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38,696 grants matching “als”
The function and regulation of the novel pregnancy-specific hexokinase HKDC1
$642,521Brian Thomas Layden · Northwestern University At Chicago · R01 · FY2015 · DK
Fibromyalgia: Interventions for pain and mood regulation
$642,383Mary Colleen Davis · Arizona State University-Tempe Campus · R01 · FY2009 · AR
Enhancing Juvenile Drug Court Outcomes with EBPs
$642,285Scott W Henggeler · Medical University Of South Carolina · R01 · FY2009 · DA
SURPRISINGLY IN MORE THAN TWENTY PERCENT OF NEARBY ELLIPTICAL GALAXIES THE DISTRIBUTION OF STARS ORBITING THE CENTRAL SUPERMASSIVE BLACK HOLE IS STRONGLY ASYMMETRIC. IN THESE GALAXIES THE STARS ARE ON APSIDALLY-ALIGNED ORBITS IN AN ECCENTRIC NUCLEAR DISK. LONG THOUGHT TO BE EXOTIC THIS CONFIGURATION IS QUITE COMMON IN OUR LOCAL UNIVERSE. DESPITE THE PREVALENCE OF ECCENTRIC DISKS HOWEVER THEIR DYNAMICS HAVE BEEN LARGELY OVERLOOKED. NAIVELY ONE MIGHT EXPECT THAT PACKING ORBITS SO CLOSELY TOGETHER WOULD MAKE THEM VIOLENTLY UNSTABLE TO GRAVITATIONAL SCATTERING OR THAT DIFFERENTIAL PRECESSION WOULD WIPE OUT THEIR LARGE-SCALE APSIDAL-ALIGNMENT.WE HAVE RECENTLY IDENTIFIED A NEW DYNAMICAL MECHANISM WHICH STABILIZES ECCENTRIC NUCLEAR DISKS (MADIGAN ET AL. 2016) THUS EXPLAINING THEIR OBSERVED UBIQUITY. THE STABILIZING MECHANISM PRODUCES OSCILLATIONS OF ORBITAL ECCENTRICITIES OF STARS IN THE DISK PUSHING MANY STARS EXTREMELY CLOSE TO THE BLACK HOLE. IF THESE DISKS FORM IN GAS-RICH MERGERS AS IS FOUND IN COSMOLOGICAL SIMULATIONS THERE WILL BE AN ENHANCED RATE OF STELLAR TIDAL DISRUPTION EVENTS (TDES) FOLLOWING THE MERGER. IN A PRELIMINARY CALCULATION WE SHOW THE TDE RATE IS INITIALLY SO HIGH THAT THE NUCLEUS WOULD APPEAR AS AN AGN OR AS A CHANGING-LOOK-QUASAR. WE THEREFORE SUGGEST THAT ACCRETION OF DENSE STELLAR MATERIAL MAY CONTRIBUTE SIGNIFICANTLY TO THE GROWTH OF SUPERMASSIVE BLACK HOLES; IF SO THIS COULD EXPLAIN THE PRESENCE OF SUPERMASSIVE BLACK HOLES IN THE EXTREMELY EARLY UNIVERSE Z>7 AS WELL AS THE PEAKING OF QUASAR ACTIVITY AROUND Z~2 WHEN THE GALAXY MERGER RATE PEAKS. OUR MODEL CAN ALSO EXPLAIN THE RECENTLY OBSERVED PREFERENCE OF TDES IN POST-MERGER POST-STARBURST (K+A) GALAXIES. HERE WE PROPOSE TO QUANTIFY THESE CALCULATIONS. WE WILL ALSO UNDERTAKE A STATISTICAL ANALYSIS OF THE LITERATURE TO DETERMINE THE TRUE OCCURRENCE RATE OF ECCENTRIC NUCLEAR DISKS.LONG AFTER THE MERGER AND THE K+A PHASE ECCENTRIC DISKS NO LONGER DIRECTLY PRODUCE TDES. HOWEVER A STABLE ECCENTRIC DISK CREATES A NON-AXISYMMETRIC POTENTIAL WHICH IN MANY WAYS MIMICS THAT OF A BINARY SUPERMASSIVE BLACK HOLE SYSTEM. TORQUES FROM THE DISK POTENTIAL IN ANALOGY WITH THE ECCENTRIC KOZAI-LIDOV MECHANISM WILL PRODUCE HIGH ECCENTRICITY ORBITS IN THE OLDER BACKGROUND STELLAR POPULATION. THIS WILL RESULT IN HYPER-VELOCITY STARS AND BINARIES. WE WILL SHOW THAT THE LATTER CAN ACCOUNT FOR THE CURRENTLY UNEXPLAINED DISTRIBUTION OF UNUSUAL CA-RICH SUPERNOVAE OBSERVED OFFSET FROM THEIR HOST GALAXIES. SINCE AN ECCENTRIC DISK CAN LAST>GYR THIS MECHANISM ALSO SIGNIFICANTLY INCREASES PREDICTED EVENT RATES OF EXTREME-MASS RATIO INSPIRALS OF COMPACT STELLAR REMNANTS INTO SUPERMASSIVE BLACK HOLES A PRIME TARGET FOR GRAVITATIONAL WAVE OBSERVATORIES.
$642,220The Regents Of The University Of Colorado · · FY2017 · National Aeronautics and Space Administration
Enhancing Juvenile Drug Court Outcomes with EBPs
$642,213Scott W Henggeler · Medical University Of South Carolina · R01 · FY2008 · DA
Planned CORR: Planned Care for Obesity and Risk Reduction
$642,148Kevin Patrick · University Of California, San Diego · R01 · FY2012 · HL
A universal recipient for protein production in eggs
$642,129Origen Therapeutics · R44 · FY2003 · GM
Prefrontal Function in Adolescent Limited vs Life Course Persistent SUD
$641,859Michael Damingo De Bellis · Duke University · R01 · FY2008 · DA
Host Immune Responses to Antigens of Malaria Parasites
$641,821Carole Long · National Institute Of Allergy And Infectious Diseases · ZIA · FY2016 · AI
Computer-aided decision model for interpreting breast MR
$641,782Alan Penn And Associates, Inc. · R44 · FY2003 · CA
Multicenter ALS Cohort Study of Oxidative Stress and Disease Progression
$641,766Hiroshi None Mitsumoto · Columbia University Health Sciences · R01 · FY2012 · ES
Effectiveness Trial of Methods for Engaging Parents Into Parenting Interventions
$641,736Emily B. Winslow · Arizona State University-Tempe Campus · R01 · FY2016 · DA
FLARES ARE ONE OF THE MOST PROMINENT PHENOMENA ON THE SOLAR DISK AND HAVE BEEN OBSERVED AND STUDIED EXTENSIVELY SINCE THE FIRST REPORT IN 1859. IT IS WIDELY ACCEPTED THAT DURING FLARES ELECTRONS ARE ACCELERATED TO HIGH ENERGIES. AS THESE ELECTRONS PROPAGATE THEY HEAT THE SOLAR ATMOSPHERE THEREBY PRODUCING DRAMATIC INCREASES IN EMISSION THROUGHOUT THE ELECTROMAGNETIC SPECTRUM. HOWEVER THE ORIGINS OF FLARE EMISSIONS IN PARTICULAR IN UV VISIBLE AND NEAR INFRARED REMAIN PUZZLING. BY TAKING ADVANTAGE OF HIGH-RESOLUTION OBSERVATIONS OBTAINED BY THE INTERFACE REGION IMAGING SPECTROGRAPH (IRIS) AND THE GOODE SOLAR TELESCOPE (GST) AT BIG BEAR SOLAR OBSERVATORY (BBSO) THIS PROPOSAL PLANS TO STUDY THE RESPONSE OF THE LOWER SOLAR ATMOSPHERE TO THE ENERGETIC ELECTRONS AT THE INITIAL PRECIPITATING SITE BY MEANS OF HIGH-RESOLUTION OBSERVATIONS AND MODELING. RECENT JOINT IRIS-GST OBSERVATIONS DISCOVERED SPECIAL PROPERTIES ON NARROW FRONTS (100 150 KM) OF PROPAGATING FLARE RIBBONS. FOR INSTANCE ENHANCED ABSORPTION IN HE I 10830 AND HIGHLY BROADENED MG II LINES WERE FOUND IN AN M1.5 FLARE (XU ET AL. APJ 2016) AND A STRONG DOPPLER SIGNAL WAS IDENTIFIED IN AN M6.6 FLARE (JING ET AL. NATURE SCIENTIFIC REPORT 2017). THESE OBSERVATIONS SUGGEST THAT INTENSE PRECIPITATIONS OF ELECTRONS CONCENTRATE ON THE VERY NARROW (LESS THAN 1 ARCSEC) LEADING EDGE OF THE FLARE RIBBON CORRESPONDING TO THE NEWLY RECONNECTED MAGNETIC LOOPS. MOTIVATED BY THESE PRELIMINARY RESULTS WE PLAN TO FURTHER INVESTIGATE THE SPECTRAL/SPATIAL DISTRIBUTION OF FLARE EMISSION IN MORE DETAIL AND PERFORM MODELING USING THE RADYN (FOR H-ALPHA AND HELIUM LINES) AND RH (FOR MG II LINES) PACKAGES. THE RADYN MODEL SOLVES THE EQUATIONS OF RADIATION HYDRODYNAMICS WITH FLARE HEATING INPUT FROM NON-THERMAL ELECTRON DISTRIBUTIONS DERIVED FROM THE REUVEN RAMATY HIGH ENERGY SOLAR SPECTROSCOPIC IMAGER (RHESSI) HXR SPECTRA. THE RH CODE SOLVES A STATIC RADIATIVE TRANSFER EQUATION INCLUDING PARTIAL REDISTRIBUTION WHICH IS NEEDED TO MOST ACCURATELY MODEL THE MG II LINE. BOTH OF THESE CODES ARE WELL TESTED AND HAVE PROVEN TO BE ROBUST AND RELIABLE BASED ON MANY PREVIOUS STUDIES. WE WILL ANALYZE DATA OBTAINED BY NASA S RHESSI AND IRIS MISSIONS AND FROM BBSO/GST THAT CURRENTLY PROVIDES THE HIGHEST SPATIAL RESOLUTION (0.034 AND 0.085 ARCSECOND/PIXEL AT H-ALPHA AND HE I 10830 RESPECTIVELY). IN THIS PROPOSAL WE PLAN TO STUDY THE RESPONSES IN LOWER SOLAR ATMOSPHERE TO THE ENERGETIC ELECTRONS AROUND THE INITIAL PRECIPITATING SITE BY ANALYZING OBSERVATIONS AND CARRYING OUT NUMERICAL SIMULATIONS. SPECIFICALLY THE FOLLOWING SCIENTIFIC ISSUES ARE BEING ADDRESSED: 1. WHAT ARE THE UNIQUE SPECTRAL PROPERTIES THAT DISTINGUISH THE RIBBON FRONT AND THE TRAILING PARTS IN MG II H-ALPHA AND HE I 10830? 2. USING NEW CONSTRAINTS FROM HIGH RESOLUTION OBSERVATIONS CAN WE DETERMINE THE PHYSICAL CONDITIONS THAT DOMINATE THE SPECTRAL CHARACTERISTICS ON THE ELECTRON PRECIPITATION SITE SUCH AS DOPPLER SHIFTS IN UV AND H-ALPHA AND ENHANCED ABSORPTION IN 10830 BLUEWING FROM NUMERICAL MODELING? FLARES ARE IDEAL LABORATORIES FOR STUDYING THE FUNDAMENTAL PROCESSES OF ENERGY TRANSFER IN ASTROPHYSICAL PLASMAS. THIS RESEARCH PROPOSAL IS HIGHLY RELEVANT TO THE HIGH-LEVEL HELIOPHYSICS DECADAL SURVEY THAT IS TO DETERMINE THE ORIGINS OF THE SUN'S ACTIVITY AND PREDICT THE VARIATIONS IN THE SPACE ENVIRONMENT; AND DISCOVER AND CHARACTERIZE FUNDAMENTAL PROCESSES THAT OCCUR BOTH WITHIN THE HELIOSPHERE AND THROUGHOUT THE UNIVERSE.
$641,714New Jersey Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds
$641,638Mary Bushnell · National Center For Complementary & Integrative Health · ZIA · FY2018 · AT
Aging and rejuvenation: An ant model to study the regulation of longevity
$641,625Danny F Reinberg · New York University School Of Medicine · R01 · FY2021 · AG
Phase II trial of tesamorelin for cognition in aging HIV-infected persons
$641,612Ronald J. Ellis · University Of California, San Diego · R01 · FY2016 · AG
SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging
$641,593William J. Jagust · University Of California Berkeley · U24 · FY2021 · AG
Aging and rejuvenation: An ant model to study the regulation of longevity
$641,567Danny F Reinberg · New York University School Of Medicine · R01 · FY2020 · AG
Aging and rejuvenation: An ant model to study the regulation of longevity
$641,511Danny F Reinberg · New York University School Of Medicine · R01 · FY2019 · AG
Defining immune cell heterogeneity in human ALS and mouse model of the disease
$641,443Serge E Przedborski · Columbia University Health Sciences · R01 · FY2020 · NS
Protein Signatures of APOE2 and Cognitive Aging
$641,431Paola Sebastiani · Tufts Medical Center · R01 · FY2021 · AG
Psychobiology And Treatment Of Perimenopausal Mood Disorders
$641,402Peter Schmidt · National Institute Of Mental Health · ZIA · FY2013 · MH
LEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders Study
$641,397Brian Kane Lee · Drexel University · R01 · FY2024 · NS
Immunoengineering
$641,377Kaitlyn Sadtler · National Institute Of Biomedical Imaging And Bioengineering · ZIA · FY2022 · EB
Studies of Host Cellular Proteins Required for viral Budding and release
$641,279Fadila Bouamr · National Institute Of Allergy And Infectious Diseases · ZIA · FY2014 · AI