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38,696 grants matching “als”
Core 2: Structural Cell Biology (SCB) Core
$746,099Gregory L Hura · University Of Calif-Lawrenc Berkeley Lab · P01 · FY2023 · CA
Mechanism of repeat expansion and chromosome fragility in Fragile X syndrome
$745,983Karen P. Usdin · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2016 · DK
Clinical feasibility study of autonomous tibial nerve stimulator for overactive bladder
$745,854Peter Jacobson · Nine Continents Medical, Inc. · R44 · FY2020 · DK
Brain Imaging And Modeling
$745,749Barry Horwitz · National Institute On Deafness And Other Communication Disorders · ZIA · FY2016 · DC
Individual Differences in Learning Potential for Language and Literacy
$745,636David Braze · Haskins Laboratories, Inc. · R01 · FY2013 · HD
PI: DOUGLAS MATSON/TUFTS UNIVERSITY"LEVITATION OBSERVATION OF DENDRITE EVOLUTION IN STEEL TERNARY AL
$745,596Trustees Of Tufts College · · FY2008 · National Aeronautics and Space Administration
Mechanisms of pain and placebo analgesia
$745,520Christian Grillon · National Center For Complementary & Integrative Health · ZIA · FY2012 · AT
Probing The Dark Matter of the Genome in the NHLBI Family Heart Study
$745,519Michael A Province · Washington University · R01 · FY2016 · HL
PET Imaging Agents for the in vivo Detection of TDP-43
$745,412Allen Bernard Reitz · Fox Chase Chemical Diversity Center, Inc · R44 · FY2017 · AG
Development Of Advanced Computer Hardware And Software
$745,223Bernard R Brooks · National Heart, Lung, And Blood Institute · ZIH · FY2023 · HL
Target Engagement Biomarkers for Alzheimer's Therapeutics
$745,159Susan M Catalano · Cognition Therapeutics, Inc. · R44 · FY2017 · AG
Core 2: Structural Cell Biology (SCB) Core
$745,064Gregory L Hura · University Of Calif-Lawrenc Berkeley Lab · P01 · FY2021 · CA
Fluorescence Microscopy
$744,972James W Putney · National Institute Of Environmental Health Sciences · ZIA · FY2009 · ES
Effectiveness of Suicide Hotline Training
$744,865Madelyn S Gould · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · R01 · FY2010 · MH
CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS
$744,861Michael G Marmot · University College London · R37 · FY2007 · AG
DYRK1A Inhibition as a Novel Treatment Approach for Alzheimer's Disease
$744,799Christopher Hulme · University Of Arizona · R01 · FY2023 · AG
Development of an integrated 4-organ animal model
$744,745Michael L Shuler · Hesperos, Llc · R44 · FY2019 · ES
Development of an integrated 4-organ animal model
$744,745Michael L Shuler · Hesperos, Llc · R44 · FY2020 · ES
Post-transcriptional regulation of energy usage: glucose and lipid metabolism
$744,680Myriam Gorospe · National Institute On Aging · ZIA · FY2014 · AG
Pre-clinical Commercialization of a Synthetically Designed, Live-attenuated RSV Vaccine
$744,622Steffen Mueller · Codagenix, Inc. · R44 · FY2018 · AI
Genetics of childhood-onset hypertension
$744,476Neil Hanchard · National Human Genome Research Institute · ZIA · FY2025 · HG
Role of myosin 1c in adaptation in the inner ear
$744,475Lynne M Coluccio · Boston Biomedical Research Institute · R01 · FY2009 · DC
GENOMIC ANALYSIS OF MEDULLOBLASTOMAS
$744,419Scott Loren Pomeroy · Boston Children'S Hospital · R01 · FY2008 · CA
G-protein Coupled Receptor Mediated Chemoattractant Sensing and Phagocytosis
$744,410Tian Jin · Niaid Extramural Activities · Z01 · FY2007 · AI
WE PROPOSE TO CONTINUE OUR ASTROMETRY OF NEOS WITH COMPETITIVELY-ALLOCATED TELESCOPES LARGER THAN 2 METERS IN DIAMETER TO HELP IMPROVE THE ACCURACY OF PREDICTIONS OF CLOSE APPROACHES AND TO PREVENT OTHER NEOS OF SCIENTIFIC INTEREST FROM BECOMING LOST. THE MINOR PLANET CENTER (MPC) HAS RECENTLY REINFORCED OUR ARGUMENT THAT FRESHLY DISCOVERED NEOS NEED TO BE FOLLOWED IMMEDIATELY AFTER THEIR DISCOVERIES (GALACHE ET AL. 2015). LONG INTERVALS BETWEEN APPARITIONS MAKE PREDICTIONS OF POSITION LESS ACCURATE AND OBJECTS TEND TO BE FAINTER DURING RETURN APPARITIONS THAN THEY WERE WHEN DISCOVERED DECREASING THE CHANCES THAT OBJECTS CAN BE RECOVERED. FOLLOWUP FOR MORE PROLONGED INTERVALS IMMEDIATELY AFTER DISCOVERY ARE ESPECIALLY NEEDED FOR CLOSELY-APPROACHING NEOS TO BE RECOVERABLE ON SUBSEQUENT APPARITIONS. BUT SUCH NEOS GET FAINTER BY 2-5 MAGS WITHIN DAYS AFTER THEIR ENCOUNTERS WITH EARTH. SO TARGETED FOLLOWUP OBSERVATIONS WITH LONGER EXPOSURE TIMES AND LARGER TELESCOPES ARE NEEDED TO FOLLOW THEM AT LEAST UNTIL THEY ARE A COUPLE OF HILL RADII FROM EARTH (~0.02 AU). THERE THE OBJECTS' TRAJECTORIES RECEDE OUT OF THEIR TEMPORARY HYPERBOLIC PATHS WITH RESPECT TO EARTH AND THE SUN'S GRAVITY RESUMES BEING THE DOMINANT EFFECT ON THEIR MOTION. AT THAT DISTANCE THE OBSERVATIONS CONSEQUENTLY PROVIDE MORE LEVERAGE ON THE DETERMINATION OF THE NEW POST-ENCOUNTER HELIOCENTRIC ORBITAL ELEMENTS WHICH ARE NEEDED TO PREDICT RETURN APPARITIONS. THE BOK 2.3-METER OF STEWARD OBSERVATORY ON KITT PEAK AND OTHER TELESCOPES WILL BE USED TO RECOVER AND DO ASTROMETRY OF HIGHPRIORITY NEOS THAT ARE TOO FAINT FOR SMALLER TELESCOPES. SOME TARGETS WILL BE SMALL FAST-MOVING CLOSE APPROACHERS AMONG WHICH CAN BE OBJECTS WITH FUTURE VIRTUAL IMPACT (VI) ORBIT SOLUTIONS AND OBJECTS THAT MAY BE THE SCIENTIFICALLY INTERESTING MONOLITHIC ROCKS WITHOUT REGOLITH. OUR OBSERVATIONS CONTRIBUTE TO THE REMOVAL OF HALF OF THE VIS THAT ARE RETIRED FROM THE IMPACT RISK LISTS. OTHER PRIORITIES FOR RECOVERY DURING OBJECTS' LATER APPARITIONS ARE FUTURE TARGETS OF RADAR NEOS FOR WHICH ALBEDOS TAXONOMIC CLASSES OR DIAMETERS HAVE BEEN DETERMINED AND POTENTIAL DESTINATIONS FOR SPACECRAFT. WE REPORT OUR OBSERVATIONS PROMPTLY TO THE MPC WHO USES OUR MEASUREMENTS TO UPDATE THEIR ORBITAL ELEMENTS. OUR PAST USE OF THE BOK AND MAYALL TELESCOPES HAS BEEN DETERMINED BY THE MPC TO PROVIDE "DRAMATIC IMPROVEMENT" TO ORBITS (T. SPAHR AND G. WILLIAMS 2014 PRIVATE COMMUNICATIONS). OUR OBSERVATIONS DECREASED FUTURE EPHEMERIS UNCERTAINTIES AN AVERAGE OF A FACTOR OF 5 AND IN SEVERAL CASES THE FUTURE EPHEMERIS UNCERTAINTY WAS REDUCED BY TWO ORDERS OF MAGNITUDE. FOR HALF OF THE POTENTIALLY HAZARDOUS ASTEROIDS (PHAS) WE OBSERVED WE ADDED ANOTHER OBSERVED OPPOSITION. WE EXTENDED THE CALENDAR SPAN OF OBSERVATIONS AN AVERAGE OF A FACTOR OF 3.8 AND REDUCED UNCERTAINTIES OF ORBITAL ELEMENTS BY AN AVERAGE OF A FACTOR OF 6. THE LEAST CONSTRAINED ORBITAL ELEMENT TENDS TO BE THE TIME OF PERIHELION PASSAGE. WE REDUCED ITS UNCERTAINTY AN AVERAGE OF A FACTOR OF 19. ALSO NUGENT ET AL. (2015) ILLUSTRATED OUR PREEMINENCE AS A PROMPT FOLLOWER-UP OF NEOS DISCOVERED BY THE NEOWISE SPACECRAFT. WITH OUR USE OF LARGER TELESCOPES SINCE 2010 JAN. WE HAVE PROVIDED 2510 LINES OF ASTROMETRY OF 427 DIFFERENT NEOS CAREFULLY SELECTED FOR SCIENTIFIC PRIORITY AND POTENTIAL CLOSE APPROACHES. (OTHER GRANTS SUPPORT OUR USE OF OUR TWO SMALLER TELESCOPES.) IN OCTOBER 2015 WE BOOSTED BOTH THE SPEED AND THE QUANTITY OF OUR OUTPUT WITH THE BOK 2.3-M BY USING OUR NEW CCD CAMERA ALONG WITH OUR OWN NEAR-REAL-TIME DATA PIPELINE SOFTWARE. COMPARED TO OUR AVERAGE OUTPUT IN OCT-DEC OF 2011-2014 WE ARE NOW OBSERVING HALF AGAIN AS MANY PHAS. SALARY SUPPORT FROM THIS NEWLY PROPOSED GRANT ALONG WITH STREAMLINING OPERATION OF THE BOK TELESCOPE AND ROUTINE COMPUTER UPGRADES WILL ALLOW THREE MORE YEARS OF OBSERVATIONS CALLED FOR BY THE INCREASING RATE OF DISCOVERY OF NEOS BY THE SURVEYS.
$744,407University Of Arizona · · FY2020 · National Aeronautics and Space Administration