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17,828 grants matching “crispr”
Molecular Imaging of Cardiac Pluripotent Stem Cells
$479,441Joseph C Wu · Stanford University · R01 · FY2018 · HL
7/11 Biochemical and Genetic Determinants of Alcohol Consumption
$479,439Yuri A Blednov · University Of Texas At Austin · U01 · FY2022 · AA
Structure, function, and evolution of the Cryptococcus MAT locus
$479,352Joseph Heitman · Duke University · R01 · FY2024 · AI
Characterization of enzymes in the vitamin K cycle
$479,297Jianke Tie · Univ Of North Carolina Chapel Hill · R01 · FY2019 · HL
Characterization of enzymes in the vitamin K cycle
$479,297Jianke Tie · Univ Of North Carolina Chapel Hill · R01 · FY2016 · HL
Characterization of enzymes in the vitamin K cycle
$479,297Jianke Tie · Univ Of North Carolina Chapel Hill · R01 · FY2017 · HL
Characterization of enzymes in the vitamin K cycle
$479,297Jianke Tie · Univ Of North Carolina Chapel Hill · R01 · FY2018 · HL
To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models
$479,228Dingcheng Gao · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · CA
To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models
$479,228Dingcheng Gao · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · CA
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation
$479,215Adam Charles Siepel · Cold Spring Harbor Laboratory · R35 · FY2019 · GM
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation
$479,215Adam Charles Siepel · Cold Spring Harbor Laboratory · R35 · FY2020 · GM
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation
$479,215Adam Charles Siepel · Cold Spring Harbor Laboratory · R35 · FY2021 · GM
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation
$479,215Adam Charles Siepel · Cold Spring Harbor Laboratory · R35 · FY2018 · GM
Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation
$479,215Adam Charles Siepel · Cold Spring Harbor Laboratory · R35 · FY2022 · GM
Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations
$479,150Paul Geeleher · St. Jude Children'S Research Hospital · R01 · FY2025 · CA
Genetics and Pathobiology of Disorders of Keratinization
$478,911Keith A Choate · Yale University · R01 · FY2017 · AR
Mechanistic studies of RNA-targeting CRISPR systems
$478,697Patrick Hsu · University Of California Berkeley · R01 · FY2020 · GM
Targeting RNA Polymerase I Transcription Machinery in Chemoresistant Ovarian Cancer
$478,672Charles Nicholson Landen · University Of Virginia · R01 · FY2024 · CA
Exploring microRNA degradation in T-cell acute lymphoblastic leukemia
$478,652Mingyi Xie · University Of Florida · R01 · FY2024 · CA
Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs
$478,589April D Pyle · University Of California Los Angeles · R01 · FY2021 · AR
Defining gene-by-environment interactions using multiplex single-cell genomics
$478,553Jose Luis McFaline-Figueroa · Columbia Univ New York Morningside · R35 · FY2021 · HG
Defining and targeting epigenetic plasticity-driven drug resistance and immune escape in melanoma
$478,486Keiran Smalley · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2023 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A GALL IS A TUMOR-LIKE GROWTH ON A PLANT THAT IS INDUCED BY ANOTHER ORGANISM (I.E., BACTERIA, FUNGI, NEMATODE, OR INSECTS). INSECT-INDUCED PLANT GALLS REPRESENT ONE OF THE MOST AMAZING AND COMPLEX INTERSPECIFIC INTERACTIONS IN NATURE, CAPTURING THE INTEREST OF NATURALISTS, ECOLOGISTS AND EVOLUTIONARY BIOLOGISTS FOR CENTURIES. INCREASINGLY, GALL-FORMING INSECTS ALSO ACT AS ECONOMICALLY IMPORTANT AGRICULTURAL PESTS, REDUCING CROP YIELDS WORLDWIDE. SURPRISINGLY, THE GENERAL MECHANISMS BEHIND INSECT GALL INDUCTION AND GROWTH ARE UNKNOWN. THIS PROPOSAL AIMS TO UNCOVER THE EVOLUTIONARILY CONSERVED MOLECULAR MECHANISMS OF GALL FORMATION BY HARNESSING THE GALLING SYSTEM OF CYNIPID WASPS ON LIVE OAKS, IN WHICH MANY SPECIES OF CYNIPIDS SUCCESSFULLY GALL THE SAME PLANT. THIS SYSTEM ALLOWS FOR POWERFUL NATURAL EXPERIMENTS TO TEST THE GENERALITY OF HOW GALLING ORGANISMS MANIPULATE PLANT GENOMES AND TO GENERATE NEW HYPOTHESES FOR INVESTIGATING PLANT CONTROL STRATEGIES AGAINST GALLING HERBIVORES ANDOTHER PESTS THAT MANIPULATE HOST PLANT DEFENSE AND IMMUNITY. ADDITIONALLY, GALLING RESEARCH HAS GREAT POTENTIAL FOR THE ADVANCEMENT OF GENETIC ENGINEERING BECAUSE GALL-FORMATION INVOLVES THE SIMULTANEOUS MANIPULATION OF THOUSANDS OF GENES IN THE PLANT - NOT POSSIBLE WITH CURRENT TECHNOLOGIES (E.G., RNAI, CRISPR). DURING THE COURSE OF THIS RESEARCH THE PI WILL; RECRUIT SUMMER UNDERGRADUATE RESEARCHERS AT UNIVERSITY OF NEW MEXICO, A FEDERALLY RECOGNIZED MINORITY-SERVING INSTITUTION; AS WELL AS ACTIVELY PARTICIPATE IN PUBLIC ENGAGEMENT OF SCIENTIFIC RESEARCH IN MULTIPLE INSTITUTIONS IN ALBUQUERQUE.
$478,413University Of New Mexico · · FY2023 · National Institute of Food and Agriculture
ERa is a novel RNA-binding protein controlling breast cancer
$478,371Davide Ruggero · University Of California, San Francisco · R01 · FY2022 · CA
Manifold representations and active learning for 21 st century biology
$478,341Bonnie Berger · Massachusetts Institute Of Technology · R35 · FY2021 · GM