Sort
91,797 grants matching “obesity”
COLORADO CLINICAL NUTRITION RESEARCH UNIT
$940,001University Of Colorado Denver · P30 · FY2000 · DK
PHARMACOLOGICAL APPROACHES TO COMBAT THE GLOBAL EPIDEMIC OF OBESITY HAVE MET WITH LIMITED SUCCESS DESPITE INTENSIVE INVESTMENTS IN THEIR DEVELOPMENT. POLYPHENOLS ARE A DIVERSE CLASS OF PHYTOCHEMICALS, NATURALLY OCCUR IN PLANT FOODS THAT INTERACT WITH NUMEROUS PATHWAYS REGULATING CELLULAR METABOLISM. THIS PROJECT INTEGRATES RESEARCH AND EDUCATION TO ADDRESS OBESITY PREVENTION BY DEVELOPING NEW MECHANISTIC KNOWLEDGE ABOUT HOW DIETARY POLYPHENOLS INFLUENCE GROWTH AND METABOLISM OF ADIPOSE TISSUE IN WAYS THAT MAY HELP TO PREVENT OBESITY. WE WILL TEST THE HYPOTHESIS THAT INCREASING POLYPHENOL-RICH FOODS (PPF) INTAKE INCREASES CELLULAR ENERGY EXPENDITURE IN WAYS THAT ARE MEANINGFUL FOR THE PREVENTION OF OBESITY. THE RESEARCH COMPONENT WILL INITIALLY FOCUS ON CHARACTERIZING THE SYNERGISTIC EFFECTS OF PPF ON ADIPOGENESIS AND METABOLISM IN AN EXPERIMENTAL HUMAN OBESITY MODEL, EMPHASIZING THE UNDERLYING MOLECULAR MECHANISMS. CONCURRENTLY, WE WILL USE THE RESEARCH FRAMEWORK CONDUCTED HEREIN TO DEVELOP AN INNOVATIVE EDUCATIONAL CURRICULUM AIMED AT EQUIPPING STUDENTS WITH THE NECESSARY TRAINING AND SKILLS TO (1) IDENTIFY POLYPHENOL-RICH PLANT FOODS, (2) COMPARE THE RISK-BENEFIT PROFILES OF WHOLE FOODS VERSUS ISOLATED POLYPHENOLS, AND (3) CRITICALLY EVALUATE THE SCIENTIFIC EVIDENCE SUPPORTING THE ROLE OF POLYPHENOLS AND PPFS IN OBESITY AND RELATED COMORBIDITIES. WE ANTICIPATE THAT THE RESEARCH FINDINGS FROM THIS PROPOSAL WILL REDEFINE OBESITY TREATMENT STRATEGIES AND PROVIDE NOVEL INSIGHTS INTO DEVELOPING MORE EFFICIENT, AFFORDABLE, NATURAL, AND SUSTAINABLE APPROACHES WITH LONG-TERM CLINICAL SIGNIFICANCE. THE EDUCATIONAL COMPONENT, WILL PROVIDE STUDENTS WITH FUNDAMENTAL KNOWLEDGE OF EVIDENCE-BASED GUIDELINES, THE ROLE OF RESEARCH IN INFORMING THESE GUIDELINES, THE GUIDELINE DEVELOPMENT PROCESS, AND HOW TO LOCATE RELEVANT GUIDELINES.
$940,000University Of Tennessee · · FY2025 · National Institute of Food and Agriculture
COLORADO CLINICAL NUTRITION RESEARCH UNIT
$940,000University Of Colorado Denver · P30 · FY2004 · DK
The Human Pancreas Analysis Program for Type 2 Diabetes
$940,000Klaus H. Kaestner · University Of Pennsylvania · U01 · FY2020 · DK
COLORADO CLINICAL NUTRITION RESEARCH UNIT
$940,000University Of Colorado Denver · P30 · FY2003 · DK
COLORADO CLINICAL NUTRITION RESEARCH UNIT
$940,000University Of Colorado Denver · P30 · FY2001 · DK
Biosynthesis, Processing And Secretion Of Neuropeptides And Pituitary Hormones
$939,895Yoke P Loh · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2010 · HD
The yellow fever vaccine saga: Defining the viral and host determinants responsible for success versus failure
$939,659Charles M. Rice · Rockefeller University · R01 · FY2019 · AI
Genetics of Coronary Artery Disease in Alaska Natives
$939,586Barbara V Howard · Medstar Health Research Institute · U01 · FY2008 · HL
Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
$939,469Jane E Freedman · Univ Of Massachusetts Med Sch Worcester · UH3 · FY2016 · TR
Methodology development to map and quantify imaged molecules in brain tissue
$939,140Amina Woods · National Institute On Drug Abuse · ZIA · FY2018 · DA
Enzymes of O-GlcNAc cycling linked to type-2 diabetes and neurodegeneration
$939,098John A. Hanover · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Targeted disruption the enzymes of O-GlcNAc cycling: Animal models of Disease
$939,098John A. Hanover · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2013 · DK
Continued studies of environment impact on puberty
$938,988Frank M Biro · Cincinnati Childrens Hosp Med Ctr · U01 · FY2012 · ES
AWI-Gen Phase 2: Genomic and environmental risk factors for cardiometabolic disease in Africans
$938,911Michele Michele Ramsay · Wits Health Consortium (Pty), Ltd · U54 · FY2020 · HG
Health Outcomes of Weight loss: Look AHEAD -Action for Health in Diabetes
$938,757Robert W Jeffery · University Of Minnesota · U01 · FY2010 · DK
University of Guam/Cancer Research Center of Hawaii Partnership (2 of 2)
$938,735Robert A Underwood · University Of Guam · U54 · FY2013 · CA
Role of Skeletal Muscle SIRT1 in the Pathogenesis of Metabolic Disorders
$938,412Vittorio Sartorelli · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · Z01 · FY2008 · AR
MASSACHUSETTS NUTRITION, PHYSICAL ACTIVITY AND OBESITY (NPAO) PROGRAM
$938,007Cheryl Bartlett · Massachusetts State Dept Of Pub Health · U58 · FY2010 · DP
Light, metabolic syndrome and Alzheimer's disease: a non-pharmacological approach
$937,999Mariana Gross Figueiro · Icahn School Of Medicine At Mount Sinai · R01 · FY2021 · AG
Linking Primary Care, Communities and Families to Prevent Obesity Among Preschool
$937,800Simone A French · University Of Minnesota · U01 · FY2016 · HD
Web-based Physical Activity Intervention for Children with ALL
$937,623Kirsten Kimberlie Ness · St. Jude Children'S Research Hospital · R01 · FY2016 · CA
Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease
$937,400Jane E Freedman · Univ Of Massachusetts Med Sch Worcester · UH3 · FY2017 · TR
GENETIC DETERMINANTS OF THE LVH PHENOTYPE
$937,040Victor G. Davila-Roman · Washington University · R01 · FY2010 · HL
CNS-Met Administrative Core
$936,807Patrick G Sullivan · University Of Kentucky · P20 · FY2024 · GM