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17,054 grants matching “genome editing”
How RNA binding proteins control effector T cell responses
$474,189Anthony T. Vella · University Of Connecticut Sch Of Med/Dnt · R01 · FY2024 · CA
Unraveling the polymodal behavior of sensory transduction receptors
$474,157Paul A Garrity · Brandeis University · R01 · FY2016 · AI
Probing the link between sensory systems and metabolism to prevent obesity
$473,991Debra Ann Fadool · Florida State University · R01 · FY2023 · DK
Religion and support for genomic healthcare: An exploratory study of the US public and faith leaders.
$473,882James M Dubois · Washington University · R01 · FY2023 · HG
Computational Methods for Identifying Non-coding Cancer Drivers
$473,876Ekta Khurana · Weill Medical Coll Of Cornell Univ · R01 · FY2021 · CA
NON-TECHNICAL SUMMARY:CEREAL CROPS PRODUCE GRAIN FOR OUR FOOD AND FEED, THEREFORE A BETTER UNDERSTANDING OF THE DEVELOPMENT OF THESE PLANTS CAN HELP TO IMPROVE CROP YIELDS. GLOBALLY, MAIZE IS OUR MOST CULTIVATED AND MOST PRODUCTIVE CEREAL CROP, AND PRIOR RESEARCH HAS FOUND THAT CHANGES IN GENES THAT MODULATE HOW THE PLANT DEVELOPS HAVE LED TO YIELD INCREASES. THIS PROJECT WILL STUDY HOW POOLS OF STEM CELLS CALLED MERISTEMS DIRECT HOW THE MAIZE PLANT GROWS AND DEVELOPS. THE MERISTEMS ARE MAINTAINED IN BALANCE BY A FEEDBACK CONTROL LOOP BETWEEN THE CLAVATA AND WUSCHEL GENES. THE PROJECT WILL USE GENETIC AND GENOMIC APPROACHES TO STUDY A NEWLY IDENTIFIED MERISTEM CONTROL GENE, FASCIATED EAR3 (FEA3), WHICH CODES FOR A CELL SURFACE RECEPTOR PROTEIN, AND OTHER CANDIDATE SIGNALING PROTEINS THAT WE IDENTIFIED BY THEIR INTERACTION WITH FEA3.EXPECTED OUTCOMES OF THIS PROJECT ARE A DEEPER UNDERSTANDING OF SIGNALING DURING MAIZE PLANT GROWTH, AND THE GENERATION OF NEW MAIZE VARIANTS THAT COULD IMPROVE INFLORESCENCE SIZE AND SEED PRODUCTIVITY, IMPORTANT TRAITS FOR FOOD, FEED AND BIOMASS PRODUCTION. THE OBJECTIVES TARGET THE PROGRAM AREA PRIORITY IN PHYSIOLOGY OF AGRICULTURAL PLANTS, IN DEVISING WAYS TO IMPROVE PRODUCTIVITY OF AGRICULTURALLY-IMPORTANT PLANTS, USING MOLECULAR, BIOCHEMICAL AND WHOLE-PLANT APPROACHES. IN PARTICULAR, THE GENES AND NETWORKS STUDIED IN THE PROJECT MAY BE APPLIED IN CONVENTIONAL BREEDING OR IN BIOTECHNOLOGY APPROACHES, FOR EXAMPLE USING CRISPR/ CAS9 GENOME EDITING, TO IMPROVE THE SUSTAINABILITY OF US AGRICULTURE BY IMPROVING CROP YIELDS.
$473,872Cold Spring Harbor Laboratory · · FY2020 · National Institute of Food and Agriculture
Rodent Cancer Models Core
$473,674John N. Norton · Duke University · P30 · FY2021 · CA
Chromatin Dynamics During Epithelial Commitment
$473,546Anthony E Oro · Stanford University · R01 · FY2020 · AR
Ink4a/ARF/Ink4b locus in Neurofibromatosis Type 1
$473,531Rebecca D Dodd · University Of Iowa · R01 · FY2025 · NS
Epigenetic Editing of Mutant C9orf72
$473,444Edward Byung-Ha Lee · University Of Pennsylvania · R01 · FY2020 · NS
Epigenetic Editing of Mutant C9orf72
$473,444Edward Byung-Ha Lee · University Of Pennsylvania · R01 · FY2019 · NS
Novel Genome Editing for the Treatment of Glaucoma
$473,396Val C Sheffield · University Of Iowa · R01 · FY2023 · EY
Regulatory mechanisms for retinal ganglion cell genesis
$473,311Xiuqian Mu · State University Of New York At Buffalo · R01 · FY2023 · EY
COLLABORATIVE RESEARCH: The role of quality control in microbial translation
$473,211Beth Lazazzera · University Of California-Los Angeles · · FY2014 · BIO
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2024 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2025 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2020 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2021 · HG
Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9
$473,100Le Cong · Stanford University · R35 · FY2022 · HG
Mechanisms of Variant ER-alpha Function in Breast Cancer
$473,080Amy Fowler · University Of Wisconsin-Madison · R01 · FY2024 · CA
DNA methylation in orofacial clefting
$473,054Robert Lipinski · University Of Wisconsin-Madison · R01 · FY2023 · DE
Identifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancer
$473,044Thales Papagiannakopoulos · New York University School Of Medicine · R37 · FY2022 · CA
Identifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancer
$473,044Thales Papagiannakopoulos · New York University School Of Medicine · R37 · FY2021 · CA
Identifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancer
$473,044Thales Papagiannakopoulos · New York University School Of Medicine · R37 · FY2020 · CA
Project III
$472,999Kyle E Orwig · Magee-Women'S Res Inst And Foundation · P50 · FY2024 · HD