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1,049,261 grants matching “t cell”
Project 1
$3,071,128Steven C. Almo · Albert Einstein College Of Medicine · U54 · FY2012 · GM
Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and Primates
$3,071,086Timothy D Harris · Johns Hopkins University · U01 · FY2024 · NS
Genetic, Cellular and Molecular Mechanisms in Autoimmunity to Retina
$3,070,748Rachel R. Caspi · National Eye Institute · ZIA · FY2019 · EY
UCSD Alzheimer's Disease Research Centers P30
$3,070,424James B Brewer · University Of California, San Diego · P30 · FY2022 · AG
Agents of Bioterrorism: Pathogenesis and host defense
$3,070,354State University New York Stony Brook · P01 · FY2004 · AI
WE PROPOSE TO ADVANCE FROM TRL-4 TO TRL-6 AN INSTRUMENT TO IDENTIFY AND QUANTIFY IN SITU THE ABUNDANCE OF COMPOUNDS OF KEY CHEMICAL AND ASTROBIOLOGICAL SIGNIFICANCE IN PLANETARY GASSES AND LIQUIDS SUCH AS ICY MOON OCEAN WATER THE MELTWATER FROM PLANETARY ICES AND THE ORGANIC SEAS AND LAKES OF TITAN. THE OVERARCHING GOAL IS TO TAKE AN EXISTING COMMERCIAL LABORATORY MEASUREMENT SYSTEM (TRL 4) AND CARRY OUT THE NECESSARY TRADES DESIGN MODIFICATIONS MINIATURIZATION AND ENVIRONMENTAL TESTING REQUIRED TO DEMONSTRATE A PROTOTYPE INSTRUMENT THAT MAY BE CREDIBLY PROPOSED FOR FLIGHT. FOR THE PURPOSES OF THIS PROPOSAL THE PROTOTYPE INSTRUMENT IS DESIGNED AND CONSTRUCTED AROUND AN IMPLEMENTATION FOR A EUROPA LANDER. THE FULL INSTRUMENT CONCEPT CONSISTS OF A FRONT END SYSTEM THAT INGESTS SMALL AMOUNTS (MG) OF ICE MELTS THE SAMPLE IN A CONTROLLED MANNER AND ANALYZES THE RESULTING VAPOR WITH A NEW CLASS OF IR LASER SPECTROMETER. THE MAJOR ADVANTAGE TO THE PROPOSED SYSTEM COMPARED TO OTHER DIRECT MEASUREMENT TECHNIQUES (E.G. GCMS OR RAMAN) IS A LARGE SAVING IN RESOURCES WHILE SIMULTANEOUSLY PROVIDING RAPID (~ 1 MIN) AND UNAMBIGUOUS SPECTRAL IDENTIFICATION OF VOLATILIZED COMPOUNDS AND DISSOLVED GASES. IT ALSO HAS SIGNIFICANT ADVANTAGES OVER REFLECTANCE SPECTROSCOPY IN TERMS OF CAPABILITIES SIMPLICITY RESOURCE ALLOCATION AND SIGNAL-TO-NOISE. FOR EXTREMELY RESOURCE CONSTRAINED MISSIONS (E.G. THE EUROPA LANDER) SUCH LOWER RESOURCE AND HIGH CAPABILITY INSTRUMENTS MAY BE THE ONLY FEASIBLE PATH TO OBTAINING HIGH PRIORITY SCIENCE. THE WORK PLAN HAS THE FOLLOWING GOALS AND OBJECTIVES: GOAL 1: PRODUCE A MEDIUM FIDELITY TRL-5 BRASSBOARD AND DEMONSTRATE OVERALL PERFORMANCE IN A SIMULATED OPERATION ENVIRONMENT WITH REALISTIC SUPPORT ELEMENTS. OBJECTIVE 1A: FINALIZE SCREENING AND SELECTION OF LASERS ELECTRONICS OPTOMECHANICS AND DETECTORS USING COMPONENTS WITH PATH TO FLIGHT; CONDUCT RADIATION TESTING OF KEY COMPONENTS. OBJECTIVE 1B: CLOSE MINIATURIZATION REPACKAGING TRADES AND FINALIZE MECHANICAL AND ELECTRICAL DESIGN INTO A CONFIGURATION THAT IS CLOSE TO THE EXPECTED FORM FIT AND FUNCTION OF FLIGHT INSTRUMENT. OBJECTIVE 1C: FABRICATE ASSEMBLE INTEGRATE AND TEST OVERALL PERFORMANCE AND MEASUREMENT OF TRACE GAS SPECTRA UNDER SIMULATED OPERATIONAL CONDITIONS. GOAL 2: PRODUCE A HIGH FIDELITY SYSTEM TRL-6 PROTOTYPE THAT ADEQUATELY ADDRESSES ALL CRITICAL SCALING ISSUES AND IS OPERATED IN A RELEVANT ENVIRONMENT TO DEMONSTRATE OPERATIONS UNDER CRITICAL ENVIRONMENTAL CONDITIONS. OBJECTIVE 2A: COMPLETE DELTA-DESIGN TRADES BASED ON KNOWLEDGE GAINED FROM TRL-5 BRASSBOARD. OBJECTIVE 2B: ASSEMBLE INTEGRATE AND TEST LASER OPTOMECHANICAL ELECTRONICS AND OPTICAL CELL SUBSYSTEMS. OBJECTIVE 2C: TEST PROTOTYPE UNDER RELEVANT CONDITIONS AND VALIDATE AGAINST PERFORMANCE DESIGN AND SCIENCE-DRIVEN MEASUREMENT REQUIREMENTS. THE PROPOSED INSTRUMENT AND DEVELOPMENT WORK IS IN CONCERT WITH THE MATISSE SCOPE AND GOALS. THE TRL RANGE IS COMPLIANT AND THE RESULT WILL BE AN INSTRUMENT PROTOTYPE PROVIDING FORM FIT AND FUNCTION OF A FLIGHT SYSTEM THAT HAS BEEN TESTED IN THE RELEVANT ENVIRONMENT.
$3,070,258Southwest Research Institute · · FY2020 · National Aeronautics and Space Administration
Systemic Autoimmunity
$3,070,148Mariana Kaplan · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2023 · AR
Molecular Characterization of HIV-Associated Tumors by Sequencing
$3,070,000David Heimbrook · Leidos Biomedical Research, Inc. · N01 · FY2012 · CA
A Data Resource for Analyzing Blood and Marrow Transplants
$3,069,930Mary M Horowitz · Medical College Of Wisconsin · U24 · FY2010 · CA
Neurocircuitry of OCD: Effects of Modulation
$3,069,435Suzanne N Haber · University Of Rochester · P50 · FY2025 · MH
Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and Primates
$3,069,339Timothy D Harris · Johns Hopkins University · U01 · FY2020 · NS
NEW METHODS FOR CANCER DETECTION
$3,069,259Weill Medical College Of Cornell Univ · P01 · FY2005 · CA
Louisiana Biomedical Research Network (LBRN)
$3,068,781Thomas R. Klei · Louisiana State Univ A&M Col Baton Rouge · P20 · FY2011 · RR
SPORE IN LUNG CANCER
$3,068,533University Of Colorado Denver · P50 · FY2002 · CA
Procurement and Characterization of Postmortem Brain Tissue
$3,068,293Karen Faith Berman · National Institute Of Mental Health · ZIC · FY2013 · MH
Systems Biology of Morphogenesis and Spatial Information Flow
$3,067,892Arthur D Lander · University Of California-Irvine · P50 · FY2007 · GM
THERAPEUTIC INDEX OF ACUTE LYMPHOBLASTIC LEUKEMIA
$3,067,890Dana-Farber Cancer Institute · P01 · FY2002 · CA
Neurocircuitry of OCD: Effects of Modulation
$3,067,776Suzanne N Haber · University Of Rochester · P50 · FY2023 · MH
Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease
$3,067,743Melissa Erin Murray · Mayo Clinic Jacksonville · R01 · FY2022 · AG
Development of novel small molecules for delaying the progression of muscular dy
$3,067,726Hugh Lee Sweeney · University Of Pennsylvania · U54 · FY2010 · NS
Nonmyeloablative haploidentical peripheral blood stem cell transplantation in congenital anemias
$3,067,391Courtney Fitzhugh · National Heart, Lung, And Blood Institute · ZIA · FY2025 · HL
Alzheimer's Disease Research Center
$3,067,248John Morris · Washington University · P30 · FY2022 · AG
Adoptive cell therapy for malignant mesothelioma and other mesothelin expressing
$3,067,127Raffit Hassan · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Bronchiectasis and chronic airway infection
$3,066,862Kenneth Olivier · National Heart, Lung, And Blood Institute · ZIA · FY2021 · HL
B cell development
$3,066,667Rafael C Casellas · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2016 · AR