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38,696 grants matching “als”
Nutiritional and Biochemical/Genetic Markers of Cancer
$737,484Jing Ma · Brigham And Women'S Hospital · R01 · FY2006 · CA
Point of care microfluidic diagnosis system for rapid and sensitive detection of
$737,477Michel G. Bergeron · Laval University · R01 · FY2013 · AI
Core 2: Structural Cell Biology (SCB) Core
$737,302Gregory L Hura · University Of Calif-Lawrenc Berkeley Lab · P01 · FY2022 · CA
Clinical Validation Center for Early Detection of Pancreatic Cancer
$737,111Anirban Maitra · University Of Tx Md Anderson Can Ctr · U01 · FY2022 · CA
JHU Center for Neuroscience Research
$736,986Alex L Kolodkin · Johns Hopkins University · P30 · FY2008 · NS
Trypanosome flagellum structure, assembly, and mechanism
$736,920Kent L Hill · University Of California Los Angeles · R01 · FY2025 · AI
The Cell Biology of Polarized Cells
$736,896Sharon Milgram · National Heart, Lung, And Blood Institute · ZIA · FY2010 · HL
Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseases
$736,876Michael Ombrello · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2016 · AR
Synaptic activity-driven Abeta generation and aggregation
$736,781John R Cirrito · Washington University · R01 · FY2024 · AG
Biology of the Eosinophilic Leukocyte
$736,753Helene Rosenberg · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
DYRK1A Inhibition as a Novel Treatment Approach for Alzheimer's Disease
$736,628Christopher Hulme · University Of Arizona · R01 · FY2024 · AG
Bio-monitoring Methylene Diphenyl Diisocyanate (MDI) exposure and body burden
$736,600Adam Wisnewski · L2 Diagnostics, Llc · R42 · FY2011 · ES
Loss of TDP-43 disrupts the prefrontal neural activity and circuitry: relevance for TDP-43 linked ADRD
$736,565Yun Li · University Of Wyoming · R01 · FY2025 · NS
CHILDHOOD ASTHMA: EARLY PREVENTION AND PHARMACOGENETICS
$736,539University Of Arizona · U10 · FY2001 · HL
Inflammation and Therapy for Respiratory Virus Infection
$736,532Helene Rosenberg · National Institute Of Allergy And Infectious Diseases · Z01 · FY2008 · AI
Developing novel strategies for personalized treatment and prevention of ALS: Leveraging the global exposome, genome, epigenome, metabolome, and inflammasome with data science in a case/control cohort
$736,527Eva L Feldman · University Of Michigan At Ann Arbor · R01 · FY2023 · NS
Collaborative Research: Plankton Community Structure and Iron Distribution in the Southern Drake Passage
$736,481Brian G Mitchell · University Of California-San Diego Scripps Inst Of Oceanography · · FY2003 · GEO
Transcriptional Regulation of Gene Expression
$736,398Alan G Hinnebusch · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2012 · HD
GENETIC TOXICOLOGY SUPPORT FOR THE NTP AND THE NIEHS
$736,330Leslie Recio · Integrated Laboratory Systems, Llc · N01 · FY2022 · ES
Nutritional and Biochemical/Genetic Markers of Cancer
$735,903Brigham And Women'S Hospital · R01 · FY2005 · CA
IMPACTS DUE TO NEAR-EARTH OBJECTS (NEOS) CAN HAVE A DEVASTATING EFFECT ON LIFE HERE ON THE EARTH. THE MOST RECENT TESTAMENT TO THIS IS THE CHELYABINSK METEOR WHICH ON FEBRUARY 15 2013 DISINTEGRATED IN AN AIRBURST WITH AN ENERGY OF ~ 500 KILOTONS OF TNT INJURING HUNDREDS OF PEOPLE AND CAUSING WIDESPREAD PROPERTY DAMAGE IN SEVERAL RUSSIAN CITIES. WHILE GROUND-BASED ASTEROID SURVEYS HAVE BEEN PROLIFIC IN FINDING NEW NEOS AND CREATING AN UP-TO-DATE INVENTORY PHYSICAL CHARACTERIZATION OF THESE OBJECTS HAS LAGGED BEHIND. THE GOAL OF THE PROPOSED RESEARCH IS TO CONTINUE OUR SURVEY OF PHYSICALLY CHARACTERIZING SMALL NEAR-EARTH ASTEROIDS (NEAS) (LESS THAN 150 METERS IN DIAMETER) TO CONSTRAIN THEIR SURFACE COMPOSITION ROTATION STATE ALBEDO AND SIZE. OUR SAMPLE POPULATION WOULD INCLUDE LOW-DELTA V TARGETS THAT ARE ACCESSIBLE TO FUTURE ROBOTIC AND HUMAN EXPLORATION. THE PROPOSED RESEARCH HAS THREE MAIN OBJECTIVES: 1) TO DETERMINE THE ROTATION STATE OF SMALL NEAS USING LIGHTCURVES FROM THE MORIS CAMERA ON 3.0-METER NASA INFRARED TELESCOPE FACILITY (IRTF). (TECHNIQUE: PHOTOMETRY; NO. OF OBJECTS: 144; V. MAGNITUDE LIMIT: BRIGHTER THAN 19.5) 2) TO COMPOSITIONALLY CHARACTERIZE SMALL NEAS I.E. DETERMINE MINERAL ABUNDANCES AND CHEMISTRY AND FIND METEORITE ANALOGS USING SPECTRAL DATA FROM THE SPEX INSTRUMENT ON THE NASA IRTF. (TECHNIQUE: SPECTROSCOPY; WAVELENGTH: 0.7-2.5 MICRONS; NO. OF OBJECTS: 144; V. MAGNITUDE LIMIT: BRIGHTER THAN 19.5) 3) TO PHYSICALLY CHARACTERIZE SMALL NEAS AND CONSTRAIN THEIR ALBEDO AND DIAMETER USING SPECTRAL DATA FROM THE SPEX INSTRUMENT ON THE NASA IRTF (TECHNIQUE: THERMAL MODELING; WAVELENGTH: 2.0-2.5 MICRONS; NO. OF OBJECTS: 40-50; V. MAGNITUDE LIMIT: BRIGHTER THAN 18.0). OUR PROPOSED RESEARCH EFFORT (OBJECTIVE 1) WILL INCREASE THE NUMBER OF OBJECTS THAT HAVE ACCURATE ROTATION PERIODS IN THIS SIZE RANGE BY 50% COMPARED TO EXISTING STUDIES (E.G. STATLER ET AL. 2013; WARNER PERS. COMM.) AND A FIVE-FOLD INCREASE IN THE NUMBER OF SMALL NEAS WITH ACCURATE SURFACE COMPOSITION ALBEDO AND METEORITE ANALOGS (OBJECTIVES 2 AND 3). THE PHASE A OF THE SURVEY THAT IS CURRENTLY IN PROGRESS (ENDING IN JUNE 2017) WOULD CHARACTERIZE 95 OF OUR 239-OBJECT SAMPLE SIZE AND WE ARE REQUESTING FIVE ADDITIONAL YEARS OF FUNDING TO OBTAIN ROTATIONAL PERIOD AND COMPOSITION OF THE REMAINING 144 OBJECTS (32 NEOS/ YEAR) . WE USED THE METHOD BY COCHRAN (1963) TO ESTIMATE THE NUMBER OF NEAS THAT NEED TO BE OBSERVED IN THIS SIZE RANGE (ABSOLUTE MAGNITUDE H GREATER THAN 20) TO OBTAIN A STATISTICALLY SIGNIFICANT RESULT WITH ~95 PERCENT CONFIDENCE LEVEL. THE PROPOSED RESEARCH WORK WILL INVOLVE OBSERVING NEAS USING GROUND-BASED TELESCOPES TO OBTAIN PHOTOMETRIC AND SPECTROSCOPIC DATA. ALL OBSERVATIONS WILL BE MADE REMOTELY AND NO FUNDING IS BEING REQUESTED FOR TRAVEL TO OBSERVING SITES. THE PI AND HIS TEAM HAVE MORE THAN A DECADE OF A SUCCESSFUL TRACK RECORD OBSERVING AND CHARACTERIZING NEAS WITH THE NASA IRTF. THE PHOTOMETRIC DATA WILL BE REDUCED AND ANALYZED USING AN IDL-BASED CODE AND SPECTROSCOPIC DATA WILL BE REDUCED AND ANALYZED USING THE SPEXTOOLS PACKAGE. THE RESULTING DATA PRODUCTS WILL BE ARCHIVED ON THE PDS SMALL BODIES NODE AND THE RESULTS WILL BE PUBLISHED AS DPS CONFERENCE ABSTRACTS AND PAPERS IN PEER-REVIEWED JOURNALS (ICARUS/APJ). THE PROPOSED RESEARCH IS RELEVANT TO NEOO PROGRAM GOAL OF MEASURING THE SIZES AND COMPOSITION OF A REPRESENTATIVE SAMPLE OF NEOS (ROSES 2016 SECTION C.6.1.2). IN ADDITION OUR INVESTIGATION WOULD FULLY CHARACTERIZE THE NEAS THAT ARE IN LOW-DELTA VELOCITY ORBITS RELATIVE TO EARTH FOR FUTURE ROBOTIC AND HUMAN MISSIONS WHICH IS OF INTEREST TO NEOO PROGRAM.
$735,611University Of Arizona · · FY2017 · National Aeronautics and Space Administration
Pathways and itinerary of clathrin-independent endocytosis
$735,523Julie G. Donaldson · National Heart, Lung, And Blood Institute · ZIA · FY2016 · HL
Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland
$735,480Helen P. Makarenkova · Scripps Research Institute, The · R01 · FY2024 · EY
Clinical Diagnostic Sequencing of Structural Variation
$735,439Michael E Talkowski · Massachusetts General Hospital · R01 · FY2015 · HD
A prospective study of CFS following infectious mononucleosis in college students
$735,377Ben Z. Katz · Lurie Children'S Hospital Of Chicago · R01 · FY2016 · AI