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27,075 grants matching “cholesterol”
RAGE, DIAPH1 and IRF7 and Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Disease
$499,778Ann Marie Schmidt · New York University School Of Medicine · P01 · FY2024 · HL
Natural Language Processing to Study Epidemiology of Statin Side Effects
$499,697Alexander Turchin · Brigham And Women'S Hospital · RC1 · FY2010 · LM
Design and synthesis of bone-selective osteogenic oxysterol-bisphosphonate analogues
$499,690Frank Stappenbeck · Max Biopharma, Inc. · R44 · FY2017 · AG
HIV SYNDROME X &PROTEASE INHIBITORS: HUMAN STUDIES
$499,676Stanford University · R01 · FY2001 · HL
HIV SYNDROME X &PROTEASE INHIBITORS: HUMAN STUDIES
$499,676Stanford University · R01 · FY2003 · HL
HIV SYNDROME X &PROTEASE INHIBITORS: HUMAN STUDIES
$499,676Stanford University · R01 · FY2004 · HL
HIV SYNDROME X &PROTEASE INHIBITORS: HUMAN STUDIES
$499,676Stanford University · R01 · FY2002 · HL
HIV Host-Cell Interactions
$499,655Michael Emerman · Fred Hutchinson Cancer Research Center · R37 · FY2009 · AI
SKELETAL PROBLEMS, EXCESS FAT ACCUMULATION AND MUSCLE ABNORMALITIES ARE IMPORTANT ECONOMIC, HEALTH AND WELFARE ISSUES FOR THE POULTRY INDUSTRY. RAPID GROWTH IN BROILERS CAUSES BONE DISORDERS, MUSCLE DEGENERATION (MYOPATHY), AND FAT FORMATION IN ABDOMINAL, INTRAMUSCULAR AND BONE MARROW AREAS. THE CURRENT APPROACHES OF REDUCING SKELETAL, MUSCULAR, AND EXCESS FAT ISSUES ARE THROUGH NUTRITION STRATEGIES AND GENETIC SELECTION. WE IDENTIFIED CERTAIN OXIDIZED CHOLESTEROL METABOLITES SUCH AS 20S OXYSTEROL ARE POTENTIAL BIOACTIVE MOLECULES TO PROMOTE BONE AND MUSCLE GROWTH AND REDUCE FAT FORMATION. THUS, THE OVERALL HYPOTHESIS IS THAT 20S OXYSTEROL WILL ENHANCE BONE FORMATION AND MUSCLE DEVELOPMENT AND REDUCE FAT FORMATION BY REGULATING CELL DIFFERENTIATION. THERE ARE THREE SPECIFIC OBJECTIVES: 1) TO DETERMINE THE PRO-MYOGENIC MECHANISM OF 20S OXYSTEROL IN CHICKENS; 2) TO DETERMINE OPTIMAL DOSAGE AND TIMING OF 20S OXYSTEROL IN OVO INJECTION; AND 3) TO DETERMINE THE LONG-TERM EFFECTS OF 20S OXYSTEROL ON GROWTH PERFORMANCE, BONE/MUSCLE FORMATION, CARCASS YIELD, AND FEED EFFICIENCY. WE ANTICIPATE THAT 20S OXYSTEROL WILL STIMULATE BONE GROWTH AND MUSCLE DEVELOPMENT AND MINIMIZE FAT FORMATION, IMPROVING SKELETAL HEALTH, LEAN MEAT PRODUCTION AND FEED EFFICIENCY IN BROILERS. THE OUTCOMES OF THIS PROJECT WILL PROVIDE A NOVEL STRATEGY TO IMPROVE WELFARE CONDITIONS, MEAT-QUALITY, AND FEED NUTRIENT UTILIZATION, REDUCING PRODUCTION COST AND ECONOMIC LOSS, INCREASING PROFITS FOR THE POULTRY INDUSTRY, AND MAKING THE POULTRY INDUSTRY MORE SUSTAINABLE.
$499,626University Of Georgia Research Foundation, Inc. · · FY2017 · National Institute of Food and Agriculture
Brain DNA Therapeutics with Trojan Horse Liposomes
$499,613William M Pardridge · Lipogene Company, Inc. · R44 · FY2016 · NS
Mevalonate Pathway Regulation of Astrocyte ApoE
$499,516Heather Ferris · University Of Virginia · R01 · FY2023 · AG
Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic Women
$499,512Lisa Chasan-Taber · University Of Massachusetts Amherst · R01 · FY2014 · DK
Liquid biopsy of solitary pulmonary nodule with extracellular vesicles
$499,472Yuan Wan · State University Of Ny,Binghamton · R37 · FY2021 · CA
Fetal Determinants of Atherosclerosis
$499,334Wulf Palinski · University Of California, San Diego · R01 · FY2006 · HL
Aging and Leydig Cell Function
$499,309Barry R Zirkin · Johns Hopkins University · R01 · FY2019 · AG
ABCA1, ApoAI and Reverse Cholesterol Transport
$499,301Jonathan D Smith · Cleveland Clinic Lerner Com-Cwru · P01 · FY2014 · HL
Genetic modifiers of the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) response
$499,271Marilyn C Cornelis · Northwestern University At Chicago · R01 · FY2021 · AG
Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
$499,244Richard W Scott · Polymedix, Inc, · R44 · FY2011 · AI
Aging and Leydig Cell Function
$499,221Barry R Zirkin · Johns Hopkins University · R01 · FY2018 · AG
A randomized double-blind placebo controlled Phase 1 SAD study in male and female healthy volunteers to assess safety, pharmacokinetics, and transient biomarker changes by the ABCA1 agonist CS6253
$499,197Jan Johansson · Artery Therapeutics, Inc. · R44 · FY2021 · AG
Pathogenesis of Dyslipidemia and Atherosclerosis in the Diabetic State
$499,125Sudha B Biddinger · Boston Children'S Hospital · R01 · FY2014 · HL
Amyloid-β Disruption of Pericyte Control of Capillary Hemodynamics
$499,103Albert Louis Gonzales · University Of Nevada Reno · R01 · FY2025 · AG
Design and synthesis of bone-selective osteogenic oxysterol-bisphosphonate analogues
$498,960Frank Stappenbeck · Max Biopharma, Inc. · R44 · FY2016 · AG
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIV
$498,879Robert G Weiss · Johns Hopkins University · R01 · FY2017 · HL
A Safe and Tolerable Niacin Analog for Treatment of Nonalcoholic Steatohepatitis
$498,785Claude Benedict · Arisaph Pharmaceuticals, Inc. · R43 · FY2015 · DK