FOLLOWING: 1. CHARACTERIZE MAGNETIC FIELD AND FORCE EVOLUTION. WE WILL SURVEY BOTH ERUPTIVE AND NON-ERUPTIVE FLARES IN THE SDO ERA AND EVALUATE THE FIELD CHANGES AND MAGNETIC FORCES IN THE SOURCE REGIONS USING HIGH-CADENCE HMI DATA. THE RESULTS WILL BE COMPARED WITH OTHER ACTIVE REGION PROPERTIES (FIELD STRENGTH FLUX CONTENT AND MAGNETIC TOPOLOGY) TO FURTHER UNDERSTAND THE SPECIFIC ROLE OF THE LORENTZ FORCE IN SOLAR ERUPTIONS. 2. CHARACTERIZE VARIOUS MOMENTUM PROCESSES. FOR ERUPTIVE EVENTS WE WILL PERFORM DETAILED STUDIES OF THE CME MASS AND DYNAMICS INCLUDING THE MOMENTUM EVOLUTION ASSOCIATED WITH THE HEIGHT-TIME TRANSITION BETWEEN PRE-ERUPTIVE SLOW RISE PHASE THROUGH THE ONSET OF CME INITIATION AND ACCELERATION. 3. QUANTIFY THE FORCE EVOLUTION AND MOMENTUM PROCESSES IN MHD MODELS. IN ORDER TO FILL THE GAP BETWEEN OBSERVATIONS OF PHOTOSPHERIC BOUNDARY EVOLUTION AND OBSERVATIONS OF THE RESULTING FLARE AND CME ERUPTION WE WILL DEVELOP NEW INITIALIZATION STATE PROCEDURES FOR THE RADMHD CODE THAT ALLOW FOR REALISTIC SOLAR ATMOSPHERE DENSITY/TEMPERATURE STRATIFICATION. WE PROPOSE TO RUN THE TORUS INSTABILITY AND MAGNETIC BREAKOUT CME ERUPTION MODELS IN RADMHD AND ANALYZE THE FORCES AND MOMENTUM EVOLUTION IN THE SIMULATIONS. THESE RESULTS WILL BE CRITICAL TO SOLVING THE LORENTZ FORCE EXCESS PROBLEM. 4. SYNTHESIZE OBSERVATIONAL AND MODELING RESULTS TO INTERPRET THE RELATION BETWEEN MAGNETIC FORCES AND MOMENTUM PROCESSES DURING FLARES AND CMES. WE WILL THEN PERFORM A REALISTIC DATA-DRIVEN CME ERUPTION USING 135 S HMI DATA BUILDING ON THE CAPABILITIES DEVELOPED FOR THE CGEM/RADMHD FRAMEWORK (FISHER ET AL. 2015). FROM MHD SIMULATION ANALYSES WE WILL BE ABLE TO CHARACTERIZE THE LORENTZ FORCE IMPULSE AND THE MOMENTUM TRANSFER DURING IDEAL AND/OR RESISTIVE INSTABILITIES FROM FLARE RECONNECTION JETS TO THE EJECTA VIA FLUID AND PARTICLES AND FOLLOW THE MOMENTUM EVOLUTION THROUGH CME PROPAGATION. WE WILL DIRECTLY COMPARE DATA-DRIVEN RADMHD RESULTS TO OBSERVATIONS. THIS WORK WILL CONTRIBUTE TO THE UNDERSTANDING OF CME AND FLARE PROCESSES AND IMPROVE OUR CAPABILITY FOR SPACE WEATHER FORECASTING. IT IS DIRECTLY RELEVANT TO THE DECADAL SURVEY GOAL DETERMINE THE ORIGINS OF THE SUN S ACTIVITY AND PREDICT THE VARIATIONS OF THE SPACE ENVIRONMENT.
$596,818Regents Of The University Of California, The · · FY2017 · National Aeronautics and Space Administration
Localized and distributed real-time fMRI approaches to facilitate self control in
$596,788Pearl H Chiu · Virginia Polytechnic Inst And St Univ · R33 · FY2011 · DA
Hematopathology Fellowship
$596,786Elaine Jaffe · Division Of Basic Sciences - Nci · ZIE · FY2015 · CA
Harnessing mitochondria transfer pathways to ameliorate Leigh Syndrome-like disease
$596,783Jonathan R Brestoff · Washington University · R01 · FY2024 · NS
School-based Health Clinics: Effects on Youth and Young Adult Sexual Behavior
$596,783Melina Bersamin · Pacific Institute For Res And Evaluation · R01 · FY2013 · HD
Strengths and weaknesses in learning in mice with ASD risk genes
$596,723Linda E. Wilbrecht · University Of California Berkeley · R01 · FY2025 · MH
A novel embryonic transcriptional cascade required for adult social and repetitive behavior
$596,694Anthony J Wynshaw-Boris · Case Western Reserve University · R01 · FY2018 · MH
Mechanobehavior distinguishes mandibular growth differences in two facial types
$596,636Laura R Iwasaki · Oregon Health & Science University · R01 · FY2019 · DE
Determining Optimal Treatment Intensity for Children with Language Impairment (LI)
$596,599Mary Beth Schmitt · University Of Texas At Austin · R01 · FY2021 · DC
Implementation of Evidence-Based Preventive Parenting Programs
$596,586Cady Berkel · Arizona State University-Tempe Campus · R01 · FY2016 · DA