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38,696 grants matching “als”
Functional Segregation Within the Whisker-Barrel Neuraxis
$620,705Mark F Jacquin · Washington University · R01 · FY2016 · NS
DELINEATING THE EVOLUTION AND ECOLOGY OF CHEMORESISTANCE IN BREAST CANCER WITH SINGLE CELL GENOMICS
$620,575Nicholas Navin · University Of Tx Md Anderson Can Ctr · R01 · FY2021 · CA
DELINEATING THE EVOLUTION AND ECOLOGY OF CHEMORESISTANCE IN BREAST CANCER WITH SINGLE CELL GENOMICS
$620,575Nicholas Navin · University Of Tx Md Anderson Can Ctr · R01 · FY2020 · CA
Actin Filament Network Remodeling, Disassembly and Turnover
$620,474Bruce L Goode · Brandeis University · R01 · FY2014 · GM
Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid Follicles
$620,422Roger Keith Reeves · Beth Israel Deaconess Medical Center · R01 · FY2020 · AI
Nucleoside and Amino Acid Analogs as Probes of HIV Replication Complexes
$620,407Stuart F. J. Le Grice · Basic Sciences · Z01 · FY2007 · CA
Measuring Sleep Problems in Children with Autism Spectrum Disorder
$620,267Lawrence D. Scahill · Emory University · R01 · FY2021 · HD
Evaluating darobactins as antimicrobial agents
$620,176Kim Lewis · Northeastern University · R01 · FY2021 · AI
Fetal 3D Study
$620,141Katherine Grantz · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2025 · HD
SARM1 functional polymorphisms and their contribution to ALS risk
$620,137Adam Joseph Bloom · Washington University · R01 · FY2023 · NS
SARM1 functional polymorphisms and their contribution to ALS risk
$620,137Adam Joseph Bloom · Washington University · R01 · FY2022 · NS
Novel Therapeutics to Target Parasite Cytochrome bc1
$620,090Michael Kevin Riscoe · Oregon Health & Science University · R01 · FY2024 · AI
Novel Therapeutics to Target Parasite Cytochrome bc1
$620,090Michael Kevin Riscoe · Oregon Health & Science University · R01 · FY2023 · AI
Novel Therapeutics to Target Parasite Cytochrome bc1
$620,090Michael Kevin Riscoe · Oregon Health & Science University · R01 · FY2025 · AI
Angiotensin II Receptors And Signaling Mechanisms
$620,007Kevin J Catt · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · Z01 · FY2008 · HD
RE-THINKING DRUG TREATMENT APPROACHES IN ALS BY TARGETING ABC EFLUX TRANSPORTERS
$620,000Thomas Jefferson University · · FY2011 · Department of Defense
INTRODUCTION A PRIMARY REASON FOR THE STUDY OF THE NEAR-EARTH OBJECT (NEO) POPULATION IS TO DETERMINE THE POTENTIAL IMPACT HAZARD FOR INDIVIDUAL OBJECTS AS WELL AS THE POPULATION AS A WHOLE. SUCH ANALYSIS REQUIRES UNDERSTANDING PHYSICAL CHARACTERISTICS BEYOND SIZE AND RAW POPULATION NUMBERS. CHIEF AMONG THESE ARE ROTATION RATE AND SPIN AXIS ALIGNMENT THOUGH OTHERS CAN BE EASILY OBTAINED WITH EVEN MODEST TELESCOPES. RECENT EFFORTS CONCENTRATING ON THE DISCOVERY AND ORBITAL DETERMINATION OF VERY SMALL NEOS DIRECTLY ADDRESS STATED NEOO OBJECTIVES WHICH ALSO INCLUDE THE CHARACTERIZATION (ROTATION RATE TAXONOMY ETC.) OF A REPRESENTATIVE SAMPLE OF NEOS. WE TAKE THIS TO MEAN NOT JUST THE SMALLEST MEMBERS OF THE NEO POPULATION OR THOSE THAT MAKE VERY CLOSE EARTH-ENCOUNTERS WITHIN A FEW DECADES. THE BEST UNDERSTANDING OF NEOS REQUIRES GIVING CONTEXT TO INDIVIDUAL RESULTS BY DEVELOPING A LARGER POPULATION SAMPLE THAT INCLUDES LARGER NEOS THAT MAY OR MAY NOT BE SUITABLE FOR A MISSION. GOALS AND OBJECTIVES ASTEROID PHOTOMETRY OUR FIRST GOAL IS TO OBTAIN A LARGE NUMBER OF NEO LIGHTCURVES AND WHEN POSSIBLE H-G PARAMETERS COLOR INDICES AND SHAPE/SPIN AXIS MODELS TO HELP PAINT A BROADER PICTURE. FIRST PRIORITY WILL BE GIVEN TO OBJECTS OF HIGHEST INTEREST: POTENTIAL MISSION TARGETS OR IMPACTORS. WHILE WE ARE MINDFUL OF THEORETICAL INTERPRETATIONS OF OUR OBSERVATIONS OUR MAIN THRUST WILL BE OPEN AND IMMEDIATE ACCESS TO OUR RESULTS TO ALLOW OTHERS TO ENGAGE IN INTERPRETING THEM AS WELL. WE WILL PROVIDE THE RAW DATA AND INITIAL ANALYSIS E.G. ROTATION PERIODS AND ANALYSIS OF ROTATION RATE STATISTICS WHICH ARE REQUIRED FOR THOSE WORKING ON A FULL CHARACTERIZATION OF THE NEA POPULATION. WE WILL NOT WORK IN ISOLATION BUT WILL COORDINATE OUR EFFORTS WITH OTHER OBSERVERS IN PARTICULAR WITH THE RADAR TEAMS WORKING OUT OF ARECIBO AND GOLDSTONE. HAND-IN-HAND WITH THESE EFFORTS WILL BE CONTINUED MAINTENANCE OF THE ASTEROID LIGHTCURVE DATABASE (LCDB; WARNER ET AL.; 2009). THE LCDB IS ONE OF THE MORE WIDELY-USED DATABASES IN ASTEROID RESEARCH. AT ALMOST ANY ASTEROID-RELATED MEETING SEVERAL POSTERS OR PRESENTATIONS HAVE PLOTS BASED ON LCDB DATA OR USED THE DATA FOR ONGOING RESEARCH. WE WILL CONTINUE TO MAINTAIN DEVELOP AND ENHANCE THE ASTEROID LIGHTCURVE DATA EXCHANGE FORMAT (ALCDEF) DATABASE WHICH NOW HOLDS MORE THAN 2.8 MILLION RAW ASTEROID PHOTOMETRIC MEASUREMENTS. THESE DATA HAVE BEEN AND WILL CONTINUE TO BE ESSENTIAL TO THOSE WORKING ON ASTEROID SHAPE/SPIN AXIS MODELING. BOTH OF THESE DATABASES WILL BE MIGRATED TO THE NASA PDS ON A REGULAR BASIS. NEO POPULATION ANALYSIS CO-I ALAN HARRIS WILL CONTINUE HIS WORK ON THE NEA POPULATION IN TERMS OF SIZE DISTRIBUTION AND THE EFFECTIVENESS OF CURRENT AND SOONTO- BE LARGE SURVEY EFFORTS TO MEET THE NASA DISCOVERY REQUIREMENTS. RECENT WORK BY OTHERS INDICATES PREVIOUS ANALYSES MAY HAVE BEEN TAINTED BY INCORRECT SIZE ESTIMATES. CO-I HARRIS WILL EXPLORE THE EXTENT AND EFFECT OF THE CHANGES IN SIZE ESTIMATES AND PROVIDE ONE OR MORE UPDATES TO HIS PREVIOUS WORK ON THE NEA POPULATION SIZE DISTRIBUTION. METHODOLOGY FOR ASTEROID PHOTOMETRY WORK WE WILL EMPLOY A CADRE OF UP TO TEN TELESCOPES (0.3-0.7 M) AT OUR OBSERVATORY COMPLEX IN LANDERS CA WHICH AVERAGES 275-300 USABLE NIGHTS A YEAR. THE ROBOTIC OPERATIONS CAN BE CONDUCTED FROM ANYWHERE THERE IS INTERNET ACCESS. DATA MEASUREMENT AND ANALYSIS WILL BE DONE WITH READILY AVAILABLE COMMERCIAL SOFTWARE. WE WILL PUBLISH OUR ANALYSIS AND DATA QUARTERLY IF NOT MORE FREQUENTLY. THIS PIPELINE PRODUCED MORE THAN 500 NEA LIGHTCURVES OVER FOUR YEARS STARTING IN MID-2013. WE EXPECT TO MAINTAIN THAT PACE. PROGRAM RELEVANCE THE PROPOSED PHOTOMETRY AND CHARACTERIZATION OF NEO MEMBERS AS WELL AS ANALYSIS OF THE NEO POPULATION SIZE DISTRIBUTION ADDRESS SPECIFIC ELEMENTS OF THE NEOO PROGRAM. THIS MAKES OUR PROPOSAL BOTH COMPLIANT AND RELEVANT TO THE C.6 SSO/NEOO PROGRAM AND OBJECTIVES.
$620,000Moredata!, Inc. · · FY2020 · National Aeronautics and Space Administration
Development of an information-rich assay for C9ORF72 as a test for ALS and FTD
$619,938Eran Bram · Asuragen, Inc. · R44 · FY2016 · NS
Preclinical Testing of Targeted Therapies for Neurofibromas
$619,877David W. Clapp · Indiana University Indianapolis · U01 · FY2008 · NS
CAREER: The influence of cation substitution on the hydrous phases of the lower mantle
$619,867Elizabeth C Thompson · University Of The South · · FY2024 · GEO
Methods for generalized ontology terms enrichment analysis
$619,862Nigam H Shah · Stanford University · R01 · FY2015 · LM
Fluorescent Probes for Multiplexed Intracellular Imaging
$619,792Kevin Burgess · Texas A&M University · P20 · FY2007 · GM
Fostering Mothers Emotionally-Responsive Parenting
$619,715Nancy E Suchman · Yale University · R01 · FY2015 · DA
Molecular endocrinology and principles of diabetes therapeutics: application to ultra-stable insulin analogs
$619,708Michael Aaron Weiss · Indiana University Indianapolis · R01 · FY2022 · DK
Molecular endocrinology and principles of diabetes therapeutics: application to ultra-stable insulin analogs
$619,708Michael Aaron Weiss · Indiana University Indianapolis · R01 · FY2021 · DK