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21,281 grants matching “influenza”
Pandemic Potential of H5N1 Influenza Viruses
$499,900Yoshihiro Kawaoka · University Of Wisconsin-Madison · R01 · FY2009 · AI
RCN: EcoHealth Net 2.0: A One Health approach to disease ecology research & education
$499,897Jonathan Epstein · Ecohealth Alliance Inc. · · FY2016 · BIO
Generation and Evaluation of KSHV VLPs as Vaccines
$499,880Gary S Hayward · Johns Hopkins University · RC2 · FY2009 · CA
Exploiting a cyclic dinucleotide-mediated immune response to reduce the burden of Coxiella burnetii infection
$499,870Alan Gabriel Goodman · Washington State University · R01 · FY2019 · AI
Electronic Support for Public Health - Vaccine Adverse Event Reporting System
$499,809Ross Lazarus · Harvard Pilgrim Health Care, Inc. · R18 · FY2007 · HS
Oregon Child Absenteeism due to Respiratory Disease Study
$499,801Jonathan L Temte · University Of Wisconsin-Madison · U01 · FY2013 · CK
Mechanisms of immunopathology of COVID-19/ARDS, and strategies to mitigate detrimental inflammatory responses
$499,801Sonja Best · National Institute Of Allergy And Infectious Diseases · ZIA · FY2024 · AI
Influenza Virus-like Particles As Vaccines
$499,800Jose M Galarza · Technovax, Inc. · R43 · FY2006 · AI
Influence of polysialic acid on leukocyte migration
$499,792Nicholas Milton Stamatos · University Of Maryland Baltimore · R01 · FY2021 · AI
Oregon Child Absenteeism due to Respiratory Disease Study
$499,791Jonathan L Temte · University Of Wisconsin-Madison · U01 · FY2015 · CK
IDENTIFICATION AND CHARACTERIZATION OF RNA STRUCTURES IN THE GENOME OF INFLUENZA VIRUS
$499,724Adrianus Cm Boon · Washington University · R01 · FY2018 · AI
Transmission dynamics and spillover of avian influenza under changing agricultura
$499,696Xiangming Xiao · University Of Oklahoma · R01 · FY2014 · AI
Household Transmission of Influenza Viruses in the Community
$499,651Carlos G Grijalva · Vanderbilt University Medical Center · U01 · FY2017 · IP
Household Transmission of Influenza Viruses in the Community
$499,639Carlos G Grijalva · Vanderbilt University Medical Center · U01 · FY2018 · IP
Novel Therapy for SARS-CoV-2 Virus Infection and Pathogenesis by Aerosol Delivery of Monoclonal Antibodies
$499,631Peter Gordon Gillespie · Oregon Health & Science University · P51 · FY2021 · OD
Studies at the Animal-Human Interface of Influenza and other Zoonotic Diseases in
$499,598Nam Van Hoang · Vietnam Department Of Animal Health · U01 · FY2013 · IP
Project 1 - Host-virus networks regulating flu replication and host responses in vivo
$499,560Adolfo Garcia-Sastre · Icahn School Of Medicine At Mount Sinai · U19 · FY2020 · AI
INFLUENZA IS ONE OF THE MOST IMPORTANT RESPIRATORY DISEASES OF SWINE, CAUSED BY INFLUENZA A VIRUSES (IAV). ALTHOUGH IAV INFECTIONS IN PIGS GENERALLY RESULT IN MILD RESPIRATORY SIGNS, IT CAN SIGNIFICANTLY IMPACT PRODUCTION EFFICIENCY IN SWINE HERDS DUE TO ITS HIGH PREVALENCEAND LEAD TO PRODUCTION LOSSES ESTIMATED TO BE $3 TO $10 PER HEAD. THE EPIDEMIOLOGY OF SWINE IAV IS COMPLEX, WITH MANY GENETICALLY DIFFERENT VIRUSES CO-CIRCULATING IN PIGS IN THE UNITED STATES. HUMAN-TO-SWINE TRANSMISSIONS HAVE BEEN REPORTED FREQUENTLY IN THE PAST DECADES AND DIRECTLY CONTRIBUTE TO THIS CURRENT DIVERSITY OF SWINE VIRUSES, COMPLICATING THE CONTROL OF THE DISEASE. ONE EVENTWAS IDENTIFIED RECENTLY: A NOVEL H3N2 VIRUS OF HUMAN ORIGIN BECAME ESTABLISHED IN SWINE HERDS IN THE U.S. AND IS NOW ONE OF THE PREDOMINANT VIRUSES IN CIRCULATION. DESPITE THE IMPORTANCE OF THESE HUMAN-TO-SWINE SPILLOVER EVENTS, LITTLE IS KNOWN ABOUT THE CIRCUMSTANCES UNDER WHICH HUMAN IAVS TRANSMIT AND BECOME ADAPTED TO SWINE. TYPICALLY, AN INFLUENZA VIRUS HAS TO UNDERGO SPECIFIC MOLECULAR CHANGES TO EFFECTIVELY REPLICATE AND TRANSMIT IN A NEW SPECIES. SUCH CHANGES RESULT FROM PRESSURES IMPOSED BY THE NEW HOST, CREATING BOTTLENECKS THAT LEAD TO THE SELECTION OF VIRUSES WITH ADVANTAGEOUS CHARACTERISTICS. WE HYPOTHESIZE THAT THESE SELECTIVE BOTTLENECKS ALTER THE VIRUS'S MOLECULAR CHARACTERISTICS EARLY ON DURING THE ADAPTATION BETWEEN HUMANS AND SWINE AND THAT THESE PROCESSES ARE DEPENDENT ON SPECIFIC HOST FACTORS. THE OBJECTIVES OF THIS PROJECT ARE TO I) FOLLOW HOW A HUMAN IAV VIRUS EVOLVES GENETICALLY OVER TIME WITHIN AN INDIVIDUAL ANIMAL AND BETWEEN ANIMALS AS IT IS TRANSMITTED IN PIGS; II) EVALUATE IF SPECIFIC COMPONENTS OF THE ANIMAL'S IMMUNE RESPONSE IMPOSE PRESSURE TO RESULT IN VIRUS EVOLUTION; III) EVALUATE HOW GENETIC CHANGES DETECTED ON THE VIRAL SURFACE PROTEINS AFFECT THE VIRUS REPLICATION CHARACTERISTICS. WE WILL EVALUATE THE GENETIC CHANGES OF HUMAN-ORIGIN IAV DURING CONSECUTIVE INFECTIONS IN PIGS. ADDITIONALLY, WE WILL EVALUATE THE VIRUS GENETIC EVOLUTION UNDER PRESSURE FROM A SWINE-SPECIFIC IMMUNE COMPONENT. ANY CHANGES THAT ARE DETECTED WILL BE EVALUATED FOR ITS EFFECT ON VIRUS REPLICATION AND FITNESS. THE RESULTS FROM THIS RESEARCH COULD HELP FILTER SWINE SURVEILLANCE DATA FOR VIRUSES THAT HAVE "ADAPTATION SIGNATURES" AND IDENTIFY NEW SPILLOVER EVENTS THAT ARE LIKELY TO BE SUSTAINED IN PIGS. FURTHERMORE, THIS INFORMATION CAN BE USED TO IMPROVE BIOSECURITY MEASURES THAT COULD DECREASE THE VIRAL SPREAD AND PREVENT THE ESTABLISHMENT OFNOVEL VIRUSES. ULTIMATELY, THIS CAN HELP REDUCE THE ECONOMIC COST OF IAV TO PRODUCERS AND THE SWINE INDUSTRY.
$499,523University Of Georgia Research Foundation, Inc. · · FY2020 · National Institute of Food and Agriculture
Chemical intervention of influenza virus RNA nuclear export
$499,523Adolfo Garcia-Sastre · Icahn School Of Medicine At Mount Sinai · R33 · FY2018 · AI
A MULTICOMPONENT VIRUS VECTORED VACCINE FOR PRRS, PCVAD AND SWINE INFLUENZA
$499,500Virginia Polytechnic Institute & State University · · FY2012 · National Institute of Food and Agriculture
Systems Immunogenetics of Influenza Virus Infection in the Collaborative Cross
$499,496Mark T Heise · Univ Of North Carolina Chapel Hill · U19 · FY2019 · AI
Enhancing Antibiotic Stewardship in Primary Care
$499,491Mark Herbert Ebell · University Of Georgia · R01 · FY2018 · HS
Pathological Evaluation of a Cystic Fibrosis Ferret Model
$499,472John F Engelhardt · University Of Iowa · RC1 · FY2009 · HL
Pathological Evaluation of a Cystic Fibrosis Ferret Model
$499,472John F Engelhardt · University Of Iowa · RC1 · FY2010 · HL
Electronic Support for Public Health - Vaccine Adverse Event Reporting System (ES
$499,405Ross Lazarus · Harvard Pilgrim Health Care, Inc. · R18 · FY2008 · HS