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23,748 grants matching “melanoma”
Cancer Cell Biology
$500,000Erwin G Van Meir · Emory University · P30 · FY2019 · CA
SPORE in Skin Cancer
$500,000John Munn Kirkwood · University Of Pittsburgh At Pittsburgh · P50 · FY2018 · CA
Phase2 trial of MEK162 & imatinib combined therapy in GIST, IND119794(09/20/2013)
$500,000Ping Chi · Sloan-Kettering Inst Can Research · R01 · FY2019 · FD
Phase2 trial of MEK162 & imatinib combined therapy in GIST, IND119794(09/20/2013)
$500,000Ping Chi · Sloan-Kettering Inst Can Research · R01 · FY2017 · FD
Research console for 4T imager
$500,000University Of Pennsylvania · S10 · FY2005 · RR
LTQ-Orbitrap Mass Spectrometer for Yale University Keck Laboratory
$500,000Erol E Gulcicek · Yale University · S10 · FY2008 · RR
Yale SPORE in Skin Cancer
$500,000Ruth Halaban · Yale University · P50 · FY2011 · CA
A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
$500,000Bryan R Haugen · University Of Colorado Denver · RC1 · FY2009 · CA
Targeting MCPyV to Overcome Immune Evasion in Merkel Cell Carcinoma
$500,000Paul Nghiem · University Of Washington · RC2 · FY2009 · CA
Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
$500,000Warren S Warren · Duke University · RC1 · FY2009 · CA
SPORE in Skin Cancer
$500,000Thomas S. Kupper · Brigham And Women'S Hospital · P50 · FY2006 · CA
Multifunctional Hollow Gold Nanospheres for Concurrent Photothermal-Chemotherapy
$500,000Y Andrew Wang · Ocean Nanotech, Llc · R44 · FY2016 · CA
DECREASED MALE FERTILITY IS A SIGNIFICANT PROBLEM IN CATTLE AND OTHER LIVESTOCK SPECIES. TO ADDRESS THIS PROBLEM, WE HAVE STUDIED THE BOVINE MALE SPECIFIC SEX CHROMOSOME - Y CHROMOSOME, AND IDENTIFIED A NOVEL GENE FAMILY, NAMED PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA, Y-LINKED (PRAMEY). COPY NUMBER VARIATION (CNV) OF PRAMEY HAS BEEN ASSOCIATED WITH BULL TESTIS SIZE, SEMEN QUALITY AND FERTILITY TRAITS. PRAMEY ENCODES A PROTEIN THAT IS HIGHLY EXPRESSED IN ALMOST ALL TYPES OF CANCER CELLS. HOWEVER, AMONG THE NON-TUMOR TISSUES, IT IS EXPRESSED IN THE TESTIS ONLY. PRAMEY IS BELIEVED TO PLAY A ROLE IN REPRODUCTION AND IMMUNE RESPONSE. THE MOLECULAR MECHANISM UNDERLYING THE FUNCTION OF PRAMEY IN REPRODUCTION IS STILL UNKNOWN. WE HYPOTHESIZE THAT PRAMEY INTERACTS WITH SIGNALING MOLECULES, INCLUDING THE PROTEIN PHOSPHATASE-1 GAMMA 2 (PP1Γ2), AND PLAYS AN ESSENTIAL ROLE IN SPERM FORMATION AND SPERM FUNCTION. THE OBJECTIVE OF THIS PROJECT IS TO DETERMINE THE ROLE OF PRAMEY IN SPERM FORMATION THROUGH TWO SPECIFIC AIMS: 1) TO DETERMINE THE ROLE OF PRAMEY IN ACROSOME FORMATION, AND 2) TO DETERMINE HOW PRAMEY REGULATES SPERM FUNCTION DURING FERTILIZATION. THE OUTCOMES OF THIS PROJECT WILL PROVIDE FUNDAMENTAL KNOWLEDGE OF THE ROLE OF THE PRAMEY GENE FAMILY DURING SPERMATOGENESIS AND FERTILIZATION, AND WILL HELP ANIMAL BREEDERS TO IMPROVE MALE FERTILITY BY IDENTIFYING HIGH-FERTILITY BULLS. THIS PROJECT IS HIGHLY INNOVATIVE, CRUCIAL AND SIGNIFICANT TO OUR UNDERSTANDING OF THE MOLECULAR MECHANISM UNDERLYING SPERM FORMATION AND SPERM FUNCTION. WE BELIEVE THAT THE OUTCOME OF THIS PROJECT HAS IMPORTANT IMPLICATIONS FOR REPRODUCTION OF CATTLE AND OTHER LIVESTOCK MAMMALS.
$500,000The Pennsylvania State University · · FY2018 · National Institute of Food and Agriculture
Clinical Trials and Information Management Support
$500,000Donald Stablein · The Emmes Company, Llc · N02 · FY2009 · CA
Targeting MCPyV to Overcome Immune Evasion in Merkel Cell Carcinoma
$500,000Paul Nghiem · University Of Washington · RC2 · FY2010 · CA
CAREER: Understanding the Molecular and Structural Composition of Aggressive Cancers using Deep Ultraviolet Spectroscopy and Imaging
$500,000Francisco E Robles · Georgia Tech Research Corporation · · FY2018 · ENG
Canine models for characterization, diagnosis, and treatment of human cancers using comparative canine-human transcriptomics
$500,000Gregory Tawa · National Center For Advancing Translational Sciences · ZIA · FY2022 · TR
Multifunctional Hollow Gold Nanospheres for Concurrent Photothermal-Chemotherapy
$500,000Y Andrew Wang · Ocean Nanotech, Llc · R44 · FY2015 · CA
Phase2 trial of MEK162 & imatinib combined therapy in GIST, IND119794(09/20/2013)
$500,000Ping Chi · Sloan-Kettering Inst Can Research · R01 · FY2018 · FD
HyperSense System for Molecular Imaging
$500,000Rahim R Rizi · University Of Pennsylvania · S10 · FY2009 · RR
Phase2 trial of MEK162 & imatinib combined therapy in GIST, IND119794(09/20/2013)
$500,000Ping Chi · Sloan-Kettering Inst Can Research · R01 · FY2020 · FD
Abramson Cancer Center Support Grant
$499,967Chi V. Dang · University Of Pennsylvania · P30 · FY2016 · CA
Detection of Prostate Cancer Genomic Signatures in Blood
$499,957Amin I Kassis · Harvard Medical School · RC1 · FY2009 · CA
A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
$499,914Bryan R Haugen · University Of Colorado Denver · RC1 · FY2010 · CA
Console for a 4.7 T small animal MRI system
$499,858Stephen B Pickup · University Of Pennsylvania · S10 · FY2008 · RR