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38,696 grants matching “als”
The relationship between child language proficiency and language of treatment on the outcomes of bilingual children with developmental language disorder
$661,040Anny P. Castilla-Earls · University Of Houston · R01 · FY2024 · DC
Tumor Microenvironment in Cancer Progression
$661,011Rosandra Kaplan · Division Of Basic Sciences - Nci · ZIA · FY2017 · CA
Immunoregulation in AIDS
$660,959Beth Israel Deaconess Medical Center · R01 · FY2005 · AI
PLATELET-DERIVED EXTRACELLULAR VESICLES TO RESTORE NEUROVASCULAR INTEGRITY IN ALS
$660,922Thomas Jefferson University · · FY2025 · Defense Health Agency
Functional reorganization of the language and domain-general multiple demand systems in aphasia
$660,848Swathi Kiran · Boston University (Charles River Campus) · R01 · FY2019 · DC
Profiles of Working Memory for Educational Research
$660,800Shelley I Gray · Arizona State University-Tempe Campus · R01 · FY2022 · DC
Institutional Career Development
$660,757Luisa A Dipietro · University Of Illinois At Chicago · KL2 · FY2017 · TR
Neurobiological predictors of spoken and written language learning
$660,757Kenneth R. Pugh · Haskins Laboratories, Inc. · R01 · FY2013 · HD
Profiles of Working Memory for Educational Research
$660,629Shelley I Gray · Arizona State University-Tempe Campus · R01 · FY2020 · DC
Genetic and Molecular Analysis of Congenital Heart Disease
$660,610Ivan Paul Moskowitz · University Of Chicago · R01 · FY2016 · HL
IT IS WIDELY UNDERSTOOD THAT ACCESS TO TECHNOLOGIES FOR LEARNING, INCLUDING HIGH SPEED INTERNET, IS NOT EQUITABLY DISTRIBUTED. THE 'DIGITAL DIVIDE' BETWEEN MINORITY, POOR AND UNDERSERVED STUDENTS AND THEIR PEERS HAS BEEN STUDIED AT LEAST SINCE 1998. THESE CHALLENGES HAVE BEEN EXACERBATED BY REMOTE LEARNING AND THE HEIGHTENED ANXIETY CAUSED BY THE COVID-19 PANDEMIC. CLOSING THE GAP AIMS TO ADDRESS THE DOUBLE-BARRIER OF LOW-INCOME LEVELS AND LOCAL INFRASTRUCTURE ISSUES THAT RURAL STUDENTS REGULARLY FACE.RURAL ELEMENTARY EDUCATORS, WHO ALSO FACE ISSUES OF CONNECTIVITY, ARE NOW TASKED WITH ADDRESSING EXISTING ISSUES (I.E., IMPLEMENTING EFFECTIVE SCIENCE CURRICULUM WITH CHALLENGED LEARNERS) IN UNFAMILIAR REMOTE DELIVERY METHODS. AS IT IS, SCIENCE IS OFTEN THE MOST DIFFICULT SUBJECT FOR MANY ELEMENTARY EDUCATORS TO DELIVER EFFECTIVELY. AS THE COVID-19 PANDEMIC AND THE SUBSEQUENT SHIFT TO REMOTE LEARNING HAVE CAUSED LOSSES IN ACADEMIC AND SEL DEVELOPMENT FOR STUDENTS AROUND THE WORLD, YOUNGER STUDENTS IN VULNERABLE OR UNDERSERVED RURAL POPULATIONS HAVE BEEN DISPROPORTIONATELY AFFECTED. ISSUES SUCH AS LEARNING LOSS AND MENTAL HEALTH ISSUES CAUSED BY SOCIAL ISOLATION AND HOME-BASED TRAUMA (INCREASED DEPRESSION, ANXIETY; DECREASED ENGAGEMENT AND SELF-MOTIVATION) HAVE DEEPENED THE DISPARITY GAPS (BROWN, ET. AL., 2020). AS A RESULT, RURAL YOUTH ARE FALLING FARTHER BEHIND THEIR MORE PRIVILEGED PEERS.TO ADDRESS THE ACADEMIC AND SOCIAL ISSUES STEMMING FROM THE COVID 19 PANDEMIC, THE 4-H NEC PROPOSES A UNIQUE MODEL THAT INFUSES SEL AND TRAUMA-INFORMED TEACHING PRACTICES TO BUILD RESILIENCE THROUGH A WHOLE CHILD APPROACH TO VIRTUAL LEARNING. THE 4-H NEC PROPOSES A UNIQUE MODEL THAT TAKES INTO ACCOUNT THREE SPECIFIC COVID-RELATED NEEDS: (1) STUDENT PARTICIPATION IMPACTED BY INEQUITABLE INTERNET ACCESS, (2) TEACHER INSTRUCTIONAL CHALLENGES CAUSED BY RAPID TRANSITIONS TO DISTANCE LEARNING, AND (3) YOUTH SOCIAL-EMOTIONAL HEALTH DEPENDENT ON WHOLE-CHILD BELONGING-ORIENTED EXPERIENCES.THROUGH A 'FLIPPED' 4-H SCHOOL ENRICHMENT APPROACH, 4-H AGRI-STEM PROFESSIONALS WILL WORK ALONGSIDE EDUCATORS, UTILIZING A 'JUST IN TIME' TRAINING MODEL TO ADDRESS CHALLENGES CAUSED BY THE MOVE TO VIRTUAL LEARNING. THE 4-H NEC PROJECT WILL PROVIDE EDUCATORS WITH DISTANCE EDUCATION CURRICULUM AND TRAINING AS WELL AS AGRI-STEM MENTORS TO ASSIST WITH DISTANCE, IN-CLASS LESSONS BASED ON AFRI'S FOOD AND AGRICULTURE PRIORITY AREAS.IN ADDITION, IN RESPONSE TO THESE ACADEMIC AND SEL NEEDS OF RURAL YOUTH, THE CLOSING THE GAP INITIATIVE WILL RAPIDLY DEPLOY "E-MENTORSHIP" STRATEGIES, COMBINING INNOVATIVE E-MENTORSHIP METHODS WITH ENGAGING EDUCATIONAL CONTENT IN AGRISCIENCE. THROUGH THE USE OF AGRI-STEM MENTORS, STUDENTS WILL EXPERIENCE A GREATER SENSE OF BELONGING IN THEIR VIRTUAL EDUCATIONAL SPACE AND SUPPORT FOR THEIR FUTURE ACADEMIC AND CAREER PATHWAYS.THE 4-H NEC 'S CLOSING THE GAP INITIATIVE WILL ENHANCE EDUCATORS CAPACITY TO SUPPORT STUDENT OUTCOMES DURING A TIME WHEN YOUTH ARE BEING CHALLENGED ACADEMICALLY, SOCIALLY, AND EMOTIONALLY. THROUGH INNOVATIVE DISTANCE ACTIVE LEARNING MODELS, YOUTH WILL NOT ONLY GET TO INTERACT VIRTUALLY WITH PEERS AND THEIR EDUCATORS, BUT WILL DEVELOP LIFE SKILLS ESSENTIAL FOR BUILDING RESILIENT YOUTH AND THRIVING COMMUNITIES. DURING THIS TIME OF COVID-ENFORCED ISOLATION, 4-H IS POSITIONED TO REACH INTO FAMILIES' HOMES TO SUPPORT HOME-BASED YOUTH DEVELOPMENT. EVEN MORE IMPORTANT THAN THE LEARNING EXPERIENCES THEMSELVES, IS THE SENSE OF BELONGING THAT COMES FROM RELATIONSHIPS WITH POSITIVE ADULT AND PEER MENTORS, WHICH TRULY MOVES THE NEEDLE ON ADDRESSING THE NEGATIVE IMPACTS OF COVID -19 ON CHILDREN'S MENTAL AND PHYSICAL HEALTH AND WELLBEING.AS A GATEWAY TO FUTURE OPPORTUNITIES WITHIN THE AGRISCIENCE FIELD, CLOSING THE GAP WILL ENGAGE INDUSTRY PARTNERS TO HELP FORGE THE CONNECTION BETWEEN YOUTH AND BUSINESSES WHILE INTRODUCING CORPORATE LEADERS TO THEIR FUTURE WORKFORCE. FROM READING STORIES TO CREATING VIDEOS, AGRISCIENCE ORGANIZATIONAL LEADERS WILL BE ASKED TO HELP SUPPORT LESSONS DESIGNED TO TIE CLASSROOMS TO THE FOOD AND AGRICULTURE SYSTEMS INDUSTRY.
$660,521University System Of New Hampshire · · FY2021 · National Institute of Food and Agriculture
Protein Phosphorylation And Regulation Of Cytoskeleton In Neuronal Systems
$660,514Harish C Pant · National Institute Of Neurological Disorders And Stroke · ZIA · FY2012 · NS
Next-generation antisense therapeutics for ALS and frontotemporal dementia
$660,421Jonathan K Watts · Univ Of Massachusetts Med Sch Worcester · R01 · FY2019 · NS
Prefrontal Function in Adolescent Limited vs Life Course Persistent SUD
$660,339Michael Damingo De Bellis · Duke University · R01 · FY2011 · DA
Social Aggression: Growth and Outcomes
$660,331Marion K. Underwood · University Of Texas Dallas · R01 · FY2012 · HD
A THREE YEAR $660K PROGRAM IS PROPOSED TO DEVELOP AND EVALUATE OCEAN COLOR SATELLITE-BASED PRIMARY PRODUCTION MODELS FOR ESTIMATING CARBON FIXATION OF FRESHWATER LAKES ON A GLOBAL SCALE AND TO PROVIDE CARBON FIXATION ESTIMATES FOR THE WORLD S FRESHWATER LAKES. GENERATION OF THIS FIRST OF ITS KIND DATA SET IS AN IMPORTANT INITIAL STEP TO DETERMINING COMPLETE FRESHWATER LAKE CARBON BUDGETS FOR THE WORLD S LAKES. THESE NEW REMOTE SENSING BASED TOOLS AND DATA PRODUCTS GENERATED AT LOCAL AND REGIONAL SCALES WOULD SUPPORT THE MONITORING REPORTING AND VERIFICATION (MRV) ASPECT OF NASA S CMS PROGRAM OBJECTIVES AND SPECIFICALLY ADDRESSES THE TWO CMS RESEARCH TOPICS USING REMOTE SENSING DATA PRODUCTS TO PRODUCE AND EVALUATE PROTOTYPE MRV SYSTEM APPROACHES AND/OR CALIBRATION AND VALIDATION DATA SETS FOR FUTURE NASA MISSIONS; AND STUDIES THAT BUILD UPON EXTEND AND/OR IMPROVE THE EXISTING CMS PRODUCTS FOR BIOMASS AND FLUX RESULTING FROM NASA S FIRST PHASES OF CMS PILOT STUDIES . THIS PROJECT BUILDS UPON AND EXTENDS A METHODOLOGY FOR ESTIMATING PRIMARY PRODUCTION ESTABLISHED IN AN INITIAL PILOT STUDY UNDER A NASA CMS PHASE 2 (2012 SOLICITATION) PROGRAM TO DEVELOP NEW REGIONAL CARBON MONITORING PRODUCTS IN THE GREAT LAKES (SHUCHMAN ET AL. 2013; FAHNENSTIEL ET AL. 2016; GRANT #NN12AP94G). SPECIFICALLY A SIMPLIFIED DEPTH INTEGRATED MODEL (DIM) FOR ESTIMATING PRIMARY PRODUCTION OR CARBON FIXATION (THEREAFTER REFERRED TO AS CARBON FIXATION) WOULD GENERATE A 2011 SNAPSHOT OF THE TOTAL CARBON FIXATION IN ALL FRESHWATER LAKES ON A 300M GRID WHILE A MORE SOPHISTICATED REGIONALLY OPTIMIZED VERTICALLY GENERALIZED PRODUCTION MODEL (VGPM) DEVELOPED UNDER THIS PROGRAM WOULD BE USED TO GENERATE ANNUAL CARBON FIXATION ESTIMATES FOR 1000 FRESHWATER LAKES OF THE WORLD FROM 2002-2011. FINALLY MONTHLY ESTIMATES OF CARBON FIXATION WOULD BE GENERATED FOR 10 OF THE WORLD S LARGEST LAKES FROM 2002-2016. IN ADDITION TO SUPPORTING CMS THE TIME SERIES OF CARBON FIXATION PRODUCTS TO BE GENERATED UNDER THIS NEW PROGRAM CAN BE USED TO PROVIDE A BETTER UNDERSTANDING OF HOW ANTHROPOGENIC FORCING INVASIVE SPECIES AND CLIMATE CHANGE AFFECT CARBON FIXATION OF THE FRESHWATER LAKES IN THE VARIOUS ECOLOGICAL REGIONS THROUGHOUT THE GLOBE. THE CARBON FIXATION ESTIMATES TO BE GENERATED UNDER THIS PROGRAM ARE ALSO USEFUL IN CALCULATING FRESHWATER FISH PRODUCTION AND BETTER UNDERSTANDING LAKE ECOSYSTEMS THROUGHOUT THE WORLD. THE GLOBOLAKES RESEARCH PROGRAMME (HTTP://WWW.GLOBOLAKES.AC.UK/) IS AN INTEGRAL PART OF THIS RESEARCH PROGRAM AND OUR GOALS FIT CLOSELY WITH THEIR RESEARCH MISSION. GLOBOLAKES IS PROVIDING A ROBUST DATABASE OF SATELLITE AND IN SITU OBSERVATIONS THAT WILL BE DIRECTLY USED IN THE GENERATION OF FRESHWATER CARBON FIXATION PRODUCTS. THE SIMPLIFIED DIM AND VGPM DEVELOPED UNDER THIS PROPOSED PROGRAM CAN UTILIZE A VARIETY OF MULTISPECTRAL SATELLITE AIRCRAFT AND UAS DATA SOURCES. THE OCEAN COLOR SATELLITE DATA THAT WILL BE USED IN THIS PROPOSED PROGRAM INCLUDES: MERIS AND VIIRS.
$659,993Michigan Technological University · · FY2020 · National Aeronautics and Space Administration
Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid Follicles
$659,902Roger Keith Reeves · Beth Israel Deaconess Medical Center · R01 · FY2019 · AI
The novel role of HLA-E restricted CD8 regulatory T cells in kidney allograft rejection
$659,836Jamil Azzi · Brigham And Women'S Hospital · R01 · FY2025 · AI
Functional and translational studies of RUNX1 and CBFB in hematopoiesis
$659,796Paul Liu · National Human Genome Research Institute · ZIA · FY2014 · HG
T cell immunity in a rare juvenile form of motor neuron disease
$659,692Ivan Marazzi · University Of California-Irvine · R01 · FY2023 · NS
Neuronal cell-cycle re-entry and neurodegeneration
$659,691Shanthini Sockanathan · Johns Hopkins University · R01 · FY2022 · AG
Neuronal cell-cycle re-entry and neurodegeneration
$659,691Shanthini Sockanathan · Johns Hopkins University · R01 · FY2023 · AG
Neuronal cell-cycle re-entry and neurodegeneration
$659,691Shanthini Sockanathan · Johns Hopkins University · R01 · FY2024 · AG
Expanding the chemical diversity of therapeutic oligonucleotides to treat neurodegenerative disorders
$659,650Anastasia Khvorova · Univ Of Massachusetts Med Sch Worcester · R01 · FY2020 · NS
Expanding the chemical diversity of therapeutic oligonucleotides to treat neurodegenerative disorders
$659,650Anastasia Khvorova · Univ Of Massachusetts Med Sch Worcester · R01 · FY2021 · NS