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17,828 grants matching “crispr”
Low-Cost CRISPR-on-Paper for Cervical Cancer Screening at the Point of Care
$473,761Changchun Liu · University Of Connecticut Sch Of Med/Dnt · U01 · FY2025 · CA
Ink4a/ARF/Ink4b locus in Neurofibromatosis Type 1
$473,531Rebecca D Dodd · University Of Iowa · R01 · FY2025 · NS
Project 2: Investigating cell intrinsic and extrinsic drivers of prostate cancer bone metastasis
$473,522Cory Abate-Shen · Columbia University Health Sciences · P01 · FY2023 · CA
Dynamic control of actin network architecture in early C. elegans embryos
$473,494Edwin Marshall Munro · University Of Chicago · R01 · FY2024 · GM
Dynamic control of actin network architecture in early C. elegans embryos
$473,494Edwin Marshall Munro · University Of Chicago · R01 · FY2023 · GM
Novel Genome Editing for the Treatment of Glaucoma
$473,396Val C Sheffield · University Of Iowa · R01 · FY2023 · EY
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
$473,363Jeffrey S. Morris · University Of Pennsylvania · R01 · FY2021 · CA
Dynamic control of actin network architecture in early C. elegans embryos
$473,354Edwin Marshall Munro · University Of Chicago · R01 · FY2021 · GM
Dynamic control of actin network architecture in early C. elegans embryos
$473,354Edwin Marshall Munro · University Of Chicago · R01 · FY2022 · GM
The SyngenicDNA and μPOET Platform: Overcoming Innate Barriers to Genetic Engineering in Bacteria.
$473,351Christopher D Johnston · Ada Forsyth Institute, Inc. · R01 · FY2018 · DE
PEANUT BREEDING HAS CONTRIBUTED GREATLY TO PRODUCTION, QUALITY AND NUTRITIONAL IMPROVEMENT THROUGH DYNAMIC AND CONTINUAL VARIETAL ENHANCEMENT, WHICH POSITIVELY IMPACTS THE PEANUT INDUSTRY. HOWEVER, CONVENTIONAL BREEDING IS A TIME-CONSUMING APPROACH, NORMALLY TAKING 10 - 12 YEARS TO PRODUCE NEW VARIETIES. IN ADDITION, TRADITIONAL BREEDING IS NOW CONSTRAINED BY A DECLINE IN EXISTING GENETIC VARIATION. GENE EDITING IS A METHOD USED TO MAKE ANY TARGETED GENETIC CHANGE TO A CHROMOSOME THAT PRODUCES A VIABLE ORGANISM. FOR THIS PROPOSAL WE WILL ASSESS THE SUITABILITY OF GENE-EDITING VIA CRISPR-BASED TRANSCRIPTION REGULATION AND CYTIDINE DEAMINASE-BASED C TO T MODIFICATION IN PEANUT. THE METHODOLOGY WE WILL USE IN THIS PROJECT IS SIMILAR WITH ELECTRICAL SWATCH TO BE ON OR OFF ON GENE EXPRESSION, RATHER THAN DIRECTLY KNOCKOUT THE GENES LIKE CUTOFF ELECTRICAL WIRE. THE RELIABLE PROTOCOLS WOULD BE USED ON OTHER GENES OF INTEREST.
$473,334Tuskegee University · · FY2018 · National Institute of Food and Agriculture
Developing a novel therapeutic strategy for overcoming TKI resistance in ALL
$473,211Shaoguang Li · Univ Of Massachusetts Med Sch Worcester · R01 · FY2019 · CA
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2024 · HG
Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types
$473,100Jesse M Engreitz · Stanford University · R35 · FY2022 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2022 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2025 · HG
Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types
$473,100Jesse M Engreitz · Stanford University · R35 · FY2023 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2020 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2021 · HG
Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types
$473,100Jesse M Engreitz · Stanford University · R35 · FY2020 · HG
Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types
$473,100Jesse M Engreitz · Stanford University · R35 · FY2021 · HG
Mechanistic Basis of Circadian Clocks in Bmal1 Knockout Mice
$473,094Akhilesh Basi Reddy · University Of Pennsylvania · R01 · FY2023 · GM
Mechanistic Basis of Circadian Clocks in Bmal1 Knockout Mice
$473,094Akhilesh Basi Reddy · University Of Pennsylvania · R01 · FY2024 · GM
Mechanistic Basis of Circadian Clocks in Bmal1 Knockout Mice
$473,094Akhilesh Basi Reddy · University Of Pennsylvania · R01 · FY2022 · GM
Mechanisms of Variant ER-alpha Function in Breast Cancer
$473,080Amy Fowler · University Of Wisconsin-Madison · R01 · FY2024 · CA