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17,054 grants matching “genome editing”
A Stem Cell Tactic to Promote Personalized Medicine
$475,862Naohiro Terada · University Of Florida · R24 · FY2016 · GM
Targeting RNA Splicing in Glioma
$475,851Shi-Yuan Cheng · Northwestern University At Chicago · R01 · FY2024 · NS
Phenotypic Assay Design and Development for Rare and Neglected Diseases
$475,656James Inglese · National Center For Advancing Translational Sciences · ZIA · FY2020 · TR
Project 2 - Investigation of human neuron models of channelopathy-associated epilepsy
$475,631Evangelos Kiskinis · Northwestern University At Chicago · U54 · FY2019 · NS
The IU/JAX Alzheimer's Disease Precision Models Center: Aging
$475,532Bruce T Lamb · Indiana University Indianapolis · U54 · FY2019 · AG
Network-based prediction and validation of causal schizophrenia genes and variants
$475,347Manolis Kellis · Broad Institute, Inc. · R01 · FY2017 · MH
Live Cell Isoform-specific Akt Analyses
$475,279Degeng Wang · Texas Tech University · R15 · FY2023 · GM
Genetically enhanced human erythrocytes generated from expandable stem cells
$475,220Linzhao Cheng · Johns Hopkins University · R01 · FY2018 · HL
Role of Bcl11b in CD4+ T cells and innate lymphoid cells
$475,151Dorina Avram · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2021 · AI
Multi-organism platform for functional analysis of Undiagnosed Diseases Network (UDN) variants
$475,000Lilianna Solnica-Krezel · Washington University · U54 · FY2020 · NS
Genetic analysis of a truncated insulin receptor.
$475,000Matthew Simon Gill · Scripps Florida · R01 · FY2019 · DK
Genetic analysis of a truncated insulin receptor.
$475,000Matthew Simon Gill · Scripps Florida · R01 · FY2020 · DK
Co-targeting the HER3 oncogenic signaling circuitry and PD-1 as a novel multimodal precision immunotherapy for HNSCC
$474,976J. Silvio Gutkind · University Of California, San Diego · R01 · FY2024 · CA
ENVIRONMENTAL STRESSES DEPRESS THE YIELDS OF MAJOR US CROPS BY AS MUCH AS 70%. DROUGHT IS ONE OF THE MOST SEVERE CLIMATE-RELATED RISKS FOR RICE PRODUCTION AND A FURTHER INCREASE IN RICE PRODUCTION MUST COME FROM HIGHLY VULNERABLE, LESS PRODUCTIVE DROUGHT-PRONE RAINFED LOWLAND AND UPLAND RICE AREAS. EVEN THOUGH RICE IS A PADDY CROP, IT IS SUSCEPTIBLE TO DROUGHT STRESS AND MANY IRRIGATED PADDY LANDS ARE NOW FREQUENTED BY TERMINAL DROUGHT. LIKEWISE, SOYBEAN PRODUCTION IS THREATENED BY DROUGHT, WHICH SEVERITY IS EVER MOUNTING DUE TO GLOBAL WARMING.CROPS SENSE AND RESPOND TO ENVIRONMENTAL STRESSES SUCH AS DROUGHT USING THEIR DELICATE CIRCUITS THAT ARE MORE COMPLICATED THAN THOSE USED IN CELL PHONES, AIRPLANES AND SATELLITES. A CIRCUIT IN PLANT CELLS CONSISTS MOLECULAR SWITCHES THAT ARE TURNED ON OR OFF BY A SET OF PROTEINS CALLED TRANSCRIPTION FACTORS, WHICH ARE ANALOGOUS TO FINGERS OPERATING SWITCHES. ANOTHER SET OF PROTEINS, ANALOGOUS TO A CHAIN OF COMMANDERS, INSTRUCT WHETHER A "FINGER"SHOULD TURN ON OR OFF A "SWITCH" UNDER SPECIFIC PHYSIOLOGICAL/DEVELOPMENTAL CONDITIONS. IN THE PREVIOUS PROJECT FUNDED BY NIFA USDA, WE DEMONSTRATED THAT A FAMILY OF THE MOLECULAR FINGERS, CALLED WRKY TRANSCRIPTION FACTORS ARE MAJOR PLAYERS IN CROPS' RESPONSES TO DROUGHT. IN 2008, WE SUGGESTED THAT SUCH MOLECULAR FINGERS "MAY PRESENT SOME OF THE BEST OPPORTUNITIES FOR INCREASING DROUGHT TOLERANCE." OUR PREVIOUS PROJECT AND OTHERS AROUND THE WORLD HAVE NOW ESTABLISHED THAT WRKY TFS ARE INDEED MAJOR PLAYERS IN DROUGHT RESPONSES. THERE IS NOW A PRESSING NEED TO PROGRESS WITH THESE GENES TOWARDS USING THEM TO IMPROVE DROUGHT TOLERANCE IN US CROP PLANTS. THAT IS THE GOAL OF THIS PROJECT.TO DO THIS, WE HAVE CHOSEN FOUR WRKY TRANSCRIPTION FACTORS (MOLECULAR FINGERS) FROM RICE AND SOYBEAN WHICH OUR DATA SUGGEST PLAY IMPORTANT ROLES IN REGULATING DROUGHT RESPONSES. WE WILL USE STATE-OF-THE-ART TECHNIQUES INCLUDING CHIP-SEQ, GENOME EDITING, PROTEIN-PROTEIN INTERACTION TECHNIQUES, PROMOTER ANALYSES, AND OVEREXPRESSION. THESE TECHNIQUES WILL ALLOW US TO DISSECT THE CIRCUITS AND PINPOINT THE KEY NODES IN THE CIRCUITS THAT INVOLVE THE MOLECULAR SWITCHES AND FINGERS IN CROPS' RESPONSES TO DROUGHT. OUR RESEARCH QUESTIONS/OBJECTIVES ARE: CAN WE IDENTIFY INTERACTING PROTEIN PARTNERS OF THE FINGER PROTEINS? CAN WE DETERMINE TARGETS OF THE FINGER PROTEINS? CAN WE USE THE FINGER PROTEINS TO OBTAIN IMPROVED DROUGHT PHENOTYPES? CAN WE USE THE FINGER PROTEINS TO OBTAIN AN INCREASE IN SOYBEAN AND RICE?US AGRICULTURE HAS A NEED TO IDENTIFY KEY MOLECULAR SWITCHES AND FINGERS THAT MIGHT BE USED FOR IMPROVING ENVIRONMENTAL STRESS RESPONSES IN CROP PLANTS. THIS PROJECT WILL FURTHER CHARACTERIZE SUCH TARGETS AND AT THE SAME TIME WILL FACILITATE DEVELOPMENT OF NEW STRATEGIES FOR IMPROVING ENVIRONMENTAL STRESS RESPONSES BASED ON A BETTER UNDERSTANDING OF THE MOLECULAR MECHANISMS OF THE FINGER PROTEINS OUTLINED IN THIS PROPOSAL. THIS PROJECT ADDRESSES THE PHYSIOLOGY OF AGRICULTURAL PLANTS PROGRAM AREA PRIORITY, "MECHANISMS OF PLANT RESPONSE TO ABIOTIC STRESSES."
$474,974Board Of Regents Of Nevada System Of Higher Education · · FY2018 · National Institute of Food and Agriculture
Biosynthesis and Synthetic Biology of Antibiotic Oligosaccharides
$474,924Brian O Bachmann · Vanderbilt University · R01 · FY2019 · AI
Protein Chemistry
$474,861Ronald T Raines · Massachusetts Institute Of Technology · R35 · FY2024 · GM
Protein Chemistry
$474,861Ronald T Raines · Massachusetts Institute Of Technology · R35 · FY2023 · GM
Defining Epidrivers of CLL Evolution in Response to Targeted Therapy
$474,745Dan Landau · Weill Medical Coll Of Cornell Univ · R01 · FY2019 · CA
Mitochondrial R-loop in sepsis-induced cardiomyopathy
$474,668Wei Huang · University Of Cincinnati · R01 · FY2025 · HL
Molecular Imaging of Cardiac Pluripotent Stem Cells
$474,504Joseph C Wu · Stanford University · R01 · FY2019 · HL
DNA methylation in orofacial clefting
$474,500Robert Lipinski · University Of Wisconsin-Madison · R01 · FY2025 · DE
Elucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neurons
$474,500Jennifer Elizabeth Phillips-Cremins · University Of Pennsylvania · R01 · FY2020 · NS
Functional Characterization of ABCA3 Genomic Variants
$474,436Jennifer Wambach · Washington University · R01 · FY2021 · HL
Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium
$474,290Jeremy F Reiter · University Of California, San Francisco · R01 · FY2023 · AR
Myosin Gene Diversity and Funciton
$474,202Leslie Anne Leinwand · University Of Colorado · R01 · FY2019 · GM