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38,696 grants matching “als”
Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's Disease
$750,835Thomas Spurgeon Wingo · Emory University · R01 · FY2023 · AG
Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's Disease
$750,835Thomas Spurgeon Wingo · Emory University · R01 · FY2024 · AG
NOVEL CAS9/GRNA RIBONUCLEOPROTEIN BIONANOPARTICLES FOR SAFE AND EFFICIENT INACTIVATION OF ALS DISEASE-CAUSING MUTATIONS
$750,798Wake Forest University Health Sciences · · FY2020 · Defense Health Agency
Suicide Prevention with Substance Using Youth Experiencing Homelessness
$750,722Natasha Slesnick · Ohio State University · R01 · FY2024 · DA
Omics, mice and men: Development of precision transfusion medicine
$750,647Mark Thomas Gladwin · University Of Maryland Baltimore · R01 · FY2024 · HL
Brain Bank Core
$750,617Ann Carolyn McKee · Boston University Medical Campus · U54 · FY2019 · NS
Project 3
$750,394J. Victor Garcia-Martinez · University Of Alabama At Birmingham · P01 · FY2025 · AI
Aging and rejuvenation: An ant model to study the regulation of longevity
$750,364Claude Desplan · New York University · R01 · FY2025 · AG
Retroviral Replication and Interactions with Host Factors
$750,316Vinay K. Pathak · Division Of Basic Sciences - Nci · ZIA · FY2018 · CA
Understanding Immune Evasion by HIV-1 Repliclones
$750,243Elias K. Halvas · University Of Pittsburgh At Pittsburgh · R01 · FY2021 · AI
Mechanisms of Cross-talk Between EphrinB and Alternate Signaling Pathways
$750,182Ira Daar · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Dementia and Psychiatric Disorders in Assisted Living
$750,007Adam Rosenblatt · Johns Hopkins University · R01 · FY2007 · MH
DMREF/Collaborative Research: High-Throughput Discovery, Development, and Demonstration of Material Systems to Enable Low-Power NEMS-Based Computation
$750,001Maarten P De Boer · Carnegie Mellon University · · FY2013 · ENG
SBIR Phase II: Novel High-Temperature Molybdenum Alumino-Silicide Heating Elements for Advanced Manufacturing Processes
$750,000Srinivas Penumella · Micropyretics Heaters Intl Inc · · FY2000 · TIP
Health Promotion and Disease Prevention Research Centers
$750,000Marc A Zimmerman · University Of Michigan At Ann Arbor · U48 · FY2023 · DP
Enhancement of User Access at the ALS -- Additional Support
$750,000National Institute Of General Medical Sciences · Y01 · FY2014 · GM
Noninvasive Brain Stimulation for Treating Addiction
$750,000Timothy Andrew Wagner · Highland Instruments, Inc. · R44 · FY2023 · DA
Interactive Telehealth and Auto-Biofeedback Sensor System for Individuals Who Use a Wheelchair
$750,000Joseph T Gwin · Biosensics, Llc · R44 · FY2017 · AG
SenSE: Smart Electropalatography for Linguistic and Medical Applications (SELMA)
$750,000Yong-Kyu Yoon · University Of Florida · · FY2020 · ENG
Noninvasive Brain Stimulation for Treating Addiction
$750,000Timothy Andrew Wagner · Highland Instruments, Inc. · R44 · FY2022 · DA
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BACKGROUND. PER- AND POLYFLUOROALKYL SUBSTANCES (PFASS) HAVE BEEN FREQUENTLY FOUND IN AGRICULTURAL IRRIGATION WATER AND SOILS. IRRIGATION WITH PFASS-CONTAMINATED WATER COULD CAUSE THE ACCUMULATION OF PFASS IN FIELD CROPS DURING PLANT GROWTH. THE SUBSEQUENT DIETARY CONSUMPTION OF PFASS-TAINTED AGRICULTURAL PRODUCT COULD IMPACT HUMAN AND ANIMAL HEALTH. HUMAN CONSUMPTION OF CROPS/VEGETABLES SHOULD BE CONSIDERED AN IMPORTANT EXPOSURE PATHWAY TO PFASS, WHICH IS COMPARABLE (IF NOT MORE IMPORTANT THAN) TO THE DRINKING WATER EXPOSURE PATHWAY. THEREFORE, IN ORDER TO IMPROVE FOOD SAFETY AND HUMAN HEALTH WHILE MAINTAINING THE PROFITABILITY OF AGRICULTURAL PRODUCTION, EFFECTIVE AND LOW-COST SOIL MANAGEMENT STRATEGIES ARE CRITICALLY NEEDED TO MITIGATE THE TRANSFER OF PFASS FROM AGRICULTURAL IRRIGATION WATER TO FRESH PRODUCE.GOAL AND HYPOTHESIS. THE OVERARCHING GOAL OF THIS PROJECT IS TO DEVELOP PRAGMATIC MANAGEMENT PRACTICES THAT CAN IMMOBILIZE PFASS IN SOILS, REDUCE THEIR BIOAVAILABILITY TO PLANTROOT UPTAKE, AND MITIGATE THEIR ACCUMULATION IN AGRICULTURAL PRODUCE. IRRIGATION WITH PFASS-CONTAMINATED WATER INTRODUCES PFASS INTO SOILS, TRANSPORT WITH WATER TO PLANT ROOT ZONE, AND ACCUMULATE IN AGRICULTURAL CROPS GROWN IN THE SOILS. IN THIS PROJECT, WE PROPOSE TO ELUCIDATE THE FATE AND TRANSPORT OF PFASS IN SOIL-WATER-PLANT SYSTEMS, AND INVESTIGATE THE FEASIBILITY TO INTERFERE WITH THE TRANSPORT OF PFASS TO FOOD CROPS USING SORBENT AMENDMENTS. THE CENTRAL HYPOTHESIS IS THAT SOIL PORE WATER IS THE MAJOR CARRIER BY WHICH PFASS ARE MOVED FROM SOIL TO PLANT ROOT ZONES. SORBENT AMENDMENTS COULD EFFECTIVELY IMMOBILIZE PFASS IN SOILS AND REDUCE THEIR BIOAVAILABLE FRACTIONS TO PLANT ROOT UPTAKE.SPECIFIC OBJECTIVES. (1) EVALUATE PFASS SORPTION, TRANSPORT AND IMMOBILIZATION IN SOILS AMENDED WITH LAYERED DOUBLE HYDROXIDE (LDH) AND AL-, FE-MODIFIED BIOCHARS. (2) DETERMINE THE BIOAVAILABILITY OF PFASS TO PLANT UPTAKE FROM SOILS AMENDED WITH LDH AND MODIFIED BIOCHARS. (3) VALIDATE THE TO-BE-DEVELOPED MANAGEMENT TO MITIGATE THE ACCUMULATION OF PFASS IN FIELD CROPS.APPROACHES. WE WILL INTEGRATE LABORATORY EXPERIMENTS OF PFASS SORPTION AND TRANSPORT IN SOILS, GREENHOUSE POT EXPERIMENTS AND FIELD PLOT TRIALS OF PLANT UPTAKE OF PFASS, AND ADVANCED LC-MS/MS ANALYSIS THAT CAN QUANTIFY PFASS AT ENVIRONMENTALLY RELEVANT CONCENTRATIONS TO UNDERSTAND THE MECHANISTIC DETERMINANTS OF PFASS MOVEMENT FROM SOIL TO PLANT. PFASS SORPTION BY SOILS, PLANT PHYSIOLOGICAL ACTIVITIES AND SOIL PORE WATER MOVEMENT ARE THE CRITICAL PROCESSES THAT WILL BE STUDIED FOR THEIR IMPACTS TO UPTAKE AND ACCUMULATION OF PFASS IN CROPS. WE WILL EXAMINE WHETHER PFASS CONCENTRATION IN SOIL PORE WATER COULD BE SIGNIFICANTLY REDUCED IN THE PRESENCE SOIL AMENDMENTS LDH AND AL- FE-MODIFIED BIOCHARS, AND WHETHER THIS APPROACH COULD EFFECTIVELY LEAD TO THE MITIGATION OF PFASS UPTAKE AND ACCUMULATION IN FIELD CROPS.EXPECTED OUTCOME AND POTENTIAL IMPACTS. THIS PROJECT WILL ADVANCE THE MECHANISTIC KNOWLEDGE ON PFASS INTERACTION WITH SOILS, LDH AND BIOCHARS, TRANSPORT FROM SOILS TO PLANT, AND PLANT ACCUMULATION RELATED TO PFASS PROPERTIES AND PLANT PHYSIOLOGICAL ACTIVITIES. THESE INDIVIDUAL PROCESSES WILL BE INTEGRATED TO EVALUATE AND MODEL THE FATE AND TRANSPORT OF PFASS IN SOIL-WATER-PLANT SYSTEMS. THE RESULTS WILL PROVIDE THE FOUNDATION ON USING LDH AND MODIFIED BIOCHARS AS SORBENT AMENDMENT TO IMMOBILIZE PFASS IN SOILS WHILE MITIGATING THE ACCUMULATION OF PFASS IN AGRICULTURAL CROPS. THE RESULTS WILL PROVIDE GUIDELINE FOR GENERATING SCIENCE-INFORMED MANAGEMENT PRACTICES WITH RESPECT TO SORBENT AMENDMENT, AND IRRIGATION WITH PFASS-CONTAMINATED WATER. THESE OUTCOMES WILL LEAD TO ACTIONABLE SOLUTIONS THAT ENSURE THE SUSTAINABLE AGRICULTURAL ENVIRONMENT AND SAFE FOOD PRODUCTION.
$750,000Michigan State University · · FY2022 · National Institute of Food and Agriculture
Prevention Research Center of Michigan
$749,991Marc A Zimmerman · University Of Michigan At Ann Arbor · U48 · FY2021 · DP
Prevention Research Center of Michigan
$749,986Marc A Zimmerman · University Of Michigan At Ann Arbor · U48 · FY2019 · DP
Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce
$749,933Sheryl Zimmerman · Univ Of North Carolina Chapel Hill · R01 · FY2023 · AG
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
$749,922Don W. Cleveland · University Of California, San Diego · R01 · FY2025 · NS