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38,696 grants matching “als”
Pediatric Percutaneous Cochlear Implantation Clinical Validation & Implementation
$626,692Robert F Labadie · Vanderbilt University · R01 · FY2011 · DC
Multifaceted role of MG53 in alleviating neuromuscular function decline in ALS
$626,652Jingsong Zhou · University Of Texas Arlington · R01 · FY2025 · NS
Adapting the SiSTA/SiHLE/WiLLOW Prevention Trilogy for Black Men
$626,603Carmela Gina Lomonaco · Sociometrics Corporation · R44 · FY2014 · MD
A neuroimaging study of twin pairs with autism
$626,552Antonio Youssef Hardan · Stanford University · R01 · FY2009 · MH
Validation of Novel Pathogenic Htt Post-Translational Modifications (PTMs)
$626,506Christopher A Ross · Johns Hopkins University · R01 · FY2016 · NS
Validation of Novel Pathogenic Htt Post-Translational Modifications (PTMs)
$626,506Christopher A Ross · Johns Hopkins University · R01 · FY2014 · NS
Validation of Novel Pathogenic Htt Post-Translational Modifications (PTMs)
$626,506Christopher A Ross · Johns Hopkins University · R01 · FY2015 · NS
Improving Recovery after Major Cancer Surgery using Patient-Reported Outcomes
$626,375Xin Shelley Wang · University Of Tx Md Anderson Can Ctr · R01 · FY2019 · CA
DNA Methylation at N6-Adenine in Placental Trophoblast Development
$626,368Zongliang Jiang · University Of Florida · R01 · FY2024 · HD
Medtable: An EMR Strategy to Promote Patient Medication Understanding and Use
$626,251Daniel G Morrow · University Of Illinois At Urbana-Champaign · R01 · FY2010 · NR
IT IS WIDELY ACCEPTED THAT NEAR-EARTH OBJECTS (NEOS) REPRESENT A GLOBAL HAZARD FOR HUMAN CIVILIZATION. AS OF THIS WRITING 16 158 NEOS HAVE BEEN DISCOVERED OF WHICH OVER 1 786 ARE CLASSIFIED AS POTENTIALLY HAZARDOUS ASTEROIDS (PHAS). WHILE WE HAVE A GOOD UNDERSTANDING OF THEIR NUMBERS SIZE DISTRIBUTION AND DYNAMICAL BEHAVIORS (E.G. BOTTKE 2002 MAINZER ET AL. 2011 COTTO-FIGUEROA ET AL. 2015 STATLER ET AL. 2013) OUR KNOWLEDGE OF THEIR BASIC MECHANICAL PROPERTIES IS POOR. THIS KNOWLEDGE BEGINS MOST EFFICIENTLY WITH A BETTER UNDERSTANDING OF THE FUNDAMENTAL MECHANICAL PROPERTIES OF THE METEORITES IN OUR COLLECTIONS. METEORITES WHICH DERIVE FROM NEOS PROVIDE A UNIQUE OPPORTUNITY TO STUDY THE FUNDAMENTAL PHYSICAL AND MECHANICAL PROPERTIES OF ASTEROIDAL MATERIALS. BUT TO DATE FEW DIRECT STUDIES OF PHYSICAL PROPERTIES HAVE BEEN CONDUCTED ON THESE MATERIALS IN CONTRAST TO EXTENSIVE CHEMICAL AND ISOTOPIC ANALYSES. ONLY A FEW MEASUREMENTS OF SOUND SPEED ELASTIC CONSTANTS AND DYNAMIC FRACTURE PROPERTIES HAVE BEEN OBTAINED (IBRAHIM&HILDEBRAND 2012 KIMBERLEY&RAMESH 2011 FLYNN&DURDA 2004) AND GENERALLY WITHOUT ATTENTION TO THE IMPORTANCE OF SCALE. IT IS IMPERATIVE TO UNDERSTAND THE PHYSICAL AND SCALE DEPENDENT PROPERTIES IN ORDER TO GAIN INSIGHT INTO FRACTURE AND IMPACT DYNAMICS. PREVIOUS RESULTS OF ASTEROID DISRUPTION STUDIES THAT ARE STILL WIDELY USED (BENZ&ASPHAUG 1999) INCLUDE THE EQUATION OF STATE FOR BASALT AND A SIMPLE GRADY-KIPP 1980 DYNAMIC FRACTURE MODEL DERIVED FROM IMPACT EXPERIMENTS. ALTHOUGH THAT MODEL IS RATE AND SCALE DEPENDENT THE PARAMETERS FOR EXTRAPOLATION TO LARGE SCALES ARE UNKNOWN FOR METEORITES. MEASURING THE STRENGTHS OF ASTEROIDAL MATERIALS AND UNDERSTANDING OF HOW IT WILL SCALE WITH SIZE IS IMPORTANT FOR DEVELOPING MITIGATION STRATEGIES FOR POTENTIAL EARTH IMPACTORS AND FOR UNDERSTANDING PROPERTIES OF IN SITU MATERIALS ON ASTEROIDS DURING HUMAN AND ROBOTIC EXPLORATION.
$626,249University Of Puerto Rico · · FY2020 · National Aeronautics and Space Administration
Marinobufagenin as a therapeutic target
$626,177Alexei Bagrov · National Institute On Aging · ZIA · FY2016 · AG
PET Imaging of neurochemical transmission in cocaine use disorders
$626,132Rajesh Narendran · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · DA
Integrative Risk Reduction and Treatment for Teen Substance Use Problems and PTSD
$626,124Carla Kmett Danielson · Medical University Of South Carolina · R01 · FY2012 · DA
Epidemiologic Study of the Late Reproductive Years
$626,036Ellen W Freeman · University Of Pennsylvania · R01 · FY2009 · AG
Epigenetic mechanisms in the medial habenula governing drug-seeking behavior
$625,964Marcelo Andres Wood · University Of California-Irvine · R01 · FY2023 · DA
Understanding Frontotemporal Dementia Using Drosophila and iPSC Models
$625,941Fen-Biao Gao · Univ Of Massachusetts Med Sch Worcester · R01 · FY2025 · NS
Nursing Home Culture Change: Evaluating Change in Practice and Quality Outcomes
$625,844Susan C Miller · Brown University · R01 · FY2015 · AG
A neuroimaging study of twin pairs with autism
$625,808Antonio Youssef Hardan · Stanford University · R01 · FY2011 · MH
Hyper-surveillance and suicides among Black youth in the U.S.
$625,807Parvati Singh · Ohio State University · R01 · FY2024 · MH
103P/HARTLEY 2 WAS STUDIED EXTENSIVELY IN 2010 BY THE EPOXI DISCOVERY MISSION (A'HEARN ET AL. 2011) AND ITS ASSOCIATED GROUND-BASED CAMPAIGN (MEECH ET AL. 2011). THE FLYBY REVEALED ONE OF THE MOST DETAILED VIEWS OF VOLATILE OUTGASSING EVER OBSERVED IN A COMET. EPOXI FOUND ABUNDANT MICRON-SIZED ICY GRAINS AS WELL AS LARGER CHUNKS RELEASED FROM A SMALL BILOBATE NUCLEUS. ALL PREVIOUS IN DEPTH ANALYSES OF EPOXI DATA HAVE FOCUSED ON THE MAJOR VOLATILES: H2O RELEASED IN THE GAS-PHASE FROM THE NUCLEUS AND THE ICY GRAINS IN THE COMA AND CO2 A PLAUSIBLE DRIVER OF THE PRIMARY NUCLEUS ACTIVITY. THIS PROJECT FILLS TWO MAJOR GAPS IN COMPREHENDING THE EPOXI DATA. WE PROPOSE THE FIRST IN DEPTH STUDY OF INTEGRATED INTENSITY AND SPECTRAL CONTENT OF THE ORGANIC EMISSION FEATURE PROMINENT IN EPOXI HRI-IR SPECTROSCOPIC DATA BETWEEN ~3-4 MICRONS. WE ALSO PROPOSE FULL EXAMINATION OF SPATIAL AND TEMPORAL RELATIONSHIPS BETWEEN VOLATILES IN THE COMA OF THIS HYPERACTIVE COMET IN PARTICULAR CO2 AND ORGANIC GASES. ORGANICS WERE NOT ADDRESSED IN PREVIOUS STUDIES AND UNDERSTANDING THEIR COMPOSITION VARIABILITY AND RELATION TO OTHER VOLATILES IS VITAL IN DETERMINING HOW VOLATILES ARE ASSOCIATED IN THE NUCLEUS. OUR GOALS CAN ONLY BE REALIZED UTILIZING COMPLEMENTARY (AND CONTEMPORANEOUS) EPOXI AND HIGH SPECTRAL RESOLUTION GROUND-BASED INFRARED (IR) SPECTRA. THIS PROJECT ADDRESSES VOLATILE ABUNDANCES AND SPATIAL RELATIONSHIPS IN THE COMA OF 103P/HARTLEY 2 IN A SYSTEMATIC INTEGRATED STUDY AT BOTH LOCAL AND GLOBAL SPATIAL SCALES. - A WEALTH OF IR SPECTRAL DATA ACQUIRED CONTEMPORANEOUSLY BY THE EPOXI HRI-IR AND KECK II NIRSPEC INSTRUMENTS ARE PUBLICLY AVAILABLE FOR DIRECT COMPARISON AND SYNERGY. - HIGH SPATIAL RESOLUTION NEAR-NUCLEUS EPOXI DATA CAPTURING ACTIVITY AND VOLATILE RELEASE FROM THE NUCLEUS WILL BE USED TO INVESTIGATE THE DISTRIBUTION OF VOLATILE ORGANICS IN THE INNERMOST COMA THE TEMPORAL VARIABILITY OF THE ORGANIC FEATURE SOURCES OF ORGANIC VOLATILE RELEASE AND THEIR CORRELATION (OR LACK THEREOF) WITH H2O AND CO2. - PREVIOUSLY ANALYZED AND WELL-UNDERSTOOD HIGH SPECTRAL RESOLUTION GROUND-BASED DATA FROM KECK ARE NEEDED TO (1) VALIDATE AND EXTEND FLUORESCENCE MODELS IN ORDER TO ESTABLISH LIMITATIONS IN INTERPRETING LOWER SPECTRAL RESOLUTION EPOXI DATA WITHIN THE INNER COMA AND (2) DETERMINE SPATIAL DISTRIBUTIONS OF GAS ROTATIONAL TEMPERATURE AND COLUMN ABUNDANCE OF VOLATILES IN THE GLOBAL COMA OF HARTLEY 2. THIS PROJECT WILL EXTEND THE SCIENTIFIC RETURN OF AND BROADEN PARTICIPATION IN THE EPOXI MISSION AND PLACE HARTLEY 2 EPOXI RESULTS INTO THE CONTEXT OF THE CONTEMPORANEOUS LARGER FIELD OF VIEW AND MUCH HIGHER SPECTRAL RESOLUTION DATA OBTAINED FROM EARTH UTILIZING THE TWO DATA SETS AS ORIGINALLY DESIGNED. OUR UNIQUELY QUALIFIED TEAM LEVERAGES EXTENSIVE EXPERTISE FROM COMET MISSIONS THE EPOXI HRI-IR ANALYSES OF H2O AND CO2 AND STATE-OF-THE-ART GROUND-BASED SPECTROSCOPY AND MODELING OF COMETS (FEAGA ET AL. 2012 2017; FOUGERE ET AL. 2013; DELLO RUSSO ET AL. 2011; BONEV ET AL. 2013; AND REFERENCES THEREIN).
$625,789University Of Maryland, College Park · · FY2020 · National Aeronautics and Space Administration
HIV prevention with adolescents: Neurocognitive deficits and treatment response
$625,749Angela D Bryan · University Of New Mexico · R01 · FY2009 · AA
Phylogenomic Studies on the Evolution of Morphological Complexity
$625,715Andreas Baxevanis · National Human Genome Research Institute · ZIA · FY2021 · HG
Determine the neurotoxicity of RNA metabolism dysfunction caused by cytoplasmic TDP-43 aggregates
$625,668Sarah H Shahmoradian · Ut Southwestern Medical Center · R01 · FY2025 · NS
A neuroimaging study of twin pairs with autism
$625,557Antonio Youssef Hardan · Stanford University · R01 · FY2012 · MH