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1,049,261 grants matching “t cell”
THE STATED PROJECT OBJECTIVES WILL BE ACHIEVED BY THE ENGINEERING AND DEMONSTRATION OF A MECHANICALLY TOUGH, CHEMICALLY STABLE, HIGH-PERFORMANCE MEMBRANE UTILIZING NAFION™ PERFLUOROSULFONIC ACID (PFSA) POLYMER MANUFACTURED ON ASSETS ENABLING GIGAWATT SCALE AND PROVEN CONSISTENCY THROUGH REPEATABILITY TRIALS FOR THE COMPOSITE MEMBRANE AND ALL SUBCOMPONENTS. TO FACILITATE THE DEVELOPMENT CYCLE, LOAD- CYCLING SHORT STACK TESTING DATA WILL BE BUTTRESSED BY SPECIFIC MEA TESTING PROTOCOLS AIMED AT ACCELERATING AND UNDERSTANDING CHEMICAL AND MECHANICAL FAILURE. IN ADDITION, EX-SITU MECHANICAL PROTOCOLS SIMULATING FAILURE MODES WILL ELUCIDATE INTERACTIONS SUCH AS THOSE BETWEEN IONOMER AND OTHER MEMBRANE SUBCOMPONENTS (SUCH AS REINFORCEMENT) AS WELL AS COMPOSITE MEMBRANE AND OTHER MEA FEATURES (I.E., POROUS TRANSPORT LAYERS (PTLS)). MEMBRANES WILL BE MANUFACTURED WHERE DIRECT INNOVATION IN ESSENTIAL SUBCOMPONENTS AND MEMBRANE PROCESSING WILL BE PAIRED WITH PARTNERSHIPS WITH KEY SUPPLIERS (REINFORCEMENT, GAS RECOMBINATION CATALYST (GRC), RADICAL SCAVENGER) TO ITERATE UPON THE BEST COMPOSITE MEMBRANE COMBINATION. IN ADDITION, SINGLE-CELL MEA TESTING CAPABILITY AT ALL RELEVANT PARTNER FACILITIES WILL BE DEPLOYED TO SCREEN MATERIALS AND WILL CONTRIBUTE CHEMICAL DURABILITY TESTING/EVALUATION PROTOCOLS TO THE ACCELERATED STRESS TEST (AST) DEVELOPMENT. MECHANICAL PORTIONS OF THE AST WILL BE CONTRIBUTED THROUGH A CUSTOM-ENGINEERED PRESSURE AND TEMPERATURE CYCLING APPARATUS, WHICH WILL BE COMBINED WITH A CHEMICAL AST TO DELIVER A “COMBINED” PROTOCOL EERE_T_540.131 TEMPLATE VERSION 3/8/2022 WORKING DRAFT CONTAINS CONFIDENTIAL, PROPRIETARY, OR PRIVILEGED INFORMATION EXEMPT FROM PUBLIC DISCLOSURE. 2 ANALOGOUS IN PRINCIPLE TO THOSE USED IN PEM FUEL CELLS. ASTS WILL BE DEVELOPED IN SINGLE CELL TEST STANDS, INTENDED TO CORRELATE WITH OBSERVED STACK FAILURES. SHORT STACK MEA EVALUATION AT ALL STAGES OF THE PROJECT WILL ALSO BE A COMPONENT OF THE PROJECT, INCREASING IN COMPLEXITY (SCALE) AS THE MEMBRANES REACH SPECIFIED MATURITY THRESHOLDS. STACK TESTING WILL COMPRISE REPRESENTATIVE LOAD PROTOCOLS FOR WHAT IS EXPECTED IN APPLICATION, ALONG WITH ASTS APPLIED ONCE SINGLE CELL PROTOCOLS HAVE BEEN DEFINED AND PROVEN TO ACCELERATE REAL FAILURE MECHANISMS. A SEMI-EMPIRICAL MODELING CAPABILITY TO PROJECT MEMBRANE LIFETIME BASED ON LOAD-CYCLING AND ACCELERATED DATA WILL FLOW FROM THE AST DEVELOPED IN THE PROJECT. IN ADDITION TO ELECTROCHEMICAL TESTS, OBSERVED/HYPOTHESIZED FAILURE MODES WILL BE USED TO DEVELOP EX- SITU PROTOCOLS AIMED AT REPLICATING HOW MEMBRANES FAIL OPERANDO, ENABLING RAPID PROTOTYPING TO EXPEDITE SOLUTIONS. WORK WILL ALSO COMPRISE THE SIMULATION OF MEA INTEGRATION ISSUES KNOWN TO CAUSE MEMBRANE DEFORMATION/FAILURE. THESE PROTOCOLS WILL BE REVISED AS NEW MECHANICAL FAILURE DATA IS AVAILABLE.
$10,000,000The Chemours Co Fc Llc · · FY2025 · Department of Energy
Secure, Real-Time Decisions on Live Data
$9,999,999Ion Stoica · University Of California-Berkeley · · FY2018 · CSE
Large scale T-Cell Epitope Discovery
$9,999,958Oregon Health & Science University · N01 · FY2009 · AI
THE PROPOSED DESIGN AND DEMONSTRATION PROJECT WILL EXPLOIT THE ENGINEERING CAPABILITIES, TECHNICAL AND MARKET KNOWLEDGE OF THE TEAM TO ADVANCE THE HDR AND HYBRID-HDR SYSTEMS, DEVELOPED DURING THE U.S. DOE EERE HYSTEEL PROJECT (DE-EE0009249), FROM TECHNOLOGY READINESS LEVEL (TRL) 4 (I.E., COMPONENT AND/OR BREADBOARD VALIDATION IN A LABORATORY ENVIRONMENT) TO TRL 6 (SYSTEM/SUBSYSTEM MODEL OR PROTOTYPE DEMONSTRATION IN A RELEVANT ENVIRONMENT). THE GOAL IS TO INSTALL AND DEMONSTRATE THE OPERATION FOR AT LEAST 3600 HR OF A 250 KWELSOLID OXIDE ELECTROLYZER CELL (SOEC) SYSTEM ABLE TO PERFORM STEAM AND CO-ELECTROLYSIS OPERATION BY EXPLOITING THE THERMAL AND CHEMICAL INTEGRATION WITH THE TOP GAS STREAM OF AN EXISTING 1.6 MILLION TONS PER YEAR DIRECT REDUCTION OF IRON (DRI) FACILITY IN TOLEDO, OH. WE PLAN TO DEMONSTRATE THE PERFORMANCE METRICS THAT WE SUCCESSFULLY ACHIEVED IN THERMODYNAMIC ANALYSES AND IN SOEC CELL AND STACK MEASUREMENT CAMPAIGNS IN A RELEVANT ENVIRONMENT. MOREOVER, WE WILL TACKLE THE MAIN CHALLENGES THAT OUR CURRENT INDUSTRIAL ADVISORY BOARD CONSIDERS AS THE BIGGEST HURDLES FOR THE IMPLEMENTATION OF THIS TECHNOLOGY AT A COMMERCIAL SCALE, NAMELY THE HOT GAS CLEANUP SYSTEM, AND THE CONTROL OF THE SYNGAS PRODUCT QUALITY IN THE REDUCING GAS STREAM. THIS PROJECT AIMS AT ELIMINATING THE BIGGEST BARRIERS FOR THE SCALEUP OF SOEC STEAM AND CO-ELECTROLYSIS APPLIED TO DRI PLANTS.
$9,995,543University Of Wisconsin System · · FY2025 · Department of Energy
Long-read DNA sequencing of Alzheimers Disease and Related Dementias cases
$9,987,628Andrew Singleton · National Institute On Aging · ZIA · FY2022 · AG
Institutional Clinical and Translational Science Award
$9,985,391Garret A Fitzgerald · University Of Pennsylvania · UL1 · FY2016 · TR
Experimental and preclinical modeling of NUP98-rearranged acute leukemia
$9,965,625Charles G. Mullighan · St. Jude Children'S Research Hospital · U54 · FY2019 · CA
Core Research Computing Facility
$9,963,289Michael Purdy · Columbia Univ New York Morningside · G20 · FY2010 · RR
Institutional Clinical and Translational Science Award
$9,961,031Garret A Fitzgerald · University Of Pennsylvania · UL1 · FY2017 · TR
Center for Genomic Studies on Mental Disorders
$9,957,606Linda M Brzustowicz · Rutgers, The State Univ Of N.J. · U24 · FY2017 · MH
Individualizing Therapy for Kidney and Heart Transplant Recipients
$9,955,156Peter Scott Heeger · Icahn School Of Medicine At Mount Sinai · U01 · FY2010 · AI
Institutional Clinical and Translational Science Award
$9,954,946Garret A Fitzgerald · University Of Pennsylvania · UL1 · FY2019 · TR
Integrated Genomics of Mucosal Infections
$9,954,734Joseph Frank Petrosino · Baylor College Of Medicine · U19 · FY2024 · AI
Inner City Asthma consortium 3 (ICAC3)
$9,949,825William W. Busse · University Of Wisconsin-Madison · UM1 · FY2014 · AI
Institutional Clinical and Translational Science Award
$9,938,391Garret A Fitzgerald · University Of Pennsylvania · UL1 · FY2020 · TR
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START)
$9,914,336Diane V Havlir · University Of California, San Francisco · U01 · FY2016 · AI
Yale Clinical and Translational Science Award
$9,903,999Brian Richard Smith · Yale University · UL1 · FY2025 · TR
Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes
$9,903,769Alexander Pemov · Division Of Cancer Epidemiology And Genetics · ZIA · FY2017 · CA
Children's Oncology Group Statistics and Data Center
$9,902,912Todd A Alonzo · Public Health Institute · U10 · FY2020 · CA
Cure Sickle Cell
$9,872,158Mary M Horowitz · Medical College Of Wisconsin · OT3 · FY2020 · HL
Northeast Biodefense Center
$9,860,235W. Ian Lipkin · Wadsworth Center · U54 · FY2006 · AI
Cancer Center Support Grant
$9,841,966Sloan-Kettering Institute For Cancer Res · P30 · FY2004 · CA
An Intermediate-Size Expanded Access Protocol for Amyotrophic Lateral Sclerosis with Pridopidine
$9,831,153Sabrina Paganoni · Massachusetts General Hospital · U01 · FY2024 · NS
Institute of Translational Health Sciences
$9,821,490Mary L. Disis · University Of Washington · UL1 · FY2016 · TR
Institute of Translational Health Sciences
$9,820,822Mary L. Disis · University Of Washington · UL1 · FY2014 · TR