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51,593 grants matching “hepatitis”
Drug eluting injectable biomaterials for next generation chemoembolization
$650,424Rahmi Oklu · Mayo Clinic Arizona · R01 · FY2022 · CA
Novel molecular imaging approaches to monitor gene and cell-based therapies
$650,363Caius Gabriel Radu · University Of California Los Angeles · R01 · FY2011 · CA
Bile acids and insulin sensitivity
$650,344Rebecca Anne Haeusler · Columbia University Health Sciences · R01 · FY2021 · DK
Small molecules targeting hepatic glucose production and insulin resistance
$650,222Pere Puigserver · Dana-Farber Cancer Inst · R01 · FY2023 · DK
Multifidelity and multiscale modeling of the spleen function in sickle cell disease with in vitro, ex vivo and in vivo validations
$650,173George Karniadakis · Brown University · R01 · FY2022 · HL
Disparities in the Diffusion of Direct-Acting Antiviral Therapy for Hepatitis C among Baby Boomers: A Mixed-Methods Study
$650,167Martin F Shapiro · Weill Medical Coll Of Cornell Univ · R01 · FY2024 · DK
MR-Image Guided Focused Ultrasound for Treatment of Liver and Renal Cancer
$650,145Kim Butts Pauly · Stanford University · R01 · FY2014 · CA
Cardiovascular Inflammation Reduction Trial (CIRT): DCC
$650,037Robert J Glynn · Brigham And Women'S Hospital · U01 · FY2012 · HL
Discovery and Assessment of Genetic Determinants of HCV and HIV Control
$650,016Raymond T Chung · Massachusetts General Hospital · R01 · FY2014 · DA
7th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013)
$650,000Chris Beyrer · Ias · R13 · FY2013 · AI
NIH-Owned Chimpanzee Research Resource at the SNPRC
$650,000Robert E Lanford · Texas Biomedical Research Institute · U42 · FY2013 · OD
Micro Analytical Immunochemistry
$650,000Heather Kalish · National Institute Of Biomedical Imaging And Bioengineering · ZIC · FY2020 · EB
8th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, BC, 19-22 July 2015
$650,000Chris Beyrer · Ias · R13 · FY2015 · AI
Immune Escape Strategies in HCV infection
$649,999University Of Colorado Denver · U19 · FY2005 · AI
Metabolic impact of FGF-21 in adipose tissue and liver of PLWH
$649,982Jordan E Lake · University Of Texas Hlth Sci Ctr Houston · R01 · FY2021 · DK
Pathophysiologic mechanisms leading to intrahepatic fat accumulation in obese youth
$649,955Nicola Santoro · University Of Kansas Medical Center · R01 · FY2023 · MD
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** IMPROVING FEED EFFICIENCY (FE) OF LIVESTOCK PRODUCTION IS ESSENTIAL TO SUSTAINABLY FEED THE GROWING WORLD POPULATION. FEEDING 9M US DAIRY COWS REQUIRES MILLIONS OF ACRES OF CROPS AND ACCOUNTS FOR HALF THE COST OF DAIRY PRODUCTION. OUR LONG-TERM GOAL IS TO UNDERSTAND METABOLIC EFFICIENCY SO THAT WE CAN IMPROVE FE IN DAIRY COWS AND THUS IMPROVE OUR ABILITY TO MORE SUSTAINABLY FEED PEOPLE. FE IN DAIRY CATTLE IS A FUNCTION OF MILK PRODUCTION RELATIVE TO BODY WEIGHT AND ENERGY REQUIRED FOR GROWTH AND MAINTENANCE.TO ACHIEVE THIS, WE WILL 1) DETERMINE IF HEPATIC AND MUSCULAR MITOCHONDRIAL EFFICIENCY AND PROTEIN TURNOVER DIFFERS BETWEEN HIGH AND LOW RFI COWS; 2) ELUCIDATE DIFFERENCES IN MAMMARY NUTRIENT EXTRACTION BETWEEN HIGH AND LOW RFI COWS; AND 3) DETERMINE IF BIOMARKERS OF WHOLE-BODY METABOLISM CAN BE USED TO IDENTIFY HIGH AND LOW RFI COWS ACROSS A BROAD POPULATION. WE WILL EXECUTE THESE OBJECTIVES IN CONJUNCTION WITH AN ONGOING FFAR GRANT (2019-2024), ENABLING US TOLEVERAGE THE PHENOTYPES NEEDED TO PROVIDE DIVERGENT POPULATIONS. THE PROPOSED PROJECT WILL FOCUS ON COLLECTION OF LIVER, MUSCLE, AND BLOOD SAMPLES FOR ANALYSES OF MITOCHONDRIAL OXIDATIVE EFFICIENCY, GENE EXPRESSION OF KEY METABOLIC PATHWAYS, UPTAKE OF ENERGY METABOLITES AND AMINO ACIDS BY MAMMARY GLAND, AND GENERATION OF MODELS TO PREDICT FE THAT CAN BE APPLIED TO POPULATIONS WHERE INDIVIDUAL FEED INTAKES CANNOT BE MEASURED.WITHIN THIS PROJECT, WE EXPECT TO IDENTIFY SOURCES OF VARIATION IN FEED EFFICIENCY BETWEEN INDIVIDUAL COWS THAT ARE FED AND MANAGED SIMILARLY. IDENTIFYING THE SOURCES OF VARIANCE WILL ALLOW FOR FURTHER IMPROVING SELECTION OF FEED EFFICIENT COWS AND TO UNDERSTAND HOW TO BETTER FEED AND MANAGE COWS TO IMPROVE FEED EFFICIENCY THROUGH LEVERAGING THESE DIFFERENCES IN NUTRIENT USE.FOCUS ON THE CONTRIBUTION OF NUTRIENT USE EFFICIENCY WILL SERVE TO FURTHER IMPROVE EFFICIENCY AND SUSTAINABILITY OF MILK PRODUCTION WHICH IS KEY TO ENSURING EFFICIENT PRODUCTION OF HIGH PROTEIN FOOD SOURCES, AND FOOD SECURITY, FOR THE GROWING WORLD POPULATION. THIS NEW KNOWLEDGE WILL INFORM GENETIC SELECTION FOR THE MOST FEED EFFICIENT COWS AND WILL ALLOW FOR NUTRITIONAND MANAGEMENT RECOMMENDATIONS TO CONTINUE OPTIMIZING ANIMAL EFFICIENCY. TOGETHER, THESE OUTCOMES WILL POSITIVELYIMPACTENVIRONMENTAL, SOCIAL, AND ECONOMICAL SUSTAINABILITY OF THE ANIMAL AGRICULTURE INDUSTRY.
$649,772University Of Wisconsin System · · FY2022 · National Institute of Food and Agriculture
Molecular basis of altered drug metabolism during pregnancy
$649,768Hyunyoung Jeong · University Of Illinois At Chicago · R01 · FY2017 · HD
Sleeping Beauty-Mediated Gene Therapy for Hemophilia
$649,762R Scott McIvor · Discovery Genomics, Inc. · R44 · FY2006 · HL
Alcohol, iNOS upregulation , leaky gut &liver disease
$649,619Rush University Medical Center · R01 · FY2004 · AA
Mechanisms of Alcoholic Liver Disease
$649,597Bin Gao · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2009 · AA
Antigenic structures of HCV envelope glycoproteins (Env)
$649,590Robyn L Stanfield · Scripps Research Institute, The · P01 · FY2025 · AI
HEPATITIS C IN NEW IDUS: IMPLICATIONS FOR HIV PREVENTION
$649,584New York Academy Of Medicine · R01 · FY2004 · DA
Integrative Polygenic Genetic Studies of Non-alcoholic Fatty Liver Disease
$649,576Elizabeth K Speliotes · University Of Michigan At Ann Arbor · R01 · FY2024 · DK
An HIV Viral Load Assay for the Point-Of-Care
$649,571Marta Fernandez-Suarez · Daktari Diagnostics, Inc. · R44 · FY2016 · AI