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17,828 grants matching “crispr”
Targeting of a Major Immune Evasion Pathway in Triple-negative Breast Cancer
$475,682Kai W Wucherpfennig · Dana-Farber Cancer Inst · R01 · FY2023 · CA
Probing the role of cysteine sulfenylation in cell signaling
$475,465Kate Suzanne Carroll · Scripps Florida · R01 · FY2018 · GM
Technical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ Level
$475,437Kevin Michael Dean · Ut Southwestern Medical Center · U54 · FY2022 · CA
Deciphering mechanisms of transcriptional repression which drive midline glioma
$475,431Richard E Phillips · University Of Pennsylvania · R01 · FY2024 · CA
Shared Resource: Genomics & Bioinformatics
$475,372Jeffrey Delrow · Fred Hutchinson Cancer Research Center · P30 · FY2020 · CA
Network-based prediction and validation of causal schizophrenia genes and variants
$475,347Manolis Kellis · Broad Institute, Inc. · R01 · FY2017 · MH
Targeting Signaling Vulnerabilities for Oral Cancer Prevention
$475,111J. Silvio Gutkind · University Of California, San Diego · R01 · FY2025 · DE
Targeting Signaling Vulnerabilities for Oral Cancer Prevention
$475,111J. Silvio Gutkind · University Of California, San Diego · R01 · FY2022 · DE
Targeting Signaling Vulnerabilities for Oral Cancer Prevention
$475,111J. Silvio Gutkind · University Of California, San Diego · R01 · FY2023 · DE
Deconstructing and targeting aneuploidy in human cancer - Resubmission - 1
$475,034Teresa Davoli · New York University School Of Medicine · R37 · FY2022 · CA
Organizational principles and functional role of 3D enhancer hubs in cell fate decisions
$474,743Effie Apostolou · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · GM
Function of asthma- and allergic disease-associated risk variants and genes in lung immune cells
$474,631Anne I. Sperling · University Of Chicago · U19 · FY2021 · AI
Molecular Imaging of Cardiac Pluripotent Stem Cells
$474,504Joseph C Wu · Stanford University · R01 · FY2019 · HL
Elucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neurons
$474,500Jennifer Elizabeth Phillips-Cremins · University Of Pennsylvania · R01 · FY2020 · NS
Mechanisms of Primary Cilium Assembly and Disassembly
$474,444David King Breslow · Yale University · R35 · FY2025 · GM
Understanding Richter's Transformation in the targeted therapies era
$474,404Rosa Lapalombella · Ohio State University · R01 · FY2021 · CA
Understanding Richter's Transformation in the targeted therapies era
$474,404Rosa Lapalombella · Ohio State University · R01 · FY2020 · CA
Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders
$474,300Andreas Robert Pfenning · Carnegie-Mellon University · DP1 · FY2018 · DA
Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders
$474,300Andreas Robert Pfenning · Carnegie-Mellon University · DP1 · FY2022 · DA
Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders
$474,300Andreas Robert Pfenning · Carnegie-Mellon University · DP1 · FY2021 · DA
Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders
$474,300Andreas Robert Pfenning · Carnegie-Mellon University · DP1 · FY2019 · DA
Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders
$474,300Andreas Robert Pfenning · Carnegie-Mellon University · DP1 · FY2020 · DA
Organizational principles and functional role of 3D enhancer hubs in cell fate decisions
$474,226Effie Apostolou · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · GM
Computational Methods for Identifying Non-coding Cancer Drivers
$473,876Ekta Khurana · Weill Medical Coll Of Cornell Univ · R01 · FY2021 · CA
NON-TECHNICAL SUMMARY:CEREAL CROPS PRODUCE GRAIN FOR OUR FOOD AND FEED, THEREFORE A BETTER UNDERSTANDING OF THE DEVELOPMENT OF THESE PLANTS CAN HELP TO IMPROVE CROP YIELDS. GLOBALLY, MAIZE IS OUR MOST CULTIVATED AND MOST PRODUCTIVE CEREAL CROP, AND PRIOR RESEARCH HAS FOUND THAT CHANGES IN GENES THAT MODULATE HOW THE PLANT DEVELOPS HAVE LED TO YIELD INCREASES. THIS PROJECT WILL STUDY HOW POOLS OF STEM CELLS CALLED MERISTEMS DIRECT HOW THE MAIZE PLANT GROWS AND DEVELOPS. THE MERISTEMS ARE MAINTAINED IN BALANCE BY A FEEDBACK CONTROL LOOP BETWEEN THE CLAVATA AND WUSCHEL GENES. THE PROJECT WILL USE GENETIC AND GENOMIC APPROACHES TO STUDY A NEWLY IDENTIFIED MERISTEM CONTROL GENE, FASCIATED EAR3 (FEA3), WHICH CODES FOR A CELL SURFACE RECEPTOR PROTEIN, AND OTHER CANDIDATE SIGNALING PROTEINS THAT WE IDENTIFIED BY THEIR INTERACTION WITH FEA3.EXPECTED OUTCOMES OF THIS PROJECT ARE A DEEPER UNDERSTANDING OF SIGNALING DURING MAIZE PLANT GROWTH, AND THE GENERATION OF NEW MAIZE VARIANTS THAT COULD IMPROVE INFLORESCENCE SIZE AND SEED PRODUCTIVITY, IMPORTANT TRAITS FOR FOOD, FEED AND BIOMASS PRODUCTION. THE OBJECTIVES TARGET THE PROGRAM AREA PRIORITY IN PHYSIOLOGY OF AGRICULTURAL PLANTS, IN DEVISING WAYS TO IMPROVE PRODUCTIVITY OF AGRICULTURALLY-IMPORTANT PLANTS, USING MOLECULAR, BIOCHEMICAL AND WHOLE-PLANT APPROACHES. IN PARTICULAR, THE GENES AND NETWORKS STUDIED IN THE PROJECT MAY BE APPLIED IN CONVENTIONAL BREEDING OR IN BIOTECHNOLOGY APPROACHES, FOR EXAMPLE USING CRISPR/ CAS9 GENOME EDITING, TO IMPROVE THE SUSTAINABILITY OF US AGRICULTURE BY IMPROVING CROP YIELDS.
$473,872Cold Spring Harbor Laboratory · · FY2020 · National Institute of Food and Agriculture