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38,696 grants matching “als”
The Mouse Connectome Project Phase III: Assembling the global neural networks of the mouse brain
$674,296Hong-Wei Dong · University Of California Los Angeles · R01 · FY2021 · MH
Project 2: Maximizing Retailers' Responsiveness to FDA Regulatory Autho p209-264
$673,955Jonathan M. Samet · University Of Southern California · P50 · FY2016 · CA
Genetic influences on alcoholism vulnerability in American Indians
$673,850David Goldman · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2009 · AA
Genetic Linkage Study in Parkinson's Disease
$673,829Boston University Medical Campus · R01 · FY2002 · NS
Michigan Center for Urban African American Aging Research
$673,811Robert Joseph Taylor · University Of Michigan At Ann Arbor · P30 · FY2022 · AG
BACKGROUND: PLANETARY REGOLITH IS THE MEDIUM BY WHICH WE INVESTIGATE THE EVOLUTION OF PLANETARY SURFACES. IT IS WHAT WE SENSE WITH REMOTE SENSING AND THE MATERIAL WE RETURN WHEN COLLECTING SAMPLES. THE DOMINANT FORCE SHAPING AND RE-SHAPING THE REGOLITH ON AIRLESS BODIES IN THE SOLAR SYSTEM IS IMPACT BOMBARDMENT. WE HAVE RECONSTITUTED THE PIONEERING LUNAR REGOLITH OVERTURN MODEL PRESENTED BY GAULT ET AL. (1974). KEY UPDATES ARE THE INCLUSION OF VARIABLE MATERIAL PROPERTIES AND SECONDARY IMPACTS. THESE UPDATES CONTRIBUTE AN IMPROVED UNDERSTANDING OF THE IMPACT PROCESSING OF THE LUNAR SURFACE AND BROADEN THE APPLICABILITY OF THE MODEL BEYOND ITS ORIGINAL INTENT. A PAPER PRESENTING THE UPDATED MODEL AND LUNAR APPLICATION INCLUDING SECONDARIES AND VALIDATION IS CURRENTLY IN REVIEW WITH ICARUS. THE PROJECT WILL PRODUCE NEW INSIGHTS FOR FOUR OBJECTS THROUGH APPLICATION OF THIS REJUVENATED REGOLITH EVOLUTION MODEL. THE THICKNESS OF THE LUNAR HIGHLANDS REGOLITH WILL BE MODELED TO PROVIDE AN ESTIMATE OF THE PRE-ORIENTALE IMPACT FLUX THAT WOULD BE REQUIRED TO GENERATE THE MEASURED REGOLITH. EXISTING ESTIMATES ARE BASED ON CRATER COUNTS; THE PROJECT WOULD SUPPLY INDEPENDENT INSIGHT. THIS NEW ESTIMATE IS RELEVANT BOTH TO THE INTENSITY OF THE FINAL BOMBARDMENT OF THE MOON AND INNER PLANETS AND TO THE AGE AT WHICH THE LUNAR CRUST SOLIDIFIED SUFFICIENTLY TO PRODUCE AN UNCONSOLIDATED FRAGMENTAL REGOLITH. THE PROJECT WILL ALSO UPDATE AND POSSIBLY ENTIRELY CHANGE A FUNDAMENTAL PARAMETER IN LUNAR GEOLOGY: THE THICKNESS OF THE HIGHLANDS REGOLITH. THE STARK DIFFERENCE BETWEEN THE ABUNDANCE OF ICE AT THE POLES OF MERCURY AND THE MOON HAS NO CURRENT EXPLANATION OTHER THAN MERCURY HAVING EXPERIENCED A RECENT SERENDIPITOUS LARGE ICY IMPACT. HOWEVER THE IMPACT FLUX AT MERCURY AT REGOLITH-PRODUCING SIZES IS SUBSTANTIALLY LOWER THAN AT THE MOON. OUR ANALYSIS WILL DETERMINE IF REGOLITH OVERTURN CAN EXPLAIN THIS UNRESOLVED PROBLEM IN SOLAR SYSTEM VOLATILES. CERES TOO POSSESSES ICE DEPOSITS IN PERMANENT SHADOW AND ITS LATITUDE DEPENDENT SHALLOW BURIED ICE DISTRIBUTION APPEARS TO BE CONSISTENT WITH THERMAL MODELS. HOWEVER THE MODEL DEPTH TO ICE NEAR THE POLES IS EXTREMELY SHALLOW AND THUS APPEARS TO BE READILY SUSCEPTIBLE TO DOMINANCE BY REGOLITH OVERTURN. THIS PROJECT WILL CLARIFY THE IMPORTANCE OF REGOLITH OVERTURN IN UNDERSTANDING SHALLOW ICE ON CERES. FINALLY EUROPA IS A LIKELY TARGET FOR SURFACE SAMPLING BY A LANDER TO SEEK EVIDENCE OF LIFE THROUGH CHARACTERIZATION OF ORGANIC MOLECULES. HOWEVER RADIATION RAPIDLY BREAKS DOWN ORGANIC MOLECULES MAKING SOME FORM OF SUBSURFACE SAMPLING DESIRABLE. THIS PROJECT WILL DETERMINE THE DEPTH TO MATERIAL THAT HAS NOT BEEN CYCLED TO THE RADIOLYTICALLY ALTERED SURFACE DIRECTLY RELEVANT TO UNDERSTANDING THE NATURE OF ANY EUROPA SAMPLE.
$673,649University Of Hawaii · · FY2020 · National Aeronautics and Space Administration
Stroke and aPL: Community-Based Clinicopathological Study
$673,564Steven R Levine · Suny Downstate Medical Center · R01 · FY2011 · HL
Genetic Linkage Study in Parkinson's Disease
$673,553Boston University Medical Campus · R01 · FY2003 · NS
Risk Factrors Associated with CFS and CF Prognosis
$673,400Leonard A Jason · De Paul University · R01 · FY2006 · AI
Geographic Variability in Time from HIV Diagnosis to Viral Suppression in the Deep South: A Roadmap to Accelerated Treatment Initiation
$673,326Aadia Rana · University Of Alabama At Birmingham · R01 · FY2021 · AI
HUMAN MISSIONS TO MARS ARE NOW UNDER ACTIVE PLANNING AT NASA. IN ORDER TO DEVELOP HARDWARE SPACESUITS AND HABITATS THAT MEET MISSION OBJECTIVES WHILE ALSO PREVENTING FORWARD CONTAMINATION THE SURVIVAL METABOLISM AND GROWTH OF TERRESTRIAL MICROORGANISMS UNDER MARS SURFACE CONDITIONS MUST BE CHARACTERIZED. RECENTLY SEVERAL BACTERIAL SPECIES WERE IDENTIFIED THAT GREW UNDER 7 MBAR 0 C AND CO2-ANOXIC ATMOSPHERES (HENCEFORTH CALLED HYPOBAROPHILES) (SCHUERGER ET AL. 2013 SCHUERGER AND NICHOLSON 2015A 2015B). HOWEVER THESE EXPERIMENTS WERE RESTRICTED TO MOSTLY NON-SPACECRAFT MICROORGANISMS AND THUS A KEY KNOWLEDGE GAP IN PLANETARY PROTECTION IS (1) WHETHER HYPOBAROPHILE MICROORGANISMS ARE PRESENT ON ACTUAL PLANETARY SPACECRAFT SCHEDULED FOR MARS LANDINGS. OTHER PLANETARY PROTECTION KNOWLEDGE GAPS FOR MARS ROBOTIC OR CREWED MISSIONS ARE: (2) WHAT IS THE RATIO OF CULTURABLE VERSUS NONCULTURABLE HYPOBAROPHILES ON PLANETARY SPACECRAFT AND (3) WHAT ARE THE LOW-TEMPERATURE AND HIGH-SALT TOLERANCE LEVELS FOR MAINTENANCE METABOLISM AND GROWTH OF SPACECRAFT HYPOBAROPHILES IN SPECIAL REGIONS ON MARS (E.G. RSL LAVA TUBE ICE CAVES AND GROUND ICE)? ANSWERS TO THESE QUESTIONS WILL CONTRIBUTE TO MODELING THE RISKS OF FORWARD CONTAMINATION OF SPECIAL REGIONS ON MARS. THE CURRENT PROPOSAL WILL FOCUS ON CHARACTERIZING MAINTENANCE METABOLISM AND GROWTH OF SPACECRAFT HYPOBAROPHILIC BACTERIA UNDER MARTIAN CONDITIONS NEAR 7 MBAR. OUR RESULTS WILL CONTRIBUTE TO (I) CHARACTERIZING THE LIMITS OF LIFE UNDER MARTIAN CONDITIONS (II) ASSIST IN THE ENUMERATION OF TERRESTRIAL BACTERIA ON MARS ROVERS OR LANDERS PRIOR TO LAUNCH AND (III) CONTRIBUTE TO DEVELOPING PLANETARY PROTECTION PROTOCOLS FOR SANITIZING HARDWARE ON ROBOTIC AND CREWED MISSIONS TO MARS. OBJECTIVE-1: CULTURABLE SPACECRAFT HYPOBAROPHILES. WE WILL UTILIZE RECENTLY DEVELOPED PROTOCOLS TO ASSAY A RANGE OF SOILS SPACECRAFT SURFACES AND SPACECRAFT ASSEMBLY FACILITY SAMPLES FOR THE PRESENCE OF CULTURABLE HYPOBAROPHILES CAPABLE OF GROWTH AT 7 MBAR. DNA FROM HYPOBAROPHILES WILL BE SANGER SEQUENCED TO ESTABLISH THEIR TAXONOMIC AFFILIATIONS. OBJECTIVE-2: NONCULTURABLE SPACECRAFT HYPOBAROPHILES. IN ADDITION WE WILL DEVELOP A STABLE ISOTOPE PROBING (SIP) PROTOCOL COUPLED TO A NEXTGEN METAGENOMIC SEQUENCING APPROACH (ILLUMINA MISEQ) TO DETERMINE THE PRESENCE OF NONCULTURABLE HYPOBAROPHILES IN THE ABOVE SAMPLES. IT IS A MODERN PARADIGM THAT>99% OF ALL ENVIRONMENTAL BACTERIA AND ARCHAEA ARE NONCULTURABLE SO WE ANTICIPATE MANY MORE NONCULTURABLE HYPOBAROPHILES TO BE DESCRIBED THAN THE CURRENT LIST OF 23 HYPOBAROPHILIC BACTERIA (SCHUERGER AND NICHOLSON 2015A 2015B). OBJECTIVE-3: GROWTH OF HYPOBAROPHILES AT LOW TEMPERATURES AND HIGH SALT CONCENTRATIONS. SPACECRAFT HYPOBAROPHILES WILL BE TESTED FOR GROWTH ON SEMI-SOLID AND LIQUID MEDIA TO DETERMINE THE MINIMUM TEMPERATURES AND MAXIMUM SALT CONCENTRATIONS REQUIRED FOR GROWTH. RESULTS WILL BE USED IN OBJECTIVE 4 AND WILL GIVE INSIGHTS INTO HOW ENVIRONMENTAL VERSATILE THE HYPOBAROPHILES MIGHT BE ON THE SURFACE OF MARS. OBJECTIVE-4: MAINTENANCE METABOLISM OF SPACECRAFT HYPOBAROPHILES. WE WILL USE NANOSIMS TO PROBE MAINTENANCE METABOLISM OF VIABLE BUT NOT DIVIDING HYPOBAROPHILIC BACTERIA BELOW THEIR RESPECTIVE LOW-TEMPERATURE AND HIGH-SALT GROWTH THRESHOLDS. NANOSIMS IS CAPABLE OF IMAGING STABLE ISOTOPES (E.G. 13C 15N) IN FIXED BACTERIAL CELLS AT 100 NM SCALES. IF THE BACTERIAL CELLS ARE METABOLICALLY ACTIVE BUT NOT CAPABLE OF CELL DIVISION THE STABLE ISOTOPES WILL BE ABSORBED AND INCORPORATED INTO CELLULAR MATERIALS. RESULTS WILL GREATLY EXPAND OUR CURRENT UNDERSTANDING OF HOW SPACECRAFT MICROORGANISMS MIGHT SURVIVE AND GROW ON THE SURFACE OF MARS IN GENERAL AND SPECIAL REGIONS IN PARTICULAR. AND THE RESULTS ARE LIKELY TO ASSIST IN CLOSING KNOWLEDGE GAPS FORESEEN IN UPCOMING HUMAN MISSIONS TO MARS.
$673,287University Of Florida · · FY2020 · National Aeronautics and Space Administration
Identifying antitumor T cell receptors for cellular immunotherapy
$673,212Sri Krishna · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Studying phenotypic states of antitumor human T cells
$673,212Sri Krishna · Division Of Basic Sciences - Nci · ZIA · FY2025 · CA
Executive Function Outcome Measures for Young Children with Down Syndrome
$673,186Deborah J Fidler · Colorado State University · R01 · FY2019 · HD
Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimer's Disease
$673,114Elisa E Konofagou · Columbia University Health Sciences · R01 · FY2020 · AG
Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetes
$673,076Katherine Bangen · University Of California, San Diego · R01 · FY2020 · AG
High Throughput Functional Dissection Of Adiposity GWAS Loci Using Model Systems
$672,946Michael A Province · Washington University · R01 · FY2022 · DK
High Throughput Functional Dissection Of Adiposity GWAS Loci Using Model Systems
$672,946Michael A Province · Washington University · R01 · FY2021 · DK
Food Delivery, Remote Monitoring, and coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)
$672,885Tapan S Mehta · University Of Alabama At Birmingham · P50 · FY2025 · MD
DIAGNOSTIC CENTER
$672,880University Of Colorado Denver · U01 · FY2000 · DK
Establishing Multi-site Feasibility and Fidelityof Yoga to Improve Management of Type-2 Diabetes
$672,782Beth C Bock · Miriam Hospital · R01 · FY2023 · AT
SCB Structural Cell Biology Core
$672,748John A Tainer · University Of Calif-Lawrenc Berkeley Lab · P01 · FY2013 · CA
Individual and community influences on alcohol use disorders and other mental health behaviors in Mexican Americans
$672,747Cindy L Ehlers · Scripps Research Institute, The · R01 · FY2019 · AA
Impact of RNA binding proteins on translation initiation and elongation.
$672,694Markus Hafner · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2022 · AR
High Throughput Functional Dissection Of Adiposity GWAS Loci Using Model Systems
$672,588Michael A Province · Washington University · R01 · FY2020 · DK