Sort
17,054 grants matching “genome editing”
Biological Validation
$439,774Cornelis Murre · Ludwig Institute For Cancer Res Ltd · U54 · FY2019 · DK
Rescuing axonal defects of human cortical neurons in hereditary spastic paraplegias
$439,725Xue-Jun Li · University Of Illinois At Chicago · R21 · FY2019 · NS
Molecular Mechanism of UV Protection in Cutaneous Melanoma
$439,675Chengyu Liang · Wistar Institute · R01 · FY2020 · ES
Development of Modular CRISPR Genome Editing Technologies and Tools
$439,437Channabasavaiah Gurumurthy · University Of Nebraska Medical Center · R35 · FY2022 · HG
Mechanisms of Delta-like 4 Endocytosis and Notch Activation During Blood Vessel Development
$439,024Erich J Kushner · University Of Denver (Colorado Seminary) · R15 · FY2021 · HL
Targeting TGFBeta-mediated IOP dysregulation in a large animal model of glaucoma
$439,016Gillian Jane McLellan · University Of Wisconsin-Madison · R21 · FY2025 · EY
Interaction between RNA interference and RNA editing pathways
$438,942Kazuko Nishikura · Wistar Institute · R01 · FY2010 · GM
Transcription Factor Genetics in Lupus
$438,893Leah Claire Kottyan · Cincinnati Childrens Hosp Med Ctr · R01 · FY2021 · AR
Neurodevelopmental Function of TBC1D7: A Core Component of the TSC Complex
$438,625Brendan D. Manning · Harvard School Of Public Health · R21 · FY2022 · NS
Identifying oligodendrocyte enhancers that govern the expression of Olig1/2
$438,625Yungki Park · State University Of New York At Buffalo · R21 · FY2019 · NS
Core F: Induced Pluripotent Stem Cell Core
$438,540Mathew Mark Blurton-Jones · University Of California-Irvine · P30 · FY2023 · AG
A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1
$438,480Kathrin M Bernt · Children'S Hosp Of Philadelphia · R01 · FY2025 · CA
NOTCH signaling on the underdeveloped cardiac vascularization of hypoplastic left heart syndrome in the hiPSC-derived vascularized cardiac organoids
$438,157Huaxiao Yang · University Of North Texas · R15 · FY2022 · HD
Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation
$438,027Laura D Attardi · Stanford University · P01 · FY2021 · CA
Engineering of PPR base editors to repair pathogenic SNPs at the level of RNA
$438,000Michael Lloyd Hayes · California State University Los Angeles · R15 · FY2021 · GM
Structural Basis of APOBEC Functions and HIV Restriction
$437,996Xiaojiang S Chen · University Of Southern California · R01 · FY2023 · AI
Generation and analysis of new mouse models to determine novel therapeutic targets for Down syndrome-associated cognitive deficits
$437,987Eugene Yu · Roswell Park Cancer Institute Corp · R01 · FY2023 · HD
OPPOSITION TO FOODS MADE FROM NEW TECHNOLOGY, ESPECIALLY GENETIC ENGINEERING, HAS BEEN INCREASING OVER TIME. RECENT ADVANCES IN GENOME-EDITING ARE WIDELY ACKNOWLEDGED TO HAVE TREMENDOUS POTENTIAL FOR BENEFICIAL RESULTS, BUT RESEARCH IS NEEDED TO UNDERSTAND THE ACCOMPANYING POTENTIAL SCIENTIFIC, ETHICAL, REGULATORY, AND SOCIAL CONSEQUENCES. SINCE GENOME EDITING IS A RELATIVELY NEW PHENOMENON, THERE IS AN OPPORTUNITY TO STUDY HOW SOCIAL INTERACTIONS AFFECT CONSUMER ACCEPTANCE OF IT. CONSUMERS OBTAIN INFORMATION ABOUT NEW TECHNOLOGY IN MANY WAYS, INCLUDING PERSONAL INTERACTIONS, SOCIAL MEDIA, AND TRADITIONAL MEDIA. THE PROPOSED PROJECT WILL EXAMINE HOW SOCIAL AND TRADITIONAL MEDIA, IN-PERSON INTERACTIONS WITH EXPERTS, AND WATCHING A VIDEO AFFECT CONSUMER ACCEPTANCE OF GENOME EDITING. WE CONSIDER THE CASE OF GENOME-EDITED HORNLESS LIVESTOCK THAT FOCUSES ON ANIMAL WELFARE. WE WILL USE TEXT-MINING ALGORITHMS ON MAJOR SOCIAL AND TRADITIONAL NEWS MEDIA WEBSITES TO UNDERSTAND THEIR IMPACT ON PUBLIC SENTIMENT ABOUT GENOME EDITING AND ANIMAL WELFARE. WE WILL HOST PUBLIC-ENGAGEMENT EVENTS AND INTERVIEWS IN CALIFORNIA AND IDAHO TO FACILITATE COMMUNICATION BETWEEN SCIENTISTS, PRODUCERS, AN ETHICIST, AND THE PUBLIC ABOUT THE USE OF GENOME EDITING FOR HORNLESS CATTLE. WE WILL TEST WHETHER THE INTERVENTION LEADS TO IMPROVED UNDERSTANDING OF HOW GENOME EDITING FOR ANIMAL WELFARE DECREASES THE POLARIZATION BY ADMINISTERING PRE- AND POST-EVENT SURVEYS. FINALLY, A ONE-MINUTE VIDEO WILL BE CREATED FOR YOUTUBE FROM FOOTAGE OF THE PUBLIC ENGAGEMENT EVENTS. SUBJECTS CAN WATCH THE VIDEO AND COMPLETE AN ONLINE SURVEY, AND THE RESULTS OF THE IN-PERSON AND ONLINE INTERVENTION CAN BE COMPARED.
$437,976Washington State University · · FY2020 · National Institute of Food and Agriculture
Engineering Efficient and Controllable Base Editors
$437,938Rahul Manu Kohli · University Of Pennsylvania · R01 · FY2023 · GM
Engineering Efficient and Controllable Base Editors
$437,938Rahul Manu Kohli · University Of Pennsylvania · R01 · FY2022 · GM
Engineering Efficient and Controllable Base Editors
$437,938Rahul Manu Kohli · University Of Pennsylvania · R01 · FY2024 · GM
Improvement of CRISPR-Cas9 specificity through allosteric modulation
$437,864Jin Liu · University Of North Texas Hlth Sci Ctr · R15 · FY2019 · HL
Project 3: Demethylation of HPV-associated head and neck cancer to trigger APOBEC synthetic lethality and enhance immune response
$437,838Karen S Anderson · Yale University · P50 · FY2021 · DE
Project 3: Demethylation of HPV-associated head and neck cancer to trigger APOBEC synthetic lethality and enhance immune response
$437,838Karen S Anderson · Yale University · P50 · FY2023 · DE
Project 1 - Genomics of Intermediate-Risk AML Progression and Relapse.
$437,796Timothy J Ley · Washington University · P01 · FY2021 · CA