Sort
17,054 grants matching “genome editing”
CRISPR editing therapy for Duchenne muscular dystrophy
$552,403Dongsheng Duan · University Of Missouri-Columbia · R01 · FY2024 · NS
Systematic approaches to deciphering regulation and function of RNA editing in brain
$552,286Xinshu Grace Xiao · University Of California Los Angeles · R01 · FY2022 · MH
Small circular mRNA vaccines
$552,247Guizhi Zhu · Virginia Commonwealth University · R01 · FY2023 · AI
Small circular mRNA vaccines
$552,247Guizhi Zhu · Virginia Commonwealth University · R01 · FY2022 · AI
Project 1: Therapeutic Gene Editing for Spinal Muscular Atrophy (Trailblazer)
$552,158Mandana Arbab · Jackson Laboratory · U19 · FY2023 · NS
Mechanisms of epithelial repair and remodeling in pulmonary fibrosis
$552,067Jonathan Andrew Kropski · Vanderbilt University Medical Center · R01 · FY2021 · HL
Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma
$552,054Giannicola Genovese · University Of Tx Md Anderson Can Ctr · R01 · FY2023 · CA
Genotype-Phenotype Discordance in Long QT Syndrome
$551,886Isabelle Deschenes · Case Western Reserve University · R01 · FY2015 · HL
Genetic Determinants of Tumor Growth and Drug Sensitivity in EGFR Mutant Lung Cancer
$551,847Katerina Abigail Politi · Yale University · R01 · FY2025 · CA
Development and characterization of mouse models of RP59 DHDDS deficiency
$551,693Steven J Pittler · University Of Alabama At Birmingham · R01 · FY2019 · EY
The Investigation of disease causing genes in C. elegans
$551,605Andy Golden · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2017 · DK
Computational and experimental methods for scalable identification of oncogenic non-coding regions
$551,605Ekta Khurana · Weill Medical Coll Of Cornell Univ · R01 · FY2025 · CA
Cellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 Vif
$551,363Jeffrey R Johnson · Icahn School Of Medicine At Mount Sinai · R01 · FY2023 · AI
Cellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 Vif
$551,363Jeffrey R Johnson · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · AI
Cellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 Vif
$551,363Jeffrey R Johnson · Icahn School Of Medicine At Mount Sinai · R01 · FY2025 · AI
Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine Candidates
$551,244Amy Kristine Bei · Yale University · R01 · FY2025 · AI
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** TARGETED GENETIC MODIFICATIONS HAVE THE POTENTIAL TO CREATE NOVEL AGRICULTURAL PRODUCTS THAT ARE FREE OF FOREIGN DNA. MODIFICATIONS THAT INVOLVE A SINGLE MUTATION ARE EXEMPT FROM THE REGULATORY PROCESS APPLIED TO TRADITIONAL BIOENGINEERED CROPS. HOWEVER, MULTIPLE GENE COPIES OR MEMBERS OF A GENE FAMILY CONTRIBUTE TO MANY AGRONOMICALLY IMPORTANT PLANT PHENOTYPES. THEREFORE, A SINGLE MUTATION IS INSUFFICIENT TO INDUCE THE DESIRED PHENOTYPE. FOR FEDERAL REGULATORY AGENCIES TO MAKE SCIENCE-BASED DECISIONS, IT IS NECESSARY TO DETERMINE IF MODIFICATIONS OF MULTIPLE GENE COPIES OR GENE FAMILY MEMBERS POSE AN INCREASED RISK TO THE ENVIRONMENT OR HUMAN HEALTH. WE WILL INVESTIGATE THE POTENTIAL FOR UNINTENDED CHANGES DUE TO CRISPR/CAS9 MODIFICATION OF FIVE AGRONOMICALLY IMPORTANT GENE FAMILIES IN SOYBEAN WHERE MULTIPLE GENE COPIES MUST BE MODIFIED TO INDUCE A DESIRED PHENOTYPE. WE WILL USE LONG-READ DNA SEQUENCING TO CHARACTERIZE THE FULL GENOMIC COMPLEMENT OF THE FIVE GENE FAMILIES IN TWO SOYBEAN VARIETIES. CRISPR/CAS9 EDITS GENERATE DOUBLE-STRANDED BREAKS IN DNA THAT CAN INDUCE CHROMOSOMAL STRUCTURAL VARIANTS. THUS, WE WILL USE LONG-READ SEQUENCING TO DETECT STRUCTURAL AND NUCLEOTIDE SEQUENCE VARIANTS POTENTIALLY INDUCED BY CRISPR/CAS9 EDITS OF MULTIPLE LINKED AND DISPERSED COPIES OF GENE FAMILY MEMBERS. VISUAL COMPARISONS AND HYPERSPECTRAL ANALYSIS WILL BE USED TO IDENTIFY ANY UNINTENDED PHENOTYPIC CHANGES IN MODIFIED PLANTS. OUR DATA WILL INCREASE UNDERSTANDING OF THE ENVIRONMENTAL RISKS ASSOCIATED WITH CRISPR/CAS9-INDUCED CHANGES IN AN IMPORTANT CROP PLANT AND PROVIDE A CONTRAST WITH VARIATION INDUCED BY UNREGULATED PRACTICES SUCH AS CONVENTIONAL BREEDING AND MUTAGENESIS.
$551,099Regents Of The University Of Minnesota · · FY2023 · National Institute of Food and Agriculture
Mechanisms of epithelial repair and remodeling in pulmonary fibrosis
$550,929Jonathan Andrew Kropski · Vanderbilt University Medical Center · R01 · FY2022 · HL
TFIIH and Transcription Regulation
$550,878Dylan J Taatjes · University Of Colorado · R01 · FY2017 · GM
Mechanisms and functions of N6-methyladenosine (m6A) in cancer
$550,845Samie R Jaffrey · Weill Medical Coll Of Cornell Univ · R01 · FY2022 · CA
Mechanisms and functions of N6-methyladenosine (m6A) in cancer
$550,845Samie R Jaffrey · Weill Medical Coll Of Cornell Univ · R01 · FY2023 · CA
Tumor selective inhibition of the WNT pathway
$550,824Lukas Edward Dow · Weill Medical Coll Of Cornell Univ · R01 · FY2024 · CA
Mechanisms of epithelial repair and remodeling in pulmonary fibrosis
$550,656Jonathan Andrew Kropski · Vanderbilt University Medical Center · R01 · FY2023 · HL
Characterizing and testing the efficacy of AAV-mediated gene therapy in a sheep model of CLN1 disease.
$550,632Jonathan D Cooper · Washington University · R01 · FY2022 · NS
Project 2
$550,489Pradeep P.a. Mammen · Ut Southwestern Medical Center · P50 · FY2021 · HD