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17,054 grants matching “genome editing”
Coordinate Gene Regulation in Animal Cells
$465,677John T Lis · Cornell University · R01 · FY2019 · GM
Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies
$465,630Suk See De Ravin · National Institute Of Allergy And Infectious Diseases · ZIA · FY2022 · AI
Functional Characterization of ABCA3 Genomic Variants
$465,602Jennifer Wambach · Washington University · R01 · FY2020 · HL
Targeting the EGFR-PI3K/mTOR Signaling Circuitry: A Network-Based Approach for Oral Cancer Precision Therapy
$465,473J. Silvio Gutkind · University Of California, San Diego · R01 · FY2019 · DE
Endocytic dynamics and surface emergent property of leukocyte Integrins
$465,366Min Wu · Yale University · R01 · FY2025 · GM
Endocytic dynamics and surface emergent property of leukocyte Integrins
$465,366Min Wu · Yale University · R01 · FY2024 · GM
Role of Bcl11b in CD4+ T cells and innate lymphoid cells
$465,213Dorina Avram · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2022 · AI
CAREER: High bandwidth nano-transistors to understand the kinetic basis for CRISPR/CAS enzymes to enhance their applications for diagnostics and therapeutics
$465,211Kiana Aran · Keck Graduate Institute · · FY2021 · ENG
Genetic control of genome maintenance in human aging and longevity
$465,159Yousin Suh · Albert Einstein College Of Medicine · P01 · FY2023 · AG
DNA methylation in orofacial clefting
$465,023Robert Lipinski · University Of Wisconsin-Madison · R01 · FY2024 · DE
A DATA-DRIVEN APPROACH TO CRISPR DESIGN FOR REDUCED OFF-TARGET ACTIVITY IN PLANT GENOME EDITING
$465,000Iowa State University Of Science And Technology · · FY2016 · National Institute of Food and Agriculture
A DATA-DRIVEN APPROACH TO CRISPR DESIGN FOR REDUCED OFF-TARGET ACTIVITY IN PLANT GENOME EDITING
$465,000Iowa State University Of Science And Technology · · FY2016 · National Institute of Food and Agriculture
AGRICULTURAL BIOLOGY IS AT THE CRUX OF OUR SUSTAINABILITY EFFORTS AS WE FACE THE DEMANDS FROM A GROWING POPULATION AND DUE TO CHANGING GLOBAL CLIMATE. IMPLEMENTING TOOLS TO TRANSFORM AGRICULTURAL PRACTICES ARE NEEDED TO KEEP PACE WITH GROWING GLOBAL FOOD AND ENERGY NEEDS. RECENT PROGRESS IN GENOME EDITING TOOLS HAVE REVOLUTIONIZED RESEARCHER ABILITIES TO GENETICALLY PROBE AND MODIFY LIVING SYSTEMS. HOWEVER, GENETIC ENGINEERING OF MATURE PLANTS AND THEIR PLASTIDS HAS REMAINED A CHALLENGE OWING TO THE NUMEROUS PHYSICAL BARRIERS NEEDING TO BE CROSSED FOR PLANT GENE EDITING. IN GENERAL, THE MOLECULAR AND CELLULAR BIOLOGY TOOLKIT FOR PLANTS IS QUITE OUTDATED: GENETIC MANIPULATION IN BACTERIAL, FUNGAL, AND MAMMALIAN SYSTEMS IS ROUTINE, WHILE TECHNOLOGIES TO GENETICALLY MANIPULATE PLANTS HAVE SELDOM BEEN UPDATED SINCE THE MID-1980S. AS A RESULT, DESPITE THE CENTRAL ROLE OF PLANTS IN GLOBAL SUSTAINABILITY, BIOENERGY, AND MEDICINE, OUR ABILITIES TO PROBE AND MANIPULATE PLANT GENES AND UNDERSTAND THE BIOSYNTHETIC PATHWAYS THAT GUIDE PLANT METABOLISM ARE STAGNANT. TO KEEP PACE WITH GROWING DEMANDS ON OUR FOOD SUPPLY AND ENERGY NEEDS, WE REQUIRE RAPID IMPROVEMENTS TO THE TOOLKIT FOR UNDERSTANDING AND CONTROLLING PLANTS AT THE MOLECULAR LEVEL.NANOMATERIALS HOLD GREAT PROMISE TO ADVANCE OUR KNOWLEDGE OF - AND TOOLSET FOR - GENE EDITING FOR PLANT SCIENCE. THIS STUDY WILL SYSTEMATICALLY CHARACTERIZE NANOMATERIAL TRANSPORT IN PLANTS, TO DEVELOP TOOLS FOR NANOPARTICLE-MEDIATED GENE EDITING OF PLANTS. THIS PROJECT IS A FIRST-OF-ITS-KIND, WHERE NANOMATERIAL-BIOMOLECULE CONJUGATES WILL BE SYSTEMATICALLY STUDIED FOR APPLICATIONS IN PLANT GENOME RESEARCH. FURTHERMORE, SUCCESS IN NANOPARTICLE-MEDIATE DELIVERY OF GENE EDITING TOOLS WILL PRODUCE A PLATFORM BY WHICH TO GENETICALLY MODIFY PLANTS WITHOUT DNA, WHICH COULD TRANSFORM OUR VIEW OF GENETICALLY MODIFIED FOODS. THE PRESENT STUDY IS FOUNDED AT THE INTERFACE OF NANOMATERIAL SCIENCE AND PLANT BIOTECHNOLOGY, WILL SYSTEMATICALLY UNRAVEL THE COMPLEXITY OF NANOMATERIAL INTERACTIONS AND TRANSPORT IN PLANTS FOR GENE EDITING.OUR GOALS ARE TO DEVELOP TOOLS TO ENABLE BROAD-SCALE PRODUCTION OF TRANSGENIC PLANTS, WHICH CAN MITIGATE THE INCREASINGLY URGENT NEED FOR SUSTAINABLE AND HIGH-YIELDING CROPS. THE STUDY OF NANOMATERIAL BIODISTRIBUTION IN PLANT SYSTEMS, AND LEVERAGING THEIR USE TO CREATE MATURE PLANT GENETIC TRANSFORMANTS WILL ENABLE A SYNTHETIC METHOD TO CREATE ROBUST CROPS TO MEET OUR GROWING FOOD AND ENERGY NEEDS.
$464,983Regents Of The University Of California, The · · FY2018 · National Institute of Food and Agriculture
Systematic identification of genetic modifiers of dysfunctional neuronal networks in Alzheimer's disease
$464,750Minghui Wang · Icahn School Of Medicine At Mount Sinai · R21 · FY2022 · AG
Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper Airway
$464,728Jayakar V Nayak · Stanford University · R01 · FY2025 · HL
Cytoskeletal Function in C. elegans Embryos
$464,648Bruce A. Bowerman · University Of Oregon · R35 · FY2019 · GM
Understanding the variability in nonsense-mediated RNA decay
$464,508Sujatha Jagannathan · University Of Colorado Denver · R35 · FY2020 · GM
Targeting CEBPA To Restore Epithelial-Mesenchymal Homeostasis In Lung Fibrosis
$464,336Qi Tan · Mayo Clinic Rochester · R01 · FY2022 · HL
NMR Studies of Retroviral Nucleic Acid Binding Proteins
$464,298Michael F. Summers · University Of Maryland Baltimore County · R01 · FY2014 · GM
Structure, function, and disease biology of MICU1/MICU2
$464,269Zenon Grabarek · Massachusetts General Hospital · R01 · FY2019 · AR
Structure, function, and disease biology of MICU1/MICU2
$464,269Zenon Grabarek · Massachusetts General Hospital · R01 · FY2020 · AR
Structure, function, and disease biology of MICU1/MICU2
$464,269Zenon Grabarek · Massachusetts General Hospital · R01 · FY2018 · AR
Unlocking the cidal activity of echinocandins against Aspergillus fumigatus
$464,216Jarrod R. Fortwendel · University Of Tennessee Health Sci Ctr · R01 · FY2022 · AI
Mdm2 Alternative Splicing in DNA Damage and Cancer
$464,185Dawn S Chandler · Ohio State University · R01 · FY2025 · CA
Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
$464,044Alice F Tarantal · University Of California At Davis · UH3 · FY2021 · EB