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38,696 grants matching “als”
CRISPR-CAS9 GENE THERAPY FOR ALS ENHANCED BY TJ-TARGETED BARRIER MODULATION
$644,352University Of Texas At Dallas · · FY2021 · Defense Health Agency
Cardioprotective Effect of Growth Hormone Releasing Hormone
$644,337Joshua M Hare · University Of Miami School Of Medicine · R01 · FY2011 · HL
Role of preexisting immunity on airborne transmission of influenza viruses
$644,203Seema S. Lakdawala · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · AI
Mechanisms of pathology and neuronal hyperactivity in a memory circuit in Alzheimer's disease
$644,186Edward S. Boyden · Massachusetts Institute Of Technology · R01 · FY2023 · AG
Mechanisms of pathology and neuronal hyperactivity in a memory circuit in Alzheimer's disease
$644,186Edward S. Boyden · Massachusetts Institute Of Technology · R01 · FY2024 · AG
Mechanisms of pathology and neuronal hyperactivity in a memory circuit in Alzheimer's disease
$644,186Edward S. Boyden · Massachusetts Institute Of Technology · R01 · FY2022 · AG
Investigation of an RNA topoisomerase complex involved in Fragile X syndrome
$643,964Weidong Wang · National Institute On Aging · ZIA · FY2015 · AG
BRIEF SUBSTANCE USE INTERVENTION FOR YOUTH IN TEEN COURT
$643,932Elizabeth J D'amico · Rand Corporation · R01 · FY2010 · DA
Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins
$643,844Tanja Mittag · St. Jude Children'S Research Hospital · R01 · FY2021 · NS
Family-Based Treatment for Parental Substance Abuse and Child Maltreatment
$643,835Cynthia Cupit Swenson · Medical University Of South Carolina · R01 · FY2011 · DA
Novel proteasome inhibitors targeting both beta5 and beta2 subunits for treatment of triple negative breast cancer
$643,772Gang Lin · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · CA
Dissecting the Multivariate Genetic Architecture of Psychiatric Diseases
$643,750Elliot Max Tucker-Drob · University Of Texas At Austin · R01 · FY2022 · MH
MRI & CT studies of the developing vocal tract
$643,713Houri K Vorperian · University Of Wisconsin-Madison · R01 · FY2014 · DC
Peer mentor training to reduce hospitalizations for children with asthma
$643,598Ashwin R Patel · Inquisithealth, Inc. · R44 · FY2016 · HD
Population-based Assessment of Treatment Patterns and Outcomes among Women with Newly Diagnosed Ductal Carcinoma in Situ
$643,594Jean M Mitchell · Georgetown University · R01 · FY2017 · CA
The role of mitochondrial calcium
$643,553Toren Finkel · National Heart, Lung, And Blood Institute · ZIA · FY2016 · HL
Preclinical development and clinical monitoring of adoptive immune therapy
$643,479Frances Hakim · Division Of Basic Sciences - Nci · ZIC · FY2016 · CA
Immune reconstitution following autologous and allogeneic stem cell transplant
$643,479Frances Hakim · Division Of Basic Sciences - Nci · ZIC · FY2016 · CA
Creating a foundation for personalized age- and sex-based immune-targeted therapies from an ALS longitudinal cohort by identifying peripheral and central immune signatures
$643,473Stephen Goutman · University Of Michigan At Ann Arbor · R01 · FY2021 · NS
SCIENCE GOALS AND OBJECTIVES THE OVERARCHING GOAL OF THIS PROPOSAL IS TO UNDERSTAND THE CHARACTERISTICS OF THE IONOSPHERIC CURRENTS OF RECONNECTION-GENERATED FAST FLOWS THAT CAUSE EITHER GLOBAL SUBSTORMS OR LOCALIZED PSEUDO BREAKUPS. SPECIFICALLY WE AIM TO QUANTITATIVELY ASSESS BOTH THE LOCALIZED AND GLOBAL RESPONSES OF EQUIVALENT IONOSPHERIC CURRENTS (EICS) AND FIELD ALIGNED CURRENTS (FACS) TO DIFFERENT TYPES OF FAST FLOWS: WITH OR WITHOUT GLOBAL SUBSTORMS; WITH DIPOLARIZATION FRONTS OR SLOWED FLOWS IN THE BREAKING REGION. THE SPECIFIC SCIENCE QUESTIONS THAT WILL BE ADDRESSED ARE: 1. WHAT ARE THE TYPICAL CHARACTERISTICS OF THE IONOSPHERIC RESPONSE OF EICS AND FACS TO DIFFERENT TYPES OF FAST FLOWS? A. HOW DO THE IONOSPHERIC CURRENTS VARY IN LATITUDE LOCAL TIME INTENSITY WITH DIFFERENT FLOWS? B. UNDER WHAT CONDITIONS DO CURRENT VORTICES APPEAR AND WHERE DO THESE VORTICES APPEAR WITH RESPECT TO THE HARANG DISCONTINUITY? 2. WHAT ARE THE TYPICAL CHARACTERISTICS OF DIFFERENT TYPES OF FAST FLOWS? A. DO THE FLUX TRANSPORT RATE AND ENTROPY OF FLOWS DETERMINE WHETHER A GLOBAL SUBSTORM CAN BE TRIGGERED? B. ARE THE CHANGES IN THE LOBE MAGNETIC FIELD STRENGTH AND OPEN LOBE MAGNETIC FLUX DIFFERENT FOR DIFFERENT TYPES OF FLOWS? 3. WHAT ARE THE POTENTIAL PHYSICAL QUANTITIES THAT DETERMINE WHETHER A FAST FLOW WILL TRIGGER A GLOBAL SUBSTORM OR A LOCALIZED PSEUDO BREAKUP? METHODOLOGY THE PROPOSED PROJECT WILL COMBINE THE FIELD AND PARTICLE DATA OF FAST FLOWS OBSERVED BY NASA S THEMIS VAN ALLEN PROBE (VAP) AND MMS; IONOSPHERIC EICS AND CURRENT AMPLITUDES (I.E. A PROXY FOR THE FACS) OBTAINED FROM THE SEC METHODS; AND A NEURAL NETWORK MODEL OF THE IONOSPHERIC CURRENTS TO ADDRESS THE ABOVE IMPORTANT SCIENCE QUESTIONS. MORE SPECIFICALLY 1. USING EXISTING LISTS OF FAST FLOWS AND SUBSTORM ONSETS GENERATED BY OUR TEAM [CHU ET AL. JGR 2015] WE WILL CATEGORIES FAST FLOWS WITH AND WITHOUT GLOBAL SUBSTORMS; FAST FLOWS WITH DIPOLARIZATION FRONT AND SLOWED FLOWS IN THE BREAKING REGION. 2. USING THE HIGH SPATIOTEMPORAL RESOLUTION DATA OF EICS OBTAINED FROM THE SPHERICAL ELEMENTARY CURRENT SYSTEM (SEC) METHOD BY OUR TEAM [WEYGAND ET AL. JGR 2011] WE WILL DEVELOP A NEURAL NETWORK (NN) MODEL OF THE IONOSPHERIC CURRENTS WHICH PROVIDES FULL LOCAL TIME COVERAGE. THIS MODEL RESOLVES THE PROBLEM THAT PERIODICALLY NO DATA ARE AVAILABLE ON THE NIGHTSIDE WHEN THE MAGNETOMETERS ARE LOCATED AT OTHER LOCAL TIMES AND GREATLY INCREASES THE NUMBER OF CONJUNCTIONS WITH SATELLITES. 3. USING THE MODELED IONOSPHERIC CURRENT DATA WE WILL CONSTRUCT THE CHARACTERISTICS OF THE IONOSPHERIC RESPONSE TO DIFFERENT CATEGORIES OF FAST FLOWS. 4. FOR DIFFERENT CATEGORIES OF FAST FLOWS WE WILL STUDY THE CHARACTERISTICS OF THESE FLOWS (ENTROPY AND FLUX TRANSPORT RATE) AND THE MAGNETOSPHERIC RESPONSE (CHANGE IN THE LOBE MAGNETIC FIELD AND AMOUNT OF FLUX RELEASED BY THE TAIL RECONNECTION). RELEVANCE TO THE DECADAL SURVEY GOALS AND THE H-SR PROGRAM OUR PROPOSED PROJECT DIRECTLY ADDRESSES THE MOST IMPORTANT QUESTIONS IN MAGNETOSPHERIC RECONNECTION WHICH IS CURRENTLY ONE OF NASA S HIGHEST PRIORITIES. THE PROPOSED RESEARCH IS HIGHLY RELEVANT TO GOAL 2 FROM THE HELIOPHYSICS DECADAL SURVEY WHICH IS TO DETERMINE THE DYNAMICS AND COUPLING OF EARTH S MAGNETOSPHERE IONOSPHERE AND ATMOSPHERE AND THEIR RESPONSE TO SOLAR AND TERRESTRIAL INPUTS . THE PROPOSED PROJECT PERFECTLY FITS THE SCOPE OF HELIOPHYSICS SR PROGRAM.
$643,295University Of California, Los Angeles · · FY2020 · National Aeronautics and Space Administration
The roles of p53 in embryonic stem cells
$643,215Jing Huang · Division Of Basic Sciences - Nci · ZIA · FY2017 · CA
Factors Associated With Variation in Cesarean Rates
$643,120Battelle Centers/Pub Hlth Res &Evaluatn · R01 · FY2004 · HD
An HXYZ-g HR-Fast-MAS probe for Dramatically Improved Biomolecular Structure Determinations
$643,090Francis David Doty · Doty Scientific, Inc. · R44 · FY2019 · GM
LEPTIN-- SIGNALING, TARGETS AND RESISTANCE
$643,059Jeffrey S Flier · Beth Israel Deaconess Medical Center · R37 · FY2006 · DK
SPEECH MOVEMENT CLASSIFICATION FOR ASSESSING AND TREATING ALS
$642,629Jordan R Green · Mgh Institute Of Health Professions · R01 · FY2014 · DC