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1,049,261 grants matching “t cell”

Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders

$10,009,752

Linda M Brzustowicz · Rutgers, The State Univ Of N.J. · U24 · FY2020 · MH

Institutional Clinical and Translational Science Award

$10,004,097

Garret A Fitzgerald · University Of Pennsylvania · UL1 · FY2018 · TR

Addendum to HIV Active and Passive Clinical Material Manufacturing

$10,000,000

David Heimbrook · Leidos Biomedical Research, Inc. · N01 · FY2014 · CA

BioFoundry: Glycoscience Resources, Education, And Training (BioF:GREAT)

$10,000,000

Lance Wells · University Of Georgia Research Foundation Inc · · FY2024 · BIO

Open Programmable Mobile Internet 2020

$10,000,000

Nick W McKeown · Stanford University · · FY2008 · CSE

AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION. AS THE WORLD POPULATION INCREASES TO 10 BILLION BY 2050, TOTAL FOOD AND MEAT PRODUCTION MUST RISE BY 70 AND 100%, RESPECTIVELY, TO SATISFY GLOBAL DEMAND. THE US FOOD PRODUCTION SYSTEM FACES SEVERAL ISSUES IN MEETING THIS DEMAND DUE TO LIMITED AVAILABLE AGRICULTURAL WATER AND LAND AND INCREASED GREENHOUSE GAS EMISSIONS. INCREASING WATER SCARCITY IN MAJOR PRODUCTION REGIONS AND INCREASING VULNERABILITY TO DISRUPTIONS FROM NATURAL DISASTERS DUE TO CLIMATE CHANGE ARE JUST SOME OF THE GROWING ISSUES THAT PROMPT THE NEED FOR NEW TECHNOLOGIES IN MEAT PRODUCTION. ALSO, A CRITICAL CHALLENGE IN FOOD SUPPLY CHAINS IS FOOD LOSS ISSUES THAT PRESENT SIGNIFICANT SUSTAINABILITY AND SECURITY CHALLENGES, WITH 60 PERCENT OF MEAT BECOMING PROCESSING WASTE (1.4 BILLION TONS FOR LIVESTOCK; 800 MILLION TONS FOR SEAFOOD). NEW SOURCES OF SUSTAINABLE PROTEIN WOULD HELP ALLEVIATE THESE CONCERNS AND ARE THE FOCUS OF THE PRESENT PROPOSAL. CULTIVATED MEAT PRODUCTION IS EMERGING AS A FEASIBLE SOLUTION TO ADDRESS IMMEDIATE SOCIETAL PROBLEMS BY DEVELOPING NEW SUSTAINABLE AGRI-FOOD SYSTEMS TO FEED A RAPIDLY GROWING GLOBAL POPULATION. THIS INDUSTRY WILL PROVIDE NUTRITIOUS AND SAFE FOODS WHILE REDUCING ENVIRONMENTAL IMPACT AND RESOURCE USAGE (78-96% FEWER GREENHOUSE GAS EMISSIONS, 99% LESS LAND USE, AND 82-96% LESS WATER USE). THIS PROJECT AIMS TO INNOVATE THE FOOD SUPPLY CHAIN FROM CELL TO FORK AND ENHANCE FOOD SUSTAINABILITY, NUTRITION, AND FOOD SECURITY BY DEVELOPING A CELL-BASED MEAT PLATFORM BASED ON THE INTEGRATION OF PHYSICAL, BIOLOGICAL, AND SOCIAL SCIENCES. CULTIVATED-MEAT PRODUCTION IS EMERGING AS AN ALTERNATIVE SOURCE OF SUSTAINABLE PROTEIN TO HELP ADDRESS NUTRITION AND FOOD SAFETY FOR CONSUMER CHOICES. THE DEVELOPMENT OF CULTIVATED-MEAT FACES MANY OBSTACLES ON AN INDUSTRIAL SCALE: (A) QUESTIONS RELATED TO CONSUMER ACCEPTANCE, PERCEPTIONS AND EXPECTATIONS; (B) TECHNICAL SOUND LIFE CYCLE AND TECHNO-ECONOMIC ANALYSES; (C) LIMITED ACCESS TO LOW-COST MEDIA AND SUITABLE CELL LINES IMPACTING SCALABILITY; (B) LACK OF AVAILABLE SUSTAINABLE BIOMATERIALS TO ACHIEVE NUTRITIOUS, SAFE, AND ORGANOLEPTICALLY ACCURATE CULTIVATED-MEAT; (C) LACK OF SYSTEMATIC APPROACHES FOR TRAINING THE NEXT GENERATION OF PROFESSIONALS. OUR CENTRAL HYPOTHESIS IS THAT A SUSTAINABLE, COST-EFFECTIVE, AND SCALABLE CULTIVATED-MEAT PLATFORM WILL INCREASE FOOD AVAILABILITY OPTIONS FOR CONSUMERS, WHILE DECREASING ENVIRONMENTAL IMPACT. THIS PROPOSED WORK AIMS TO DEVELOP NEW ADOPTABLE TECHNO-ECONOMICALLY VIABLE CULTIVATED-MEAT SYSTEMS AND DEVELOP NEW EDUCATIONAL PLATFORMS FOR TRAINING FUTURE PROFESSIONALS THROUGH SPECIFIC AIMS: 1. EVALUATE CONSUMER ACCEPTANCE AND CONSUMER WILLINGNESS-TO-PAY FOR CULTIVATED MEATS, AS WELL AS FLAVOR PROFILES; 2. ANALYZE THE ENVIRONMENTAL PERFORMANCE OF CULTIVATED MEAT PRODUCTS IN THE US; 3. OUTREACH, EXTENSION, AND EDUCATING THE NEXT GENERATION OF PROFESSIONALS FOR WORKFORCE DEVELOPMENT; 4. DEVELOP A SUSTAINABLE PLURIPOTENT STEM-CELL LINE PLATFORM; 5. DEVELOP ECONOMICALLY VIABLE SERUM-FREE MEDIA; 6. DEVELOP SUSTAINABLE BIOMATERIALS SCAFFOLDS, AND TISSUE ENGINEERING STRATEGIES, TO SUPPORT MEAT QUALITY; 7. OPTIMIZE THE PROCESSES AND BIOMATERIALS INTEGRATION TO ENHANCE NUTRITIONAL VALUE, QUALITY, AND SAFETY.

$10,000,000

Trustees Of Tufts College · · FY2021 · National Institute of Food and Agriculture

NCI Cancer Genomics Commons

$10,000,000

David Heimbrook · Leidos Biomedical Research, Inc. · N01 · FY2014 · CA

NCI Cancer Genomics Commons

$10,000,000

David Heimbrook · Leidos Biomedical Research, Inc. · N01 · FY2013 · CA

THE STATED PROJECT OBJECTIVES WILL BE ACHIEVED BY THE ENGINEERING AND DEMONSTRATION OF A MECHANICALLY TOUGH, CHEMICALLY STABLE, HIGH-PERFORMANCE MEMBRANE UTILIZING NAFION™ PERFLUOROSULFONIC ACID (PFSA) POLYMER MANUFACTURED ON ASSETS ENABLING GIGAWATT SCALE AND PROVEN CONSISTENCY THROUGH REPEATABILITY TRIALS FOR THE COMPOSITE MEMBRANE AND ALL SUBCOMPONENTS. TO FACILITATE THE DEVELOPMENT CYCLE, LOAD- CYCLING SHORT STACK TESTING DATA WILL BE BUTTRESSED BY SPECIFIC MEA TESTING PROTOCOLS AIMED AT ACCELERATING AND UNDERSTANDING CHEMICAL AND MECHANICAL FAILURE. IN ADDITION, EX-SITU MECHANICAL PROTOCOLS SIMULATING FAILURE MODES WILL ELUCIDATE INTERACTIONS SUCH AS THOSE BETWEEN IONOMER AND OTHER MEMBRANE SUBCOMPONENTS (SUCH AS REINFORCEMENT) AS WELL AS COMPOSITE MEMBRANE AND OTHER MEA FEATURES (I.E., POROUS TRANSPORT LAYERS (PTLS)). MEMBRANES WILL BE MANUFACTURED WHERE DIRECT INNOVATION IN ESSENTIAL SUBCOMPONENTS AND MEMBRANE PROCESSING WILL BE PAIRED WITH PARTNERSHIPS WITH KEY SUPPLIERS (REINFORCEMENT, GAS RECOMBINATION CATALYST (GRC), RADICAL SCAVENGER) TO ITERATE UPON THE BEST COMPOSITE MEMBRANE COMBINATION. IN ADDITION, SINGLE-CELL MEA TESTING CAPABILITY AT ALL RELEVANT PARTNER FACILITIES WILL BE DEPLOYED TO SCREEN MATERIALS AND WILL CONTRIBUTE CHEMICAL DURABILITY TESTING/EVALUATION PROTOCOLS TO THE ACCELERATED STRESS TEST (AST) DEVELOPMENT. MECHANICAL PORTIONS OF THE AST WILL BE CONTRIBUTED THROUGH A CUSTOM-ENGINEERED PRESSURE AND TEMPERATURE CYCLING APPARATUS, WHICH WILL BE COMBINED WITH A CHEMICAL AST TO DELIVER A “COMBINED” PROTOCOL EERE_T_540.131 TEMPLATE VERSION 3/8/2022 WORKING DRAFT CONTAINS CONFIDENTIAL, PROPRIETARY, OR PRIVILEGED INFORMATION EXEMPT FROM PUBLIC DISCLOSURE. 2 ANALOGOUS IN PRINCIPLE TO THOSE USED IN PEM FUEL CELLS. ASTS WILL BE DEVELOPED IN SINGLE CELL TEST STANDS, INTENDED TO CORRELATE WITH OBSERVED STACK FAILURES. SHORT STACK MEA EVALUATION AT ALL STAGES OF THE PROJECT WILL ALSO BE A COMPONENT OF THE PROJECT, INCREASING IN COMPLEXITY (SCALE) AS THE MEMBRANES REACH SPECIFIED MATURITY THRESHOLDS. STACK TESTING WILL COMPRISE REPRESENTATIVE LOAD PROTOCOLS FOR WHAT IS EXPECTED IN APPLICATION, ALONG WITH ASTS APPLIED ONCE SINGLE CELL PROTOCOLS HAVE BEEN DEFINED AND PROVEN TO ACCELERATE REAL FAILURE MECHANISMS. A SEMI-EMPIRICAL MODELING CAPABILITY TO PROJECT MEMBRANE LIFETIME BASED ON LOAD-CYCLING AND ACCELERATED DATA WILL FLOW FROM THE AST DEVELOPED IN THE PROJECT. IN ADDITION TO ELECTROCHEMICAL TESTS, OBSERVED/HYPOTHESIZED FAILURE MODES WILL BE USED TO DEVELOP EX- SITU PROTOCOLS AIMED AT REPLICATING HOW MEMBRANES FAIL OPERANDO, ENABLING RAPID PROTOTYPING TO EXPEDITE SOLUTIONS. WORK WILL ALSO COMPRISE THE SIMULATION OF MEA INTEGRATION ISSUES KNOWN TO CAUSE MEMBRANE DEFORMATION/FAILURE. THESE PROTOCOLS WILL BE REVISED AS NEW MECHANICAL FAILURE DATA IS AVAILABLE.

$10,000,000

The Chemours Co Fc Llc · · FY2025 · Department of Energy

Center for Integrated Cellular Analysis

$10,000,000

Rahul Satija · New York Genome Center · RM1 · FY2025 · HG

Cancer Center Support Grant (Comprehensive)

Cancer Center Support Grant

Research Services Core (RSC)

Cancer Center Support Grant

Cancer Center Support Grant

Cancer Center Support Grant

Hormone-Related Cancers

Children's Oncology Group Statistics and Data Center

Cancer Center Support Grant (Comprehensive)

Targeting EWSR1-FLI1 through Functional, Structural and Chemical Approaches

CMPB Central Pathology Support

Cancer Center Support Grant

Inner City Asthma consortium 3 (ICAC3)

REGIONAL PRIMATE RESEARCH CENTER

Inter- and Intra-Species Comparative Sequencing

Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders

Institutional Clinical and Translational Science Award

Addendum to HIV Active and Passive Clinical Material Manufacturing

BioFoundry: Glycoscience Resources, Education, And Training (BioF:GREAT)

Open Programmable Mobile Internet 2020

NCI Cancer Genomics Commons

NCI Cancer Genomics Commons

Center for Integrated Cellular Analysis