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1,049,261 grants matching “t cell”
A Tolerance Approach to Xenotransplantation
$3,278,603Megan Sykes · Columbia University Health Sciences · P01 · FY2023 · AI
SUGAR-seq: A New Technology for Single-Cell Glycan and Gene Expression Profiling in AD
$3,278,468Linda C Hsieh-Wilson · California Institute Of Technology · RF1 · FY2018 · AG
Role of Ubiquitin Ligases and Deubiquitinases in Host Defense against Mycobacterium tuberculosis
$3,278,392Michael Shiloh · Ut Southwestern Medical Center · R01 · FY2025 · AI
MRI: Acquisition of an Aberration Corrected High Resolution Analytical Transmission Electron Micro. for Advanced Materials Research
$3,277,750Ray W Carpenter · Arizona State University · · FY2008 · MPS
Stat transcription factors in immunoregulation and autoimmune disease
$3,277,674John O'Shea · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2012 · AR
Protein Trafficking In The Endosomal-Lysosomal System
$3,277,245Juan Bonifacino · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2025 · HD
Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
$3,277,040Barbara B O'Brien · Westat, Inc. · N01 · FY2010 · CA
B cell development
$3,276,931Rafael C Casellas · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2017 · AR
Transgenic Resources for Neuroscience Research
$3,276,800James Pickel · National Institute Of Mental Health · ZIC · FY2020 · MH
Border Biomedical Research Center
$3,276,683Robert Kirken · University Of Texas El Paso · G12 · FY2017 · MD
Southern Research Specialized Biocontainment Screening Center (SRSBSC)
$3,275,776Colleen B Jonsson · Southern Research Institute · U54 · FY2009 · HG
The Risks and Opportunities of Homeostatic Repopulation
$3,275,730Stuart Johnston Knechtle · Duke University · U19 · FY2023 · AI
The role of blood and brain 5-hydroxymethylcytosine in linking vascular risk factors to ADRD in older White and Black persons
$3,275,232Zoe Arvanitakis · Rush University Medical Center · RF1 · FY2021 · AG
Sphingolipid Biology of Neurodegeneration
$3,274,941Richard Proia · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2023 · DK
Systematic Development of Antiretroviral Intravaginal Rings for HIV Prevention
$3,274,930Marc Michael Baum · Oak Crest Institute Of Science · U19 · FY2014 · AI
WE PROPOSE TO IMPLEMENT A MULTI-PLATFORM MULTI-SCALE MULTI-MONTH AUTONOMOUS ARRAY AT TWO EXPORTS SITES TO MEASURE UPPER OCEAN COMMUNITY STRUCTURE SINKING CELLS AGGREGATES AND FECAL PELLETS PHYSICAL EXPORT AND MIGRATING ZOOPLANKTON. THESE OBSERVATIONS WILL COMPLEMENT SHIP-BASED PROGRAMS BY SPANNING A WIDER RANGE OF ECOSYSTEM STATES AND PROVIDING A DIVERSE DATASET FOR EXPORTS MODELING. THE MEASUREMENTS WILL RESOLVE EVOLUTION OF DOMINANT PATHWAYS AND QUANTIFY FLUXES FOR CARBON EXPORT FROM THE EUPHOTIC ZONE TO THE UPPER TWILIGHT ZONE AS WELL AS ATTENUATION FLUX IN THE UPPER TWILIGHT ZONE. THIS EFFORT WILL ALSO DEMONSTRATE THE CAPABILITY TO MEASURE EXPORT FLUXES USING A COMBINATION OF IN SITU MEASUREMENTS AND SATELLITE REMOTE SENSING THUS SERVING AS A PROTOTYPE FOR FUTURE OPERATIONAL SYSTEMS. WE HYPOTHESIZE THAT DOMINANT EXPORT PATHWAYS AND EFFICIENCIES DIFFER BETWEEN ATLANTIC AND PACIFIC SITES BASED ON RELATIVE PHASING OF NET COMMUNITY PRODUCTION (NCP) AND CARBON EXPORT (EZ) FROM THE EUPHOTIC ZONE. IN THE PACIFIC WHERE NCP AND EZ VARY IN PHASE EXPORT WILL BE DOMINATED BY ZOOPLANKTON DIEL MIGRATION AND SLOW-SINKING PELLET FLUXES WITH A SMALLER ROLE FOR PHYSICAL EXPORT AND A WEAKER EXPORT EFFICIENCY. IN CONTRAST DECOUPLING OF NCP AND EZ IN THE ATLANTIC WILL PRODUCE BOTH MORE VARIABLE AND MORE EFFICIENT EXPORT ASSOCIATED WITH FAST-SINKING AGGREGATES PHYSICAL TRANSPORT AND LOW RESPIRATION RATES. SMALL-SCALE PHYSICAL AND ECOSYSTEM VARIATIONS IN THE ATLANTIC WILL ENHANCE SUBMESOCALE EDDY FLUX WHICH MAY CONSTITUTE UP TO HALF OF TOTAL EXPORT DURING SPRINGTIME RESTRATIFICATION. WE PROPOSE THAT SIMILAR IN SITU MEASUREMENTS WILL PERMIT IMPROVED EXPORT PREDICTIONS IN OTHER OCEANIC REGIONS BASED ON REMOTE-SENSING OBSERVATIONS.
$3,274,262University Of Washington · · FY2020 · National Aeronautics and Space Administration
RAG and AID biology
$3,274,017Rafael C Casellas · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2011 · AR
Graft-versus-leukemia
$3,273,957Austin J Barrett · National Heart, Lung, And Blood Institute · ZIA · FY2010 · HL
Inorganic Toxicology
$3,273,492Michael Waalkes · National Institute Of Environmental Health Sciences · ZIA · FY2013 · ES
SCCOR in Host Factors in Chronic Lung Disease
$3,273,022Richard C Boucher · Univ Of North Carolina Chapel Hill · P50 · FY2009 · HL
Autophagy in aging: testing geroscience in Alzheimer's disease
$3,272,577Ana M. Cuervo · Albert Einstein College Of Medicine · P01 · FY2020 · AG
Health Effects and Geochemistry of Arsenic and Manganese
$3,272,308Joseph H Graziano · Columbia University Health Sciences · P42 · FY2010 · ES
Vulnerability of SARS- CoV-2 Infection in Lung Cancer Based on Serological Antibody Analyses
$3,271,928Fred R Hirsch · Icahn School Of Medicine At Mount Sinai · U54 · FY2023 · CA
Vaccination and infection: indicators of immunological health and responsiveness
$3,271,801Mark M Davis · Stanford University · U19 · FY2011 · AI
Mechanisms, modeling and therapies of retinal and macular neurodegeneration
$3,271,791Anand Swaroop · National Eye Institute · ZIA · FY2023 · EY