Sort
1,049,261 grants matching “t cell”
IDeA Network for Biomedical Research Excellence
$2,995,404James L Kenyon · University Of Nevada Reno · P20 · FY2011 · RR
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** IT NOW APPEARS CERTAIN THAT SARS-COV-2 WILL PERSIST IN ANIMALS AS LONG AS IT IS PREVALENT IN HUMANS. THE IMPLICATIONS OF MULTIPLE MAMMAL SPECIES CONTRACTING SARS-COV-2 ARE UNCLEAR, BUT MOUNTING EVIDENCE SUGGESTS THAT SOME ANIMALS MAY EXPERIENCE FATAL DISEASE, AND THAT ANIMAL SPECIES WILL SERVE BOTH AS STABLE RESERVOIRS OF VIRAL VARIANTS THAT WERE PREVIOUSLY DOMINANT IN HUMANS, AND AS NEW RESERVOIRS FOR NEW VARIANTS. MANY OF THESE NEW RESERVOIRS ARE COMMON WILDLIFE SPECIES, SUCH AS WHITE-TAILED DEER, DEER MICE AND RED FOX, WHICH OCCUR IN RELATIVELY HIGH ABUNDANCES IN SOME SYSTEMS AND HIGHLIGHT PATHWAYS OF SECONDARY SPILLOVER TRANSMISSION TO HUMANS LIVING IN CLOSE PROXIMITY. TO UNDERSTAND THE FUTURE OF SARS-COV-2 IN MAMMAL COMMUNITIES, THIS PROJECT WILL ADVANCE OUR CURRENTLY LIMITED CAPACITY TO PREDICT ANIMAL HOST SPECIES, NOVEL ZOONOTIC VARIANTS, AND THE POTENTIAL INTERACTIONS AMONG MULTIPLE SPECIES THAT COMPRISE MAMMAL COMMUNITIES. TO ACHIEVE THIS, THIS PROJECT INTEGRATES LEADING EDGEADVANCES IN ARTIFICIAL INTELLIGENCE, VIROLOGY, AND ECOLOGICAL THEORY IN FOUR SPECIFIC AIMS: AIM 1 MAKES PREDICTIONS ABOUT FUTURE ZOONOTIC VARIANTS OF SARS-COV-2 AND THEIR EVOLUTIONARY TRAJECTORIES BY ADVANCING METHODS IN CONTROLLED GENERATIVE AI. AIM 2 PREDICTS WHICH PARTICULAR MAMMALIAN SPECIES ARE SUITABLE HOSTS FOR EXISTING AND FUTURE ZOONOTIC VARIANTS, EXTENDING PREDICTIONS EVEN TO SPECIES FOR WHICH HOST CELL RECEPTOR (ACE2) SEQUENCES ARE STILL UNKNOWN. AIM 3 CONDUCTS SAFE AND EFFICIENT EMPIRICAL VALIDATIONS OF PREDICTIONS MADE IN AIMS 1 AND 2 BY TESTING CELL ENTRY USING A PSEUDOTYPED VIRUS PLATFORM FOR A SUBSET OF ZOONOTIC VARIANTS AND ANIMAL CELL RECEPTORS. AIM 4 ADVANCES THEORY FOR DISEASE TRANSMISSION IN WILDLIFE COMMUNITIES BY BUILDING A FRAMEWORK THAT ACCOUNTS FOR SPECIES DISTRIBUTIONS, THEIR ECOLOGICAL INTERACTIONS (SUCH AS PREDATION AND COMPETITION), AND FINE-SCALE CONTACT PATTERNS THAT INFLUENCE TRANSMISSION AMONG INDIVIDUAL ANIMALS. TOGETHER THESE METHODS ENABLE SPATIALLY EXPLICIT PREDICTIONS ABOUT SARS-COV-2 DYNAMICS IN MAMMAL COMMUNITIES. THIS MODEL WILL BE APPLIED TO THE NORTHEASTERN FOREST COMMUNITY USING 30 YEARS OF DATA FOR MULTIPLE MAMMAL SPECIES AND ONGOING SARS-COV-2 SURVEILLANCE. COLLECTIVELY, THE TOOLS DEVELOPED IN THIS PROJECT WILL LEAD TO THE RAPID PREDICTION AND VALIDATION OF ANIMAL HOSTS FOR CURRENT AND FUTURE VARIANTS OF SARS-COV-2. GIVEN THE PERSISTENT AND GROWING RISK OF ZOONOTIC EMERGENCE FROM ANIMAL HOSTS, THE INNOVATIONS DEVELOPED IN THIS PROJECT WILL ADVANCE RISK ASSESSMENT CAPACITY FOR WILDLIFE, DOMESTIC ANIMALS, AND HUMANS BY HELPING TO PREDICT AND TARGET PARTICULAR VIRUSES, THEIR VARIANTS, AND THEIR MULTIPLE HOST SPECIES, WHILE ALSO INTEGRATING THE DYNAMIC ECOLOGICAL CONTEXT IN WHICH SPECIES INTERACTIONS AND TRANSMISSION CULMINATE TO INFORM ZOONOTIC RISK IN COMPLEX SYSTEMS.
$2,995,370University Of South Florida · · FY2023 · National Institute of Food and Agriculture
REDOX ROBUST SOLID OXIDE FUEL CELL (SOFC) STACKS FOR AFFORDABLE, RELIABLE, DISTRIBUTED GENERATION POWER SYSTEMS
$2,995,126Redox Power Systems Llc · · FY2017 · Department of Energy
Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment
$2,995,042Thomas Friedman · National Institute On Deafness And Other Communication Disorders · ZIA · FY2017 · DC
NRT-URoL: Synthesizing Biology Across Scales – A Convergent Synthetic Biology Training Program
$2,994,994Julius B Lucks · Northwestern University · · FY2020 · EDU
Immunobiology and Immune Therapy for Merkel Cell Carcinoma
$2,994,993Paul Nghiem · University Of Washington · P01 · FY2025 · CA
Idaho INBRE Program
$2,994,932Carolyn Hovde Bohach · University Of Idaho · P20 · FY2008 · RR
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
$2,994,848Stephen C Harrison · Boston Children'S Hospital · P01 · FY2023 · AI
Comparative Analysis Of Completely Sequenced Genomes
$2,994,840Eugene V Koonin · National Library Of Medicine · ZIA · FY2014 · LM
Children's Oncology Group Chair's Grant
$2,994,733Gregory H Reaman · National Childhood Cancer Foundation · U10 · FY2006 · CA
Microbiota and Allergic Asthma Precision Prevention (MAAP2)
$2,994,595Christine C Johnson · Henry Ford Health System · P01 · FY2022 · AI
FLOURESCENT PROBES & IMAGING FOR NETWORKS & PATHWAYS
$2,994,410Alan S Waggoner · Carnegie-Mellon University · U54 · FY2008 · RR
Basic Research Support for the CCR
$2,994,352Thomas A Misteli · Division Of Basic Sciences - Nci · ZIC · FY2023 · CA
Age-dependent activation of microglia inflammatory state and its epigenetic modulation
$2,994,272Anne Schaefer · Icahn School Of Medicine At Mount Sinai · RF1 · FY2020 · AG
Reverse Engineering the Brain Stem Circuits that Govern Exploratory Behavior
$2,994,145David Kleinfeld · University Of California, San Diego · U19 · FY2019 · NS
Assay Development and High Throughput Screening (ADHTS) Core
$2,993,464Jeffrey Dage · Indiana University Indianapolis · U54 · FY2025 · AG
NIH Hematology Oncology Fellowship Program
$2,993,446Marijo Bilusic · Division Of Basic Sciences - Nci · ZIE · FY2020 · CA
Safety and Efficacy of Allogeneic Cardiosphere-derived Stem Cells After MI
$2,993,268Rachel Ruckdeschel Smith · Capricor, Inc. · RC3 · FY2010 · HL
Virulence Factors and Cell Death
$2,993,066Robert Liddington · Sanford Burnham Prebys Medical Discovery Institute · P01 · FY2007 · AI
MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER
$2,992,802David Alan Feinberg · University Of California Berkeley · U01 · FY2020 · EB
NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - DNA METHYLATION
$2,992,624Carol Rhodes · University Of Washington · N02 · FY2023 · HL
HYPOTHALAMIC NEUROCIRCUIT REMODELING TO TREAT DIABETES
$2,992,500Zaman Mirzadeh · St. Joseph'S Hospital And Medical Center · DP2 · FY2020 · DK
Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)
$2,992,416Joel Moss · National Heart, Lung, And Blood Institute · ZIA · FY2020 · HL
NEW; TITLE: MODELING OF CELLULOSE, HEMICELLULOSE AND LIGIN-CARBOHYDRATE COMPLEX FORMATION AND REGULATION TO UNDERSTAND PLANT CELL WALL STRUCTURE; PI:
$2,992,050North Carolina State University · · FY2011 · Department of Energy
Yale Center for Mendelian Genomics
$2,991,825Richard P Lifton · Yale University · UM1 · FY2017 · HG