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38,696 grants matching “als”
Cyclic EphA4 peptide antagonists for neuroprotection in ALS
$689,360Elena B Pasquale · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2017 · NS
Animal models of eye diseases
$689,129Sheldon Miller · National Eye Institute · ZIA · FY2012 · EY
Genetic Epidemiology of Complex Traits
$689,122Joan E. Bailey-Wilson · National Human Genome Research Institute · ZIA · FY2018 · HG
Oligodendrocyte Progenitors and Mechanisms of Human Vascular White Matter Injury
$689,003Stephen Arthur Back · Oregon Health & Science University · R01 · FY2022 · NS
Brain-spanning and scale-crossing circuitry mediating drive function and dysfunction
$688,891Karl Alexander Deisseroth · Stanford University · R01 · FY2023 · MH
Phase II Clinical Trial of Polyphenon E in Prostate Cancer
$688,824Nagi B Kumar · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2011 · CA
ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next Steps
$688,498Hugh P Garavan · University Of Vermont & St Agric College · R01 · FY2024 · DA
Collaborative Research: Mechanisms of nutrient input at the shelf margin supporting persistent winter phytoplankton blooms downstream of the Charleston Bump
$688,415Harvey E Seim · University Of North Carolina At Chapel Hill · · FY2010 · GEO
Genomics and Proteomics of Head and Neck Cancer
$688,364Carter Van Waes · National Institute On Deafness And Other Communication Disorders · ZIA · FY2012 · DC
Signal and Transcription Factor Network interactions in Head and Neck Cancer
$688,364Carter Van Waes · National Institute On Deafness And Other Communication Disorders · ZIA · FY2012 · DC
NF-kappaB in pathogenesis and therapy of head and neck cancer
$688,364Carter Van Waes · National Institute On Deafness And Other Communication Disorders · ZIA · FY2012 · DC
The study of neuro-vascular interactions in the developing heart
$688,347Yosuke Mukoyama · National Heart, Lung, And Blood Institute · ZIA · FY2019 · HL
The study of neuro-vascular interactions in the central nervous system
$688,347Yosuke Mukoyama · National Heart, Lung, And Blood Institute · ZIA · FY2019 · HL
Cyclic EphA4 peptide antagonists for neuroprotection in ALS
$688,311Elena B Pasquale · Sanford Burnham Prebys Medical Discovery Institute · R01 · FY2016 · NS
THE SPATIAL DISTRIBUTION OF PHYTOPLANKTON BIOMASS AND ITS PHOTOPHYSIOLOGICAL RESPONSES TO THE ENVIRONMENT IN THE UPPER OCEAN POTENTIALLY CAN BE INFERRED FROM SATELLITE PLATFORMS (E.G. MODIS AND HISTORICALLY MERIS) BY ANALYZING THE VARIATIONS IN SOLAR INDUCED FLUORESCENCE (SIF) ORIGINATING FROM CHLOROPHYLL A. ALTHOUGH THE SIF ALGORITHM IS POTENTIALLY MOST ADVANTAGEOUS IN CASE 2 WATERS WHERE DOM AND SUSPENDED SEDIMENTS INTERFERE WITH CHLOROPHYLL ALGORITHMS BASED ON BLUE-GREEN WATER LEAVING RADIANCES THE APPLICATION OF SIF TO UNDERSTANDING EITHER PHYTOPLANKTON PHOTOPHYSIOLOGY OR CARBON FIXATION ON A GLOBAL SCALE HAS NOT YET BEEN ACHIEVED. THE VARIABILITY IN SIF QUANTUM YIELDS APPEARS TO CORRELATE WITH ENVIRONMENTAL FORCING BUT THE MECHANISMS RESPONSIBLE FOR AND THE INTERPRETATION OF THIS VARIABILITY ARE FUNDAMENTALLY NOT KNOWN DUE TO VERY LIMITED FIELD STUDIES OF BIOPHYSICALLY RELATED PROCESSES. WITHIN THE FRAMEWORK OF THE NASA OBB FUNDED PROJECT ON THE APPLICATION OF LIFETIME ANALYSES IN THE UPPER OCEAN TO THE INTERPRETATION OF SATELLITE-BASED SOLAR INDUCED CHLOROPHYLL FLUORESCENCE SIGNALS (NNX08AC24G) WE DESIGNED AND CONSTRUCTED A SEA-GOING INSTRUMENT PACKAGE TO DIRECTLY AND SIMULTANEOUSLY MEASURE LIFETIMES AND QUANTUM YIELDS OF PHYTOPLANKTON CHLOROPHYLL A FLUORESCENCE IN THE OCEAN. THE QUANTUM YIELDS ARE ACCURATELY CALCULATED FROM PICOSECOND-RESOLVED MEASUREMENTS OF FLUORESCENCE LIFETIMES AND ALLOWED FOR THE FIRST VALIDATION AND CALIBRATION OF THE SATELLITE-BASED RETRIEVALS OF SIF QUANTUM YIELDS. THIS NOVEL TECHNOLOGY WAS DEPLOYED ON TEN CRUISES IN THE ATLANTIC PACIFIC ARCTIC AND SOUTHERN OCEANS SPANNING FIVE YEARS TO INFER THE VARIABILITY IN PHYTOPLANKTON PHYSIOLOGY AND SIF SIGNALS IN MAJOR BIOGEOCHEMICAL PROVINCES OF THE OCEAN. THE COMBINATION OF AMPLITUDE-BASED VARIABLE FLUORESCENCE AND LIFETIME MEASUREMENTS ALLOWED US TO DEDUCE THE GLOBAL BUDGETS OF FATE OF SOLAR RADIATION ABSORBED BY PHYTOPLANKTON FOR THE FIRST TIME. THE RESULTS OF THIS RESEARCH ARE SUMMARIZED IN A PAPER IN SCIENCE (LIN ET AL. 2016). HERE WE PROPOSE TO EXPAND THESE ROBUST AND HIGHLY SENSITIVE TECHNOLOGIES TO ELUCIDATE THE PATTERNS OF GLOBAL DISTRIBUTIONS OF QUANTUM YIELDS OF CHLOROPHYLL FLUORESCENCE IN THE OCEAN. THIS EFFORT IS ESSENTIAL TO INTERPRETING THE VARIABILITY OF SATELLITE-BASED RETRIEVALS OF SIF QUANTUM YIELDS IN RELATION TO PHYTOPLANKTON PHOTOPHYSIOLOGICAL RESPONSES TO ENVIRONMENTAL FORCING; E.G. NUTRIENT AVAILABILITY ON BASIN MESO-SCALE AND SMALLER SPATIAL SCALES. SPECIFICALLY WE PROPOSE TO CONSTRUCT AND DEPLOY A NETWORK OF FIVE PAIRED CALIBRATED INSTRUMENTS TO BE USED BY THE OCEANOGRAPHIC COMMUNITY THROUGHOUT THE WORLD. THE RESULTING DATA WILL BE ANALYZED AND ARCHIVED AT RUTGERS UNIVERSITY AND DISTRIBUTED TO THE COMMUNITY VIA COLLABORATION WITH THE OCEAN COLOR PROGRAM AT GSFC. WE ENVISION THAT THIS PROJECT WILL PROVIDE THE SCIENTIFIC BACKGROUND FOR THE INTERPRETATION OF THE VARIABILITY IN SOLAR INDUCED FLUORESCENCE SIGNALS IN THE OCEAN HELP TO IMPROVE MODIS CHLOROPHYLL BASED BIOMASS ALGORITHMS (AND POTENTIALLY FOLLOW-ON SENSORS ON OTHER SATELLITES) AND PROVIDE CRUCIAL PHYSIOLOGICAL INFORMATION NEEDED FOR BETTER ESTIMATES OF PRIMARY PRODUCTION FROM REMOTE SENSING OF THE OCEAN COLOR AND SOLAR INDUCED FLUORESCENCE. WE SUGGEST THAT RELATING THE SPACE-BASED ESTIMATES TO IN SITU MEASUREMENTS OF CHLOROPHYLL FLUORESCENCE LIFETIMES WILL PROVIDE A PATHWAY TO ROBUSTLY OBSERVE HOW PHOTOBIOLOGICAL ENERGY UTILIZATION AND DISSIPATION PROCESSES IN THE GLOBAL OCEAN POTENTIALLY CHANGE IN THE FUTURE.
$688,291Rutgers, The State University · · FY2020 · National Aeronautics and Space Administration
Expanding the Chemical Diversity of Therapeutic Oligonucleotides
$688,196Anastasia Khvorova · Univ Of Massachusetts Med Sch Worcester · R01 · FY2023 · NS
Expanding the Chemical Diversity of Therapeutic Oligonucleotides
$688,196Anastasia Khvorova · Univ Of Massachusetts Med Sch Worcester · R01 · FY2025 · NS
Trial of Ascertaining Individual Preferences for Loved Ones' Role in End-of-life
$688,155Marie T. Nolan · Johns Hopkins University · R01 · FY2011 · NR
Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce
$688,137Sheryl Zimmerman · Univ Of North Carolina Chapel Hill · R01 · FY2025 · AG
VALIDATING UBC9 AS A MOLECULAR TARGET TO DEVELOP A THERAPY FOR ALL FORMS OF ALS
$687,779J.David Gladstone Institutes · · FY2018 · Department of the Army
Molecular Basis for Pre-Receptor Modulation of Plant Hormones by Acyl Acid Amido Synthetases
$687,763Joseph M Jez · Washington University · · FY2012 · BIO
SCB Structural Cell Biology Core
$687,687John A Tainer · University Of Calif-Lawrenc Berkeley Lab · P01 · FY2014 · CA
Genetic Markers of Long-Term Mumps Vaccine Immunity
$687,634Richard B Kennedy · Mayo Clinic Rochester · R01 · FY2020 · AI
Intensive Outpatient Protocol for High Risk Suicidal Teens
$687,538Anthony Nmn Spirito · Brown University · R01 · FY2015 · MH
Neisserial porins and antigen presenting cells
$687,504Lee Mark Wetzler · Boston Medical Center · R01 · FY2018 · AI